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Protein

Scm-like with four MBT domains protein 1

Gene

Sfmbt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Scm-like with four MBT domains protein 1
Gene namesi
Name:Sfmbt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi61999 Sfmbt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000719681 – 863Scm-like with four MBT domains protein 1Add BLAST863

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei764PhosphoserineCombined sources1
Modified residuei772PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JMD2
PRIDEiQ9JMD2

PTM databases

iPTMnetiQ9JMD2
PhosphoSitePlusiQ9JMD2

Expressioni

Tissue specificityi

Highly expressed in the testis, low expression was detected in brain, kidney, heart and lung.1 Publication

Gene expression databases

BgeeiENSRNOG00000016645
GenevisibleiQ9JMD2 RN

Interactioni

Subunit structurei

Interacts with MYOD1 (By similarity). Component of the SLC (SFMBT1-LSD1-CoREST) corepressor complex, which also contains KDM1A/LSD1 and RCOR1/CoREST. Interacts with KDM1A/LSD1 and RCOR1/CoREST. Interacts with MYOD1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022865

Structurei

3D structure databases

ProteinModelPortaliQ9JMD2
SMRiQ9JMD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 120MBT 1Add BLAST101
Repeati128 – 232MBT 2Add BLAST105
Repeati242 – 346MBT 3Add BLAST105
Repeati354 – 451MBT 4Add BLAST98
Domaini793 – 861SAMAdd BLAST69

Domaini

The MBT repeats mediate binding to histones tails; however, in contrast to other MBT repeats, does not bind specific histone lysine modifications. The MBT repeats lack the conserved Asp and aromatic cage at conserved positions (By similarity).By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3766 Eukaryota
ENOG410Y4AQ LUCA
GeneTreeiENSGT00760000119024
HOGENOMiHOG000004859
HOVERGENiHBG085238
InParanoidiQ9JMD2
OMAiKCSENCS
PhylomeDBiQ9JMD2
TreeFamiTF316498

Family and domain databases

CDDicd09581 SAM_Scm-like-4MBT1_2, 1 hit
Gene3Di1.20.1380.20, 1 hit
InterProiView protein in InterPro
IPR004092 Mbt
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR037604 Scm-like-4MBT1/2_SAM
IPR021987 SLED
IPR038348 SLED_sf
PfamiView protein in Pfam
PF02820 MBT, 4 hits
PF00536 SAM_1, 1 hit
PF12140 SLED, 1 hit
SMARTiView protein in SMART
SM00561 MBT, 4 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51079 MBT, 4 hits

Sequencei

Sequence statusi: Complete.

Q9JMD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGEQQLDAD LGSGVEVEEF SWEDYLEETG ATTAPYASFK HVDICLQSGF
60 70 80 90 100
APGMKLEVAL RKDPETYWVA TVITACEQLL LLRYEGYGED RKADFWCDIR
110 120 130 140 150
RAGLYPIGWC QQNKKTLEAP EGIRDKVSDW SAFLQRTLTG ACGPPVALLE
160 170 180 190 200
GLRNGRNPLD LIAPGSRLEC QDFRDSVSTW IVTVVENIGG RLKLQYEGLE
210 220 230 240 250
RHDGFEHWLY YLDPFLHHIG WAAQQGYELQ PPLAIRHLKN EADWQEILAR
260 270 280 290 300
VKEEEPLPSY LFKDKQVIRT HEFSINMKLE AVDPWSPFGI SPATIAKVFD
310 320 330 340 350
DKYFLVEIDD LRPEDHARRS FVCHANSPGI FPVQWSLKNG LHINPPPGFR
360 370 380 390 400
SQDFDWADYL KQCGAEAAPQ KCFPQSVSEH QFKENMKLEA VNPLFPEEVS
410 420 430 440 450
IATVTAVRGS YLWLQLEGSK KPVPEFIVSV ESMNIFPLGW CETNGHPLST
460 470 480 490 500
PRRARGHKLR KIAVVQPEKQ ILSSRTVHEG LKNQLNSPHS VMINGKYCCP
510 520 530 540 550
KIYFNHRCFS GPYLNKGRIA ELPQCVGPGN CVLVLREVLT LLINAAYKPS
560 570 580 590 600
RVLRELQLDK DSVWHGCGEV LKAKYKGKSY RATVEIVRTA DRVTEFCRQT
610 620 630 640 650
CIKLECCPNL FGPRMVLDTC SENCSVLTKT KYTHYYGKKK NKRIGRPPGG
660 670 680 690 700
HSNLSCALKK TSKRRKRRKN IFVHKKKRSS ASVDNTPVGS PQGSGGEDED
710 720 730 740 750
DADDGDDDSL TEGSTSEQQD ELHEESEVSE KKSCSPSPTQ SEMSTPLPPD
760 770 780 790 800
TQTDKREAQT SSLSDGENKP PSPKEIRIEV DERLHLDSNP LKWSVADVVR
810 820 830 840 850
FIRSTDCAPL ARIFLDQEID GQALLLLTLP TVQECMDLKL GPAIKLCHHI
860
ERIKFAFYEQ FAN
Length:863
Mass (Da):97,506
Last modified:June 7, 2005 - v2
Checksum:i4045B1505385123B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195Q → H in BAA96304 (PubMed:10806358).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032164 mRNA Translation: BAA96304.1
BC081770 mRNA Translation: AAH81770.1
RefSeqiNP_113835.2, NM_031647.2
XP_006252718.1, XM_006252656.3
XP_006252719.1, XM_006252657.3
XP_006252720.1, XM_006252658.2
XP_008769225.1, XM_008771003.2
XP_008769226.1, XM_008771004.2
XP_008769227.1, XM_008771005.2
XP_008769228.1, XM_008771006.2
XP_017455728.1, XM_017600239.1
UniGeneiRn.14839

Genome annotation databases

EnsembliENSRNOT00000022865; ENSRNOP00000022865; ENSRNOG00000016645
ENSRNOT00000084713; ENSRNOP00000074701; ENSRNOG00000016645
GeneIDi58967
KEGGirno:58967
UCSCiRGD:61999 rat

Similar proteinsi

Entry informationi

Entry nameiSMBT1_RAT
AccessioniPrimary (citable) accession number: Q9JMD2
Secondary accession number(s): Q66HN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: April 25, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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