Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9JMA9

- S6A14_MOUSE

UniProt

Q9JMA9 - S6A14_MOUSE

Protein

Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

Gene

Slc6a14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na+/Cl--dependent manner.2 Publications

    GO - Molecular functioni

    1. amine transmembrane transporter activity Source: MGI
    2. neurotransmitter:sodium symporter activity Source: InterPro

    GO - Biological processi

    1. amine transport Source: GOC
    2. amino acid transport Source: UniProtKB-KW
    3. response to toxic substance Source: Ensembl

    Keywords - Biological processi

    Amino-acid transport, Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
    Alternative name(s):
    Amino acid transporter ATB0+
    Colonic system B0+ amino acid transporter CATB0+
    Solute carrier family 6 member 14
    Gene namesi
    Name:Slc6a14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1890216. Slc6a14.

    Subcellular locationi

    GO - Cellular componenti

    1. brush border membrane Source: Ensembl
    2. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 638638Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)PRO_0000214796Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9JMA9.

    PTM databases

    PhosphoSiteiQ9JMA9.

    Expressioni

    Tissue specificityi

    Expressed in the distal region of the intestinal tract: cecum and colon.2 Publications

    Gene expression databases

    ArrayExpressiQ9JMA9.
    BgeeiQ9JMA9.
    GenevestigatoriQ9JMA9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JMA9.
    SMRiQ9JMA9. Positions 35-598.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini131 – 230100ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini580 – 63859CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei231 – 25121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei344 – 36421Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei395 – 41521Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei453 – 47321Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei476 – 49621Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei524 – 54421Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei559 – 57921Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    GeneTreeiENSGT00740000115427.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiQ9JMA9.
    KOiK05038.
    OMAiNCSYWAD.
    OrthoDBiEOG793B71.
    PhylomeDBiQ9JMA9.
    TreeFamiTF343812.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR00176. NANEUSMPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JMA9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRLKCPNFF KCRQKEKVTA SSENFHVGEN DENQERGNWS KKSDYLLSMV    50
    GYAVGLGNVW RFPYLTYTNG GGAFLIPYAI MLALAGLPLF FLECSLGQFA 100
    SLGPVSVWRI LPLFQGVGIT MVLISVFVAI YYNVIIAYSL YYLFASFQSV 150
    LPWANCSSWA DENCSRTPIV TGCNVSIGAG EMFMNISWVN TNNLTCLNGS 200
    EVFRPGQLPS EQYWDKVTLQ RSSGMDETGV VVWYLALCLL LAWLIVGAAL 250
    FKGIKSSGKV VYFTALFPYV VLLILLIRGA TLEGASKGIS YYIGAQSNFT 300
    KLREAEVWKD AATQIFYSLS VAWGGLVALS SYNKFNNNCY SDAIIVCLTN 350
    CLTSVFAGFA IFSILGHMAH ISGKEVSQVV KSGFDLAFIA YPEALAQLPA 400
    GPFWSILFFF MLLTLGLDSQ FASIETITTT FQDLFPKAMK RMRVPITLGC 450
    CLILFLLGLL CVTQAGIYWV HLIDHFCAGW GILIAAILEI AGIIWIYGGN 500
    RFIEDIEMMI GAKRWIFWLW WRACWFVITP ILLSAILVWS LVKFHRPDYA 550
    DIPYPDWGVA LGWCMIIFCI IWIPIMAIIK IVQAEGNILQ RIISCCRPAS 600
    NWGPYLEKHR GERYRDMAEP AKETDHEIPT ISGSTKPE 638
    Length:638
    Mass (Da):71,456
    Last modified:October 1, 2000 - v1
    Checksum:i5D5A78E2DF7E7612
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti90 – 901F → V in AAD49320. 1 PublicationCurated
    Sequence conflicti123 – 1231L → P in AAD49320. 1 PublicationCurated
    Sequence conflicti192 – 1921N → S in AAK43541. (PubMed:11306607)Curated
    Sequence conflicti323 – 3231W → C in AAD49320. 1 PublicationCurated
    Sequence conflicti341 – 3411S → P in AAD49320. 1 PublicationCurated
    Sequence conflicti350 – 3501N → K in AAD49320. 1 PublicationCurated
    Sequence conflicti597 – 5971R → I in BAB31272. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033285 mRNA. Translation: BAA94300.1.
    AF320226 mRNA. Translation: AAK43541.1.
    AF161714 mRNA. Translation: AAD49320.1.
    AK018553 mRNA. Translation: BAB31272.1.
    CCDSiCCDS30051.1.
    RefSeqiNP_064433.3. NM_020049.4.
    UniGeneiMm.253984.

    Genome annotation databases

    EnsembliENSMUST00000033414; ENSMUSP00000033414; ENSMUSG00000031089.
    GeneIDi56774.
    KEGGimmu:56774.
    UCSCiuc009sur.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033285 mRNA. Translation: BAA94300.1 .
    AF320226 mRNA. Translation: AAK43541.1 .
    AF161714 mRNA. Translation: AAD49320.1 .
    AK018553 mRNA. Translation: BAB31272.1 .
    CCDSi CCDS30051.1.
    RefSeqi NP_064433.3. NM_020049.4.
    UniGenei Mm.253984.

    3D structure databases

    ProteinModelPortali Q9JMA9.
    SMRi Q9JMA9. Positions 35-598.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9JMA9.

    Proteomic databases

    PRIDEi Q9JMA9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033414 ; ENSMUSP00000033414 ; ENSMUSG00000031089 .
    GeneIDi 56774.
    KEGGi mmu:56774.
    UCSCi uc009sur.2. mouse.

    Organism-specific databases

    CTDi 11254.
    MGIi MGI:1890216. Slc6a14.

    Phylogenomic databases

    eggNOGi COG0733.
    GeneTreei ENSGT00740000115427.
    HOGENOMi HOG000116406.
    HOVERGENi HBG071421.
    InParanoidi Q9JMA9.
    KOi K05038.
    OMAi NCSYWAD.
    OrthoDBi EOG793B71.
    PhylomeDBi Q9JMA9.
    TreeFami TF343812.

    Miscellaneous databases

    NextBioi 313306.
    PROi Q9JMA9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JMA9.
    Bgeei Q9JMA9.
    Genevestigatori Q9JMA9.

    Family and domain databases

    InterProi IPR000175. Na/ntran_symport.
    [Graphical view ]
    PANTHERi PTHR11616. PTHR11616. 1 hit.
    Pfami PF00209. SNF. 1 hit.
    [Graphical view ]
    PRINTSi PR00176. NANEUSMPORT.
    PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a mouse colonic system B(0+) amino acid transporter related to amino acid absorption in colon."
      Ugawa S., Sunouchi Y., Ueda T., Takahashi E., Saishin Y., Shimada S.
      Am. J. Physiol. 281:G365-G370(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: ddY.
    2. "Na(+)- and Cl(-)-coupled active transport of nitric oxide synthase inhibitors via amino acid transport system B(0,+)."
      Hatanaka T., Nakanishi T., Huang W., Leibach F.H., Prasad P.D., Ganapathy V., Ganapathy M.E.
      J. Clin. Invest. 107:1035-1043(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: C57BL/6.
      Tissue: Colon.
    3. Revell L., Sloan J.L., Mager S.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Lung.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Colon.

    Entry informationi

    Entry nameiS6A14_MOUSE
    AccessioniPrimary (citable) accession number: Q9JMA9
    Secondary accession number(s): Q91Y60, Q9D317, Q9R183
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3