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Protein

Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Gene

Inpp5j

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles.

Catalytic activityi

D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate.1 Publication
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of microtubule polymerization Source: RGD
  • negative regulation of neuron projection development Source: RGD
  • negative regulation of peptidyl-serine phosphorylation Source: Ensembl
  • phosphatidylinositol dephosphorylation Source: InterPro

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-RNO-1660499 Synthesis of PIPs at the plasma membrane
R-RNO-1855183 Synthesis of IP2, IP, and Ins in the cytosol
R-RNO-1855204 Synthesis of IP3 and IP4 in the cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC:3.1.3.56)
Alternative name(s):
Inositol polyphosphate 5-phosphatase J
Proline-rich inositol polyphosphate 5-phosphatase
Gene namesi
Name:Inpp5j
Synonyms:Pib5pa, Pipp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi620541 Inpp5j

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097401 – 1001Phosphatidylinositol 4,5-bisphosphate 5-phosphatase AAdd BLAST1001

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei56Omega-N-methylarginine; alternateBy similarity1
Modified residuei65Omega-N-methylarginineBy similarity1
Modified residuei76Asymmetric dimethylarginineBy similarity1
Modified residuei83Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei83Omega-N-methylarginine; alternateBy similarity1
Modified residuei171PhosphoserineCombined sources1
Modified residuei292PhosphoserineBy similarity1
Modified residuei325PhosphoserineBy similarity1
Modified residuei898PhosphoserineBy similarity1
Modified residuei985PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on Ser/Thr residues.

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ9JMC1
PRIDEiQ9JMC1

PTM databases

iPTMnetiQ9JMC1
PhosphoSitePlusiQ9JMC1

Expressioni

Tissue specificityi

Expressed in heart, brain, kidney, stomach, small intestine and lung. Not expressed in spleen, thymus, skeletal muscle, testis and skin.1 Publication

Gene expression databases

BgeeiENSRNOG00000019361
GenevisibleiQ9JMC1 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026293

Structurei

3D structure databases

ProteinModelPortaliQ9JMC1
SMRiQ9JMC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni420 – 723CatalyticSequence analysisAdd BLAST304
Regioni724 – 835Required for ruffle localizationBy similarityAdd BLAST112

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi6 – 11RSXSXX motif 16
Motifi346 – 351SH3-bindingSequence analysis6
Motifi351 – 356RSXSXX motif 26
Motifi869 – 874RSXSXX motif 36
Motifi880 – 885RSXSXX motif 46
Motifi906 – 911RSXSXX motif 56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi50 – 387Pro-richAdd BLAST338
Compositional biasi835 – 932Ser-richAdd BLAST98

Domaini

The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein.

Sequence similaritiesi

Keywords - Domaini

Repeat, SH3-binding

Phylogenomic databases

eggNOGiKOG0565 Eukaryota
COG5411 LUCA
GeneTreeiENSGT00760000119075
HOGENOMiHOG000046051
HOVERGENiHBG082135
InParanoidiQ9JMC1
KOiK01106
OMAiALAPFNF
OrthoDBiEOG091G055L
PhylomeDBiQ9JMC1
TreeFamiTF317034

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000300 IPPc
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JMC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGQSRSGSA KSGTRTGLGP LPGTHGALQT GTPSKKVNSS FQLPAKNTGP
60 70 80 90 100
TPSEPRLALA PVGPRAAVSP PSERPRLALS SPRPILAPLS TAGEQKRPPP
110 120 130 140 150
HRSSKPAPTS VGQLVVSAAA GPKPPPVASV SILAPKSLGQ LVISASAMPR
160 170 180 190 200
PTPAPLGPIL SPTSRDQKQL SPTSVGPKPA LATSGLSLAL ASQEQPPQSP
210 220 230 240 250
SSPSPVPSPV LSPSQESHLA PATVTSTPAS ERQLPARQKD TAVRRPIPPA
260 270 280 290 300
DGCLHTPVQA AGLATSPPRA QTSSDPRLSP SFRARPEAPR HSPEDPVLPP
310 320 330 340 350
PPQTLPLDVS SGLPESGTRS PGLLSPTFRP GIPSNQTVPP PLPKPPRSPS
360 370 380 390 400
RSPSRSPNRS PCVPPAPEVA LPRPVTQGAG PGKCPSPNLQ TQESPVATAT
410 420 430 440 450
SPTSSWSAQP TCKSDPGFRI TVVTWNVGTA MPPDDVTSLL HLGGGHDSDG
460 470 480 490 500
ADMIAIGLQE VNSMINKRLK DALFTDQWSE LFMDALGPFN FVLVSTVRMQ
510 520 530 540 550
GVILLLFAKY YHLPFLRDVQ TDCTRTGLGG YWGNKGGVSV RLAAFGHMLC
560 570 580 590 600
FLNCHLPAHM DKAEQRKDNF QTILSLQQFQ GPGAHGILDH DLVFWFGDLN
610 620 630 640 650
FRIESYDLHF VKFAIDSNQL HQLWEKDQLN MAKNTWPILK GFQEGPLNFA
660 670 680 690 700
PTFKFDVGTN KYDTSAKKRK PAWTDRILWK VKAPSGGPSP SGRESHRLQV
710 720 730 740 750
TQHSYRSHME YTVSDHKPVA ARFLLQFAFR DDVPLVRLEV ADEWARPEQA
760 770 780 790 800
VVRYRVETVF ARSSWDWIGL YRVGFRHCKD YVAYVWAKHE EVDGNIYQVT
810 820 830 840 850
FSEESLPKGH GDFILGYYSH HHSILIGVTE PFQISLPTSE SASSSTDSSG
860 870 880 890 900
TSSEGEDDST LELLAPKSRS PSPGKSKRHR SRSPGLARFP SLALRPSSRE
910 920 930 940 950
RRGGSRSPSP QSRQLPRVAP DRGHSSGSRG SSEEGPSGPP GPWAFPPAVP
960 970 980 990 1000
RSLGLLPALR LETVDPGGGG SWGPDQEAPD PNSLSPSPQG RLGLEDGGLG

P
Length:1,001
Mass (Da):107,208
Last modified:October 1, 2000 - v1
Checksum:i7BE7741FEF8F3FAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032551 mRNA Translation: BAA90553.1
RefSeqiNP_598246.1, NM_133562.1
UniGeneiRn.23872

Genome annotation databases

EnsembliENSRNOT00000026293; ENSRNOP00000026293; ENSRNOG00000019361
GeneIDi171088
KEGGirno:171088
UCSCiRGD:620541 rat

Similar proteinsi

Entry informationi

Entry nameiPI5PA_RAT
AccessioniPrimary (citable) accession number: Q9JMC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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