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Q9JMA7

- CP341_MOUSE

UniProt

Q9JMA7 - CP341_MOUSE

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Protein

Cytochrome P450 3A41

Gene
Cyp3a41a, Cyp3a41
Cyp3a41b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi443 – 4431Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_216259. Miscellaneous substrates.

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
Cytochrome P450 3A41 (EC:1.14.14.1)
Gene namesi
Name:Cyp3a41a
Synonyms:Cyp3a41
AND
Name:Cyp3a41b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5
MGIiMGI:1858451. Cyp3a41a.
MGI:3714859. Cyp3a41b.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Cytochrome P450 3A41PRO_0000051813Add
BLAST

Proteomic databases

MaxQBiQ9JMA7.
PaxDbiQ9JMA7.
PRIDEiQ9JMA7.

PTM databases

PhosphoSiteiQ9JMA7.

Expressioni

Tissue specificityi

Expressed in liver. Also expressed in the kidneys of female mice, with traces in the stomach, ovary, and heart of female mice and in the testis of male mice.

Developmental stagei

Detected immediately after birth in the livers of animals of both sexes, but increases with age in females, whereas it is gradually reduced in males, resulting in predominantly female-specific expression in livers.

Gene expression databases

BgeeiQ9JMA7.
GenevestigatoriQ9JMA7.

Interactioni

Protein-protein interaction databases

IntActiQ9JMA7. 3 interactions.
MINTiMINT-4091744.

Structurei

3D structure databases

ProteinModelPortaliQ9JMA7.
SMRiQ9JMA7. Positions 29-498.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00730000110610.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiB2RQU5.
KOiK07424.
OrthoDBiEOG744TBS.
TreeFamiTF105087.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JMA7-1 [UniParc]FASTAAdd to Basket

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MNLFSALSLD TWVLLAIILV LLYRYGTRTH GLFKKQGIPG PKPLPFLGTV    50
LNYYKGLWKF DMECYEKYGK TWGLFDGQMP LFVITDPEMI KNVLVKECFS 100
VFTNRREFGP VGIMSKAISI SKDEEWKRYR ALLSPTFTSG KLKEMFPVIE 150
QYGDILVKYL MQEAEKGKPV TMKDVLGAYS IDVITSTSFG VNVDSLNNPE 200
DPFVEKAKGI LRVDFFDPLV FSVVLFPFLT PVYEMLNICM FPKDSIEFFK 250
KFVNRMKESR LDSKQKHRVD FLQLMMNAHN NSKDKDSHKA LSDMEITAQS 300
IVFIFAGYET TSSTLSFTLY CLATHPDIQK KLQEEIDETL PNKAPPTYDT 350
VMEMEYLDMV LNETLRLYPI GNRLERFCKK DVELNGVYIP KGSTVMIPSY 400
ALHHDPQHWP EPEEFQPERF SKENKGSIDP YLYMPFGIGP RNCIGMRFAF 450
MTMKLALTKV MQNFSFQPCQ ETQIPLKLSR QGLLQPEKPI VLKVVPRDVV 500
ITGA 504
Length:504
Mass (Da):57,987
Last modified:July 27, 2011 - v2
Checksum:i1F6455156C073479
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421K → T in BAA95951. 1 Publication
Sequence conflicti42 – 421K → T in AAI38084. 1 Publication
Sequence conflicti42 – 421K → T in AAI38085. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033414 mRNA. Translation: BAA95951.1.
AC124483 Genomic DNA. No translation available.
AC166648 Genomic DNA. No translation available.
BC138083 mRNA. Translation: AAI38084.1.
BC138084 mRNA. Translation: AAI38085.1.
CCDSiCCDS19863.1.
CCDS39389.1.
RefSeqiNP_001098629.1. NM_001105159.1.
NP_059092.2. NM_017396.3.
UniGeneiMm.379071.
Mm.489591.

Genome annotation databases

EnsembliENSMUST00000075837; ENSMUSP00000075234; ENSMUSG00000075552.
ENSMUST00000094111; ENSMUSP00000091659; ENSMUSG00000075551.
GeneIDi100041375.
53973.
KEGGimmu:100041375.
mmu:53973.
UCSCiuc012egw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033414 mRNA. Translation: BAA95951.1 .
AC124483 Genomic DNA. No translation available.
AC166648 Genomic DNA. No translation available.
BC138083 mRNA. Translation: AAI38084.1 .
BC138084 mRNA. Translation: AAI38085.1 .
CCDSi CCDS19863.1.
CCDS39389.1.
RefSeqi NP_001098629.1. NM_001105159.1.
NP_059092.2. NM_017396.3.
UniGenei Mm.379071.
Mm.489591.

3D structure databases

ProteinModelPortali Q9JMA7.
SMRi Q9JMA7. Positions 29-498.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9JMA7. 3 interactions.
MINTi MINT-4091744.

PTM databases

PhosphoSitei Q9JMA7.

Proteomic databases

MaxQBi Q9JMA7.
PaxDbi Q9JMA7.
PRIDEi Q9JMA7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075837 ; ENSMUSP00000075234 ; ENSMUSG00000075552 .
ENSMUST00000094111 ; ENSMUSP00000091659 ; ENSMUSG00000075551 .
GeneIDi 100041375.
53973.
KEGGi mmu:100041375.
mmu:53973.
UCSCi uc012egw.1. mouse.

Organism-specific databases

CTDi 100041375.
53973.
MGIi MGI:1858451. Cyp3a41a.
MGI:3714859. Cyp3a41b.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00730000110610.
HOGENOMi HOG000039127.
HOVERGENi HBG108567.
InParanoidi B2RQU5.
KOi K07424.
OrthoDBi EOG744TBS.
TreeFami TF105087.

Enzyme and pathway databases

Reactomei REACT_216259. Miscellaneous substrates.

Miscellaneous databases

NextBioi 310861.
PROi Q9JMA7.
SOURCEi Search...

Gene expression databases

Bgeei Q9JMA7.
Genevestigatori Q9JMA7.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel female-specific member of the CYP3A gene subfamily in the mouse liver."
    Sakuma T., Takai M., Endo Y., Kuroiwa M., Ohara A., Jarukamjorn K., Honma R., Nemoto N.
    Arch. Biochem. Biophys. 377:153-162(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ddY.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCP341_MOUSE
AccessioniPrimary (citable) accession number: Q9JMA7
Secondary accession number(s): B2RQU5, E9QJT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi