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Q9JM63 (KCJ10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-sensitive inward rectifier potassium channel 10
Alternative name(s):
Inward rectifier K(+) channel Kir4.1
Potassium channel, inwardly rectifying subfamily J member 10
Gene names
Name:Kcnj10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium By similarity.

Subunit structure

Seems to form heterodimer with Kir5.1/KCNJ16 By similarity. Interacts with INADL. Ref.3

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily. [View classification]

Ontologies

Keywords
   Biological processIon transport
Potassium transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
Potassium
   Molecular functionIon channel
Voltage-gated channel
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processL-glutamate uptake involved in synaptic transmission

Inferred from mutant phenotype PubMed 17942730. Source: MGI

adult walking behavior

Inferred from mutant phenotype PubMed 10908613PubMed 17942730. Source: MGI

central nervous system myelination

Inferred from mutant phenotype PubMed 17942730. Source: MGI

inflammatory response

Inferred from electronic annotation. Source: Ensembl

membrane hyperpolarization

Inferred from electronic annotation. Source: Ensembl

oligodendrocyte development

Inferred from mutant phenotype PubMed 17942730. Source: MGI

optic nerve development

Inferred from electronic annotation. Source: Ensembl

potassium ion homeostasis

Inferred from mutant phenotype PubMed 16306174PubMed 17942730. Source: MGI

potassium ion import

Inferred from electronic annotation. Source: Ensembl

potassium ion transmembrane transport

Inferred from mutant phenotype PubMed 10908613PubMed 17869537PubMed 19515915PubMed 20074622PubMed 20651251. Source: MGI

potassium ion transport

Inferred from direct assay Ref.3. Source: MGI

protein homotetramerization

Inferred from electronic annotation. Source: Ensembl

regulation of long-term neuronal synaptic plasticity

Inferred from mutant phenotype PubMed 17942730. Source: MGI

regulation of membrane potential

Inferred from mutant phenotype PubMed 19515915PubMed 20074622. Source: MGI

regulation of resting membrane potential

Inferred from mutant phenotype PubMed 10908613PubMed 16306174PubMed 17942730. Source: MGI

regulation of sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

response to blue light

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to mineralocorticoid

Inferred from electronic annotation. Source: Ensembl

visual perception

Inferred from mutant phenotype PubMed 10908613PubMed 15359216. Source: MGI

   Cellular_componentapical plasma membrane

Inferred from electronic annotation. Source: Ensembl

basolateral plasma membrane

Inferred from direct assay PubMed 20651251. Source: MGI

dystrophin-associated glycoprotein complex

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Inferred by curator Ref.3. Source: MGI

microvillus

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay PubMed 15310750. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

inward rectifier potassium channel activity

Inferred from mutant phenotype PubMed 19515915PubMed 20074622PubMed 20651251. Source: MGI

potassium channel activity

Inferred from direct assay Ref.3. Source: MGI

protein binding

Inferred from physical interaction PubMed 15310750Ref.3. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379ATP-sensitive inward rectifier potassium channel 10
PRO_0000154954

Regions

Topological domain1 – 6464Cytoplasmic By similarity
Transmembrane65 – 8925Helical; Name=M1; By similarity
Topological domain90 – 11425Extracellular By similarity
Intramembrane115 – 12612Helical; Pore-forming; Name=H5; By similarity
Intramembrane127 – 1337Pore-forming; By similarity
Topological domain134 – 1429Extracellular By similarity
Transmembrane143 – 16422Helical; Name=M2; By similarity
Topological domain165 – 379215Cytoplasmic By similarity
Nucleotide binding210 – 2178ATP Potential
Motif128 – 1336Selectivity filter By similarity

Sites

Site1581Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JM63 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 7FF08446B7F43453

FASTA37942,432
        10         20         30         40         50         60 
MTSVAKVYYS QTTQTESRPL VAPGIRRRRV LTKDGRSNVR MEHIADKRFL YLKDLWTTFI 

        70         80         90        100        110        120 
DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELG PPANHTPCVV QVHTLTGAFL 

       130        140        150        160        170        180 
FSLESQTTIG YGFRYISEEC PLAIVLLIAQ LVLTTILEIF ITGTFLAKIA RPKKRAETIR 

       190        200        210        220        230        240 
FSQHAVVASH NGKPCLMIRV ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV 

       250        260        270        280        290        300 
DTASDSPFLI LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY 

       310        320        330        340        350        360 
LPEEILWGYE FTPAISLSAS GKYIADFSLF DQVVKVASPS GLRDSTVRYG DPEKLKLEES 

       370 
LREQAEKEGS ALSVRISNV 

« Hide

References

[1]Inanobe A., Takahashi K., Tanemoto M., Fujita A., Kurachi Y.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Identification of an inward rectifier potassium channel gene expressed in mouse cortical astrocytes."
Li L., Head V., Timpe L.C.
Glia 33:57-71(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1 and ICR.
Tissue: Brain.
[3]"CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins."
Kurschner C., Mermelstein P.G., Holden W.T., Surmeier D.J.
Mol. Cell. Neurosci. 11:161-172(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH INADL.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB039879 mRNA. Translation: BAA92432.1.
AF322631 mRNA. Translation: AAG42845.1.
CCDSCCDS15512.1.
RefSeqNP_001034573.1. NM_001039484.1.
UniGeneMm.254563.

3D structure databases

ProteinModelPortalQ9JM63.
SMRQ9JM63. Positions 27-339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200895. 1 interaction.
IntActQ9JM63. 2 interactions.
MINTMINT-1891836.
STRING10090.ENSMUSP00000054356.

Proteomic databases

MaxQBQ9JM63.
PaxDbQ9JM63.
PRIDEQ9JM63.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000056136; ENSMUSP00000054356; ENSMUSG00000044708.
GeneID16513.
KEGGmmu:16513.
UCSCuc007dqj.1. mouse.

Organism-specific databases

CTD3766.
MGIMGI:1194504. Kcnj10.

Phylogenomic databases

eggNOGNOG284842.
GeneTreeENSGT00690000102074.
HOVERGENHBG006178.
InParanoidQ9JM63.
KOK05003.
OMAFYHVVDD.
OrthoDBEOG7GFB4Z.
PhylomeDBQ9JM63.
TreeFamTF313676.

Gene expression databases

ArrayExpressQ9JM63.
BgeeQ9JM63.
GenevestigatorQ9JM63.

Family and domain databases

Gene3D2.60.40.1400. 1 hit.
InterProIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003269. K_chnl_inward-rec_Kir1.2.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF21. PTHR11767:SF21. 1 hit.
PfamPF01007. IRK. 1 hit.
[Graphical view]
PIRSFPIRSF005465. GIRK_kir. 1 hit.
PRINTSPR01322. KIR12CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMSSF81296. SSF81296. 1 hit.
ProtoNetSearch...

Other

ChiTaRSKCNJ10. mouse.
NextBio289861.
PROQ9JM63.
SOURCESearch...

Entry information

Entry nameKCJ10_MOUSE
AccessionPrimary (citable) accession number: Q9JM63
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot