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Protein

Actin-related protein 2/3 complex subunit 3

Gene

Arpc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 3
Alternative name(s):
Arp2/3 complex 21 kDa subunit
Short name:
p21-ARC
Gene namesi
Name:Arpc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1928375 Arpc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001240432 – 178Actin-related protein 2/3 complex subunit 3Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei47PhosphotyrosineCombined sources1
Modified residuei56N6-acetyllysineBy similarity1
Modified residuei61N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9JM76
MaxQBiQ9JM76
PaxDbiQ9JM76
PeptideAtlasiQ9JM76
PRIDEiQ9JM76
TopDownProteomicsiQ9JM76

PTM databases

iPTMnetiQ9JM76
PhosphoSitePlusiQ9JM76
SwissPalmiQ9JM76

Expressioni

Gene expression databases

BgeeiENSMUSG00000029465
CleanExiMM_ARPC3
ExpressionAtlasiQ9JM76 baseline and differential
GenevisibleiQ9JM76 MM

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207939, 2 interactors
IntActiQ9JM76, 5 interactors
MINTiQ9JM76
STRINGi10090.ENSMUSP00000099584

Structurei

3D structure databases

ProteinModelPortaliQ9JM76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC3 family.Curated

Phylogenomic databases

eggNOGiKOG3155 Eukaryota
ENOG4111FTG LUCA
GeneTreeiENSGT00390000018018
HOGENOMiHOG000161465
HOVERGENiHBG050581
InParanoidiQ9JM76
KOiK05756
OMAiKWWLSFT
OrthoDBiEOG091G0OUM
PhylomeDBiQ9JM76
TreeFamiTF314598

Family and domain databases

Gene3Di1.10.1760.10, 1 hit
InterProiView protein in InterPro
IPR007204 ARPC3
IPR036753 ARPC3_sf
PANTHERiPTHR12391 PTHR12391, 1 hit
PfamiView protein in Pfam
PF04062 P21-Arc, 1 hit
PIRSFiPIRSF016315 ARP2/3_P21-Arc, 1 hit
SUPFAMiSSF69060 SSF69060, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JM76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAYHSSLMD PDTKLIGNMA LLPLRSQFKG PAPRETKDTD IVDEAIYYFK
60 70 80 90 100
ANVFFKNYEI KNEADRTLIY ITLYISECLK KLQKCNSKSQ GEKEMYTLGI
110 120 130 140 150
TNFPIPGEPG FPLNAIYAKP ASKQEDEMMR AYLQQLRQET GLRLCEKVFD
160 170
PQSDKPSKWW TCFVKRQFMN KSLSGPGQ
Length:178
Mass (Da):20,525
Last modified:January 23, 2007 - v3
Checksum:i6B4F467F89BF4BAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038243 mRNA Translation: BAA90788.1
AK003485 mRNA Translation: BAB22813.1
AK005437 mRNA Translation: BAB24031.1
AK171651 mRNA Translation: BAE42588.1
BC013618 mRNA Translation: AAH13618.1
BC054440 mRNA Translation: AAH54440.1
CCDSiCCDS19648.1
RefSeqiNP_062798.1, NM_019824.4
UniGeneiMm.275942

Genome annotation databases

EnsembliENSMUST00000102525; ENSMUSP00000099584; ENSMUSG00000029465
GeneIDi56378
KEGGimmu:56378
UCSCiuc008zlf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiARPC3_MOUSE
AccessioniPrimary (citable) accession number: Q9JM76
Secondary accession number(s): Q3TAT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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