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Protein

Cytokine receptor-like factor 1

Gene

Crlf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development (By similarity). Plays an essential role in the initiation and/or maintenance of suckling in neonatal mice.By similarity1 Publication

GO - Molecular functioni

  1. cytokine binding Source: MGI
  2. protein heterodimerization activity Source: BHF-UCL

GO - Biological processi

  1. negative regulation of motor neuron apoptotic process Source: BHF-UCL
  2. negative regulation of neuron apoptotic process Source: MGI
  3. positive regulation of cell proliferation Source: MGI
  4. positive regulation of tyrosine phosphorylation of Stat3 protein Source: MGI
  5. ureteric bud development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine receptor-like factor 1
Alternative name(s):
Cytokine receptor-like molecule 3
Short name:
CRLM-3
Cytokine-like factor 1
Short name:
CLF-1
Novel cytokine receptor 6
Short name:
NR6
Gene namesi
Name:Crlf1
Synonyms:Crlm3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1340030. Crlf1.

Subcellular locationi

  1. Secreted By similarity

GO - Cellular componenti

  1. CRLF-CLCF1 complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 425392Cytokine receptor-like factor 1PRO_0000011040Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi146 ↔ 156By similarity
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi187 ↔ 198By similarity
Modified residuei222 – 2221Phosphoserine1 Publication
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi385 – 3851N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9JM58.
PaxDbiQ9JM58.
PRIDEiQ9JM58.

PTM databases

PhosphoSiteiQ9JM58.

Expressioni

Tissue specificityi

Widely expressed in the embryo. Not detected in the brain of adult mice.1 Publication

Gene expression databases

BgeeiQ9JM58.
CleanExiMM_CRLF1.
ExpressionAtlasiQ9JM58. baseline and differential.
GenevestigatoriQ9JM58.

Interactioni

Subunit structurei

Forms covalently linked di- and tetramers. Forms a heteromeric complex with cardiotrophin-like cytokine (CLC); the CRLF1/CLC complex is a ligand for the ciliary neurotrophic factor receptor (CNTFR) (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9JM58. 1 interaction.
MINTiMINT-8178437.

Structurei

3D structure databases

ProteinModelPortaliQ9JM58.
SMRiQ9JM58. Positions 46-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 134100Ig-like C2-typeAdd
BLAST
Domaini140 – 23596Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini240 – 344105Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi330 – 3345WSXWS motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG43001.
GeneTreeiENSGT00530000063112.
HOGENOMiHOG000111972.
HOVERGENiHBG051119.
InParanoidiQ9JM58.
OMAiKHAYGCS.
OrthoDBiEOG7WX08H.
PhylomeDBiQ9JM58.
TreeFamiTF106501.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR015152. Growth/epo_recpt_lig-bind.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF09067. EpoR_lig-bind. 1 hit.
PF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JM58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAGRPGPVA QSARRPPRPL SSLWSPLLLC VLGVPRGGSG AHTAVISPQD
60 70 80 90 100
PTLLIGSSLQ ATCSIHGDTP GATAEGLYWT LNGRRLPSEL SRLLNTSTLA
110 120 130 140 150
LALANLNGSR QQSGDNLVCH ARDGSILAGS CLYVGLPPEK PFNISCWSRN
160 170 180 190 200
MKDLTCRWTP GAHGETFLHT NYSLKYKLRW YGQDNTCEEY HTVGPHSCHI
210 220 230 240 250
PKDLALFTPY EIWVEATNRL GSARSDVLTL DVLDVVTTDP PPDVHVSRVG
260 270 280 290 300
GLEDQLSVRW VSPPALKDFL FQAKYQIRYR VEDSVDWKVV DDVSNQTSCR
310 320 330 340 350
LAGLKPGTVY FVQVRCNPFG IYGSKKAGIW SEWSHPTAAS TPRSERPGPG
360 370 380 390 400
GGVCEPRGGE PSSGPVRREL KQFLGWLKKH AYCSNLSFRL YDQWRAWMQK
410 420
SHKTRNQDEG ILPSGRRGAA RGPAG
Length:425
Mass (Da):46,662
Last modified:October 1, 2000 - v1
Checksum:i910535C629CA7056
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040038 mRNA. Translation: BAA92777.1.
CCDSiCCDS22369.1.
RefSeqiNP_061297.1. NM_018827.2.
UniGeneiMm.335584.

Genome annotation databases

EnsembliENSMUST00000008032; ENSMUSP00000008032; ENSMUSG00000007888.
GeneIDi12931.
KEGGimmu:12931.
UCSCiuc009maj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040038 mRNA. Translation: BAA92777.1.
CCDSiCCDS22369.1.
RefSeqiNP_061297.1. NM_018827.2.
UniGeneiMm.335584.

3D structure databases

ProteinModelPortaliQ9JM58.
SMRiQ9JM58. Positions 46-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JM58. 1 interaction.
MINTiMINT-8178437.

PTM databases

PhosphoSiteiQ9JM58.

Proteomic databases

MaxQBiQ9JM58.
PaxDbiQ9JM58.
PRIDEiQ9JM58.

Protocols and materials databases

DNASUi12931.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008032; ENSMUSP00000008032; ENSMUSG00000007888.
GeneIDi12931.
KEGGimmu:12931.
UCSCiuc009maj.1. mouse.

Organism-specific databases

CTDi9244.
MGIiMGI:1340030. Crlf1.

Phylogenomic databases

eggNOGiNOG43001.
GeneTreeiENSGT00530000063112.
HOGENOMiHOG000111972.
HOVERGENiHBG051119.
InParanoidiQ9JM58.
OMAiKHAYGCS.
OrthoDBiEOG7WX08H.
PhylomeDBiQ9JM58.
TreeFamiTF106501.

Miscellaneous databases

NextBioi282600.
PROiQ9JM58.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JM58.
CleanExiMM_CRLF1.
ExpressionAtlasiQ9JM58. baseline and differential.
GenevestigatoriQ9JM58.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR015152. Growth/epo_recpt_lig-bind.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF09067. EpoR_lig-bind. 1 hit.
PF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Hiroyama T., Iwama A., Nakamura Y., Nakauchi H.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: FUNCTION, TISSUE SPECIFICITY.
  3. "Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry."
    Jin W.-H., Dai J., Zhou H., Xia Q.-C., Zou H.-F., Zeng R.
    Rapid Commun. Mass Spectrom. 18:2169-2176(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-222.

Entry informationi

Entry nameiCRLF1_MOUSE
AccessioniPrimary (citable) accession number: Q9JM58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.