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Q9JMD3

- PCTL_MOUSE

UniProt

Q9JMD3 - PCTL_MOUSE

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Protein

PCTP-like protein

Gene
Stard10, Pctpl, Sdccag28, Sdccagg28
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes By similarity. May play metabolic roles in sperm maturation or fertilization.1 Publication

GO - Molecular functioni

  1. lipid binding Source: UniProtKB-KW

GO - Biological processi

  1. bile acid secretion Source: MGI
  2. positive regulation of peroxisome proliferator activated receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
PCTP-like protein
Short name:
PCTP-L
Alternative name(s):
START domain-containing protein 10
Short name:
StARD10
Serologically defined colon cancer antigen 28 homolog
StAR-related lipid transfer protein 10
Gene namesi
Name:Stard10
Synonyms:Pctpl, Sdccag28, Sdccagg28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1860093. Stard10.

Subcellular locationi

Cell projectionciliumflagellum. Cytoplasm By similarity. Membrane By similarity
Note: Mainly cytosolic By similarity. In testis was predominantly detected at the flagella of elongated spermatids, with a strong signal also found at the tail of epididymal sperm.1 Publication

GO - Cellular componenti

  1. cilium Source: UniProtKB-KW
  2. cytosol Source: MGI
  3. intercellular canaliculus Source: MGI
  4. membrane Source: MGI
  5. microvillus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Flagellum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291PCTP-like proteinPRO_0000220662Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei94 – 941N6-succinyllysine1 Publication
Modified residuei197 – 1971N6-succinyllysine1 Publication
Modified residuei202 – 2021N6-succinyllysine1 Publication
Modified residuei284 – 2841Phosphoserine; by CK2

Post-translational modificationi

Phosphorylation at Ser-284 by CK2 negatively regulates lipid transfer activity, possibly by decreasing membrane association By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9JMD3.
PaxDbiQ9JMD3.
PRIDEiQ9JMD3.

PTM databases

PhosphoSiteiQ9JMD3.

Expressioni

Tissue specificityi

Testis, kidney, liver, and intestine with the highest level in the testis.

Developmental stagei

During male germ cell development, it was detected first in the 23-day-old mouse testis, and the signal increased with age.

Gene expression databases

ArrayExpressiQ9JMD3.
BgeeiQ9JMD3.
CleanExiMM_STARD10.
GenevestigatoriQ9JMD3.

Interactioni

Protein-protein interaction databases

IntActiQ9JMD3. 1 interaction.
MINTiMINT-1855443.

Structurei

3D structure databases

ProteinModelPortaliQ9JMD3.
SMRiQ9JMD3. Positions 42-198.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 224211STARTAdd
BLAST

Sequence similaritiesi

Contains 1 START domain.

Phylogenomic databases

eggNOGiNOG292439.
GeneTreeiENSGT00510000047611.
HOVERGENiHBG031807.
InParanoidiQ9JMD3.
PhylomeDBiQ9JMD3.
TreeFamiTF354285.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF01852. START. 1 hit.
[Graphical view]
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JMD3-1 [UniParc]FASTAAdd to Basket

« Hide

MEKPAASTEP QGSRPALGRE SVQVPDDQDF RSFRSECEAE VGWNLTYSKA    50
GVSVWVQAVE MDRTLHKIKC RMECCDVPAE TLYDVLHDIE YRKKWDSNVI 100
ETFDIARLTV NADVGYYSWR CPKPLKNRDV ITLRSWLPMG ADYIIMNYSV 150
KHPKYPPRKD LVRAVSIQTG YLIQSTGPKS CVITYLAQVD PKGSLPKWVV 200
NKSSQFLAPK AMKKMYKACI KYPEWKQKHQ PHFKPWLHPE QSPLPSLALS 250
ELSVQHADSL ENIDESAVTE SREERAGGAG GEGSDDDTSL T 291
Length:291
Mass (Da):32,951
Last modified:October 1, 2000 - v1
Checksum:i598467C430D97080
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB031550 mRNA. Translation: BAA92233.1.
CCDSiCCDS21509.1.
RefSeqiNP_064374.1. NM_019990.4.
UniGeneiMm.28896.

Genome annotation databases

EnsembliENSMUST00000032927; ENSMUSP00000032927; ENSMUSG00000030688.
ENSMUST00000164479; ENSMUSP00000133002; ENSMUSG00000030688.
GeneIDi56018.
KEGGimmu:56018.
UCSCiuc009ioi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB031550 mRNA. Translation: BAA92233.1 .
CCDSi CCDS21509.1.
RefSeqi NP_064374.1. NM_019990.4.
UniGenei Mm.28896.

3D structure databases

ProteinModelPortali Q9JMD3.
SMRi Q9JMD3. Positions 42-198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9JMD3. 1 interaction.
MINTi MINT-1855443.

PTM databases

PhosphoSitei Q9JMD3.

Proteomic databases

MaxQBi Q9JMD3.
PaxDbi Q9JMD3.
PRIDEi Q9JMD3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032927 ; ENSMUSP00000032927 ; ENSMUSG00000030688 .
ENSMUST00000164479 ; ENSMUSP00000133002 ; ENSMUSG00000030688 .
GeneIDi 56018.
KEGGi mmu:56018.
UCSCi uc009ioi.1. mouse.

Organism-specific databases

CTDi 10809.
MGIi MGI:1860093. Stard10.

Phylogenomic databases

eggNOGi NOG292439.
GeneTreei ENSGT00510000047611.
HOVERGENi HBG031807.
InParanoidi Q9JMD3.
PhylomeDBi Q9JMD3.
TreeFami TF354285.

Miscellaneous databases

ChiTaRSi STARD10. mouse.
NextBioi 311762.
PROi Q9JMD3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JMD3.
Bgeei Q9JMD3.
CleanExi MM_STARD10.
Genevestigatori Q9JMD3.

Family and domain databases

Gene3Di 3.30.530.20. 1 hit.
InterProi IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view ]
Pfami PF01852. START. 1 hit.
[Graphical view ]
SMARTi SM00234. START. 1 hit.
[Graphical view ]
PROSITEi PS50848. START. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of phosphatidylcholine transfer protein-like protein gene expressed in murine haploid germ cells."
    Yamanaka M., Koga M., Tanaka H., Nakamura Y., Ohta H., Yomogida K., Tsuchida J., Iguchi N., Nojima H., Nozaki M., Matsumiya K., Okuyama A., Toshimori K., Nishimune Y.
    Biol. Reprod. 62:1694-1701(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Testis.
  2. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-94; LYS-197 AND LYS-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPCTL_MOUSE
AccessioniPrimary (citable) accession number: Q9JMD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi