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Protein

Prostaglandin E synthase

Gene

Ptges

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).By similarity

Catalytic activityi

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.

Cofactori

glutathioneBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei118GlutathioneBy similarity1
Binding sitei127GlutathioneBy similarity1
Binding sitei131GlutathioneBy similarity1
Binding sitei135GlutathioneBy similarity1

GO - Molecular functioni

  • glutathione binding Source: UniProtKB
  • prostaglandin-D synthase activity Source: MGI
  • prostaglandin-E synthase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

Enzyme and pathway databases

BRENDAi5.3.99.3. 3474.
ReactomeiR-MMU-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E synthase (EC:5.3.99.3)
Short name:
mPGES-1
Alternative name(s):
Microsomal prostaglandin E synthase 1
Gene namesi
Name:Ptges
Synonyms:Pges
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1927593. Ptges.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13LumenalBy similarityAdd BLAST13
Transmembranei14 – 42HelicalBy similarityAdd BLAST29
Topological domaini43 – 61CytoplasmicBy similarityAdd BLAST19
Transmembranei62 – 91HelicalBy similarityAdd BLAST30
Topological domaini92 – 96LumenalBy similarity5
Transmembranei97 – 120HelicalBy similarityAdd BLAST24
Topological domaini121 – 124CytoplasmicBy similarity4
Transmembranei125 – 153HelicalBy similarityAdd BLAST29

GO - Cellular componenti

  • cytoplasm Source: MGI
  • integral component of membrane Source: UniProtKB
  • nuclear envelope lumen Source: MGI
  • perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2046261.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002177471 – 153Prostaglandin E synthaseAdd BLAST153

Proteomic databases

MaxQBiQ9JM51.
PaxDbiQ9JM51.
PRIDEiQ9JM51.

PTM databases

iPTMnetiQ9JM51.
PhosphoSitePlusiQ9JM51.

Expressioni

Gene expression databases

BgeeiENSMUSG00000050737.
CleanExiMM_PTGES.
GenevisibleiQ9JM51. MM.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi211054. 1 interactor.
STRINGi10090.ENSMUSP00000099916.

Structurei

3D structure databases

ProteinModelPortaliQ9JM51.
SMRiQ9JM51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 39Glutathione bindingBy similarityAdd BLAST11
Regioni71 – 78Glutathione bindingBy similarity8
Regioni111 – 114Glutathione bindingBy similarity4

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY81. Eukaryota.
ENOG4111VJG. LUCA.
GeneTreeiENSGT00390000011980.
HOGENOMiHOG000231759.
HOVERGENiHBG052470.
InParanoidiQ9JM51.
KOiK15729.
OMAiCFSMALQ.
OrthoDBiEOG091G14I4.
PhylomeDBiQ9JM51.
TreeFamiTF105327.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JM51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPGLVMES GQVLPAFLLC STLLVIKMYA VAVITGQMRL RKKAFANPED
60 70 80 90 100
ALKRGGLQYY RSDPDVERCL RAHRNDMETI YPFLFLGFVY SFLGPNPLIA
110 120 130 140 150
WIHFLVVLTG RVVHTVAYLG KLNPRLRSGA YVLAQFSCFS MALQILWEVA

HHL
Length:153
Mass (Da):17,286
Last modified:October 1, 2000 - v1
Checksum:i08A1AF2D288D53F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041997 mRNA. Translation: BAA96083.1.
AB035323 mRNA. Translation: BAB71813.1.
AK010757 mRNA. Translation: BAB27163.1.
AK033752 mRNA. Translation: BAC28463.1.
AK172621 mRNA. Translation: BAE43099.1.
BC024960 mRNA. Translation: AAH24960.1.
CCDSiCCDS15889.1.
RefSeqiNP_071860.1. NM_022415.3.
UniGeneiMm.28768.

Genome annotation databases

EnsembliENSMUST00000102852; ENSMUSP00000099916; ENSMUSG00000050737.
GeneIDi64292.
KEGGimmu:64292.
UCSCiuc008jcz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041997 mRNA. Translation: BAA96083.1.
AB035323 mRNA. Translation: BAB71813.1.
AK010757 mRNA. Translation: BAB27163.1.
AK033752 mRNA. Translation: BAC28463.1.
AK172621 mRNA. Translation: BAE43099.1.
BC024960 mRNA. Translation: AAH24960.1.
CCDSiCCDS15889.1.
RefSeqiNP_071860.1. NM_022415.3.
UniGeneiMm.28768.

3D structure databases

ProteinModelPortaliQ9JM51.
SMRiQ9JM51.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211054. 1 interactor.
STRINGi10090.ENSMUSP00000099916.

Chemistry databases

ChEMBLiCHEMBL2046261.

PTM databases

iPTMnetiQ9JM51.
PhosphoSitePlusiQ9JM51.

Proteomic databases

MaxQBiQ9JM51.
PaxDbiQ9JM51.
PRIDEiQ9JM51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102852; ENSMUSP00000099916; ENSMUSG00000050737.
GeneIDi64292.
KEGGimmu:64292.
UCSCiuc008jcz.1. mouse.

Organism-specific databases

CTDi9536.
MGIiMGI:1927593. Ptges.

Phylogenomic databases

eggNOGiENOG410IY81. Eukaryota.
ENOG4111VJG. LUCA.
GeneTreeiENSGT00390000011980.
HOGENOMiHOG000231759.
HOVERGENiHBG052470.
InParanoidiQ9JM51.
KOiK15729.
OMAiCFSMALQ.
OrthoDBiEOG091G14I4.
PhylomeDBiQ9JM51.
TreeFamiTF105327.

Enzyme and pathway databases

BRENDAi5.3.99.3. 3474.
ReactomeiR-MMU-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Miscellaneous databases

PROiQ9JM51.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050737.
CleanExiMM_PTGES.
GenevisibleiQ9JM51. MM.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTGES_MOUSE
AccessioniPrimary (citable) accession number: Q9JM51
Secondary accession number(s): Q3T9C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.