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Protein

Scm-like with four MBT domains protein 1

Gene

Sfmbt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Differentiation, Spermatogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Scm-like with four MBT domains protein 1
Gene namesi
Name:Sfmbt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi61999. Sfmbt1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 863863Scm-like with four MBT domains protein 1PRO_0000071968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei764 – 7641PhosphoserineCombined sources
Modified residuei772 – 7721PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JMD2.
PRIDEiQ9JMD2.

PTM databases

iPTMnetiQ9JMD2.
PhosphoSiteiQ9JMD2.

Expressioni

Tissue specificityi

Highly expressed in the testis, low expression was detected in brain, kidney, heart and lung.1 Publication

Gene expression databases

BgeeiENSRNOG00000016645.
GenevisibleiQ9JMD2. RN.

Interactioni

Subunit structurei

Interacts with MYOD1 (By similarity). Component of the SLC (SFMBT1-LSD1-CoREST) corepressor complex, which also contains KDM1A/LSD1 and RCOR1/CoREST. Interacts with KDM1A/LSD1 and RCOR1/CoREST. Interacts with MYOD1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022865.

Structurei

3D structure databases

ProteinModelPortaliQ9JMD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati20 – 120101MBT 1Add
BLAST
Repeati128 – 232105MBT 2Add
BLAST
Repeati242 – 346105MBT 3Add
BLAST
Repeati354 – 45198MBT 4Add
BLAST
Domaini793 – 86169SAMAdd
BLAST

Domaini

The MBT repeats mediate binding to histones tails; however, in contrast to other MBT repeats, does not bind specific histone lysine modifications. The MBT repeats lack the conserved Asp and aromatic cage at conserved positions (By similarity).By similarity

Sequence similaritiesi

Contains 4 MBT repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3766. Eukaryota.
ENOG410Y4AQ. LUCA.
GeneTreeiENSGT00760000119024.
HOGENOMiHOG000004859.
HOVERGENiHBG085238.
InParanoidiQ9JMD2.
OMAiKCSENCS.
PhylomeDBiQ9JMD2.
TreeFamiTF316498.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR021987. DUF3588.
IPR004092. Mbt.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF12140. DUF3588. 1 hit.
PF02820. MBT. 4 hits.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00561. MBT. 4 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS51079. MBT. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JMD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGEQQLDAD LGSGVEVEEF SWEDYLEETG ATTAPYASFK HVDICLQSGF
60 70 80 90 100
APGMKLEVAL RKDPETYWVA TVITACEQLL LLRYEGYGED RKADFWCDIR
110 120 130 140 150
RAGLYPIGWC QQNKKTLEAP EGIRDKVSDW SAFLQRTLTG ACGPPVALLE
160 170 180 190 200
GLRNGRNPLD LIAPGSRLEC QDFRDSVSTW IVTVVENIGG RLKLQYEGLE
210 220 230 240 250
RHDGFEHWLY YLDPFLHHIG WAAQQGYELQ PPLAIRHLKN EADWQEILAR
260 270 280 290 300
VKEEEPLPSY LFKDKQVIRT HEFSINMKLE AVDPWSPFGI SPATIAKVFD
310 320 330 340 350
DKYFLVEIDD LRPEDHARRS FVCHANSPGI FPVQWSLKNG LHINPPPGFR
360 370 380 390 400
SQDFDWADYL KQCGAEAAPQ KCFPQSVSEH QFKENMKLEA VNPLFPEEVS
410 420 430 440 450
IATVTAVRGS YLWLQLEGSK KPVPEFIVSV ESMNIFPLGW CETNGHPLST
460 470 480 490 500
PRRARGHKLR KIAVVQPEKQ ILSSRTVHEG LKNQLNSPHS VMINGKYCCP
510 520 530 540 550
KIYFNHRCFS GPYLNKGRIA ELPQCVGPGN CVLVLREVLT LLINAAYKPS
560 570 580 590 600
RVLRELQLDK DSVWHGCGEV LKAKYKGKSY RATVEIVRTA DRVTEFCRQT
610 620 630 640 650
CIKLECCPNL FGPRMVLDTC SENCSVLTKT KYTHYYGKKK NKRIGRPPGG
660 670 680 690 700
HSNLSCALKK TSKRRKRRKN IFVHKKKRSS ASVDNTPVGS PQGSGGEDED
710 720 730 740 750
DADDGDDDSL TEGSTSEQQD ELHEESEVSE KKSCSPSPTQ SEMSTPLPPD
760 770 780 790 800
TQTDKREAQT SSLSDGENKP PSPKEIRIEV DERLHLDSNP LKWSVADVVR
810 820 830 840 850
FIRSTDCAPL ARIFLDQEID GQALLLLTLP TVQECMDLKL GPAIKLCHHI
860
ERIKFAFYEQ FAN
Length:863
Mass (Da):97,506
Last modified:June 7, 2005 - v2
Checksum:i4045B1505385123B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951Q → H in BAA96304 (PubMed:10806358).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032164 mRNA. Translation: BAA96304.1.
BC081770 mRNA. Translation: AAH81770.1.
RefSeqiNP_113835.2. NM_031647.2.
XP_006252718.1. XM_006252656.2.
XP_006252719.1. XM_006252657.2.
XP_006252720.1. XM_006252658.1.
XP_008769225.1. XM_008771003.1.
XP_008769226.1. XM_008771004.1.
XP_008769227.1. XM_008771005.1.
XP_008769228.1. XM_008771006.1.
UniGeneiRn.14839.

