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Protein

AP-3 complex subunit beta-2

Gene

Ap3b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.1 Publication

GO - Biological processi

  • anterograde axonal transport Source: UniProtKB
  • anterograde synaptic vesicle transport Source: UniProtKB
  • intracellular protein transport Source: MGI
  • vesicle-mediated transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit beta-2
Alternative name(s):
Adaptor protein complex AP-3 subunit beta-2
Adaptor-related protein complex 3 subunit beta-2
Beta-3B-adaptin
Clathrin assembly protein complex 3 beta-2 large chain
Gene namesi
Name:Ap3b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1100869. Ap3b2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937491 – 1082AP-3 complex subunit beta-2Add BLAST1082

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei272PhosphoserineCombined sources1
Modified residuei282PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JME5.
PaxDbiQ9JME5.
PeptideAtlasiQ9JME5.
PRIDEiQ9JME5.

PTM databases

iPTMnetiQ9JME5.
PhosphoSitePlusiQ9JME5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000062444.
CleanExiMM_AP3B2.
ExpressionAtlasiQ9JME5. baseline and differential.
GenevisibleiQ9JME5. MM.

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) (By similarity). AP-3 associates with the BLOC-1 complex.By similarity

Protein-protein interaction databases

BioGridi198133. 1 interactor.
IntActiQ9JME5. 2 interactors.
MINTiMINT-4087974.
STRINGi10090.ENSMUSP00000080739.

Structurei

3D structure databases

ProteinModelPortaliQ9JME5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi646 – 798Glu/Ser-richAdd BLAST153

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1060. Eukaryota.
COG5096. LUCA.
GeneTreeiENSGT00530000063546.
HOGENOMiHOG000033978.
HOVERGENiHBG050519.
InParanoidiQ9JME5.
KOiK12397.
OMAiHQCELRG.
OrthoDBiEOG091G01OB.
PhylomeDBiQ9JME5.
TreeFamiTF314605.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
2.60.40.1150. 1 hit.
InterProiIPR026740. AP3_beta.
IPR029390. AP3B_C.
IPR026739. AP_beta.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR013037. Clathrin_b-adaptin_app_Ig-like.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view]
PANTHERiPTHR11134. PTHR11134. 2 hits.
PfamiPF01602. Adaptin_N. 1 hit.
PF14796. AP3B1_C. 1 hit.
[Graphical view]
PIRSFiPIRSF037096. AP3_complex_beta. 1 hit.
SMARTiSM01355. AP3B1_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49348. SSF49348. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JME5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAPAYSED KGGSAGPGEP EYGHDPASGG IFSSDYKRHD DLKEMLDTNK
60 70 80 90 100
DSLKLEAMKR IVAMIARGKN ASDLFPAVVK NVACKNIEVK KLVYVYLVRY
110 120 130 140 150
AEEQQDLALL SISTFQRGLK DPNQLIRASA LRVLSSIRVP IIVPIMMLAI
160 170 180 190 200
KEAASDMSPY VRKTAAHAIP KLYSLDSDQK DQLIEVIEKL LADKTTLVAG
210 220 230 240 250
SVVMAFEEVC PERIDLIHKN YRKLCNLLID VEEWGQVVII SMLTRYARTQ
260 270 280 290 300
FLSPTQNESL LEENPEKAFY GSEEDEAKGP GSEEAATAAL PARKPYVMDP
310 320 330 340 350
DHRLLLRNTK PLLQSRSAAV VMAVAQLYFH LAPKAEVGVI AKALVRLLRS
360 370 380 390 400
HSEVQYVVLQ NVATMSIKRR GMFEPYLKSF YIRSTDPTQI KILKLEVLTN
410 420 430 440 450
LANETNIPTV LREFQTYIRS MDKDFVAATI QAIGRCATNI GRVRDTCLNG
460 470 480 490 500
LVQLLSNRDE LVVAESVVVI KKLLQMQPAQ HGEIIKHLAK LTDNIQVPMA
510 520 530 540 550
RASILWLIGE YCEHVPKIAP DVLRKMAKSF TAEEDIVKLQ VINLAAKLYL
560 570 580 590 600
TNSKQTKLLT QYVLSLAKYD QNYDIRDRAR FTRQLIVPSE QGGALSRHAK
610 620 630 640 650
KLFLAPKPAP ILESSFKDRD HFQLGSLSHL LNAKATGYQE LPDWPEEAPD
660 670 680 690 700
PSVRNVEVPE WTKCSNREKR KEKEKPFYSD SEGESGPTES ADSEPESESE
710 720 730 740 750
SESKSSSGSG SGESSSESDN EEEDEEKGGG SESEQSEEED EKKKKTKKKK
760 770 780 790 800
ASEGHREGSS SEEGSDSSSS SESEVTSESE EEQVEPASWR KKTPPGSKSA
810 820 830 840 850
PVAKEISLLD LEDFTPPSVQ PVSPPMVVST SLAADLEGLT LTDSSLVPSL
860 870 880 890 900
LSPVSSIGRQ ELLHRVAGEG LSVDYAFSRQ PFSGDPHMVS LHIYFSNNSE
910 920 930 940 950
TPIKGLHVGT PKLPAGISIQ EFPEIESLAP GESTTTVMGI NFCDSTQAAN
960 970 980 990 1000
FQLCTQTRQF YVSIQPPVGE LMAPVFMSEN EFKKEQGKLT GMNEITEKLT
1010 1020 1030 1040 1050
LPDTCRSDHM VVQKVTATAN LGRVPCGTSD EYRFAGRTLT SGSLVLLTLD
1060 1070 1080
ARAAGAAQLT VNSEKMVIGT MLVKDVIQAL TQ
Length:1,082
Mass (Da):119,193
Last modified:October 25, 2004 - v2
Checksum:iA2FEB20E83E16A52
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti734E → D in BAA92765 (PubMed:10679242).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY528675 mRNA. Translation: AAS18679.1.
BC139378 mRNA. Translation: AAI39379.1.
BC139379 mRNA. Translation: AAI39380.1.
AK134504 mRNA. Translation: BAE22164.1.
AB030202 mRNA. Translation: BAA92765.1.
CCDSiCCDS21403.1.
RefSeqiNP_067467.2. NM_021492.3.
UniGeneiMm.322894.

Genome annotation databases

EnsembliENSMUST00000082090; ENSMUSP00000080739; ENSMUSG00000062444.
GeneIDi11775.
KEGGimmu:11775.
UCSCiuc009iby.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY528675 mRNA. Translation: AAS18679.1.
BC139378 mRNA. Translation: AAI39379.1.
BC139379 mRNA. Translation: AAI39380.1.
AK134504 mRNA. Translation: BAE22164.1.
AB030202 mRNA. Translation: BAA92765.1.
CCDSiCCDS21403.1.
RefSeqiNP_067467.2. NM_021492.3.
UniGeneiMm.322894.

3D structure databases

ProteinModelPortaliQ9JME5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198133. 1 interactor.
IntActiQ9JME5. 2 interactors.
MINTiMINT-4087974.
STRINGi10090.ENSMUSP00000080739.

PTM databases

iPTMnetiQ9JME5.
PhosphoSitePlusiQ9JME5.

Proteomic databases

MaxQBiQ9JME5.
PaxDbiQ9JME5.
PeptideAtlasiQ9JME5.
PRIDEiQ9JME5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082090; ENSMUSP00000080739; ENSMUSG00000062444.
GeneIDi11775.
KEGGimmu:11775.
UCSCiuc009iby.1. mouse.

Organism-specific databases

CTDi8120.
MGIiMGI:1100869. Ap3b2.

Phylogenomic databases

eggNOGiKOG1060. Eukaryota.
COG5096. LUCA.
GeneTreeiENSGT00530000063546.
HOGENOMiHOG000033978.
HOVERGENiHBG050519.
InParanoidiQ9JME5.
KOiK12397.
OMAiHQCELRG.
OrthoDBiEOG091G01OB.
PhylomeDBiQ9JME5.
TreeFamiTF314605.

Miscellaneous databases

PROiQ9JME5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062444.
CleanExiMM_AP3B2.
ExpressionAtlasiQ9JME5. baseline and differential.
GenevisibleiQ9JME5. MM.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
2.60.40.1150. 1 hit.
InterProiIPR026740. AP3_beta.
IPR029390. AP3B_C.
IPR026739. AP_beta.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR013037. Clathrin_b-adaptin_app_Ig-like.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view]
PANTHERiPTHR11134. PTHR11134. 2 hits.
PfamiPF01602. Adaptin_N. 1 hit.
PF14796. AP3B1_C. 1 hit.
[Graphical view]
PIRSFiPIRSF037096. AP3_complex_beta. 1 hit.
SMARTiSM01355. AP3B1_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49348. SSF49348. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAP3B2_MOUSE
AccessioniPrimary (citable) accession number: Q9JME5
Secondary accession number(s): B2RTK2
, Q3UYP8, Q6QR53, Q8R1E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 25, 2004
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.