Q9JMA7 (CP341_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 3A41
EC=1.14.14.1

Gene names

Name:	Cyp3a41a
Synonyms:	Cyp3a41
AND
Name:	Cyp3a41b

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein Potential. Microsome membrane; Peripheral membrane protein Potential.
Tissue specificity	Expressed in liver. Also expressed in the kidneys of female mice, with traces in the stomach, ovary, and heart of female mice and in the testis of male mice.
Developmental stage	Detected immediately after birth in the livers of animals of both sexes, but increases with age in females, whereas it is gradually reduced in males, resulting in predominantly female-specific expression in livers.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 504	504	Cytochrome P450 3A41		PRO_0000051813
Sites
	Metal binding	443	1	Iron (heme axial ligand) By similarity
Experimental info
	Sequence conflict	42	1	K → T in BAA95951. Ref.1
	Sequence conflict	42	1	K → T in AAI38084. Ref.3
	Sequence conflict	42	1	K → T in AAI38085. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9JMA7 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 1F6455156C073479	FASTA	504	57,987
	10 20 30 40 50 60 MNLFSALSLD TWVLLAIILV LLYRYGTRTH GLFKKQGIPG PKPLPFLGTV LNYYKGLWKF 70 80 90 100 110 120 DMECYEKYGK TWGLFDGQMP LFVITDPEMI KNVLVKECFS VFTNRREFGP VGIMSKAISI 130 140 150 160 170 180 SKDEEWKRYR ALLSPTFTSG KLKEMFPVIE QYGDILVKYL MQEAEKGKPV TMKDVLGAYS 190 200 210 220 230 240 IDVITSTSFG VNVDSLNNPE DPFVEKAKGI LRVDFFDPLV FSVVLFPFLT PVYEMLNICM 250 260 270 280 290 300 FPKDSIEFFK KFVNRMKESR LDSKQKHRVD FLQLMMNAHN NSKDKDSHKA LSDMEITAQS 310 320 330 340 350 360 IVFIFAGYET TSSTLSFTLY CLATHPDIQK KLQEEIDETL PNKAPPTYDT VMEMEYLDMV 370 380 390 400 410 420 LNETLRLYPI GNRLERFCKK DVELNGVYIP KGSTVMIPSY ALHHDPQHWP EPEEFQPERF 430 440 450 460 470 480 SKENKGSIDP YLYMPFGIGP RNCIGMRFAF MTMKLALTKV MQNFSFQPCQ ETQIPLKLSR 490 500 QGLLQPEKPI VLKVVPRDVV ITGA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel female-specific member of the CYP3A gene subfamily in the mouse liver." Sakuma T., Takai M., Endo Y., Kuroiwa M., Ohara A., Jarukamjorn K., Honma R., Nemoto N. Arch. Biochem. Biophys. 377:153-162(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ddY. Tissue: Liver.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB033414 mRNA. Translation: BAA95951.1. AC124483 Genomic DNA. No translation available. AC166648 Genomic DNA. No translation available. BC138083 mRNA. Translation: AAI38084.1. BC138084 mRNA. Translation: AAI38085.1.
IPI	IPI00125340.
RefSeq	NP_001098629.1. NM_001105159.1. NP_059092.2. NM_017396.3.
UniGene	Mm.379071. Mm.489591.
3D structure databases
ProteinModelPortal	Q9JMA7.
SMR	Q9JMA7. Positions 29-498.
ModBase	Search...
PTM databases
PhosphoSite	Q9JMA7.
Proteomic databases
PaxDb	Q9JMA7.
PRIDE	Q9JMA7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000075837; ENSMUSP00000075234; ENSMUSG00000075552. ENSMUST00000094111; ENSMUSP00000091659; ENSMUSG00000075551.
GeneID	100041375. 53973.
KEGG	mmu:100041375. mmu:53973.
UCSC	uc009amx.1. mouse.
Organism-specific databases
CTD	100041375. 53973.
MGI	MGI:1858451. Cyp3a41a. MGI:3714859. Cyp3a41b.
Phylogenomic databases
eggNOG	COG2124.
GeneTree	ENSGT00540000069787.
HOGENOM	HOG000039127.
HOVERGEN	HBG108567.
InParanoid	B2RQU5.
KO	K07424.
OrthoDB	EOG4ZW59X.
Gene expression databases
Bgee	Q9JMA7.
Genevestigator	Q9JMA7.
GermOnline	ENSMUSG00000075551. Mus musculus. ENSMUSG00000075552. Mus musculus.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR008072. Cyt_P450_E_CYP3A. IPR002402. Cyt_P450_E_grp-II. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00464. EP450II. PR01689. EP450IICYP3A. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	310861.
SOURCE	Search...

Entry information

Entry name

CP341_MOUSE

Accession

Primary (citable) accession number: Q9JMA7
Secondary accession number(s): B2RQU5, E9QJT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program