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Q9JME5

- AP3B2_MOUSE

UniProt

Q9JME5 - AP3B2_MOUSE

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Protein
AP-3 complex subunit beta-2
Gene
Ap3b2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.1 Publication

GO - Biological processi

  1. anterograde axon cargo transport Source: UniProtKB
  2. anterograde synaptic vesicle transport Source: UniProtKB
  3. intracellular protein transport Source: MGI
  4. vesicle-mediated transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit beta-2
Alternative name(s):
Adaptor protein complex AP-3 subunit beta-2
Adaptor-related protein complex 3 subunit beta-2
Beta-3B-adaptin
Clathrin assembly protein complex 3 beta-2 large chain
Gene namesi
Name:Ap3b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1100869. Ap3b2.

Subcellular locationi

Golgi apparatus. Cytoplasmic vesicleclathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Golgi apparatus By similarity
Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex By similarity.

GO - Cellular componenti

  1. AP-3 adaptor complex Source: InterPro
  2. clathrin-coated vesicle membrane Source: UniProtKB-SubCell
  3. nucleus Source: Ensembl
  4. trans-Golgi network Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10821082AP-3 complex subunit beta-2
PRO_0000193749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei272 – 2721Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JME5.
PaxDbiQ9JME5.
PRIDEiQ9JME5.

PTM databases

PhosphoSiteiQ9JME5.

Expressioni

Gene expression databases

ArrayExpressiQ9JME5.
BgeeiQ9JME5.
CleanExiMM_AP3B2.
GenevestigatoriQ9JME5.

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) By similarity. AP-3 associates with the BLOC-1 complex.

Protein-protein interaction databases

BioGridi198133. 1 interaction.
IntActiQ9JME5. 2 interactions.
MINTiMINT-4087974.

Structurei

3D structure databases

ProteinModelPortaliQ9JME5.
SMRiQ9JME5. Positions 41-628.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi646 – 798153Glu/Ser-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5096.
GeneTreeiENSGT00530000063546.
HOGENOMiHOG000033978.
HOVERGENiHBG050519.
InParanoidiQ3UYP8.
KOiK12397.
OMAiWRKKTPP.
OrthoDBiEOG74R1QG.
PhylomeDBiQ9JME5.
TreeFamiTF314605.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026740. AP3_beta.
IPR029390. AP3B_C.
IPR026739. AP_beta.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view]
PANTHERiPTHR11134. PTHR11134. 1 hit.
PfamiPF01602. Adaptin_N. 1 hit.
PF14796. AP3B1_C. 1 hit.
[Graphical view]
PIRSFiPIRSF037096. AP3_complex_beta. 1 hit.
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49348. SSF49348. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JME5-1 [UniParc]FASTAAdd to Basket

« Hide

MSAAPAYSED KGGSAGPGEP EYGHDPASGG IFSSDYKRHD DLKEMLDTNK     50
DSLKLEAMKR IVAMIARGKN ASDLFPAVVK NVACKNIEVK KLVYVYLVRY 100
AEEQQDLALL SISTFQRGLK DPNQLIRASA LRVLSSIRVP IIVPIMMLAI 150
KEAASDMSPY VRKTAAHAIP KLYSLDSDQK DQLIEVIEKL LADKTTLVAG 200
SVVMAFEEVC PERIDLIHKN YRKLCNLLID VEEWGQVVII SMLTRYARTQ 250
FLSPTQNESL LEENPEKAFY GSEEDEAKGP GSEEAATAAL PARKPYVMDP 300
DHRLLLRNTK PLLQSRSAAV VMAVAQLYFH LAPKAEVGVI AKALVRLLRS 350
HSEVQYVVLQ NVATMSIKRR GMFEPYLKSF YIRSTDPTQI KILKLEVLTN 400
LANETNIPTV LREFQTYIRS MDKDFVAATI QAIGRCATNI GRVRDTCLNG 450
LVQLLSNRDE LVVAESVVVI KKLLQMQPAQ HGEIIKHLAK LTDNIQVPMA 500
RASILWLIGE YCEHVPKIAP DVLRKMAKSF TAEEDIVKLQ VINLAAKLYL 550
TNSKQTKLLT QYVLSLAKYD QNYDIRDRAR FTRQLIVPSE QGGALSRHAK 600
KLFLAPKPAP ILESSFKDRD HFQLGSLSHL LNAKATGYQE LPDWPEEAPD 650
PSVRNVEVPE WTKCSNREKR KEKEKPFYSD SEGESGPTES ADSEPESESE 700
SESKSSSGSG SGESSSESDN EEEDEEKGGG SESEQSEEED EKKKKTKKKK 750
ASEGHREGSS SEEGSDSSSS SESEVTSESE EEQVEPASWR KKTPPGSKSA 800
PVAKEISLLD LEDFTPPSVQ PVSPPMVVST SLAADLEGLT LTDSSLVPSL 850
LSPVSSIGRQ ELLHRVAGEG LSVDYAFSRQ PFSGDPHMVS LHIYFSNNSE 900
TPIKGLHVGT PKLPAGISIQ EFPEIESLAP GESTTTVMGI NFCDSTQAAN 950
FQLCTQTRQF YVSIQPPVGE LMAPVFMSEN EFKKEQGKLT GMNEITEKLT 1000
LPDTCRSDHM VVQKVTATAN LGRVPCGTSD EYRFAGRTLT SGSLVLLTLD 1050
ARAAGAAQLT VNSEKMVIGT MLVKDVIQAL TQ 1082
Length:1,082
Mass (Da):119,193
Last modified:October 25, 2004 - v2
Checksum:iA2FEB20E83E16A52
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti734 – 7341E → D in BAA92765. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY528675 mRNA. Translation: AAS18679.1.
BC139378 mRNA. Translation: AAI39379.1.
BC139379 mRNA. Translation: AAI39380.1.
AK134504 mRNA. Translation: BAE22164.1.
AB030202 mRNA. Translation: BAA92765.1.
CCDSiCCDS21403.1.
RefSeqiNP_067467.2. NM_021492.3.
UniGeneiMm.322894.

Genome annotation databases

EnsembliENSMUST00000082090; ENSMUSP00000080739; ENSMUSG00000062444.
GeneIDi11775.
KEGGimmu:11775.
UCSCiuc009iby.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY528675 mRNA. Translation: AAS18679.1 .
BC139378 mRNA. Translation: AAI39379.1 .
BC139379 mRNA. Translation: AAI39380.1 .
AK134504 mRNA. Translation: BAE22164.1 .
AB030202 mRNA. Translation: BAA92765.1 .
CCDSi CCDS21403.1.
RefSeqi NP_067467.2. NM_021492.3.
UniGenei Mm.322894.

3D structure databases

ProteinModelPortali Q9JME5.
SMRi Q9JME5. Positions 41-628.
ModBasei Search...

Protein-protein interaction databases

BioGridi 198133. 1 interaction.
IntActi Q9JME5. 2 interactions.
MINTi MINT-4087974.

PTM databases

PhosphoSitei Q9JME5.

Proteomic databases

MaxQBi Q9JME5.
PaxDbi Q9JME5.
PRIDEi Q9JME5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082090 ; ENSMUSP00000080739 ; ENSMUSG00000062444 .
GeneIDi 11775.
KEGGi mmu:11775.
UCSCi uc009iby.1. mouse.

Organism-specific databases

CTDi 8120.
MGIi MGI:1100869. Ap3b2.

Phylogenomic databases

eggNOGi COG5096.
GeneTreei ENSGT00530000063546.
HOGENOMi HOG000033978.
HOVERGENi HBG050519.
InParanoidi Q3UYP8.
KOi K12397.
OMAi WRKKTPP.
OrthoDBi EOG74R1QG.
PhylomeDBi Q9JME5.
TreeFami TF314605.

Miscellaneous databases

NextBioi 279567.
PROi Q9JME5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JME5.
Bgeei Q9JME5.
CleanExi MM_AP3B2.
Genevestigatori Q9JME5.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR026740. AP3_beta.
IPR029390. AP3B_C.
IPR026739. AP_beta.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view ]
PANTHERi PTHR11134. PTHR11134. 1 hit.
Pfami PF01602. Adaptin_N. 1 hit.
PF14796. AP3B1_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF037096. AP3_complex_beta. 1 hit.
SUPFAMi SSF48371. SSF48371. 2 hits.
SSF49348. SSF49348. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Ap3b2, a neuron specific subunit of adaptor protein complex 3 (AP-3)."
    Seong E., Burmeister M.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-738.
    Strain: C57BL/6J.
    Tissue: Embryonic head.
  4. "Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains."
    Inoue S., Sano H., Ohta M.
    Biochem. Biophys. Res. Commun. 268:553-561(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 608-1082.
    Tissue: Brain.
  5. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  6. "The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse."
    Larimore J., Tornieri K., Ryder P.V., Gokhale A., Zlatic S.A., Craige B., Lee J.D., Talbot K., Pare J.F., Smith Y., Faundez V.
    Mol. Biol. Cell 22:4854-4867(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ASSOCIATION WITH THE BLOC-1 COMPLEX.

Entry informationi

Entry nameiAP3B2_MOUSE
AccessioniPrimary (citable) accession number: Q9JME5
Secondary accession number(s): B2RTK2
, Q3UYP8, Q6QR53, Q8R1E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 25, 2004
Last modified: September 3, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi