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Protein

Thrombospondin type-1 domain-containing protein 1

Gene

Thsd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • hematopoietic progenitor cell differentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin type-1 domain-containing protein 1
Alternative name(s):
Transmembrane molecule with thrombospondin module
Gene namesi
Name:Thsd1
Synonyms:Tmtsp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1929096. Thsd1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 412ExtracellularSequence analysisAdd BLAST388
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 851CytoplasmicSequence analysisAdd BLAST418

GO - Cellular componenti

  • cell periphery Source: MGI
  • cell surface Source: MGI
  • cytoplasm Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000024958525 – 851Thrombospondin type-1 domain-containing protein 1Add BLAST827

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...)Sequence analysis1
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1
Glycosylationi110N-linked (GlcNAc...)Sequence analysis1
Glycosylationi135N-linked (GlcNAc...)Sequence analysis1
Glycosylationi304N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi351 ↔ 386PROSITE-ProRule annotation
Disulfide bondi355 ↔ 391PROSITE-ProRule annotation
Disulfide bondi366 ↔ 376PROSITE-ProRule annotation
Modified residuei462PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JM61.
PRIDEiQ9JM61.

PTM databases

iPTMnetiQ9JM61.
PhosphoSitePlusiQ9JM61.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031480.
CleanExiMM_THSD1.

Interactioni

Protein-protein interaction databases

IntActiQ9JM61. 1 interactor.
MINTiMINT-4114699.

Structurei

3D structure databases

ProteinModelPortaliQ9JM61.
SMRiQ9JM61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini339 – 392TSP type-1PROSITE-ProRule annotationAdd BLAST54

Sequence similaritiesi

Contains 1 TSP type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG2S. Eukaryota.
ENOG410Z44J. LUCA.
HOGENOMiHOG000230926.
HOVERGENiHBG079998.
InParanoidiQ9JM61.
PhylomeDBiQ9JM61.
TreeFamiTF333148.

Family and domain databases

InterProiIPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00090. TSP_1. 1 hit.
[Graphical view]
SMARTiSM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 1 hit.
PROSITEiPS50092. TSP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JM61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPMLKDFSN LLLVVLCDYV LGEAEYLLLQ EPVHVALSDR TVSVGFHYLS
60 70 80 90 100
DVNGTLRNVS VMLWEANTNR TLTTKYLLTN QAQGTLQFEC FYFKEAGDYW
110 120 130 140 150
FVMIPEVTDN GTQVPLWEKS AFLKVEWPVF HIDLNRTAKA AEGTFQVGVF
160 170 180 190 200
TTQPLCLFPV DKPDMLVDVI FTDRLPEARA SLGQPLEIRA SKRTKLTQGQ
210 220 230 240 250
WVEFGCAPVG VEAYVTVMLR LLGQDSVIAS TGPIDLAQKF GYKLMMAPEV
260 270 280 290 300
TCESVLEVMV LPPPCVFVQG VLAVYKEAPK RPEERTFQVA ENRLPLGERR
310 320 330 340 350
TVFNCTLFDV GKNKYCFNFG IVKKGHFSAK ECMLIQRNIE TWGPWQPWSP
360 370 380 390 400
CSTTCGDAVR ERRRLCVTSF PSRPSCSGMS SETSPCSLEE CAVFRPPGPS
410 420 430 440 450
PVSPQDPVKS NNVVTVTGIS LCLFIIFATV LITLWRRFGR APKCSTPVRH
460 470 480 490 500
NSIHSPGFRK NSDEENICEL SEPRGSFSDA GDGPRGSPGD TGIPLTYRCS
510 520 530 540 550
ASAPPEDEAS GSESFQSNAQ KIIPPLFSYR LAQQQLKEMK KKGLTETTKV
560 570 580 590 600
YHVSQSPLTD TVVDATASPP LDLECPEEAA ASKFRIKSPF LDQPGAGTGE
610 620 630 640 650
RPPSRLDGIV PPPGCAVSPS QTLIQKSQIR STGGRDGSSE RCHSRSSLFR
660 670 680 690 700
RTASFHETKQ SRPFRERSLS ALTPRQVPAY SSRMRTWDQM EDRCRPPSRS
710 720 730 740 750
THLLPERPEH FQGAGRTSSP LGPLSKSYTV GHPRRKPDPG DRQAGLVAGA
760 770 780 790 800
EKMEPHRAHR GPSPSHRSAS RKQSSPIFLK DSYQKVSQLS PSHFRKDKCQ
810 820 830 840 850
SFPIHPEFAF YDNTSFRLTE AEQRMLDLPG YFGSNEEDET TSTLSVEKLV

I
Length:851
Mass (Da):94,696
Last modified:October 3, 2006 - v2
Checksum:i2D157E7253FE902D
GO

Sequence cautioni

The sequence BAC33850 differs from that shown. Reason: Frameshift at position 744.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti625Q → R in BAA92685 (Ref. 1) Curated1
Sequence conflicti625Q → R in AAI19604 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039946 mRNA. Translation: BAA92685.1.
AK049636 mRNA. Translation: BAC33850.1. Frameshift.
BC119603 mRNA. Translation: AAI19604.1.
CCDSiCCDS22172.1.
RefSeqiNP_062522.1. NM_019576.2.
XP_006509236.1. XM_006509173.3.
XP_006509237.1. XM_006509174.3.
UniGeneiMm.32067.

Genome annotation databases

GeneIDi56229.
KEGGimmu:56229.
UCSCiuc009lcv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039946 mRNA. Translation: BAA92685.1.
AK049636 mRNA. Translation: BAC33850.1. Frameshift.
BC119603 mRNA. Translation: AAI19604.1.
CCDSiCCDS22172.1.
RefSeqiNP_062522.1. NM_019576.2.
XP_006509236.1. XM_006509173.3.
XP_006509237.1. XM_006509174.3.
UniGeneiMm.32067.

3D structure databases

ProteinModelPortaliQ9JM61.
SMRiQ9JM61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JM61. 1 interactor.
MINTiMINT-4114699.

PTM databases

iPTMnetiQ9JM61.
PhosphoSitePlusiQ9JM61.

Proteomic databases

PaxDbiQ9JM61.
PRIDEiQ9JM61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56229.
KEGGimmu:56229.
UCSCiuc009lcv.2. mouse.

Organism-specific databases

CTDi55901.
MGIiMGI:1929096. Thsd1.

Phylogenomic databases

eggNOGiENOG410IG2S. Eukaryota.
ENOG410Z44J. LUCA.
HOGENOMiHOG000230926.
HOVERGENiHBG079998.
InParanoidiQ9JM61.
PhylomeDBiQ9JM61.
TreeFamiTF333148.

Miscellaneous databases

PROiQ9JM61.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031480.
CleanExiMM_THSD1.

Family and domain databases

InterProiIPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00090. TSP_1. 1 hit.
[Graphical view]
SMARTiSM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 1 hit.
PROSITEiPS50092. TSP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHSD1_MOUSE
AccessioniPrimary (citable) accession number: Q9JM61
Secondary accession number(s): Q8C7Q9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 2, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.