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Protein

Cdc42 effector protein 4

Gene

Cdc42ep4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell shape

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 4
Alternative name(s):
Binder of Rho GTPases 4
Gene namesi
Name:Cdc42ep4
Synonyms:Borg4, Cep4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1929760. Cdc42ep4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126561 – 349Cdc42 effector protein 4Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5N6-methyllysineBy similarity1
Modified residuei18PhosphoserineCombined sources1
Modified residuei64PhosphoserineCombined sources1
Modified residuei103PhosphoserineBy similarity1
Modified residuei107PhosphoserineCombined sources1
Modified residuei116PhosphoserineBy similarity1
Modified residuei136PhosphoserineBy similarity1
Modified residuei138PhosphoserineBy similarity1
Modified residuei140PhosphoserineBy similarity1
Modified residuei154PhosphoserineCombined sources1
Modified residuei165PhosphoserineBy similarity1
Modified residuei223PhosphoserineCombined sources1
Modified residuei285PhosphoserineBy similarity1
Modified residuei288PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9JM96.
PaxDbiQ9JM96.
PeptideAtlasiQ9JM96.
PRIDEiQ9JM96.

PTM databases

iPTMnetiQ9JM96.
PhosphoSitePlusiQ9JM96.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000041598.
CleanExiMM_CDC42EP4.
ExpressionAtlasiQ9JM96. baseline and differential.
GenevisibleiQ9JM96. MM.

Interactioni

Subunit structurei

Interacts with CDC42 and RHOQ, in a GTP-dependent manner.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208129. 1 interactor.
IntActiQ9JM96. 1 interactor.
MINTiMINT-1342086.
STRINGi10090.ENSMUSP00000060227.

Structurei

3D structure databases

ProteinModelPortaliQ9JM96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 41CRIBPROSITE-ProRule annotationAdd BLAST15

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated

Phylogenomic databases

eggNOGiENOG410IJDS. Eukaryota.
ENOG4111HZ4. LUCA.
GeneTreeiENSGT00730000110869.
HOGENOMiHOG000231054.
HOVERGENiHBG052803.
InParanoidiQ9JM96.
OMAiQPDKEFS.
OrthoDBiEOG091G0CZS.
PhylomeDBiQ9JM96.
TreeFamiTF331725.

Family and domain databases

InterProiView protein in InterPro
IPR029273. Cdc42_effect.
IPR000095. CRIB_dom.
PfamiView protein in Pfam
PF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
SMARTiView protein in SMART
SM00285. PBD. 1 hit.
PROSITEiView protein in PROSITE
PS50108. CRIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JM96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPILKQLVSS SVNSKRRSRA DLTAEMISAP LGDFRHTMHV GRAGDAFGDT
60 70 80 90 100
SFLTSKAREA DDESLDEQAS ASKLSLLSRK FRGSKRSQSV TRGDREQRDM
110 120 130 140 150
LGSLRDSALF VKNAMSLPQL NEKEAAEKDS SKLPKSLSSS PVKKADARDG
160 170 180 190 200
GPKSPHRNGA TGPHSPDPLL DEQAFGDLMD LPIMPKVSYG LKHAESILSF
210 220 230 240 250
HIDLGPSMLG DVLSIMDKDQ WGSEEEEEAG GYRDKEGPSS IVQAPPVLEV
260 270 280 290 300
VPPLGRQESK ASWDQASMLP PHAVEDDGWA VVAPSPSSAR SVGSHTTRDS
310 320 330 340
SSLSSYTSGV LEERSPAFRG PDRVAAAPPR QPDKEFCFMD EEEEDEIRV
Length:349
Mass (Da):37,869
Last modified:October 1, 2000 - v1
Checksum:i7C44125A7083E16B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143K → R in AAD47822 (PubMed:10490598).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035088 mRNA. Translation: BAA95932.1.
AK075739 mRNA. Translation: BAC35920.1.
AK165318 mRNA. Translation: BAE38136.1.
BC003857 mRNA. Translation: AAH03857.1.
AF165114 mRNA. Translation: AAD47822.1.
CCDSiCCDS25604.1.
RefSeqiNP_001156818.1. NM_001163346.1.
NP_064390.1. NM_020006.2.
XP_006533880.1. XM_006533817.2.
XP_006533881.1. XM_006533818.3.
XP_006533882.1. XM_006533819.2.
XP_017170175.1. XM_017314686.1.
UniGeneiMm.293378.

Genome annotation databases

EnsembliENSMUST00000053536; ENSMUSP00000060227; ENSMUSG00000041598.
ENSMUST00000106616; ENSMUSP00000102227; ENSMUSG00000041598.
GeneIDi56699.
KEGGimmu:56699.
UCSCiuc007mfb.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiBORG4_MOUSE
AccessioniPrimary (citable) accession number: Q9JM96
Secondary accession number(s): Q3TNF3, Q9QZT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families