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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

Gene

Gng13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
  • sensory perception of taste Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiR-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
Gene namesi
Name:Gng13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1925616. Gng13.

Subcellular locationi

GO - Cellular componenti

  • dendrite Source: MGI
  • heterotrimeric G-protein complex Source: MGI
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6464Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13PRO_0000012673Add
BLAST
Propeptidei65 – 673Removed in mature formBy similarityPRO_0000012674

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641Cysteine methyl esterBy similarity
Lipidationi64 – 641S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ9JMF3.
PaxDbiQ9JMF3.
PeptideAtlasiQ9JMF3.
PRIDEiQ9JMF3.

PTM databases

iPTMnetiQ9JMF3.
PhosphoSiteiQ9JMF3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025739.
GenevisibleiQ9JMF3. MM.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-46321N.
IntActiQ9JMF3. 1 interaction.
STRINGi10090.ENSMUSP00000110760.

Structurei

3D structure databases

ProteinModelPortaliQ9JMF3.
SMRiQ9JMF3. Positions 8-57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00530000064157.
HOVERGENiHBG098057.
InParanoidiQ9JMF3.
KOiK04547.
OMAiKWIEECV.
OrthoDBiEOG091G17J0.
PhylomeDBiQ9JMF3.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
[Graphical view]
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JMF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEWDVPQMK KEVESLKYQL AFKREMSSKT IPELLKWIED GIPKDPFLNP
60
DLMKNNPWVE KAKCTIL
Length:67
Mass (Da):7,979
Last modified:October 1, 2000 - v1
Checksum:i1FB8D74EB5CE50F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029485 mRNA. Translation: AAK40268.1.
AB030194 mRNA. Translation: BAA92757.1.
AK018778 mRNA. Translation: BAB31403.1.
BC048431 mRNA. Translation: AAH48431.1.
BC059712 mRNA. Translation: AAH59712.1.
CCDSiCCDS37503.1.
RefSeqiNP_071867.1. NM_022422.5.
XP_006524842.1. XM_006524779.2.
UniGeneiMm.171123.

Genome annotation databases

EnsembliENSMUST00000115108; ENSMUSP00000110760; ENSMUSG00000025739.
ENSMUST00000172002; ENSMUSP00000131648; ENSMUSG00000025739.
GeneIDi64337.
KEGGimmu:64337.
UCSCiuc008bbi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029485 mRNA. Translation: AAK40268.1.
AB030194 mRNA. Translation: BAA92757.1.
AK018778 mRNA. Translation: BAB31403.1.
BC048431 mRNA. Translation: AAH48431.1.
BC059712 mRNA. Translation: AAH59712.1.
CCDSiCCDS37503.1.
RefSeqiNP_071867.1. NM_022422.5.
XP_006524842.1. XM_006524779.2.
UniGeneiMm.171123.

3D structure databases

ProteinModelPortaliQ9JMF3.
SMRiQ9JMF3. Positions 8-57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46321N.
IntActiQ9JMF3. 1 interaction.
STRINGi10090.ENSMUSP00000110760.

PTM databases

iPTMnetiQ9JMF3.
PhosphoSiteiQ9JMF3.

Proteomic databases

MaxQBiQ9JMF3.
PaxDbiQ9JMF3.
PeptideAtlasiQ9JMF3.
PRIDEiQ9JMF3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115108; ENSMUSP00000110760; ENSMUSG00000025739.
ENSMUST00000172002; ENSMUSP00000131648; ENSMUSG00000025739.
GeneIDi64337.
KEGGimmu:64337.
UCSCiuc008bbi.2. mouse.

Organism-specific databases

CTDi51764.
MGIiMGI:1925616. Gng13.

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00530000064157.
HOVERGENiHBG098057.
InParanoidiQ9JMF3.
KOiK04547.
OMAiKWIEECV.
OrthoDBiEOG091G17J0.
PhylomeDBiQ9JMF3.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiR-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.

Miscellaneous databases

PROiQ9JMF3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025739.
GenevisibleiQ9JMF3. MM.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
[Graphical view]
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBG13_MOUSE
AccessioniPrimary (citable) accession number: Q9JMF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.