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Protein

Protein Tob2

Gene

Tob2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.By similarity

GO - Molecular functioni

  • transcription corepressor activity Source: GO_Central
  • vitamin D receptor binding Source: MGI

GO - Biological processi

  • negative regulation of cell proliferation Source: InterPro
  • negative regulation of osteoclast differentiation Source: MGI
  • positive regulation of ossification Source: MGI
  • regulation of gene expression Source: MGI
  • signaling Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Tob2
Alternative name(s):
Transducer of erbB-2 2
Gene namesi
Name:Tob2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1888525. Tob2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438161 – 345Protein Tob2Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei255PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JM55.
PaxDbiQ9JM55.
PRIDEiQ9JM55.

PTM databases

PhosphoSitePlusiQ9JM55.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000048546.
CleanExiMM_TOB2.
ExpressionAtlasiQ9JM55. baseline and differential.
GenevisibleiQ9JM55. MM.

Interactioni

Subunit structurei

Associates with CAF1.By similarity

GO - Molecular functioni

  • vitamin D receptor binding Source: MGI

Protein-protein interaction databases

BioGridi208229. 2 interactors.
IntActiQ9JM55. 1 interactor.
STRINGi10090.ENSMUSP00000061390.

Structurei

3D structure databases

ProteinModelPortaliQ9JM55.
SMRiQ9JM55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOVERGENiHBG006617.
InParanoidiQ9JM55.
KOiK14443.
OMAiMQYPSQS.
OrthoDBiEOG091G0LEQ.
PhylomeDBiQ9JM55.
TreeFamiTF105274.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
IPR009818. Ataxin-2_C.
IPR015676. Tob1/2.
IPR015678. Tob2.
[Graphical view]
PANTHERiPTHR17537. PTHR17537. 1 hit.
PTHR17537:SF3. PTHR17537:SF3. 1 hit.
PfamiPF07742. BTG. 1 hit.
PF07145. PAM2. 2 hits.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JM55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLEIKVALN FIISYLYNKL PRRRADLFGE ELERLLRKKY EGHWYPEKPL
60 70 80 90 100
KGSGFRCVHI GEVVDPVVEL AAKRSGLAVE DVRANVPEEL SVWIDPFEVS
110 120 130 140 150
YQIGEKGVVK VLYLGDSEAS GTPELDKEIK SSFNPDAQVF VPIGSQDSSL
160 170 180 190 200
SSSPSPSFGQ SPSPTFIPRS AQPITFTTAS FAATKFGSTK MKKGGGASGG
210 220 230 240 250
VSVGGSGAGG QQPPPQQPRM ARSPTKNLLK HKSLSLSMHS LNLIPANPAP
260 270 280 290 300
QSQLSPNAKE FVYNGGGSPS LFFDGVEGPS TSTTAPFGSG GASTCNSSSF
310 320 330 340
DVSQVFGGGA NSLFLEKSPF VEGLSYNLNT MQYPNQPFQP VVLAN
Length:345
Mass (Da):36,798
Last modified:October 1, 2000 - v1
Checksum:i6DC28348E68AC976
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041225 Genomic DNA. Translation: BAA94606.1.
BC011163 mRNA. Translation: AAH11163.1.
CCDSiCCDS27673.1.
RefSeqiNP_065253.1. NM_020507.3.
UniGeneiMm.323595.

Genome annotation databases

EnsembliENSMUST00000050467; ENSMUSP00000061390; ENSMUSG00000048546.
GeneIDi57259.
KEGGimmu:57259.
UCSCiuc007wxm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041225 Genomic DNA. Translation: BAA94606.1.
BC011163 mRNA. Translation: AAH11163.1.
CCDSiCCDS27673.1.
RefSeqiNP_065253.1. NM_020507.3.
UniGeneiMm.323595.

3D structure databases

ProteinModelPortaliQ9JM55.
SMRiQ9JM55.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208229. 2 interactors.
IntActiQ9JM55. 1 interactor.
STRINGi10090.ENSMUSP00000061390.

PTM databases

PhosphoSitePlusiQ9JM55.

Proteomic databases

EPDiQ9JM55.
PaxDbiQ9JM55.
PRIDEiQ9JM55.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050467; ENSMUSP00000061390; ENSMUSG00000048546.
GeneIDi57259.
KEGGimmu:57259.
UCSCiuc007wxm.1. mouse.

Organism-specific databases

CTDi10766.
MGIiMGI:1888525. Tob2.

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOVERGENiHBG006617.
InParanoidiQ9JM55.
KOiK14443.
OMAiMQYPSQS.
OrthoDBiEOG091G0LEQ.
PhylomeDBiQ9JM55.
TreeFamiTF105274.

Miscellaneous databases

PROiQ9JM55.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048546.
CleanExiMM_TOB2.
ExpressionAtlasiQ9JM55. baseline and differential.
GenevisibleiQ9JM55. MM.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
IPR009818. Ataxin-2_C.
IPR015676. Tob1/2.
IPR015678. Tob2.
[Graphical view]
PANTHERiPTHR17537. PTHR17537. 1 hit.
PTHR17537:SF3. PTHR17537:SF3. 1 hit.
PfamiPF07742. BTG. 1 hit.
PF07145. PAM2. 2 hits.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOB2_MOUSE
AccessioniPrimary (citable) accession number: Q9JM55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.