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Protein

Calmodulin-4

Gene

Calm4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in the early stage of ectopic ossification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi21 – 32121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi57 – 68122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi93 – 104123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-4
Alternative name(s):
Calcium-binding protein Dd112
Gene namesi
Name:Calm4
Synonyms:Dd112
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1931464. Calm4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 148147Calmodulin-4PRO_0000073856Add
BLAST

Proteomic databases

MaxQBiQ9JM83.
PRIDEiQ9JM83.

PTM databases

PhosphoSiteiQ9JM83.

Expressioni

Gene expression databases

BgeeiQ9JM83.
CleanExiMM_CALM4.
GenevisibleiQ9JM83. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041636.

Structurei

3D structure databases

ProteinModelPortaliQ9JM83.
SMRiQ9JM83. Positions 5-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 4336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini44 – 7936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini80 – 11536EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini116 – 14833EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ9JM83.
KOiK02183.
OMAiNYEEFAR.
OrthoDBiEOG7GFB71.
PhylomeDBiQ9JM83.
TreeFamiTF339519.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JM83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHGFTKEEV AEFQAAFNRF DKNKDGHISV EELGDVMKQL GKNLPEKDLK
60 70 80 90 100
ALISKLDTDG DGKISFEEFL TAIEKYKKGH RAGELRAVFN VLDQNGDGYI
110 120 130 140
TVDELKESLS KLGESLSQEE LEDMIRVADV DQDGKVKYEE FVRLHVEN
Length:148
Mass (Da):16,767
Last modified:June 1, 2001 - v2
Checksum:i2AE22BC738AD2F9D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91E → V in BAB22914 (PubMed:16141072).Curated
Sequence conflicti124 – 1241M → V in BAB22914 (PubMed:16141072).Curated
Sequence conflicti146 – 1483VEN → I in BAA95412 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036744 Genomic DNA. Translation: BAA95412.1.
AK009956 mRNA. Translation: BAB26608.1.
AK009664 mRNA. Translation: BAB26425.1.
AK003648 mRNA. Translation: BAB22914.1.
CCDSiCCDS26215.1.
RefSeqiNP_064420.2. NM_020036.4.
UniGeneiMm.21075.

Genome annotation databases

EnsembliENSMUST00000042219; ENSMUSP00000041636; ENSMUSG00000033765.
GeneIDi80796.
KEGGimmu:80796.
UCSCiuc007pjb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036744 Genomic DNA. Translation: BAA95412.1.
AK009956 mRNA. Translation: BAB26608.1.
AK009664 mRNA. Translation: BAB26425.1.
AK003648 mRNA. Translation: BAB22914.1.
CCDSiCCDS26215.1.
RefSeqiNP_064420.2. NM_020036.4.
UniGeneiMm.21075.

3D structure databases

ProteinModelPortaliQ9JM83.
SMRiQ9JM83. Positions 5-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041636.

PTM databases

PhosphoSiteiQ9JM83.

Proteomic databases

MaxQBiQ9JM83.
PRIDEiQ9JM83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042219; ENSMUSP00000041636; ENSMUSG00000033765.
GeneIDi80796.
KEGGimmu:80796.
UCSCiuc007pjb.1. mouse.

Organism-specific databases

CTDi80796.
MGIiMGI:1931464. Calm4.

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ9JM83.
KOiK02183.
OMAiNYEEFAR.
OrthoDBiEOG7GFB71.
PhylomeDBiQ9JM83.
TreeFamiTF339519.

Miscellaneous databases

NextBioi350136.
PROiQ9JM83.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JM83.
CleanExiMM_CALM4.
GenevisibleiQ9JM83. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DD112, a novel mouse gene implicated in the early stage of ectopic ossification."
    Ikegawa S., Nakamura Y.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Tongue.

Entry informationi

Entry nameiCALM4_MOUSE
AccessioniPrimary (citable) accession number: Q9JM83
Secondary accession number(s): Q9CR31, Q9D1E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.