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Q9JMD3 (PCTL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
PCTP-like protein

Short name=PCTP-L
Alternative name(s):
START domain-containing protein 10
Short name=StARD10
Serologically defined colon cancer antigen 28 homolog
StAR-related lipid transfer protein 10
Gene names
Name:Stard10
Synonyms:Pctpl, Sdccag28, Sdccagg28
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes By similarity. May play metabolic roles in sperm maturation or fertilization. Ref.1

Subcellular location

Cell projectionciliumflagellum. Cytoplasm By similarity. Membrane By similarity. Note: Mainly cytosolic By similarity. In testis was predominantly detected at the flagella of elongated spermatids, with a strong signal also found at the tail of epididymal sperm. Ref.1

Tissue specificity

Testis, kidney, liver, and intestine with the highest level in the testis.

Developmental stage

During male germ cell development, it was detected first in the 23-day-old mouse testis, and the signal increased with age.

Post-translational modification

Phosphorylation at Ser-284 by CK2 negatively regulates lipid transfer activity, possibly by decreasing membrane association By similarity.

Sequence similarities

Contains 1 START domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 291291PCTP-like protein
PRO_0000220662

Regions

Domain14 – 224211START

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue941N6-succinyllysine Ref.2
Modified residue1971N6-succinyllysine Ref.2
Modified residue2021N6-succinyllysine Ref.2
Modified residue2841Phosphoserine; by CK2

Sequences

Sequence LengthMass (Da)Tools
Q9JMD3 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 598467C430D97080

FASTA29132,951
        10         20         30         40         50         60 
MEKPAASTEP QGSRPALGRE SVQVPDDQDF RSFRSECEAE VGWNLTYSKA GVSVWVQAVE 

        70         80         90        100        110        120 
MDRTLHKIKC RMECCDVPAE TLYDVLHDIE YRKKWDSNVI ETFDIARLTV NADVGYYSWR 

       130        140        150        160        170        180 
CPKPLKNRDV ITLRSWLPMG ADYIIMNYSV KHPKYPPRKD LVRAVSIQTG YLIQSTGPKS 

       190        200        210        220        230        240 
CVITYLAQVD PKGSLPKWVV NKSSQFLAPK AMKKMYKACI KYPEWKQKHQ PHFKPWLHPE 

       250        260        270        280        290 
QSPLPSLALS ELSVQHADSL ENIDESAVTE SREERAGGAG GEGSDDDTSL T 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of phosphatidylcholine transfer protein-like protein gene expressed in murine haploid germ cells."
Yamanaka M., Koga M., Tanaka H., Nakamura Y., Ohta H., Yomogida K., Tsuchida J., Iguchi N., Nojima H., Nozaki M., Matsumiya K., Okuyama A., Toshimori K., Nishimune Y.
Biol. Reprod. 62:1694-1701(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
Tissue: Testis.
[2]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-94; LYS-197 AND LYS-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB031550 mRNA. Translation: BAA92233.1.
CCDSCCDS21509.1.
RefSeqNP_064374.1. NM_019990.4.
UniGeneMm.28896.

3D structure databases

ProteinModelPortalQ9JMD3.
SMRQ9JMD3. Positions 42-198.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9JMD3. 1 interaction.
MINTMINT-1855443.

PTM databases

PhosphoSiteQ9JMD3.

Proteomic databases

MaxQBQ9JMD3.
PaxDbQ9JMD3.
PRIDEQ9JMD3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032927; ENSMUSP00000032927; ENSMUSG00000030688.
ENSMUST00000164479; ENSMUSP00000133002; ENSMUSG00000030688.
GeneID56018.
KEGGmmu:56018.
UCSCuc009ioi.1. mouse.

Organism-specific databases

CTD10809.
MGIMGI:1860093. Stard10.

Phylogenomic databases

eggNOGNOG292439.
GeneTreeENSGT00510000047611.
HOVERGENHBG031807.
InParanoidQ9JMD3.
PhylomeDBQ9JMD3.
TreeFamTF354285.

Gene expression databases

ArrayExpressQ9JMD3.
BgeeQ9JMD3.
CleanExMM_STARD10.
GenevestigatorQ9JMD3.

Family and domain databases

Gene3D3.30.530.20. 1 hit.
InterProIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamPF01852. START. 1 hit.
[Graphical view]
SMARTSM00234. START. 1 hit.
[Graphical view]
PROSITEPS50848. START. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSTARD10. mouse.
NextBio311762.
PROQ9JMD3.
SOURCESearch...

Entry information

Entry namePCTL_MOUSE
AccessionPrimary (citable) accession number: Q9JMD3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot