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Protein

Actin-related protein 2/3 complex subunit 3

Gene

Arpc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.
R-MMU-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 3
Alternative name(s):
Arp2/3 complex 21 kDa subunit
Short name:
p21-ARC
Gene namesi
Name:Arpc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1928375. Arpc3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001240432 – 178Actin-related protein 2/3 complex subunit 3Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei47PhosphotyrosineCombined sources1
Modified residuei56N6-acetyllysineBy similarity1
Modified residuei61N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9JM76.
MaxQBiQ9JM76.
PaxDbiQ9JM76.
PeptideAtlasiQ9JM76.
PRIDEiQ9JM76.
TopDownProteomicsiQ9JM76.

PTM databases

iPTMnetiQ9JM76.
PhosphoSitePlusiQ9JM76.
SwissPalmiQ9JM76.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029465.
CleanExiMM_ARPC3.
ExpressionAtlasiQ9JM76. baseline and differential.
GenevisibleiQ9JM76. MM.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207939. 1 interactor.
IntActiQ9JM76. 4 interactors.
MINTiMINT-1857076.
STRINGi10090.ENSMUSP00000099584.

Structurei

3D structure databases

ProteinModelPortaliQ9JM76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC3 family.Curated

Phylogenomic databases

eggNOGiKOG3155. Eukaryota.
ENOG4111FTG. LUCA.
GeneTreeiENSGT00390000018018.
HOGENOMiHOG000161465.
HOVERGENiHBG050581.
InParanoidiQ9JM76.
KOiK05756.
OMAiKWWLSFT.
OrthoDBiEOG091G0OUM.
PhylomeDBiQ9JM76.
TreeFamiTF314598.

Family and domain databases

Gene3Di1.10.1760.10. 1 hit.
InterProiView protein in InterPro
IPR007204. ARPC3.
IPR036753. ARPC3_sf.
PANTHERiPTHR12391. PTHR12391. 1 hit.
PfamiView protein in Pfam
PF04062. P21-Arc. 1 hit.
PIRSFiPIRSF016315. ARP2/3_P21-Arc. 1 hit.
SUPFAMiSSF69060. SSF69060. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JM76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAYHSSLMD PDTKLIGNMA LLPLRSQFKG PAPRETKDTD IVDEAIYYFK
60 70 80 90 100
ANVFFKNYEI KNEADRTLIY ITLYISECLK KLQKCNSKSQ GEKEMYTLGI
110 120 130 140 150
TNFPIPGEPG FPLNAIYAKP ASKQEDEMMR AYLQQLRQET GLRLCEKVFD
160 170
PQSDKPSKWW TCFVKRQFMN KSLSGPGQ
Length:178
Mass (Da):20,525
Last modified:January 23, 2007 - v3
Checksum:i6B4F467F89BF4BAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038243 mRNA. Translation: BAA90788.1.
AK003485 mRNA. Translation: BAB22813.1.
AK005437 mRNA. Translation: BAB24031.1.
AK171651 mRNA. Translation: BAE42588.1.
BC013618 mRNA. Translation: AAH13618.1.
BC054440 mRNA. Translation: AAH54440.1.
CCDSiCCDS19648.1.
RefSeqiNP_062798.1. NM_019824.4.
UniGeneiMm.275942.

Genome annotation databases

EnsembliENSMUST00000102525; ENSMUSP00000099584; ENSMUSG00000029465.
GeneIDi56378.
KEGGimmu:56378.
UCSCiuc008zlf.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiARPC3_MOUSE
AccessioniPrimary (citable) accession number: Q9JM76
Secondary accession number(s): Q3TAT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families