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Q9JMA7

- CP341_MOUSE

UniProt

Q9JMA7 - CP341_MOUSE

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Protein
Cytochrome P450 3A41
Gene
Cyp3a41a, Cyp3a41
Cyp3a41b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi443 – 4431Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_216259. Miscellaneous substrates.

    Names & Taxonomyi

    Organism-specific databases

    Protein namesi
    Recommended name:
    Cytochrome P450 3A41 (EC:1.14.14.1)
    Gene namesi
    Name:Cyp3a41a
    Synonyms:Cyp3a41
    AND
    Name:Cyp3a41b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5
    MGIiMGI:1858451. Cyp3a41a.
    MGI:3714859. Cyp3a41b.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Cytochrome P450 3A41
    PRO_0000051813Add
    BLAST

    Proteomic databases

    MaxQBiQ9JMA7.
    PaxDbiQ9JMA7.
    PRIDEiQ9JMA7.

    PTM databases

    PhosphoSiteiQ9JMA7.

    Expressioni

    Tissue specificityi

    Expressed in liver. Also expressed in the kidneys of female mice, with traces in the stomach, ovary, and heart of female mice and in the testis of male mice.

    Developmental stagei

    Detected immediately after birth in the livers of animals of both sexes, but increases with age in females, whereas it is gradually reduced in males, resulting in predominantly female-specific expression in livers.

    Gene expression databases

    BgeeiQ9JMA7.
    GenevestigatoriQ9JMA7.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9JMA7. 3 interactions.
    MINTiMINT-4091744.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JMA7.
    SMRiQ9JMA7. Positions 29-498.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00730000110610.
    HOGENOMiHOG000039127.
    HOVERGENiHBG108567.
    InParanoidiB2RQU5.
    KOiK07424.
    OrthoDBiEOG744TBS.
    TreeFamiTF105087.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JMA7-1 [UniParc]FASTAAdd to Basket

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    MNLFSALSLD TWVLLAIILV LLYRYGTRTH GLFKKQGIPG PKPLPFLGTV    50
    LNYYKGLWKF DMECYEKYGK TWGLFDGQMP LFVITDPEMI KNVLVKECFS 100
    VFTNRREFGP VGIMSKAISI SKDEEWKRYR ALLSPTFTSG KLKEMFPVIE 150
    QYGDILVKYL MQEAEKGKPV TMKDVLGAYS IDVITSTSFG VNVDSLNNPE 200
    DPFVEKAKGI LRVDFFDPLV FSVVLFPFLT PVYEMLNICM FPKDSIEFFK 250
    KFVNRMKESR LDSKQKHRVD FLQLMMNAHN NSKDKDSHKA LSDMEITAQS 300
    IVFIFAGYET TSSTLSFTLY CLATHPDIQK KLQEEIDETL PNKAPPTYDT 350
    VMEMEYLDMV LNETLRLYPI GNRLERFCKK DVELNGVYIP KGSTVMIPSY 400
    ALHHDPQHWP EPEEFQPERF SKENKGSIDP YLYMPFGIGP RNCIGMRFAF 450
    MTMKLALTKV MQNFSFQPCQ ETQIPLKLSR QGLLQPEKPI VLKVVPRDVV 500
    ITGA 504
    Length:504
    Mass (Da):57,987
    Last modified:July 27, 2011 - v2
    Checksum:i1F6455156C073479
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421K → T in BAA95951. 1 Publication
    Sequence conflicti42 – 421K → T in AAI38084. 1 Publication
    Sequence conflicti42 – 421K → T in AAI38085. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033414 mRNA. Translation: BAA95951.1.
    AC124483 Genomic DNA. No translation available.
    AC166648 Genomic DNA. No translation available.
    BC138083 mRNA. Translation: AAI38084.1.
    BC138084 mRNA. Translation: AAI38085.1.
    CCDSiCCDS19863.1.
    CCDS39389.1.
    RefSeqiNP_001098629.1. NM_001105159.1.
    NP_059092.2. NM_017396.3.
    UniGeneiMm.379071.
    Mm.489591.

    Genome annotation databases

    EnsembliENSMUST00000075837; ENSMUSP00000075234; ENSMUSG00000075552.
    ENSMUST00000094111; ENSMUSP00000091659; ENSMUSG00000075551.
    GeneIDi100041375.
    53973.
    KEGGimmu:100041375.
    mmu:53973.
    UCSCiuc012egw.1. mouse.