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Q9JMA7 (CP341_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A41

EC=1.14.14.1
Gene names
Name:Cyp3a41a
Synonyms:Cyp3a41
AND
Name:Cyp3a41b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein Potential. Microsome membrane; Peripheral membrane protein Potential.

Tissue specificity

Expressed in liver. Also expressed in the kidneys of female mice, with traces in the stomach, ovary, and heart of female mice and in the testis of male mice.

Developmental stage

Detected immediately after birth in the livers of animals of both sexes, but increases with age in females, whereas it is gradually reduced in males, resulting in predominantly female-specific expression in livers.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Cytochrome P450 3A41
PRO_0000051813

Sites

Metal binding4431Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict421K → T in BAA95951. Ref.1
Sequence conflict421K → T in AAI38084. Ref.3
Sequence conflict421K → T in AAI38085. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9JMA7 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 1F6455156C073479

FASTA50457,987
        10         20         30         40         50         60 
MNLFSALSLD TWVLLAIILV LLYRYGTRTH GLFKKQGIPG PKPLPFLGTV LNYYKGLWKF 

        70         80         90        100        110        120 
DMECYEKYGK TWGLFDGQMP LFVITDPEMI KNVLVKECFS VFTNRREFGP VGIMSKAISI 

       130        140        150        160        170        180 
SKDEEWKRYR ALLSPTFTSG KLKEMFPVIE QYGDILVKYL MQEAEKGKPV TMKDVLGAYS 

       190        200        210        220        230        240 
IDVITSTSFG VNVDSLNNPE DPFVEKAKGI LRVDFFDPLV FSVVLFPFLT PVYEMLNICM 

       250        260        270        280        290        300 
FPKDSIEFFK KFVNRMKESR LDSKQKHRVD FLQLMMNAHN NSKDKDSHKA LSDMEITAQS 

       310        320        330        340        350        360 
IVFIFAGYET TSSTLSFTLY CLATHPDIQK KLQEEIDETL PNKAPPTYDT VMEMEYLDMV 

       370        380        390        400        410        420 
LNETLRLYPI GNRLERFCKK DVELNGVYIP KGSTVMIPSY ALHHDPQHWP EPEEFQPERF 

       430        440        450        460        470        480 
SKENKGSIDP YLYMPFGIGP RNCIGMRFAF MTMKLALTKV MQNFSFQPCQ ETQIPLKLSR 

       490        500 
QGLLQPEKPI VLKVVPRDVV ITGA 

« Hide

References

« Hide 'large scale' references
[1]"A novel female-specific member of the CYP3A gene subfamily in the mouse liver."
Sakuma T., Takai M., Endo Y., Kuroiwa M., Ohara A., Jarukamjorn K., Honma R., Nemoto N.
Arch. Biochem. Biophys. 377:153-162(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ddY.
Tissue: Liver.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB033414 mRNA. Translation: BAA95951.1.
AC124483 Genomic DNA. No translation available.
AC166648 Genomic DNA. No translation available.
BC138083 mRNA. Translation: AAI38084.1.
BC138084 mRNA. Translation: AAI38085.1.
CCDSCCDS19863.1.
CCDS39389.1.
RefSeqNP_001098629.1. NM_001105159.1.
NP_059092.2. NM_017396.3.
UniGeneMm.379071.
Mm.489591.

3D structure databases

ProteinModelPortalQ9JMA7.
SMRQ9JMA7. Positions 29-498.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9JMA7. 3 interactions.
MINTMINT-4091744.

PTM databases

PhosphoSiteQ9JMA7.

Proteomic databases

MaxQBQ9JMA7.
PaxDbQ9JMA7.
PRIDEQ9JMA7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000075837; ENSMUSP00000075234; ENSMUSG00000075552.
ENSMUST00000094111; ENSMUSP00000091659; ENSMUSG00000075551.
GeneID100041375.
53973.
KEGGmmu:100041375.
mmu:53973.
UCSCuc012egw.1. mouse.

Organism-specific databases

CTD100041375.
53973.
MGIMGI:1858451. Cyp3a41a.
MGI:3714859. Cyp3a41b.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00730000110610.
HOGENOMHOG000039127.
HOVERGENHBG108567.
InParanoidB2RQU5.
KOK07424.
OrthoDBEOG744TBS.
TreeFamTF105087.

Gene expression databases

BgeeQ9JMA7.
GenevestigatorQ9JMA7.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio310861.
PROQ9JMA7.
SOURCESearch...

Entry information

Entry nameCP341_MOUSE
AccessionPrimary (citable) accession number: Q9JMA7
Secondary accession number(s): B2RQU5, E9QJT9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot