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Q9JM58 (CRLF1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytokine receptor-like factor 1
Alternative name(s):
Cytokine receptor-like molecule 3
Short name=CRLM-3
Cytokine-like factor 1
Short name=CLF-1
Novel cytokine receptor 6
Short name=NR6
Gene names
Name:Crlf1
Synonyms:Crlm3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development By similarity. Plays an essential role in the initiation and/or maintenance of suckling in neonatal mice. Ref.2

Subunit structure

Forms covalently linked di- and tetramers. Forms a heteromeric complex with cardiotrophin-like cytokine (CLC); the CRLF1/CLC complex is a ligand for the ciliary neurotrophic factor receptor (CNTFR) By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Widely expressed in the embryo. Not detected in the brain of adult mice. Ref.2

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 3 subfamily.

Contains 2 fibronectin type-III domains.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 425392Cytokine receptor-like factor 1
PRO_0000011040

Regions

Domain35 – 134100Ig-like C2-type
Domain140 – 23596Fibronectin type-III 1
Domain240 – 344105Fibronectin type-III 2
Motif330 – 3345WSXWS motif

Amino acid modifications

Modified residue2221Phosphoserine Ref.3
Glycosylation951N-linked (GlcNAc...) Potential
Glycosylation1071N-linked (GlcNAc...) Potential
Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation1711N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential
Glycosylation3851N-linked (GlcNAc...) Potential
Disulfide bond146 ↔ 156 By similarity
Disulfide bond187 ↔ 198 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JM58 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 910535C629CA7056

FASTA42546,662
        10         20         30         40         50         60 
MPAGRPGPVA QSARRPPRPL SSLWSPLLLC VLGVPRGGSG AHTAVISPQD PTLLIGSSLQ 

        70         80         90        100        110        120 
ATCSIHGDTP GATAEGLYWT LNGRRLPSEL SRLLNTSTLA LALANLNGSR QQSGDNLVCH 

       130        140        150        160        170        180 
ARDGSILAGS CLYVGLPPEK PFNISCWSRN MKDLTCRWTP GAHGETFLHT NYSLKYKLRW 

       190        200        210        220        230        240 
YGQDNTCEEY HTVGPHSCHI PKDLALFTPY EIWVEATNRL GSARSDVLTL DVLDVVTTDP 

       250        260        270        280        290        300 
PPDVHVSRVG GLEDQLSVRW VSPPALKDFL FQAKYQIRYR VEDSVDWKVV DDVSNQTSCR 

       310        320        330        340        350        360 
LAGLKPGTVY FVQVRCNPFG IYGSKKAGIW SEWSHPTAAS TPRSERPGPG GGVCEPRGGE 

       370        380        390        400        410        420 
PSSGPVRREL KQFLGWLKKH AYCSNLSFRL YDQWRAWMQK SHKTRNQDEG ILPSGRRGAA 


RGPAG 

« Hide

References

[1]Hiroyama T., Iwama A., Nakamura Y., Nakauchi H.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Suckling defect in mice lacking the soluble haemopoietin receptor NR6."
Alexander W.S., Rakar S., Robb L., Farley A., Willson T.A., Zhang J.-G., Hartley L., Kikuchi Y., Kojima T., Nomura H., Hasegawa M., Maeda M., Fabri L., Jachno K., Nash A., Metcalf D., Nicola N.A., Hilton D.J.
Curr. Biol. 9:605-608(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[3]"Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry."
Jin W.-H., Dai J., Zhou H., Xia Q.-C., Zou H.-F., Zeng R.
Rapid Commun. Mass Spectrom. 18:2169-2176(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-222.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB040038 mRNA. Translation: BAA92777.1.
CCDSCCDS22369.1.
RefSeqNP_061297.1. NM_018827.2.
UniGeneMm.335584.

3D structure databases

ProteinModelPortalQ9JM58.
SMRQ9JM58. Positions 46-342.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9JM58. 1 interaction.
MINTMINT-8178437.

PTM databases

PhosphoSiteQ9JM58.

Proteomic databases

PaxDbQ9JM58.
PRIDEQ9JM58.

Protocols and materials databases

DNASU12931.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000008032; ENSMUSP00000008032; ENSMUSG00000007888.
GeneID12931.
KEGGmmu:12931.
UCSCuc009maj.1. mouse.

Organism-specific databases

CTD9244.
MGIMGI:1340030. Crlf1.

Phylogenomic databases

eggNOGNOG43001.
GeneTreeENSGT00530000063112.
HOGENOMHOG000111972.
HOVERGENHBG051119.
InParanoidQ9JM58.
OMAKHAYGCS.
OrthoDBEOG7WX08H.
PhylomeDBQ9JM58.
TreeFamTF106501.

Gene expression databases

ArrayExpressQ9JM58.
BgeeQ9JM58.
CleanExMM_CRLF1.
GenevestigatorQ9JM58.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR003961. Fibronectin_type3.
IPR015152. Growth/epo_recpt_lig-bind.
IPR013783. Ig-like_fold.
[Graphical view]
PfamPF09067. EpoR_lig-bind. 1 hit.
PF00041. fn3. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
PROSITEPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio282600.
PROQ9JM58.
SOURCESearch...

Entry information

Entry nameCRLF1_MOUSE
AccessionPrimary (citable) accession number: Q9JM58
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot