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Protein

Calmodulin-4

Gene

Calm4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in the early stage of ectopic ossification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi57 – 682PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi93 – 1043PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: MGI

GO - Biological processi

  • cellular response to leukemia inhibitory factor Source: MGI

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-4
Alternative name(s):
Calcium-binding protein Dd112
Gene namesi
Name:Calm4
Synonyms:Dd112
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1931464. Calm4.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000738561 – 148Calmodulin-4Add BLAST148

Proteomic databases

MaxQBiQ9JM83.
PaxDbiQ9JM83.
PRIDEiQ9JM83.

PTM databases

iPTMnetiQ9JM83.
PhosphoSitePlusiQ9JM83.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033765.
CleanExiMM_CALM4.
GenevisibleiQ9JM83. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041636.

Structurei

3D structure databases

ProteinModelPortaliQ9JM83.
SMRiQ9JM83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini80 – 115EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini116 – 148EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ9JM83.
KOiK02183.
OMAiYKSAFSA.
OrthoDBiEOG091G0RVC.
PhylomeDBiQ9JM83.
TreeFamiTF339519.

Family and domain databases

CDDicd00051. EFh. 2 hits.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13499. EF-hand_7. 2 hits.
SMARTiView protein in SMART
SM00054. EFh. 4 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.

Sequencei

Sequence statusi: Complete.

Q9JM83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHGFTKEEV AEFQAAFNRF DKNKDGHISV EELGDVMKQL GKNLPEKDLK
60 70 80 90 100
ALISKLDTDG DGKISFEEFL TAIEKYKKGH RAGELRAVFN VLDQNGDGYI
110 120 130 140
TVDELKESLS KLGESLSQEE LEDMIRVADV DQDGKVKYEE FVRLHVEN
Length:148
Mass (Da):16,767
Last modified:June 1, 2001 - v2
Checksum:i2AE22BC738AD2F9D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9E → V in BAB22914 (PubMed:16141072).Curated1
Sequence conflicti124M → V in BAB22914 (PubMed:16141072).Curated1
Sequence conflicti146 – 148VEN → I in BAA95412 (Ref. 1) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036744 Genomic DNA. Translation: BAA95412.1.
AK009956 mRNA. Translation: BAB26608.1.
AK009664 mRNA. Translation: BAB26425.1.
AK003648 mRNA. Translation: BAB22914.1.
CCDSiCCDS26215.1.
RefSeqiNP_064420.2. NM_020036.4.
UniGeneiMm.21075.

Genome annotation databases

EnsembliENSMUST00000042219; ENSMUSP00000041636; ENSMUSG00000033765.
GeneIDi80796.
KEGGimmu:80796.
UCSCiuc007pjb.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCALM4_MOUSE
AccessioniPrimary (citable) accession number: Q9JM83
Secondary accession number(s): Q9CR31, Q9D1E9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: August 30, 2017
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot