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Q9JMA9

- S6A14_MOUSE

UniProt

Q9JMA9 - S6A14_MOUSE

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Protein

Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

Gene

Slc6a14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na+/Cl--dependent manner.2 Publications

GO - Molecular functioni

  1. amine transmembrane transporter activity Source: MGI
  2. neurotransmitter:sodium symporter activity Source: InterPro

GO - Biological processi

  1. amine transport Source: GOC
  2. amino acid transport Source: UniProtKB-KW
  3. response to toxic substance Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_230460. Amino acid transport across the plasma membrane.
REACT_253228. Na+/Cl- dependent neurotransmitter transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
Alternative name(s):
Amino acid transporter ATB0+
Colonic system B0+ amino acid transporter CATB0+
Solute carrier family 6 member 14
Gene namesi
Name:Slc6a14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1890216. Slc6a14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei45 – 6521Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei72 – 9221Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei110 – 13021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini131 – 230100ExtracellularSequence AnalysisAdd
BLAST
Transmembranei231 – 25121Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei257 – 27721Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei311 – 33121Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei344 – 36421Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei395 – 41521Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei453 – 47321Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei476 – 49621Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei524 – 54421Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei559 – 57921Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini580 – 63859CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. brush border membrane Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)PRO_0000214796Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9JMA9.

PTM databases

PhosphoSiteiQ9JMA9.

Expressioni

Tissue specificityi

Expressed in the distal region of the intestinal tract: cecum and colon.2 Publications

Gene expression databases

BgeeiQ9JMA9.
ExpressionAtlasiQ9JMA9. baseline and differential.
GenevestigatoriQ9JMA9.

Structurei

3D structure databases

ProteinModelPortaliQ9JMA9.
SMRiQ9JMA9. Positions 35-598.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ9JMA9.
KOiK05038.
OMAiNCSYWAD.
OrthoDBiEOG793B71.
PhylomeDBiQ9JMA9.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JMA9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRLKCPNFF KCRQKEKVTA SSENFHVGEN DENQERGNWS KKSDYLLSMV
60 70 80 90 100
GYAVGLGNVW RFPYLTYTNG GGAFLIPYAI MLALAGLPLF FLECSLGQFA
110 120 130 140 150
SLGPVSVWRI LPLFQGVGIT MVLISVFVAI YYNVIIAYSL YYLFASFQSV
160 170 180 190 200
LPWANCSSWA DENCSRTPIV TGCNVSIGAG EMFMNISWVN TNNLTCLNGS
210 220 230 240 250
EVFRPGQLPS EQYWDKVTLQ RSSGMDETGV VVWYLALCLL LAWLIVGAAL
260 270 280 290 300
FKGIKSSGKV VYFTALFPYV VLLILLIRGA TLEGASKGIS YYIGAQSNFT
310 320 330 340 350
KLREAEVWKD AATQIFYSLS VAWGGLVALS SYNKFNNNCY SDAIIVCLTN
360 370 380 390 400
CLTSVFAGFA IFSILGHMAH ISGKEVSQVV KSGFDLAFIA YPEALAQLPA
410 420 430 440 450
GPFWSILFFF MLLTLGLDSQ FASIETITTT FQDLFPKAMK RMRVPITLGC
460 470 480 490 500
CLILFLLGLL CVTQAGIYWV HLIDHFCAGW GILIAAILEI AGIIWIYGGN
510 520 530 540 550
RFIEDIEMMI GAKRWIFWLW WRACWFVITP ILLSAILVWS LVKFHRPDYA
560 570 580 590 600
DIPYPDWGVA LGWCMIIFCI IWIPIMAIIK IVQAEGNILQ RIISCCRPAS
610 620 630
NWGPYLEKHR GERYRDMAEP AKETDHEIPT ISGSTKPE
Length:638
Mass (Da):71,456
Last modified:October 1, 2000 - v1
Checksum:i5D5A78E2DF7E7612
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 901F → V in AAD49320. 1 PublicationCurated
Sequence conflicti123 – 1231L → P in AAD49320. 1 PublicationCurated
Sequence conflicti192 – 1921N → S in AAK43541. (PubMed:11306607)Curated
Sequence conflicti323 – 3231W → C in AAD49320. 1 PublicationCurated
Sequence conflicti341 – 3411S → P in AAD49320. 1 PublicationCurated
Sequence conflicti350 – 3501N → K in AAD49320. 1 PublicationCurated
Sequence conflicti597 – 5971R → I in BAB31272. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033285 mRNA. Translation: BAA94300.1.
AF320226 mRNA. Translation: AAK43541.1.
AF161714 mRNA. Translation: AAD49320.1.
AK018553 mRNA. Translation: BAB31272.1.
CCDSiCCDS30051.1.
RefSeqiNP_064433.3. NM_020049.4.
UniGeneiMm.253984.

