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Q9JMA9

- S6A14_MOUSE

UniProt

Q9JMA9 - S6A14_MOUSE

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Protein
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
Gene
Slc6a14
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na+/Cl--dependent manner.2 Publications

GO - Molecular functioni

  1. amine transmembrane transporter activity Source: MGI
  2. neurotransmitter:sodium symporter activity Source: InterPro

GO - Biological processi

  1. amine transport Source: GOC
  2. amino acid transport Source: UniProtKB-KW
  3. response to toxic substance Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
Alternative name(s):
Amino acid transporter ATB0+
Colonic system B0+ amino acid transporter CATB0+
Solute carrier family 6 member 14
Gene namesi
Name:Slc6a14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1890216. Slc6a14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei45 – 6521Helical; Name=1; Reviewed prediction
Add
BLAST
Transmembranei72 – 9221Helical; Name=2; Reviewed prediction
Add
BLAST
Transmembranei110 – 13021Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini131 – 230100Extracellular Reviewed prediction
Add
BLAST
Transmembranei231 – 25121Helical; Name=4; Reviewed prediction
Add
BLAST
Transmembranei257 – 27721Helical; Name=5; Reviewed prediction
Add
BLAST
Transmembranei311 – 33121Helical; Name=6; Reviewed prediction
Add
BLAST
Transmembranei344 – 36421Helical; Name=7; Reviewed prediction
Add
BLAST
Transmembranei395 – 41521Helical; Name=8; Reviewed prediction
Add
BLAST
Transmembranei453 – 47321Helical; Name=9; Reviewed prediction
Add
BLAST
Transmembranei476 – 49621Helical; Name=10; Reviewed prediction
Add
BLAST
Transmembranei524 – 54421Helical; Name=11; Reviewed prediction
Add
BLAST
Transmembranei559 – 57921Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini580 – 63859Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. brush border membrane Source: Ensembl
  2. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
PRO_0000214796Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi155 – 1551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi163 – 1631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi174 – 1741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi185 – 1851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi193 – 1931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi198 – 1981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi298 – 2981N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9JMA9.

PTM databases

PhosphoSiteiQ9JMA9.

Expressioni

Tissue specificityi

Expressed in the distal region of the intestinal tract: cecum and colon.2 Publications

Gene expression databases

ArrayExpressiQ9JMA9.
BgeeiQ9JMA9.
GenevestigatoriQ9JMA9.

Structurei

3D structure databases

ProteinModelPortaliQ9JMA9.
SMRiQ9JMA9. Positions 35-598.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00740000115427.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ9JMA9.
KOiK05038.
OMAiNCSYWAD.
OrthoDBiEOG793B71.
PhylomeDBiQ9JMA9.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JMA9-1 [UniParc]FASTAAdd to Basket

« Hide

MDRLKCPNFF KCRQKEKVTA SSENFHVGEN DENQERGNWS KKSDYLLSMV    50
GYAVGLGNVW RFPYLTYTNG GGAFLIPYAI MLALAGLPLF FLECSLGQFA 100
SLGPVSVWRI LPLFQGVGIT MVLISVFVAI YYNVIIAYSL YYLFASFQSV 150
LPWANCSSWA DENCSRTPIV TGCNVSIGAG EMFMNISWVN TNNLTCLNGS 200
EVFRPGQLPS EQYWDKVTLQ RSSGMDETGV VVWYLALCLL LAWLIVGAAL 250
FKGIKSSGKV VYFTALFPYV VLLILLIRGA TLEGASKGIS YYIGAQSNFT 300
KLREAEVWKD AATQIFYSLS VAWGGLVALS SYNKFNNNCY SDAIIVCLTN 350
CLTSVFAGFA IFSILGHMAH ISGKEVSQVV KSGFDLAFIA YPEALAQLPA 400
GPFWSILFFF MLLTLGLDSQ FASIETITTT FQDLFPKAMK RMRVPITLGC 450
CLILFLLGLL CVTQAGIYWV HLIDHFCAGW GILIAAILEI AGIIWIYGGN 500
RFIEDIEMMI GAKRWIFWLW WRACWFVITP ILLSAILVWS LVKFHRPDYA 550
DIPYPDWGVA LGWCMIIFCI IWIPIMAIIK IVQAEGNILQ RIISCCRPAS 600
NWGPYLEKHR GERYRDMAEP AKETDHEIPT ISGSTKPE 638
Length:638
Mass (Da):71,456
Last modified:October 1, 2000 - v1
Checksum:i5D5A78E2DF7E7612
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 901F → V in AAD49320. 1 Publication
Sequence conflicti123 – 1231L → P in AAD49320. 1 Publication
Sequence conflicti192 – 1921N → S in AAK43541. 1 Publication
Sequence conflicti323 – 3231W → C in AAD49320. 1 Publication
Sequence conflicti341 – 3411S → P in AAD49320. 1 Publication
Sequence conflicti350 – 3501N → K in AAD49320. 1 Publication
Sequence conflicti597 – 5971R → I in BAB31272. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033285 mRNA. Translation: BAA94300.1.
AF320226 mRNA. Translation: AAK43541.1.
AF161714 mRNA. Translation: AAD49320.1.
AK018553 mRNA. Translation: BAB31272.1.
CCDSiCCDS30051.1.
RefSeqiNP_064433.3. NM_020049.4.
UniGeneiMm.253984.

