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Q9JMF3

- GBG13_MOUSE

UniProt

Q9JMF3 - GBG13_MOUSE

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Protein
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
Gene
Gng13
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. G-protein beta-subunit binding Source: UniProt
  2. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
  2. sensory perception of taste Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
Gene namesi
Name:Gng13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1925616. Gng13.

Subcellular locationi

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: MGI
  2. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6464Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
PRO_0000012673Add
BLAST
Propeptidei65 – 673Removed in mature form By similarity
PRO_0000012674

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641Cysteine methyl ester By similarity
Lipidationi64 – 641S-farnesyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ9JMF3.
PaxDbiQ9JMF3.
PRIDEiQ9JMF3.

Expressioni

Gene expression databases

BgeeiQ9JMF3.
GenevestigatoriQ9JMF3.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

DIPiDIP-46321N.
IntActiQ9JMF3. 1 interaction.
STRINGi10090.ENSMUSP00000110760.

Structurei

3D structure databases

ProteinModelPortaliQ9JMF3.
SMRiQ9JMF3. Positions 8-57.

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.

Phylogenomic databases

eggNOGiNOG293449.
GeneTreeiENSGT00530000064157.
HOVERGENiHBG098057.
InParanoidiQ9JMF3.
KOiK04547.
OMAiYAIESEH.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ9JMF3.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
[Graphical view]
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JMF3-1 [UniParc]FASTAAdd to Basket

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MEEWDVPQMK KEVESLKYQL AFKREMSSKT IPELLKWIED GIPKDPFLNP   50
DLMKNNPWVE KAKCTIL 67
Length:67
Mass (Da):7,979
Last modified:October 1, 2000 - v1
Checksum:i1FB8D74EB5CE50F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY029485 mRNA. Translation: AAK40268.1.
AB030194 mRNA. Translation: BAA92757.1.
AK018778 mRNA. Translation: BAB31403.1.
BC048431 mRNA. Translation: AAH48431.1.
BC059712 mRNA. Translation: AAH59712.1.
CCDSiCCDS37503.1.
RefSeqiNP_071867.1. NM_022422.5.
XP_006524842.1. XM_006524779.1.
UniGeneiMm.171123.

Genome annotation databases

EnsembliENSMUST00000115108; ENSMUSP00000110760; ENSMUSG00000025739.
ENSMUST00000172002; ENSMUSP00000131648; ENSMUSG00000025739.
GeneIDi64337.
KEGGimmu:64337.
UCSCiuc008bbi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY029485 mRNA. Translation: AAK40268.1 .
AB030194 mRNA. Translation: BAA92757.1 .
AK018778 mRNA. Translation: BAB31403.1 .
BC048431 mRNA. Translation: AAH48431.1 .
BC059712 mRNA. Translation: AAH59712.1 .
CCDSi CCDS37503.1.
RefSeqi NP_071867.1. NM_022422.5.
XP_006524842.1. XM_006524779.1.
UniGenei Mm.171123.

3D structure databases

ProteinModelPortali Q9JMF3.
SMRi Q9JMF3. Positions 8-57.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-46321N.
IntActi Q9JMF3. 1 interaction.
STRINGi 10090.ENSMUSP00000110760.

Proteomic databases

MaxQBi Q9JMF3.
PaxDbi Q9JMF3.
PRIDEi Q9JMF3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000115108 ; ENSMUSP00000110760 ; ENSMUSG00000025739 .
ENSMUST00000172002 ; ENSMUSP00000131648 ; ENSMUSG00000025739 .
GeneIDi 64337.
KEGGi mmu:64337.
UCSCi uc008bbi.2. mouse.

Organism-specific databases

CTDi 51764.
MGIi MGI:1925616. Gng13.

Phylogenomic databases

eggNOGi NOG293449.
GeneTreei ENSGT00530000064157.
HOVERGENi HBG098057.
InParanoidi Q9JMF3.
KOi K04547.
OMAi YAIESEH.
OrthoDBi EOG7H1JP7.
PhylomeDBi Q9JMF3.
TreeFami TF319909.

Enzyme and pathway databases

Reactomei REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.

Miscellaneous databases

NextBioi 320031.
PROi Q9JMF3.
SOURCEi Search...

Gene expression databases

Bgeei Q9JMF3.
Genevestigatori Q9JMF3.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
[Graphical view ]
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium."
    Huang L., Shanker Y.G., Dubauskaite J., Zheng J.Z., Yan W., Rosenzweig S., Spielman A.I., Max M., Margolskee R.F.
    Nat. Neurosci. 2:1055-1062(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains."
    Inoue S., Sano H., Ohta M.
    Biochem. Biophys. Res. Commun. 268:553-561(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGBG13_MOUSE
AccessioniPrimary (citable) accession number: Q9JMF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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