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Protein

Contactin-6

Gene

Cntn6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus (By similarity). Involved in motor coordination.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Notch signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-447041. CHL1 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-6
Alternative name(s):
Neural recognition molecule NB-3
Short name:
mNB-3
Gene namesi
Name:Cntn6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1858223. Cntn6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile, the formation and organization of all nuclei and layers throughout the brains are apparently normal. They are however slow to learn to stay on the rotating rod in the rotorod test during repeated trials, and display dysfunction of equilibrium and vestibular senses in the wire hang and horizontal rod-walking tests.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001472920 – 999Contactin-6Add BLAST980
PropeptideiPRO_00000147301000 – 1028Removed in mature formSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 100PROSITE-ProRule annotation
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi144 ↔ 196PROSITE-ProRule annotation
Glycosylationi193N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi249 ↔ 297PROSITE-ProRule annotation
Disulfide bondi339 ↔ 386PROSITE-ProRule annotation
Glycosylationi368N-linked (GlcNAc...)Sequence analysis1
Glycosylationi377N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi431 ↔ 479PROSITE-ProRule annotation
Glycosylationi468N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi521 ↔ 577PROSITE-ProRule annotation
Glycosylationi659N-linked (GlcNAc...)Sequence analysis1
Glycosylationi765N-linked (GlcNAc...)Sequence analysis1
Glycosylationi860N-linked (GlcNAc...)Sequence analysis1
Glycosylationi865N-linked (GlcNAc...)Sequence analysis1
Modified residuei882PhosphotyrosineBy similarity1
Glycosylationi895N-linked (GlcNAc...)Sequence analysis1
Glycosylationi931N-linked (GlcNAc...)Sequence analysis1
Glycosylationi956N-linked (GlcNAc...)Sequence analysis1
Glycosylationi957N-linked (GlcNAc...)Sequence analysis1
Lipidationi999GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JMB8.
PRIDEiQ9JMB8.

PTM databases

PhosphoSitePlusiQ9JMB8.

Expressioni

Tissue specificityi

Expressed in brain. In brain, it is preferentially expressed in the accessory olfactory bulb, layers II/III and V of the cerebral cortex, piriform cortex, anterior thalamic nuclei, locus coeruleus of the pons and mesencephalic trigeminal nucleus and in Purkinje cells of the cerebellum.1 Publication

Developmental stagei

Highly expressed after birth, reaching a maximum at the postnatal day 7, and declines thereafter in the cerebrum, whereas it increases in the cerebellum to adulthood.1 Publication

Gene expression databases

BgeeiENSMUSG00000030092.
CleanExiMM_CNTN6.
ExpressionAtlasiQ9JMB8. baseline and differential.
GenevisibleiQ9JMB8. MM.

Interactioni

Subunit structurei

Interacts with PTPRG.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Chl1P702325EBI-7703151,EBI-7703109

Protein-protein interaction databases

IntActiQ9JMB8. 1 interactor.
MINTiMINT-6439843.
STRINGi10090.ENSMUSP00000086623.

Structurei

Secondary structure

11028
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi132 – 134Combined sources3
Beta strandi140 – 142Combined sources3
Beta strandi148 – 151Combined sources4
Beta strandi153 – 159Combined sources7
Beta strandi172 – 174Combined sources3
Turni176 – 178Combined sources3
Beta strandi181 – 185Combined sources5
Helixi188 – 190Combined sources3
Beta strandi192 – 200Combined sources9
Turni201 – 204Combined sources4
Beta strandi205 – 208Combined sources4
Beta strandi212 – 216Combined sources5
Beta strandi225 – 231Combined sources7
Beta strandi235 – 240Combined sources6
Beta strandi245 – 248Combined sources4
Beta strandi250 – 255Combined sources6
Beta strandi258 – 263Combined sources6
Beta strandi274 – 276Combined sources3
Turni277 – 280Combined sources4
Beta strandi281 – 284Combined sources4
Helixi289 – 291Combined sources3
Beta strandi293 – 301Combined sources9
Beta strandi304 – 315Combined sources12
Beta strandi602 – 609Combined sources8
Beta strandi611 – 619Combined sources9
Beta strandi630 – 636Combined sources7
Beta strandi640 – 642Combined sources3
Beta strandi647 – 654Combined sources8
Beta strandi659 – 663Combined sources5
Beta strandi670 – 678Combined sources9
Beta strandi683 – 686Combined sources4
Beta strandi705 – 709Combined sources5
Beta strandi716 – 722Combined sources7
Helixi726 – 728Combined sources3
Beta strandi731 – 733Combined sources3
Beta strandi735 – 742Combined sources8
Beta strandi749 – 755Combined sources7
Beta strandi760 – 764Combined sources5
Beta strandi773 – 782Combined sources10
Beta strandi793 – 796Combined sources4
Beta strandi810 – 812Combined sources3
Beta strandi814 – 817Combined sources4
Beta strandi819 – 822Combined sources4
Beta strandi837 – 845Combined sources9
Beta strandi850 – 858Combined sources9
Beta strandi863 – 866Combined sources4
Beta strandi874 – 883Combined sources10
Beta strandi894 – 897Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E55X-ray2.70A/B597-900[»]
5E5UX-ray2.00B/D119-316[»]
ProteinModelPortaliQ9JMB8.
SMRiQ9JMB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 117Ig-like C2-type 1Add BLAST86
Domaini122 – 208Ig-like C2-type 2Add BLAST87
Domaini227 – 308Ig-like C2-type 3Add BLAST82
Domaini318 – 402Ig-like C2-type 4Add BLAST85
Domaini408 – 502Ig-like C2-type 5Add BLAST95
Domaini500 – 587Ig-like C2-type 6Add BLAST88
Domaini600 – 698Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini703 – 800Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini805 – 901Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST97
Domaini902 – 996Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST95

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ9JMB8.
KOiK06764.
OMAiCLNWEHV.
OrthoDBiEOG091G00X7.
PhylomeDBiQ9JMB8.
TreeFamiTF351103.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR033009. Contactin-6.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF52. PTHR10489:SF52. 1 hit.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JMB8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLWKLVIL LPLINSCAGE GRFSRPIFIQ EPQDVIFPLD LSRSEIILTC
60 70 80 90 100
TANGYPSPHY RWKQNGTDID FGMTYHYRLD GGSLAISSPR TDQDIGIYQC
110 120 130 140 150
LATNPVGTIL SRKAKLQFAY IEDFETKTRS TVSVREGQGV VLLCGPPPHF
160 170 180 190 200
GELSYAWTFN DSPLYVQEDK RRFVSQDTGN LYFAKVEPSD VGNYTCFVTN
210 220 230 240 250
KEAHRSVQGP PTPLVLRTDG VMGEYEPKIE VRFPETIQAA KDSSIKLECF
260 270 280 290 300
ALGNPVPDIS WKRLDGSPMP GKIKYSKSQA ILEIPKFQQE DEGFYECIAG
310 320 330 340 350
NLRGRNLAKG QLIFYAPPEW EQKIQNTYLS IYDSLFWECK ASGNPNPSYT
360 370 380 390 400
WLKNGQRLNT EERIQIENGT LIITMLNISD SGIYQCAAEN KYQTIYANAE
410 420 430 440 450
LRVLASAPDF SKNPIKKISV VQVGGDISIE CKPNAFPKAS ISWKRGTENL
460 470 480 490 500
KQSKRVLFLE DGSLKICNVT RADAGSYTCV ATNQFGNGKS SGGLVVKERT
510 520 530 540 550
IITVPPSKMD VTVGESIVLP CQVSHDPTME VLFVWYFNGD IIDLKKGVAH
560 570 580 590 600
FERIGGESVG DLMIRNIQLG HSGKYLCTVQ TTLERLSAVA DIIVRGPPGP
610 620 630 640 650
PEDVKVEHIS STTSQLSWRP GPDNNSPIQI FTIQTRTPFS VGWQAVATVP
660 670 680 690 700
EILNGQTYNA TVVGLSPWVE YEFRVVAGNN IGIGEPSKPS ELLRTKASVP
710 720 730 740 750
NVAPGNINGG GGSRSELVIT WEAIPEELQN GEGFGYIVMF RPVGTTAWMK
760 770 780 790 800
ERVALVESSK FIYRNESIMP LSPFEVKVGV YNNEGEGSLS TVTIVYSGED
810 820 830 840 850
EPQLAPRGTS VQSFSASEME VSWNAIAWNR NTGRVLGYEV LYWTDNSKES
860 870 880 890 900
MIGKIRVSGN VTTKNITGLR ANTIYFASVR AYNTAGTGPS SLPVNVTTKK
910 920 930 940 950
SPPSQPPANI AWKLSNSKLC LNWEHVKTME NESEVLGYKI LYRQNRQSKT
960 970 980 990 1000
HILETNNTSA ELLVPFEEDY LIEIRTVSDG GDGSSSEEIR IPKMSSLSST
1010 1020
GVQISKPSTQ SLSMVGVFYC FAIHPLSR
Length:1,028
Mass (Da):113,761
Last modified:November 23, 2004 - v2
Checksum:iB233ED300881B101
GO
Isoform 2 (identifier: Q9JMB8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-78: Missing.

