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Protein

Cytokine receptor-like factor 1

Gene

Crlf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development (By similarity). Plays an essential role in the initiation and/or maintenance of suckling in neonatal mice.By similarity1 Publication

GO - Molecular functioni

  • cytokine binding Source: MGI
  • protein heterodimerization activity Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-6788467. IL-6-type cytokine receptor ligand interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine receptor-like factor 1
Alternative name(s):
Cytokine receptor-like molecule 3
Short name:
CRLM-3
Cytokine-like factor 1
Short name:
CLF-1
Novel cytokine receptor 6
Short name:
NR6
Gene namesi
Name:Crlf1
Synonyms:Crlm3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1340030. Crlf1.

Subcellular locationi

GO - Cellular componenti

  • CRLF-CLCF1 complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000001104034 – 425Cytokine receptor-like factor 1Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi95N-linked (GlcNAc...)Sequence analysis1
Glycosylationi107N-linked (GlcNAc...)Sequence analysis1
Glycosylationi143N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi146 ↔ 156By similarity
Glycosylationi171N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi187 ↔ 198By similarity
Modified residuei222Phosphoserine1 Publication1
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Glycosylationi385N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9JM58.
PaxDbiQ9JM58.
PeptideAtlasiQ9JM58.
PRIDEiQ9JM58.

PTM databases

iPTMnetiQ9JM58.
PhosphoSitePlusiQ9JM58.

Expressioni

Tissue specificityi

Widely expressed in the embryo. Not detected in the brain of adult mice.1 Publication

Gene expression databases

BgeeiENSMUSG00000007888.
CleanExiMM_CRLF1.
ExpressionAtlasiQ9JM58. baseline and differential.
GenevisibleiQ9JM58. MM.

Interactioni

Subunit structurei

Forms covalently linked di- and tetramers. Forms a heteromeric complex with cardiotrophin-like cytokine (CLC); the CRLF1/CLC complex is a ligand for the ciliary neurotrophic factor receptor (CNTFR) (By similarity).By similarity

GO - Molecular functioni

  • cytokine binding Source: MGI
  • protein heterodimerization activity Source: BHF-UCL

Protein-protein interaction databases

IntActiQ9JM58. 1 interactor.
MINTiMINT-8178437.
STRINGi10090.ENSMUSP00000008032.

Structurei

3D structure databases

ProteinModelPortaliQ9JM58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 134Ig-like C2-typeAdd BLAST100
Domaini140 – 235Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini240 – 344Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST105

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi330 – 334WSXWS motif5

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IV7Y. Eukaryota.
ENOG410Z87J. LUCA.
GeneTreeiENSGT00530000063112.
HOGENOMiHOG000111972.
HOVERGENiHBG051119.
InParanoidiQ9JM58.
OMAiKHAYGCS.
OrthoDBiEOG091G07OT.
PhylomeDBiQ9JM58.
TreeFamiTF106501.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR015152. Growth/epo_recpt_lig-bind.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF09067. EpoR_lig-bind. 1 hit.
PF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JM58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAGRPGPVA QSARRPPRPL SSLWSPLLLC VLGVPRGGSG AHTAVISPQD
60 70 80 90 100
PTLLIGSSLQ ATCSIHGDTP GATAEGLYWT LNGRRLPSEL SRLLNTSTLA
110 120 130 140 150
LALANLNGSR QQSGDNLVCH ARDGSILAGS CLYVGLPPEK PFNISCWSRN
160 170 180 190 200
MKDLTCRWTP GAHGETFLHT NYSLKYKLRW YGQDNTCEEY HTVGPHSCHI
210 220 230 240 250
PKDLALFTPY EIWVEATNRL GSARSDVLTL DVLDVVTTDP PPDVHVSRVG
260 270 280 290 300
GLEDQLSVRW VSPPALKDFL FQAKYQIRYR VEDSVDWKVV DDVSNQTSCR
310 320 330 340 350
LAGLKPGTVY FVQVRCNPFG IYGSKKAGIW SEWSHPTAAS TPRSERPGPG
360 370 380 390 400
GGVCEPRGGE PSSGPVRREL KQFLGWLKKH AYCSNLSFRL YDQWRAWMQK
410 420
SHKTRNQDEG ILPSGRRGAA RGPAG
Length:425
Mass (Da):46,662
Last modified:October 1, 2000 - v1
Checksum:i910535C629CA7056
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040038 mRNA. Translation: BAA92777.1.
CCDSiCCDS22369.1.
RefSeqiNP_061297.1. NM_018827.3.
UniGeneiMm.335584.

Genome annotation databases

EnsembliENSMUST00000008032; ENSMUSP00000008032; ENSMUSG00000007888.
GeneIDi12931.
KEGGimmu:12931.
UCSCiuc009maj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040038 mRNA. Translation: BAA92777.1.
CCDSiCCDS22369.1.
RefSeqiNP_061297.1. NM_018827.3.
UniGeneiMm.335584.

3D structure databases

ProteinModelPortaliQ9JM58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JM58. 1 interactor.
MINTiMINT-8178437.
STRINGi10090.ENSMUSP00000008032.

PTM databases

iPTMnetiQ9JM58.
PhosphoSitePlusiQ9JM58.

Proteomic databases

MaxQBiQ9JM58.
PaxDbiQ9JM58.
PeptideAtlasiQ9JM58.
PRIDEiQ9JM58.

Protocols and materials databases

DNASUi12931.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008032; ENSMUSP00000008032; ENSMUSG00000007888.
GeneIDi12931.
KEGGimmu:12931.
UCSCiuc009maj.1. mouse.

Organism-specific databases

CTDi9244.
MGIiMGI:1340030. Crlf1.

Phylogenomic databases

eggNOGiENOG410IV7Y. Eukaryota.
ENOG410Z87J. LUCA.
GeneTreeiENSGT00530000063112.
HOGENOMiHOG000111972.
HOVERGENiHBG051119.
InParanoidiQ9JM58.
OMAiKHAYGCS.
OrthoDBiEOG091G07OT.
PhylomeDBiQ9JM58.
TreeFamiTF106501.

Enzyme and pathway databases

ReactomeiR-MMU-6788467. IL-6-type cytokine receptor ligand interactions.

Miscellaneous databases

PROiQ9JM58.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007888.
CleanExiMM_CRLF1.
ExpressionAtlasiQ9JM58. baseline and differential.
GenevisibleiQ9JM58. MM.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR015152. Growth/epo_recpt_lig-bind.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF09067. EpoR_lig-bind. 1 hit.
PF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRLF1_MOUSE
AccessioniPrimary (citable) accession number: Q9JM58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.