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Q9JMA7

- CP341_MOUSE

UniProt

Q9JMA7 - CP341_MOUSE

Protein

Cytochrome P450 3A41

Gene

Cyp3a41a

more
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi443 – 4431Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_216259. Miscellaneous substrates.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A41 (EC:1.14.14.1)
    Gene namesi
    Name:Cyp3a41a
    Synonyms:Cyp3a41
    AND
    Name:Cyp3a41b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1858451. Cyp3a41a.
    MGI:3714859. Cyp3a41b.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Cytochrome P450 3A41PRO_0000051813Add
    BLAST

    Proteomic databases

    MaxQBiQ9JMA7.
    PaxDbiQ9JMA7.
    PRIDEiQ9JMA7.

    PTM databases

    PhosphoSiteiQ9JMA7.

    Expressioni

    Tissue specificityi

    Expressed in liver. Also expressed in the kidneys of female mice, with traces in the stomach, ovary, and heart of female mice and in the testis of male mice.

    Developmental stagei

    Detected immediately after birth in the livers of animals of both sexes, but increases with age in females, whereas it is gradually reduced in males, resulting in predominantly female-specific expression in livers.

    Gene expression databases

    BgeeiQ9JMA7.
    GenevestigatoriQ9JMA7.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9JMA7. 3 interactions.
    MINTiMINT-4091744.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JMA7.
    SMRiQ9JMA7. Positions 29-498.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00730000110610.
    HOGENOMiHOG000039127.
    HOVERGENiHBG108567.
    InParanoidiB2RQU5.
    KOiK07424.
    OrthoDBiEOG744TBS.
    TreeFamiTF105087.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JMA7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLFSALSLD TWVLLAIILV LLYRYGTRTH GLFKKQGIPG PKPLPFLGTV    50
    LNYYKGLWKF DMECYEKYGK TWGLFDGQMP LFVITDPEMI KNVLVKECFS 100
    VFTNRREFGP VGIMSKAISI SKDEEWKRYR ALLSPTFTSG KLKEMFPVIE 150
    QYGDILVKYL MQEAEKGKPV TMKDVLGAYS IDVITSTSFG VNVDSLNNPE 200
    DPFVEKAKGI LRVDFFDPLV FSVVLFPFLT PVYEMLNICM FPKDSIEFFK 250
    KFVNRMKESR LDSKQKHRVD FLQLMMNAHN NSKDKDSHKA LSDMEITAQS 300
    IVFIFAGYET TSSTLSFTLY CLATHPDIQK KLQEEIDETL PNKAPPTYDT 350
    VMEMEYLDMV LNETLRLYPI GNRLERFCKK DVELNGVYIP KGSTVMIPSY 400
    ALHHDPQHWP EPEEFQPERF SKENKGSIDP YLYMPFGIGP RNCIGMRFAF 450
    MTMKLALTKV MQNFSFQPCQ ETQIPLKLSR QGLLQPEKPI VLKVVPRDVV 500
    ITGA 504
    Length:504
    Mass (Da):57,987
    Last modified:July 27, 2011 - v2
    Checksum:i1F6455156C073479
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421K → T in BAA95951. (PubMed:10775455)Curated
    Sequence conflicti42 – 421K → T in AAI38084. (PubMed:15489334)Curated
    Sequence conflicti42 – 421K → T in AAI38085. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033414 mRNA. Translation: BAA95951.1.
    AC124483 Genomic DNA. No translation available.
    AC166648 Genomic DNA. No translation available.
    BC138083 mRNA. Translation: AAI38084.1.
    BC138084 mRNA. Translation: AAI38085.1.
    CCDSiCCDS19863.1.
    CCDS39389.1.
    RefSeqiNP_001098629.1. NM_001105159.1.
    NP_059092.2. NM_017396.3.
    UniGeneiMm.379071.
    Mm.489591.

    Genome annotation databases

    EnsembliENSMUST00000075837; ENSMUSP00000075234; ENSMUSG00000075552.
    ENSMUST00000094111; ENSMUSP00000091659; ENSMUSG00000075551.
    GeneIDi100041375.
    53973.
    KEGGimmu:100041375.
    mmu:53973.
    UCSCiuc012egw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033414 mRNA. Translation: BAA95951.1 .
    AC124483 Genomic DNA. No translation available.
    AC166648 Genomic DNA. No translation available.
    BC138083 mRNA. Translation: AAI38084.1 .
    BC138084 mRNA. Translation: AAI38085.1 .
    CCDSi CCDS19863.1.
    CCDS39389.1.
    RefSeqi NP_001098629.1. NM_001105159.1.
    NP_059092.2. NM_017396.3.
    UniGenei Mm.379071.
    Mm.489591.

    3D structure databases

    ProteinModelPortali Q9JMA7.
    SMRi Q9JMA7. Positions 29-498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9JMA7. 3 interactions.
    MINTi MINT-4091744.

    PTM databases

    PhosphoSitei Q9JMA7.

    Proteomic databases

    MaxQBi Q9JMA7.
    PaxDbi Q9JMA7.
    PRIDEi Q9JMA7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075837 ; ENSMUSP00000075234 ; ENSMUSG00000075552 .
    ENSMUST00000094111 ; ENSMUSP00000091659 ; ENSMUSG00000075551 .
    GeneIDi 100041375.
    53973.
    KEGGi mmu:100041375.
    mmu:53973.
    UCSCi uc012egw.1. mouse.

    Organism-specific databases

    CTDi 100041375.
    53973.
    MGIi MGI:1858451. Cyp3a41a.
    MGI:3714859. Cyp3a41b.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00730000110610.
    HOGENOMi HOG000039127.
    HOVERGENi HBG108567.
    InParanoidi B2RQU5.
    KOi K07424.
    OrthoDBi EOG744TBS.
    TreeFami TF105087.

    Enzyme and pathway databases

    Reactomei REACT_216259. Miscellaneous substrates.

    Miscellaneous databases

    NextBioi 310861.
    PROi Q9JMA7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JMA7.
    Genevestigatori Q9JMA7.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel female-specific member of the CYP3A gene subfamily in the mouse liver."
      Sakuma T., Takai M., Endo Y., Kuroiwa M., Ohara A., Jarukamjorn K., Honma R., Nemoto N.
      Arch. Biochem. Biophys. 377:153-162(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ddY.
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCP341_MOUSE
    AccessioniPrimary (citable) accession number: Q9JMA7
    Secondary accession number(s): B2RQU5, E9QJT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3