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Protein

ATP-sensitive inward rectifier potassium channel 10

Gene

Kcnj10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei158 – 1581Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi210 – 2178ATPSequence Analysis

GO - Molecular functioni

  1. ATP-activated inward rectifier potassium channel activity Source: GO_Central
  2. ATP binding Source: UniProtKB-KW
  3. inward rectifier potassium channel activity Source: MGI
  4. potassium channel activity Source: MGI

GO - Biological processi

  1. adult walking behavior Source: MGI
  2. central nervous system myelination Source: MGI
  3. inflammatory response Source: Ensembl
  4. L-glutamate uptake involved in synaptic transmission Source: MGI
  5. membrane hyperpolarization Source: Ensembl
  6. oligodendrocyte development Source: MGI
  7. optic nerve development Source: Ensembl
  8. potassium ion homeostasis Source: MGI
  9. potassium ion import Source: GO_Central
  10. potassium ion transmembrane transport Source: MGI
  11. potassium ion transport Source: MGI
  12. protein homotetramerization Source: Ensembl
  13. regulation of long-term neuronal synaptic plasticity Source: MGI
  14. regulation of membrane potential Source: MGI
  15. regulation of resting membrane potential Source: MGI
  16. regulation of sensory perception of pain Source: Ensembl
  17. response to blue light Source: Ensembl
  18. response to glucocorticoid Source: Ensembl
  19. response to mineralocorticoid Source: Ensembl
  20. visual perception Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

ReactomeiREACT_286807. Potassium transport channels.
REACT_308732. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_339334. Activation of G protein gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 10
Alternative name(s):
Inward rectifier K(+) channel Kir4.1
Potassium channel, inwardly rectifying subfamily J member 10
Gene namesi
Name:Kcnj10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1194504. Kcnj10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6464CytoplasmicBy similarityAdd
BLAST
Transmembranei65 – 8925Helical; Name=M1By similarityAdd
BLAST
Topological domaini90 – 11425ExtracellularBy similarityAdd
BLAST
Intramembranei115 – 12612Helical; Pore-forming; Name=H5By similarityAdd
BLAST
Intramembranei127 – 1337Pore-formingBy similarity
Topological domaini134 – 1429ExtracellularBy similarity
Transmembranei143 – 16422Helical; Name=M2By similarityAdd
BLAST
Topological domaini165 – 379215CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. astrocyte projection Source: Ensembl
  3. basolateral plasma membrane Source: MGI
  4. integral component of plasma membrane Source: GO_Central
  5. microvillus Source: Ensembl
  6. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379ATP-sensitive inward rectifier potassium channel 10PRO_0000154954Add
BLAST

Proteomic databases

MaxQBiQ9JM63.
PaxDbiQ9JM63.
PRIDEiQ9JM63.

Expressioni

Gene expression databases

BgeeiQ9JM63.
ExpressionAtlasiQ9JM63. baseline and differential.
GenevestigatoriQ9JM63.

Interactioni

Subunit structurei

Seems to form heterodimer with Kir5.1/KCNJ16 (By similarity). Interacts with INADL.By similarity1 Publication

Protein-protein interaction databases

BioGridi200895. 1 interaction.
IntActiQ9JM63. 2 interactions.
MINTiMINT-1891836.
STRINGi10090.ENSMUSP00000054356.