Genome annotation databases

EnsembliENSRNOT00000022865; ENSRNOP00000022865; ENSRNOG00000016645.
ENSRNOT00000084713; ENSRNOP00000074701; ENSRNOG00000016645.
GeneIDi58967.
KEGGirno:58967.
UCSCiRGD:61999. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032164 mRNA. Translation: BAA96304.1.
BC081770 mRNA. Translation: AAH81770.1.
RefSeqiNP_113835.2. NM_031647.2.
XP_006252718.1. XM_006252656.2.
XP_006252719.1. XM_006252657.2.
XP_006252720.1. XM_006252658.1.
XP_008769225.1. XM_008771003.1.
XP_008769226.1. XM_008771004.1.
XP_008769227.1. XM_008771005.1.
XP_008769228.1. XM_008771006.1.
UniGeneiRn.14839.

3D structure databases

ProteinModelPortaliQ9JMD2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022865.

PTM databases

iPTMnetiQ9JMD2.
PhosphoSiteiQ9JMD2.

Proteomic databases

PaxDbiQ9JMD2.
PRIDEiQ9JMD2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022865; ENSRNOP00000022865; ENSRNOG00000016645.
ENSRNOT00000084713; ENSRNOP00000074701; ENSRNOG00000016645.
GeneIDi58967.
KEGGirno:58967.
UCSCiRGD:61999. rat.

Organism-specific databases

CTDi51460.
RGDi61999. Sfmbt1.

Phylogenomic databases

eggNOGiKOG3766. Eukaryota.
ENOG410Y4AQ. LUCA.
GeneTreeiENSGT00760000119024.
HOGENOMiHOG000004859.
HOVERGENiHBG085238.
InParanoidiQ9JMD2.
OMAiKCSENCS.
PhylomeDBiQ9JMD2.
TreeFamiTF316498.

Miscellaneous databases

PROiQ9JMD2.

Gene expression databases

BgeeiENSRNOG00000016645.
GenevisibleiQ9JMD2. RN.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR021987. DUF3588.
IPR004092. Mbt.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF12140. DUF3588. 1 hit.
PF02820. MBT. 4 hits.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00561. MBT. 4 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS51079. MBT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMBT1_RAT
AccessioniPrimary (citable) accession number: Q9JMD2
Secondary accession number(s): Q66HN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: September 7, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.