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Q9JMF3

- GBG13_MOUSE

UniProt

Q9JMF3 - GBG13_MOUSE

Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

Gene

Gng13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
  1. Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

    GO - Molecular functioni

    1. G-protein beta-subunit binding Source: UniProt
    2. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
    2. sensory perception of taste Source: MGI

    Keywords - Molecular functioni

    Transducer

    Enzyme and pathway databases

    ReactomeiREACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_221970. Ca2+ pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
    Gene namesi
    Name:Gng13
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1925616. Gng13.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: MGI
    2. membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6464Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13PRO_0000012673Add
    BLAST
    Propeptidei65 – 673Removed in mature formBy similarityPRO_0000012674

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei64 – 641Cysteine methyl esterBy similarity
    Lipidationi64 – 641S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    MaxQBiQ9JMF3.
    PaxDbiQ9JMF3.
    PRIDEiQ9JMF3.

    Expressioni

    Gene expression databases

    BgeeiQ9JMF3.
    GenevestigatoriQ9JMF3.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma.

    Protein-protein interaction databases

    DIPiDIP-46321N.
    IntActiQ9JMF3. 1 interaction.
    STRINGi10090.ENSMUSP00000110760.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JMF3.
    SMRiQ9JMF3. Positions 8-57.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G protein gamma family.Curated

    Phylogenomic databases

    eggNOGiNOG293449.
    GeneTreeiENSGT00530000064157.
    HOVERGENiHBG098057.
    InParanoidiQ9JMF3.
    KOiK04547.
    OMAiYAIESEH.
    OrthoDBiEOG7H1JP7.
    PhylomeDBiQ9JMF3.
    TreeFamiTF319909.

    Family and domain databases

    Gene3Di4.10.260.10. 1 hit.
    InterProiIPR015898. G-protein_gamma-like_dom.
    [Graphical view]
    PfamiPF00631. G-gamma. 1 hit.
    [Graphical view]
    SMARTiSM00224. GGL. 1 hit.
    [Graphical view]
    SUPFAMiSSF48670. SSF48670. 1 hit.
    PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JMF3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEWDVPQMK KEVESLKYQL AFKREMSSKT IPELLKWIED GIPKDPFLNP   50
    DLMKNNPWVE KAKCTIL 67
    Length:67
    Mass (Da):7,979
    Last modified:October 1, 2000 - v1
    Checksum:i1FB8D74EB5CE50F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY029485 mRNA. Translation: AAK40268.1.
    AB030194 mRNA. Translation: BAA92757.1.
    AK018778 mRNA. Translation: BAB31403.1.
    BC048431 mRNA. Translation: AAH48431.1.
    BC059712 mRNA. Translation: AAH59712.1.
    CCDSiCCDS37503.1.
    RefSeqiNP_071867.1. NM_022422.5.
    XP_006524842.1. XM_006524779.1.
    UniGeneiMm.171123.

    Genome annotation databases

    EnsembliENSMUST00000115108; ENSMUSP00000110760; ENSMUSG00000025739.
    ENSMUST00000172002; ENSMUSP00000131648; ENSMUSG00000025739.
    GeneIDi64337.
    KEGGimmu:64337.
    UCSCiuc008bbi.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY029485 mRNA. Translation: AAK40268.1 .
    AB030194 mRNA. Translation: BAA92757.1 .
    AK018778 mRNA. Translation: BAB31403.1 .
    BC048431 mRNA. Translation: AAH48431.1 .
    BC059712 mRNA. Translation: AAH59712.1 .
    CCDSi CCDS37503.1.
    RefSeqi NP_071867.1. NM_022422.5.
    XP_006524842.1. XM_006524779.1.
    UniGenei Mm.171123.

    3D structure databases

    ProteinModelPortali Q9JMF3.
    SMRi Q9JMF3. Positions 8-57.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-46321N.
    IntActi Q9JMF3. 1 interaction.
    STRINGi 10090.ENSMUSP00000110760.

    Proteomic databases

    MaxQBi Q9JMF3.
    PaxDbi Q9JMF3.
    PRIDEi Q9JMF3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000115108 ; ENSMUSP00000110760 ; ENSMUSG00000025739 .
    ENSMUST00000172002 ; ENSMUSP00000131648 ; ENSMUSG00000025739 .
    GeneIDi 64337.
    KEGGi mmu:64337.
    UCSCi uc008bbi.2. mouse.

    Organism-specific databases

    CTDi 51764.
    MGIi MGI:1925616. Gng13.

    Phylogenomic databases

    eggNOGi NOG293449.
    GeneTreei ENSGT00530000064157.
    HOVERGENi HBG098057.
    InParanoidi Q9JMF3.
    KOi K04547.
    OMAi YAIESEH.
    OrthoDBi EOG7H1JP7.
    PhylomeDBi Q9JMF3.
    TreeFami TF319909.

    Enzyme and pathway databases

    Reactomei REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_221970. Ca2+ pathway.

    Miscellaneous databases

    NextBioi 320031.
    PROi Q9JMF3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JMF3.
    Genevestigatori Q9JMF3.

    Family and domain databases

    Gene3Di 4.10.260.10. 1 hit.
    InterProi IPR015898. G-protein_gamma-like_dom.
    [Graphical view ]
    Pfami PF00631. G-gamma. 1 hit.
    [Graphical view ]
    SMARTi SM00224. GGL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48670. SSF48670. 1 hit.
    PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium."
      Huang L., Shanker Y.G., Dubauskaite J., Zheng J.Z., Yan W., Rosenzweig S., Spielman A.I., Max M., Margolskee R.F.
      Nat. Neurosci. 2:1055-1062(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains."
      Inoue S., Sano H., Ohta M.
      Biochem. Biophys. Res. Commun. 268:553-561(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiGBG13_MOUSE
    AccessioniPrimary (citable) accession number: Q9JMF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3