Structurei

3D structure databases

ProteinModelPortaliQ9JM63.
SMRiQ9JM63. Positions 27-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi128 – 1336Selectivity filterBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG284842.
GeneTreeiENSGT00760000118842.
HOVERGENiHBG006178.
InParanoidiQ9JM63.
KOiK05003.
OMAiGTWFAFG.
OrthoDBiEOG7GFB4Z.
PhylomeDBiQ9JM63.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003269. K_chnl_inward-rec_Kir1.2.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF21. PTHR11767:SF21. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01322. KIR12CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JM63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSVAKVYYS QTTQTESRPL VAPGIRRRRV LTKDGRSNVR MEHIADKRFL
60 70 80 90 100
YLKDLWTTFI DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELG
110 120 130 140 150
PPANHTPCVV QVHTLTGAFL FSLESQTTIG YGFRYISEEC PLAIVLLIAQ
160 170 180 190 200
LVLTTILEIF ITGTFLAKIA RPKKRAETIR FSQHAVVASH NGKPCLMIRV
210 220 230 240 250
ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV DTASDSPFLI
260 270 280 290 300
LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY
310 320 330 340 350
LPEEILWGYE FTPAISLSAS GKYIADFSLF DQVVKVASPS GLRDSTVRYG
360 370
DPEKLKLEES LREQAEKEGS ALSVRISNV
Length:379
Mass (Da):42,432
Last modified:September 30, 2000 - v1
Checksum:i7FF08446B7F43453
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039879 mRNA. Translation: BAA92432.1.
AF322631 mRNA. Translation: AAG42845.1.
CCDSiCCDS15512.1.
RefSeqiNP_001034573.1. NM_001039484.1.
XP_006496740.2. XM_006496677.2.
UniGeneiMm.254563.

Genome annotation databases

EnsembliENSMUST00000056136; ENSMUSP00000054356; ENSMUSG00000044708.
GeneIDi16513.
KEGGimmu:16513.
UCSCiuc007dqj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039879 mRNA. Translation: BAA92432.1.
AF322631 mRNA. Translation: AAG42845.1.
CCDSiCCDS15512.1.
RefSeqiNP_001034573.1. NM_001039484.1.
XP_006496740.2. XM_006496677.2.
UniGeneiMm.254563.

3D structure databases

ProteinModelPortaliQ9JM63.
SMRiQ9JM63. Positions 27-339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200895. 1 interaction.
IntActiQ9JM63. 2 interactions.
MINTiMINT-1891836.
STRINGi10090.ENSMUSP00000054356.

Proteomic databases

MaxQBiQ9JM63.
PaxDbiQ9JM63.
PRIDEiQ9JM63.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056136; ENSMUSP00000054356; ENSMUSG00000044708.
GeneIDi16513.
KEGGimmu:16513.
UCSCiuc007dqj.1. mouse.

Organism-specific databases

CTDi3766.
MGIiMGI:1194504. Kcnj10.

Phylogenomic databases

eggNOGiNOG284842.
GeneTreeiENSGT00760000118842.
HOVERGENiHBG006178.
InParanoidiQ9JM63.
KOiK05003.
OMAiGTWFAFG.
OrthoDBiEOG7GFB4Z.
PhylomeDBiQ9JM63.
TreeFamiTF313676.

Enzyme and pathway databases

ReactomeiREACT_286807. Potassium transport channels.
REACT_308732. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_339334. Activation of G protein gated Potassium channels.

Miscellaneous databases

ChiTaRSiKcnj10. mouse.
NextBioi289861.
PROiQ9JM63.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JM63.
ExpressionAtlasiQ9JM63. baseline and differential.
GenevestigatoriQ9JM63.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003269. K_chnl_inward-rec_Kir1.2.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF21. PTHR11767:SF21. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01322. KIR12CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Inanobe A., Takahashi K., Tanemoto M., Fujita A., Kurachi Y.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of an inward rectifier potassium channel gene expressed in mouse cortical astrocytes."
    Li L., Head V., Timpe L.C.
    Glia 33:57-71(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1 and ICR.
    Tissue: Brain.
  3. "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins."
    Kurschner C., Mermelstein P.G., Holden W.T., Surmeier D.J.
    Mol. Cell. Neurosci. 11:161-172(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INADL.

Entry informationi

Entry nameiKCJ10_MOUSE
AccessioniPrimary (citable) accession number: Q9JM63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2001
Last sequence update: September 30, 2000
Last modified: March 31, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.