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Protein

Dolichyldiphosphatase 1

Gene

Dolpp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.1 Publication

Catalytic activityi

Dolichyl diphosphate + H2O = dolichyl phosphate + phosphate.1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • dolichyldiphosphatase activity Source: UniProtKB

GO - Biological processi

  • lipid biosynthetic process Source: GO_Central
  • protein N-linked glycosylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.6.1.43. 3474.
ReactomeiR-MMU-446199. Synthesis of Dolichyl-phosphate.
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichyldiphosphatase 1 (EC:3.6.1.43)
Alternative name(s):
Dolichyl pyrophosphate phosphatase 1
Protein 2-23
Gene namesi
Name:Dolpp1
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914093. Dolpp1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei130 – 15021HelicalSequence analysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of endoplasmic reticulum membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Dolichyldiphosphatase 1PRO_0000215627Add
BLAST

Proteomic databases

MaxQBiQ9JMF7.
PaxDbiQ9JMF7.
PeptideAtlasiQ9JMF7.
PRIDEiQ9JMF7.

Expressioni

Tissue specificityi

Widely expressed with highest levels in brain, kidney, lung and intestine.1 Publication

Gene expression databases

BgeeiENSMUSG00000026856.
CleanExiMM_DOLPP1.
ExpressionAtlasiQ9JMF7. baseline and differential.
GenevisibleiQ9JMF7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028209.

Structurei

3D structure databases

ProteinModelPortaliQ9JMF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dolichyldiphosphatase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3146. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00390000013112.
HOGENOMiHOG000201506.
HOVERGENiHBG051392.
InParanoidiQ9JMF7.
KOiK07252.
OMAiLWFEYTN.
OrthoDBiEOG091G0P7L.
PhylomeDBiQ9JMF7.
TreeFamiTF323451.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JMF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADGQCSLP ASWRPVTLTH VEYPAGDLSG HLLAYLSLSP IFVVVGFLTL
60 70 80 90 100
IIFKRELHTI SFLGGLALNQ GVNWLIKHVI QEPRPCGGPH TAVGTKYGMP
110 120 130 140 150
SSHSQFMWFF SVYSFLFLYL RMHQTNNARF LDLLWRHVLS LGLLTAAFLV
160 170 180 190 200
SYSRVYLLYH TWSQVFYGGV AGSLMAVAWF IITQEILTPL FPRIAAWPIS
210 220 230
EFFLIRDTSL IPNVLWFEYT VTRAEARNRQ RKLGTKLQ
Length:238
Mass (Da):27,099
Last modified:October 1, 2000 - v1
Checksum:i64E5E3165FC8BDBB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931V → A in AAH26544 (PubMed:15489334).Curated
Sequence conflicti174 – 1741L → S in BAB27187 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030189 mRNA. Translation: BAA92753.1.
AK002544 mRNA. Translation: BAC24998.1. Sequence problems.
AK010797 mRNA. Translation: BAB27187.1.
AK044141 mRNA. Translation: BAC31797.1.
AK053923 mRNA. Translation: BAC35595.1.
BC026544 mRNA. Translation: AAH26544.1.
CCDSiCCDS15881.1.
RefSeqiNP_001277437.1. NM_001290508.1.
NP_001277438.1. NM_001290509.1.
NP_065062.1. NM_020329.4.
XP_006498270.1. XM_006498207.2.
UniGeneiMm.285167.

Genome annotation databases

EnsembliENSMUST00000028209; ENSMUSP00000028209; ENSMUSG00000026856.
GeneIDi57170.
KEGGimmu:57170.
UCSCiuc008jci.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030189 mRNA. Translation: BAA92753.1.
AK002544 mRNA. Translation: BAC24998.1. Sequence problems.
AK010797 mRNA. Translation: BAB27187.1.
AK044141 mRNA. Translation: BAC31797.1.
AK053923 mRNA. Translation: BAC35595.1.
BC026544 mRNA. Translation: AAH26544.1.
CCDSiCCDS15881.1.
RefSeqiNP_001277437.1. NM_001290508.1.
NP_001277438.1. NM_001290509.1.
NP_065062.1. NM_020329.4.
XP_006498270.1. XM_006498207.2.
UniGeneiMm.285167.

3D structure databases

ProteinModelPortaliQ9JMF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028209.

Proteomic databases

MaxQBiQ9JMF7.
PaxDbiQ9JMF7.
PeptideAtlasiQ9JMF7.
PRIDEiQ9JMF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028209; ENSMUSP00000028209; ENSMUSG00000026856.
GeneIDi57170.
KEGGimmu:57170.
UCSCiuc008jci.2. mouse.

Organism-specific databases

CTDi57171.
MGIiMGI:1914093. Dolpp1.

Phylogenomic databases

eggNOGiKOG3146. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00390000013112.
HOGENOMiHOG000201506.
HOVERGENiHBG051392.
InParanoidiQ9JMF7.
KOiK07252.
OMAiLWFEYTN.
OrthoDBiEOG091G0P7L.
PhylomeDBiQ9JMF7.
TreeFamiTF323451.

Enzyme and pathway databases

UniPathwayiUPA00378.
BRENDAi3.6.1.43. 3474.
ReactomeiR-MMU-446199. Synthesis of Dolichyl-phosphate.

Miscellaneous databases

ChiTaRSiDolpp1. mouse.
PROiQ9JMF7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026856.
CleanExiMM_DOLPP1.
ExpressionAtlasiQ9JMF7. baseline and differential.
GenevisibleiQ9JMF7. MM.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDOPP1_MOUSE
AccessioniPrimary (citable) accession number: Q9JMF7
Secondary accession number(s): Q8BN02, Q8R0P7, Q9CRF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.