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Protein

Cytochrome P450 3A41

Gene

Cyp3a41a

more
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi443Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • regulation of gene expression Source: MGI

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211958 Miscellaneous substrates
R-MMU-211981 Xenobiotics
R-MMU-5423646 Aflatoxin activation and detoxification
R-MMU-9027307 Biosynthesis of maresin-like SPMs

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A41 (EC:1.14.14.1)
Gene namesi
Name:Cyp3a41a
Synonyms:Cyp3a41
AND
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1858451 Cyp3a41a
MGI:3714859 Cyp3a41b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3637781

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518131 – 504Cytochrome P450 3A41Add BLAST504

Proteomic databases

MaxQBiQ9JMA7
PaxDbiQ9JMA7
PeptideAtlasiQ9JMA7
PRIDEiQ9JMA7

PTM databases

iPTMnetiQ9JMA7
PhosphoSitePlusiQ9JMA7
SwissPalmiQ9JMA7

Expressioni

Tissue specificityi

Expressed in liver. Also expressed in the kidneys of female mice, with traces in the stomach, ovary, and heart of female mice and in the testis of male mice.

Developmental stagei

Detected immediately after birth in the livers of animals of both sexes, but increases with age in females, whereas it is gradually reduced in males, resulting in predominantly female-specific expression in livers.

Gene expression databases

BgeeiENSMUSG00000075551
GenevisibleiQ9JMA7 MM

Interactioni

Protein-protein interaction databases

IntActiQ9JMA7, 3 interactors
MINTiQ9JMA7
STRINGi10090.ENSMUSP00000091659

Structurei

3D structure databases

ProteinModelPortaliQ9JMA7
SMRiQ9JMA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0158 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140779
HOGENOMiHOG000039127
HOVERGENiHBG108567
InParanoidiQ9JMA7
KOiK07424
OMAiYCEAVIS
OrthoDBiEOG091G0JNC
TreeFamiTF105087

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JMA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLFSALSLD TWVLLAIILV LLYRYGTRTH GLFKKQGIPG PKPLPFLGTV
60 70 80 90 100
LNYYKGLWKF DMECYEKYGK TWGLFDGQMP LFVITDPEMI KNVLVKECFS
110 120 130 140 150
VFTNRREFGP VGIMSKAISI SKDEEWKRYR ALLSPTFTSG KLKEMFPVIE
160 170 180 190 200
QYGDILVKYL MQEAEKGKPV TMKDVLGAYS IDVITSTSFG VNVDSLNNPE
210 220 230 240 250
DPFVEKAKGI LRVDFFDPLV FSVVLFPFLT PVYEMLNICM FPKDSIEFFK
260 270 280 290 300
KFVNRMKESR LDSKQKHRVD FLQLMMNAHN NSKDKDSHKA LSDMEITAQS
310 320 330 340 350
IVFIFAGYET TSSTLSFTLY CLATHPDIQK KLQEEIDETL PNKAPPTYDT
360 370 380 390 400
VMEMEYLDMV LNETLRLYPI GNRLERFCKK DVELNGVYIP KGSTVMIPSY
410 420 430 440 450
ALHHDPQHWP EPEEFQPERF SKENKGSIDP YLYMPFGIGP RNCIGMRFAF
460 470 480 490 500
MTMKLALTKV MQNFSFQPCQ ETQIPLKLSR QGLLQPEKPI VLKVVPRDVV

ITGA
Length:504
Mass (Da):57,987
Last modified:July 27, 2011 - v2
Checksum:i1F6455156C073479
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42K → T in BAA95951 (PubMed:10775455).Curated1
Sequence conflicti42K → T in AAI38084 (PubMed:15489334).Curated1
Sequence conflicti42K → T in AAI38085 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033414 mRNA Translation: BAA95951.1
AC124483 Genomic DNA No translation available.
AC166648 Genomic DNA No translation available.
BC138083 mRNA Translation: AAI38084.1
BC138084 mRNA Translation: AAI38085.1
CCDSiCCDS39389.1
RefSeqiNP_001098629.1, NM_001105159.1
NP_059092.2, NM_017396.3
UniGeneiMm.379071
Mm.489591

Genome annotation databases

EnsembliENSMUST00000075837; ENSMUSP00000075234; ENSMUSG00000075552
ENSMUST00000094111; ENSMUSP00000091659; ENSMUSG00000075551
GeneIDi100041375
53973
KEGGimmu:100041375
mmu:53973
UCSCiuc012egw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCP341_MOUSE
AccessioniPrimary (citable) accession number: Q9JMA7
Secondary accession number(s): B2RQU5, E9QJT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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