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Protein

START domain-containing protein 10

Gene

Stard10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes (By similarity). May play metabolic roles in sperm maturation or fertilization.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • bile acid secretion Source: MGI
  • lipid transport Source: UniProtKB-KW
  • positive regulation of peroxisome proliferator activated receptor signaling pathway Source: MGI

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-1483191 Synthesis of PC

Names & Taxonomyi

Protein namesi
Recommended name:
START domain-containing protein 10
Short name:
StARD10
Alternative name(s):
PCTP-like protein
Short name:
PCTP-L
Serologically defined colon cancer antigen 28 homolog
StAR-related lipid transfer protein 10
Gene namesi
Name:Stard10
Synonyms:Pctpl, Sdccag28, Sdccagg28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1860093 Stard10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Flagellum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002206621 – 291START domain-containing protein 10Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei94N6-succinyllysineCombined sources1
Modified residuei197N6-succinyllysineCombined sources1
Modified residuei202N6-succinyllysineCombined sources1
Modified residuei253PhosphoserineBy similarity1
Modified residuei259PhosphoserineBy similarity1
Modified residuei284PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Ser-284 by CK2 negatively regulates lipid transfer activity, possibly by decreasing membrane association.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9JMD3
PaxDbiQ9JMD3
PRIDEiQ9JMD3

PTM databases

iPTMnetiQ9JMD3
PhosphoSitePlusiQ9JMD3

Expressioni

Tissue specificityi

Testis, kidney, liver, and intestine with the highest level in the testis.

Developmental stagei

During male germ cell development, it was detected first in the 23-day-old mouse testis, and the signal increased with age.

Gene expression databases

BgeeiENSMUSG00000030688
CleanExiMM_STARD10
ExpressionAtlasiQ9JMD3 baseline and differential
GenevisibleiQ9JMD3 MM

Interactioni

Protein-protein interaction databases

IntActiQ9JMD3, 1 interactor
MINTiQ9JMD3
STRINGi10090.ENSMUSP00000032927

Structurei

3D structure databases

ProteinModelPortaliQ9JMD3
SMRiQ9JMD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 224STARTPROSITE-ProRule annotationAdd BLAST211

Phylogenomic databases

eggNOGiENOG410IPC8 Eukaryota
ENOG4110QPY LUCA
GeneTreeiENSGT00510000047611
HOVERGENiHBG031807
InParanoidiQ9JMD3
PhylomeDBiQ9JMD3
TreeFamiTF354285

Family and domain databases

Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom
PfamiView protein in Pfam
PF01852 START, 1 hit
SMARTiView protein in SMART
SM00234 START, 1 hit
PROSITEiView protein in PROSITE
PS50848 START, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JMD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKPAASTEP QGSRPALGRE SVQVPDDQDF RSFRSECEAE VGWNLTYSKA
60 70 80 90 100
GVSVWVQAVE MDRTLHKIKC RMECCDVPAE TLYDVLHDIE YRKKWDSNVI
110 120 130 140 150
ETFDIARLTV NADVGYYSWR CPKPLKNRDV ITLRSWLPMG ADYIIMNYSV
160 170 180 190 200
KHPKYPPRKD LVRAVSIQTG YLIQSTGPKS CVITYLAQVD PKGSLPKWVV
210 220 230 240 250
NKSSQFLAPK AMKKMYKACI KYPEWKQKHQ PHFKPWLHPE QSPLPSLALS
260 270 280 290
ELSVQHADSL ENIDESAVTE SREERAGGAG GEGSDDDTSL T
Length:291
Mass (Da):32,951
Last modified:October 1, 2000 - v1
Checksum:i598467C430D97080
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031550 mRNA Translation: BAA92233.1
CCDSiCCDS21509.1
RefSeqiNP_064374.1, NM_019990.4
UniGeneiMm.28896

Genome annotation databases

EnsembliENSMUST00000032927; ENSMUSP00000032927; ENSMUSG00000030688
ENSMUST00000164479; ENSMUSP00000133002; ENSMUSG00000030688
ENSMUST00000210192; ENSMUSP00000148114; ENSMUSG00000030688
GeneIDi56018
KEGGimmu:56018
UCSCiuc009ioi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSTA10_MOUSE
AccessioniPrimary (citable) accession number: Q9JMD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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