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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

Gene

Gng13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. G-protein beta-subunit binding Source: UniProtKB
  2. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
  2. sensory perception of taste Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_231304. Glucagon-type ligand receptors.
REACT_248547. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_250590. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_259776. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
Gene namesi
Name:Gng13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1925616. Gng13.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. dendrite Source: MGI
  2. heterotrimeric G-protein complex Source: MGI
  3. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6464Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13PRO_0000012673Add
BLAST
Propeptidei65 – 673Removed in mature formBy similarityPRO_0000012674

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641Cysteine methyl esterBy similarity
Lipidationi64 – 641S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ9JMF3.
PaxDbiQ9JMF3.
PRIDEiQ9JMF3.

Expressioni

Gene expression databases

BgeeiQ9JMF3.
GenevestigatoriQ9JMF3.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

DIPiDIP-46321N.
IntActiQ9JMF3. 1 interaction.
STRINGi10090.ENSMUSP00000110760.

Structurei

3D structure databases

ProteinModelPortaliQ9JMF3.
SMRiQ9JMF3. Positions 8-57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG293449.
GeneTreeiENSGT00530000064157.
HOVERGENiHBG098057.
InParanoidiQ9JMF3.
KOiK04547.
OMAiKWIEECV.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ9JMF3.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
[Graphical view]
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JMF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEWDVPQMK KEVESLKYQL AFKREMSSKT IPELLKWIED GIPKDPFLNP
60
DLMKNNPWVE KAKCTIL
Length:67
Mass (Da):7,979
Last modified:October 1, 2000 - v1
Checksum:i1FB8D74EB5CE50F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029485 mRNA. Translation: AAK40268.1.
AB030194 mRNA. Translation: BAA92757.1.
AK018778 mRNA. Translation: BAB31403.1.
BC048431 mRNA. Translation: AAH48431.1.
BC059712 mRNA. Translation: AAH59712.1.
CCDSiCCDS37503.1.
RefSeqiNP_071867.1. NM_022422.5.
XP_006524842.1. XM_006524779.1.
UniGeneiMm.171123.

Genome annotation databases

EnsembliENSMUST00000115108; ENSMUSP00000110760; ENSMUSG00000025739.
ENSMUST00000172002; ENSMUSP00000131648; ENSMUSG00000025739.
GeneIDi64337.
KEGGimmu:64337.
UCSCiuc008bbi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029485 mRNA. Translation: AAK40268.1.
AB030194 mRNA. Translation: BAA92757.1.
AK018778 mRNA. Translation: BAB31403.1.
BC048431 mRNA. Translation: AAH48431.1.
BC059712 mRNA. Translation: AAH59712.1.
CCDSiCCDS37503.1.
RefSeqiNP_071867.1. NM_022422.5.
XP_006524842.1. XM_006524779.1.
UniGeneiMm.171123.

3D structure databases

ProteinModelPortaliQ9JMF3.
SMRiQ9JMF3. Positions 8-57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46321N.
IntActiQ9JMF3. 1 interaction.
STRINGi10090.ENSMUSP00000110760.

Proteomic databases

MaxQBiQ9JMF3.
PaxDbiQ9JMF3.
PRIDEiQ9JMF3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115108; ENSMUSP00000110760; ENSMUSG00000025739.
ENSMUST00000172002; ENSMUSP00000131648; ENSMUSG00000025739.
GeneIDi64337.
KEGGimmu:64337.
UCSCiuc008bbi.2. mouse.

Organism-specific databases

CTDi51764.
MGIiMGI:1925616. Gng13.

Phylogenomic databases

eggNOGiNOG293449.
GeneTreeiENSGT00530000064157.
HOVERGENiHBG098057.
InParanoidiQ9JMF3.
KOiK04547.
OMAiKWIEECV.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ9JMF3.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiREACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_231304. Glucagon-type ligand receptors.
REACT_248547. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_250590. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_259776. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

Miscellaneous databases

NextBioi320031.
PROiQ9JMF3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JMF3.
GenevestigatoriQ9JMF3.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
[Graphical view]
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium."
    Huang L., Shanker Y.G., Dubauskaite J., Zheng J.Z., Yan W., Rosenzweig S., Spielman A.I., Max M., Margolskee R.F.
    Nat. Neurosci. 2:1055-1062(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains."
    Inoue S., Sano H., Ohta M.
    Biochem. Biophys. Res. Commun. 268:553-561(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGBG13_MOUSE
AccessioniPrimary (citable) accession number: Q9JMF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.