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Protein

AP-3 complex subunit beta-2

Gene

Ap3b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.1 Publication

GO - Biological processi

  • anterograde axonal transport Source: UniProtKB
  • anterograde synaptic vesicle transport Source: UniProtKB
  • intracellular protein transport Source: MGI
  • vesicle-mediated transport Source: MGI

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit beta-2
Alternative name(s):
Adaptor protein complex AP-3 subunit beta-2
Adaptor-related protein complex 3 subunit beta-2
Beta-3B-adaptin
Clathrin assembly protein complex 3 beta-2 large chain
Gene namesi
Name:Ap3b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1100869 Ap3b2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937491 – 1082AP-3 complex subunit beta-2Add BLAST1082

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei272PhosphoserineCombined sources1
Modified residuei282PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JME5
PaxDbiQ9JME5
PeptideAtlasiQ9JME5
PRIDEiQ9JME5

PTM databases

iPTMnetiQ9JME5
PhosphoSitePlusiQ9JME5

Expressioni

Gene expression databases

BgeeiENSMUSG00000062444
CleanExiMM_AP3B2
ExpressionAtlasiQ9JME5 baseline and differential
GenevisibleiQ9JME5 MM

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) (By similarity). AP-3 associates with the BLOC-1 complex.By similarity

Protein-protein interaction databases

BioGridi198133, 2 interactors
IntActiQ9JME5, 2 interactors
MINTiQ9JME5
STRINGi10090.ENSMUSP00000080739

Structurei

3D structure databases

ProteinModelPortaliQ9JME5
SMRiQ9JME5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi646 – 798Glu/Ser-richAdd BLAST153

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1060 Eukaryota
COG5096 LUCA
GeneTreeiENSGT00530000063546
HOGENOMiHOG000033978
HOVERGENiHBG050519
InParanoidiQ9JME5
KOiK12397
OMAiIITQMAK
OrthoDBiEOG091G01OB
PhylomeDBiQ9JME5
TreeFamiTF314605

Family and domain databases

InterProiView protein in InterPro
IPR026740 AP3_beta
IPR029390 AP3B_C
IPR026739 AP_beta
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR013041 Clathrin_app_Ig-like_sf
PANTHERiPTHR11134 PTHR11134, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF14796 AP3B1_C, 1 hit
PIRSFiPIRSF037096 AP3_complex_beta, 1 hit
SMARTiView protein in SMART
SM01355 AP3B1_C, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF49348 SSF49348, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JME5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAPAYSED KGGSAGPGEP EYGHDPASGG IFSSDYKRHD DLKEMLDTNK
60 70 80 90 100
DSLKLEAMKR IVAMIARGKN ASDLFPAVVK NVACKNIEVK KLVYVYLVRY
110 120 130 140 150
AEEQQDLALL SISTFQRGLK DPNQLIRASA LRVLSSIRVP IIVPIMMLAI
160 170 180 190 200
KEAASDMSPY VRKTAAHAIP KLYSLDSDQK DQLIEVIEKL LADKTTLVAG
210 220 230 240 250
SVVMAFEEVC PERIDLIHKN YRKLCNLLID VEEWGQVVII SMLTRYARTQ
260 270 280 290 300
FLSPTQNESL LEENPEKAFY GSEEDEAKGP GSEEAATAAL PARKPYVMDP
310 320 330 340 350
DHRLLLRNTK PLLQSRSAAV VMAVAQLYFH LAPKAEVGVI AKALVRLLRS
360 370 380 390 400
HSEVQYVVLQ NVATMSIKRR GMFEPYLKSF YIRSTDPTQI KILKLEVLTN
410 420 430 440 450
LANETNIPTV LREFQTYIRS MDKDFVAATI QAIGRCATNI GRVRDTCLNG
460 470 480 490 500
LVQLLSNRDE LVVAESVVVI KKLLQMQPAQ HGEIIKHLAK LTDNIQVPMA
510 520 530 540 550
RASILWLIGE YCEHVPKIAP DVLRKMAKSF TAEEDIVKLQ VINLAAKLYL
560 570 580 590 600
TNSKQTKLLT QYVLSLAKYD QNYDIRDRAR FTRQLIVPSE QGGALSRHAK
610 620 630 640 650
KLFLAPKPAP ILESSFKDRD HFQLGSLSHL LNAKATGYQE LPDWPEEAPD
660 670 680 690 700
PSVRNVEVPE WTKCSNREKR KEKEKPFYSD SEGESGPTES ADSEPESESE
710 720 730 740 750
SESKSSSGSG SGESSSESDN EEEDEEKGGG SESEQSEEED EKKKKTKKKK
760 770 780 790 800
ASEGHREGSS SEEGSDSSSS SESEVTSESE EEQVEPASWR KKTPPGSKSA
810 820 830 840 850
PVAKEISLLD LEDFTPPSVQ PVSPPMVVST SLAADLEGLT LTDSSLVPSL
860 870 880 890 900
LSPVSSIGRQ ELLHRVAGEG LSVDYAFSRQ PFSGDPHMVS LHIYFSNNSE
910 920 930 940 950
TPIKGLHVGT PKLPAGISIQ EFPEIESLAP GESTTTVMGI NFCDSTQAAN
960 970 980 990 1000
FQLCTQTRQF YVSIQPPVGE LMAPVFMSEN EFKKEQGKLT GMNEITEKLT
1010 1020 1030 1040 1050
LPDTCRSDHM VVQKVTATAN LGRVPCGTSD EYRFAGRTLT SGSLVLLTLD
1060 1070 1080
ARAAGAAQLT VNSEKMVIGT MLVKDVIQAL TQ
Length:1,082
Mass (Da):119,193
Last modified:October 25, 2004 - v2
Checksum:iA2FEB20E83E16A52
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti734E → D in BAA92765 (PubMed:10679242).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY528675 mRNA Translation: AAS18679.1
BC139378 mRNA Translation: AAI39379.1
BC139379 mRNA Translation: AAI39380.1
AK134504 mRNA Translation: BAE22164.1
AB030202 mRNA Translation: BAA92765.1
CCDSiCCDS21403.1
RefSeqiNP_067467.2, NM_021492.3
UniGeneiMm.322894

Genome annotation databases

EnsembliENSMUST00000082090; ENSMUSP00000080739; ENSMUSG00000062444
GeneIDi11775
KEGGimmu:11775
UCSCiuc009iby.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAP3B2_MOUSE
AccessioniPrimary (citable) accession number: Q9JME5
Secondary accession number(s): B2RTK2
, Q3UYP8, Q6QR53, Q8R1E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 25, 2004
Last modified: April 25, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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