Genome annotation databases

EnsembliENSMUST00000033414; ENSMUSP00000033414; ENSMUSG00000031089.
GeneIDi56774.
KEGGimmu:56774.
UCSCiuc009sur.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033285 mRNA. Translation: BAA94300.1 .
AF320226 mRNA. Translation: AAK43541.1 .
AF161714 mRNA. Translation: AAD49320.1 .
AK018553 mRNA. Translation: BAB31272.1 .
CCDSi CCDS30051.1.
RefSeqi NP_064433.3. NM_020049.4.
UniGenei Mm.253984.

3D structure databases

ProteinModelPortali Q9JMA9.
SMRi Q9JMA9. Positions 35-598.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9JMA9.

Proteomic databases

PRIDEi Q9JMA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033414 ; ENSMUSP00000033414 ; ENSMUSG00000031089 .
GeneIDi 56774.
KEGGi mmu:56774.
UCSCi uc009sur.2. mouse.

Organism-specific databases

CTDi 11254.
MGIi MGI:1890216. Slc6a14.

Phylogenomic databases

eggNOGi COG0733.
GeneTreei ENSGT00760000118857.
HOGENOMi HOG000116406.
HOVERGENi HBG071421.
InParanoidi Q9JMA9.
KOi K05038.
OMAi NCSYWAD.
OrthoDBi EOG793B71.
PhylomeDBi Q9JMA9.
TreeFami TF343812.

Enzyme and pathway databases

Reactomei REACT_230460. Amino acid transport across the plasma membrane.
REACT_253228. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

NextBioi 313306.
PROi Q9JMA9.
SOURCEi Search...

Gene expression databases

Bgeei Q9JMA9.
ExpressionAtlasi Q9JMA9. baseline and differential.
Genevestigatori Q9JMA9.

Family and domain databases

InterProi IPR000175. Na/ntran_symport.
[Graphical view ]
PANTHERi PTHR11616. PTHR11616. 1 hit.
Pfami PF00209. SNF. 1 hit.
[Graphical view ]
PRINTSi PR00176. NANEUSMPORT.
PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a mouse colonic system B(0+) amino acid transporter related to amino acid absorption in colon."
    Ugawa S., Sunouchi Y., Ueda T., Takahashi E., Saishin Y., Shimada S.
    Am. J. Physiol. 281:G365-G370(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: ddY.
  2. "Na(+)- and Cl(-)-coupled active transport of nitric oxide synthase inhibitors via amino acid transport system B(0,+)."
    Hatanaka T., Nakanishi T., Huang W., Leibach F.H., Prasad P.D., Ganapathy V., Ganapathy M.E.
    J. Clin. Invest. 107:1035-1043(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Colon.
  3. Revell L., Sloan J.L., Mager S.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Lung.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Colon.

Entry informationi

Entry nameiS6A14_MOUSE
AccessioniPrimary (citable) accession number: Q9JMA9
Secondary accession number(s): Q91Y60, Q9D317, Q9R183
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3