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Q9JM63

- KCJ10_MOUSE

UniProt

Q9JM63 - KCJ10_MOUSE

Protein

ATP-sensitive inward rectifier potassium channel 10

Gene

Kcnj10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei158 – 1581Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi210 – 2178ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. inward rectifier potassium channel activity Source: MGI
    3. potassium channel activity Source: MGI
    4. protein binding Source: MGI

    GO - Biological processi

    1. adult walking behavior Source: MGI
    2. central nervous system myelination Source: MGI
    3. inflammatory response Source: Ensembl
    4. L-glutamate uptake involved in synaptic transmission Source: MGI
    5. membrane hyperpolarization Source: Ensembl
    6. oligodendrocyte development Source: MGI
    7. optic nerve development Source: Ensembl
    8. potassium ion homeostasis Source: MGI
    9. potassium ion import Source: Ensembl
    10. potassium ion transmembrane transport Source: MGI
    11. potassium ion transport Source: MGI
    12. protein homotetramerization Source: Ensembl
    13. regulation of long-term neuronal synaptic plasticity Source: MGI
    14. regulation of membrane potential Source: MGI
    15. regulation of resting membrane potential Source: MGI
    16. regulation of sensory perception of pain Source: Ensembl
    17. response to blue light Source: Ensembl
    18. response to glucocorticoid Source: Ensembl
    19. response to mineralocorticoid Source: Ensembl
    20. visual perception Source: MGI

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199080. Potassium transport channels.
    REACT_208837. Activation of G protein gated Potassium channels.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-sensitive inward rectifier potassium channel 10
    Alternative name(s):
    Inward rectifier K(+) channel Kir4.1
    Potassium channel, inwardly rectifying subfamily J member 10
    Gene namesi
    Name:Kcnj10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1194504. Kcnj10.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: MGI
    3. dystrophin-associated glycoprotein complex Source: Ensembl
    4. integral component of plasma membrane Source: MGI
    5. microvillus Source: Ensembl
    6. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379ATP-sensitive inward rectifier potassium channel 10PRO_0000154954Add
    BLAST

    Proteomic databases

    MaxQBiQ9JM63.
    PaxDbiQ9JM63.
    PRIDEiQ9JM63.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9JM63.
    BgeeiQ9JM63.
    GenevestigatoriQ9JM63.

    Interactioni

    Subunit structurei

    Seems to form heterodimer with Kir5.1/KCNJ16 By similarity. Interacts with INADL.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi200895. 1 interaction.
    IntActiQ9JM63. 2 interactions.
    MINTiMINT-1891836.
    STRINGi10090.ENSMUSP00000054356.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JM63.
    SMRiQ9JM63. Positions 27-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6464CytoplasmicBy similarityAdd
    BLAST
    Topological domaini90 – 11425ExtracellularBy similarityAdd
    BLAST
    Topological domaini134 – 1429ExtracellularBy similarity
    Topological domaini165 – 379215CytoplasmicBy similarityAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei115 – 12612Helical; Pore-forming; Name=H5By similarityAdd
    BLAST
    Intramembranei127 – 1337Pore-formingBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei65 – 8925Helical; Name=M1By similarityAdd
    BLAST
    Transmembranei143 – 16422Helical; Name=M2By similarityAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi128 – 1336Selectivity filterBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG284842.
    GeneTreeiENSGT00690000102074.
    HOVERGENiHBG006178.
    InParanoidiQ9JM63.
    KOiK05003.
    OMAiFYHVVDD.
    OrthoDBiEOG7GFB4Z.
    PhylomeDBiQ9JM63.
    TreeFamiTF313676.

    Family and domain databases

    Gene3Di2.60.40.1400. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003269. K_chnl_inward-rec_Kir1.2.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view]
    PANTHERiPTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF21. PTHR11767:SF21. 1 hit.
    PfamiPF01007. IRK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005465. GIRK_kir. 1 hit.
    PRINTSiPR01322. KIR12CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9JM63-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSVAKVYYS QTTQTESRPL VAPGIRRRRV LTKDGRSNVR MEHIADKRFL    50
    YLKDLWTTFI DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELG 100
    PPANHTPCVV QVHTLTGAFL FSLESQTTIG YGFRYISEEC PLAIVLLIAQ 150
    LVLTTILEIF ITGTFLAKIA RPKKRAETIR FSQHAVVASH NGKPCLMIRV 200
    ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV DTASDSPFLI 250
    LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY 300
    LPEEILWGYE FTPAISLSAS GKYIADFSLF DQVVKVASPS GLRDSTVRYG 350
    DPEKLKLEES LREQAEKEGS ALSVRISNV 379
    Length:379
    Mass (Da):42,432
    Last modified:October 1, 2000 - v1
    Checksum:i7FF08446B7F43453
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039879 mRNA. Translation: BAA92432.1.
    AF322631 mRNA. Translation: AAG42845.1.
    CCDSiCCDS15512.1.
    RefSeqiNP_001034573.1. NM_001039484.1.
    UniGeneiMm.254563.

    Genome annotation databases

    EnsembliENSMUST00000056136; ENSMUSP00000054356; ENSMUSG00000044708.
    GeneIDi16513.
    KEGGimmu:16513.
    UCSCiuc007dqj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039879 mRNA. Translation: BAA92432.1 .
    AF322631 mRNA. Translation: AAG42845.1 .
    CCDSi CCDS15512.1.
    RefSeqi NP_001034573.1. NM_001039484.1.
    UniGenei Mm.254563.

    3D structure databases

    ProteinModelPortali Q9JM63.
    SMRi Q9JM63. Positions 27-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200895. 1 interaction.
    IntActi Q9JM63. 2 interactions.
    MINTi MINT-1891836.
    STRINGi 10090.ENSMUSP00000054356.

    Proteomic databases

    MaxQBi Q9JM63.
    PaxDbi Q9JM63.
    PRIDEi Q9JM63.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000056136 ; ENSMUSP00000054356 ; ENSMUSG00000044708 .
    GeneIDi 16513.
    KEGGi mmu:16513.
    UCSCi uc007dqj.1. mouse.

    Organism-specific databases

    CTDi 3766.
    MGIi MGI:1194504. Kcnj10.

    Phylogenomic databases

    eggNOGi NOG284842.
    GeneTreei ENSGT00690000102074.
    HOVERGENi HBG006178.
    InParanoidi Q9JM63.
    KOi K05003.
    OMAi FYHVVDD.
    OrthoDBi EOG7GFB4Z.
    PhylomeDBi Q9JM63.
    TreeFami TF313676.

    Enzyme and pathway databases

    Reactomei REACT_199080. Potassium transport channels.
    REACT_208837. Activation of G protein gated Potassium channels.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Miscellaneous databases

    ChiTaRSi KCNJ10. mouse.
    NextBioi 289861.
    PROi Q9JM63.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JM63.
    Bgeei Q9JM63.
    Genevestigatori Q9JM63.

    Family and domain databases

    Gene3Di 2.60.40.1400. 1 hit.
    InterProi IPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003269. K_chnl_inward-rec_Kir1.2.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view ]
    PANTHERi PTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF21. PTHR11767:SF21. 1 hit.
    Pfami PF01007. IRK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005465. GIRK_kir. 1 hit.
    PRINTSi PR01322. KIR12CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Inanobe A., Takahashi K., Tanemoto M., Fujita A., Kurachi Y.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification of an inward rectifier potassium channel gene expressed in mouse cortical astrocytes."
      Li L., Head V., Timpe L.C.
      Glia 33:57-71(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1 and ICR.
      Tissue: Brain.
    3. "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins."
      Kurschner C., Mermelstein P.G., Holden W.T., Surmeier D.J.
      Mol. Cell. Neurosci. 11:161-172(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH INADL.

    Entry informationi

    Entry nameiKCJ10_MOUSE
    AccessioniPrimary (citable) accession number: Q9JM63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3