Show »
Length:1,011
Mass (Da):111,647
Checksum:i2063EDAD11A2B3A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti262K → R in BAA92367 (PubMed:10717476).Curated1
Sequence conflicti892L → P in BAA92367 (PubMed:10717476).Curated1
Sequence conflicti921L → V in BAA92367 (PubMed:10717476).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01196862 – 78Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032602 mRNA. Translation: BAA92367.1.
AK052972 mRNA. Translation: BAC35227.1.
BC076594 mRNA. Translation: AAH76594.1.
CCDSiCCDS20394.1. [Q9JMB8-1]
RefSeqiNP_059079.2. NM_017383.3. [Q9JMB8-1]
XP_006506444.1. XM_006506381.3. [Q9JMB8-1]
XP_006506445.1. XM_006506382.3. [Q9JMB8-1]
XP_006506446.1. XM_006506383.3. [Q9JMB8-1]
XP_006506447.1. XM_006506384.2. [Q9JMB8-2]
XP_017177167.1. XM_017321678.1. [Q9JMB8-1]
XP_017177168.1. XM_017321679.1. [Q9JMB8-1]
UniGeneiMm.321671.

Genome annotation databases

EnsembliENSMUST00000089215; ENSMUSP00000086623; ENSMUSG00000030092. [Q9JMB8-1]
ENSMUST00000162872; ENSMUSP00000124025; ENSMUSG00000030092. [Q9JMB8-1]
GeneIDi53870.
KEGGimmu:53870.
UCSCiuc009dco.1. mouse. [Q9JMB8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032602 mRNA. Translation: BAA92367.1.
AK052972 mRNA. Translation: BAC35227.1.
BC076594 mRNA. Translation: AAH76594.1.
CCDSiCCDS20394.1. [Q9JMB8-1]
RefSeqiNP_059079.2. NM_017383.3. [Q9JMB8-1]
XP_006506444.1. XM_006506381.3. [Q9JMB8-1]
XP_006506445.1. XM_006506382.3. [Q9JMB8-1]
XP_006506446.1. XM_006506383.3. [Q9JMB8-1]
XP_006506447.1. XM_006506384.2. [Q9JMB8-2]
XP_017177167.1. XM_017321678.1. [Q9JMB8-1]
XP_017177168.1. XM_017321679.1. [Q9JMB8-1]
UniGeneiMm.321671.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E55X-ray2.70A/B597-900[»]
5E5UX-ray2.00B/D119-316[»]
ProteinModelPortaliQ9JMB8.
SMRiQ9JMB8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JMB8. 1 interactor.
MINTiMINT-6439843.
STRINGi10090.ENSMUSP00000086623.

PTM databases

PhosphoSitePlusiQ9JMB8.

Proteomic databases

PaxDbiQ9JMB8.
PRIDEiQ9JMB8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089215; ENSMUSP00000086623; ENSMUSG00000030092. [Q9JMB8-1]
ENSMUST00000162872; ENSMUSP00000124025; ENSMUSG00000030092. [Q9JMB8-1]
GeneIDi53870.
KEGGimmu:53870.
UCSCiuc009dco.1. mouse. [Q9JMB8-1]

Organism-specific databases

CTDi27255.
MGIiMGI:1858223. Cntn6.

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ9JMB8.
KOiK06764.
OMAiCLNWEHV.
OrthoDBiEOG091G00X7.
PhylomeDBiQ9JMB8.
TreeFamiTF351103.

Enzyme and pathway databases

ReactomeiR-MMU-447041. CHL1 interactions.

Miscellaneous databases

ChiTaRSiCntn6. mouse.
PROiQ9JMB8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030092.
CleanExiMM_CNTN6.
ExpressionAtlasiQ9JMB8. baseline and differential.
GenevisibleiQ9JMB8. MM.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR033009. Contactin-6.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF52. PTHR10489:SF52. 1 hit.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNTN6_MOUSE
AccessioniPrimary (citable) accession number: Q9JMB8
Secondary accession number(s): Q8C6X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.