Genome annotation databases

EnsembliENSMUST00000033414; ENSMUSP00000033414; ENSMUSG00000031089.
GeneIDi56774.
KEGGimmu:56774.
UCSCiuc009sur.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033285 mRNA. Translation: BAA94300.1 .
AF320226 mRNA. Translation: AAK43541.1 .
AF161714 mRNA. Translation: AAD49320.1 .
AK018553 mRNA. Translation: BAB31272.1 .
CCDSi CCDS30051.1.
RefSeqi NP_064433.3. NM_020049.4.
UniGenei Mm.253984.

3D structure databases

ProteinModelPortali Q9JMA9.
SMRi Q9JMA9. Positions 35-598.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9JMA9.

Proteomic databases

PRIDEi Q9JMA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033414 ; ENSMUSP00000033414 ; ENSMUSG00000031089 .
GeneIDi 56774.
KEGGi mmu:56774.
UCSCi uc009sur.2. mouse.

Organism-specific databases

CTDi 11254.
MGIi MGI:1890216. Slc6a14.

Phylogenomic databases

eggNOGi COG0733.
GeneTreei ENSGT00740000115427.
HOGENOMi HOG000116406.
HOVERGENi HBG071421.
InParanoidi Q9JMA9.
KOi K05038.
OMAi NCSYWAD.
OrthoDBi EOG793B71.
PhylomeDBi Q9JMA9.
TreeFami TF343812.

Miscellaneous databases

NextBioi 313306.
PROi Q9JMA9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JMA9.
Bgeei Q9JMA9.
Genevestigatori Q9JMA9.

Family and domain databases

InterProi IPR000175. Na/ntran_symport.
[Graphical view ]
PANTHERi PTHR11616. PTHR11616. 1 hit.
Pfami PF00209. SNF. 1 hit.
[Graphical view ]
PRINTSi PR00176. NANEUSMPORT.
PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a mouse colonic system B(0+) amino acid transporter related to amino acid absorption in colon."
    Ugawa S., Sunouchi Y., Ueda T., Takahashi E., Saishin Y., Shimada S.
    Am. J. Physiol. 281:G365-G370(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: ddY.
  2. "Na(+)- and Cl(-)-coupled active transport of nitric oxide synthase inhibitors via amino acid transport system B(0,+)."
    Hatanaka T., Nakanishi T., Huang W., Leibach F.H., Prasad P.D., Ganapathy V., Ganapathy M.E.
    J. Clin. Invest. 107:1035-1043(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Colon.
  3. Revell L., Sloan J.L., Mager S.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Lung.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Colon.

Entry informationi

Entry nameiS6A14_MOUSE
AccessioniPrimary (citable) accession number: Q9JMA9
Secondary accession number(s): Q91Y60, Q9D317, Q9R183
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi