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Protein

Importin-13

Gene

Ipo13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13 (By similarity).By similarity

GO - Molecular functioni

  • glucocorticoid receptor binding Source: RGD

GO - Biological processi

  • glucocorticoid receptor import into nucleus Source: RGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-13
Short name:
Imp13
Alternative name(s):
Late gestation lung 2 protein
Gene namesi
Name:Ipo13
Synonyms:Imp13, Lgl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620071. Ipo13.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • NLS-dependent protein nuclear import complex Source: RGD
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 963963Importin-13PRO_0000120760Add
BLAST

Proteomic databases

PaxDbiQ9JM04.
PRIDEiQ9JM04.

Expressioni

Tissue specificityi

Expressed in fetal brain, heart, intestine and kidney.1 Publication

Developmental stagei

Differentially expressed in fetal lung with highest levels at gestational days 14 to 16.1 Publication

Inductioni

By cortisol.1 Publication

Interactioni

Subunit structurei

Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.By similarity

GO - Molecular functioni

  • glucocorticoid receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026844.

Structurei

3D structure databases

ProteinModelPortaliQ9JM04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 5431HEAT 1Add
BLAST
Domaini45 – 11167Importin N-terminalPROSITE-ProRule annotationAdd
BLAST
Repeati56 – 8833HEAT 2Add
BLAST
Repeati95 – 13541HEAT 3Add
BLAST
Repeati142 – 17938HEAT 4Add
BLAST
Repeati194 – 23138HEAT 5Add
BLAST
Repeati236 – 26833HEAT 6Add
BLAST
Repeati276 – 32550HEAT 7Add
BLAST
Repeati330 – 37243HEAT 8Add
BLAST
Repeati375 – 43864HEAT 9Add
BLAST
Repeati440 – 47637HEAT 10Add
BLAST
Repeati487 – 52236HEAT 11Add
BLAST
Repeati524 – 55835HEAT 12Add
BLAST
Repeati562 – 60039HEAT 13Add
BLAST
Repeati603 – 64846HEAT 14Add
BLAST
Repeati676 – 71641HEAT 15Add
BLAST
Repeati720 – 75435HEAT 16Add
BLAST
Repeati761 – 80343HEAT 17Add
BLAST
Repeati815 – 84531HEAT 18Add
BLAST
Repeati860 – 89334HEAT 19Add
BLAST
Repeati897 – 93135HEAT 20Add
BLAST

Sequence similaritiesi

Belongs to the importin beta family.Curated
Contains 20 HEAT repeats.Curated
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2022. Eukaryota.
ENOG410XT8Y. LUCA.
HOGENOMiHOG000049153.
HOVERGENiHBG052141.
InParanoidiQ9JM04.
PhylomeDBiQ9JM04.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JM04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERREEQLGA AGAGAAPALD FTVENVEKAL HQLYYDPNIE NKNLAQKWLM
60 70 80 90 100
QAQVSPQAWH FSWQLLQPDK VPEIQYFGAS ALHIKISRYW SDIPTDQYES
110 120 130 140 150
LKAHSFTQIT RFASGSKIVL TRLCVALASL ALSMMPDAWP CAVADMVRLF
160 170 180 190 200
QAEDSPVDSQ GRCLALLELL TVLPEEFQTS RLPQYRKGLV RASLAVECGA
210 220 230 240 250
VFPLLEQLLQ QPSSPSCVRQ KVLKCFSSWV QLEVPLQDCE ALIQAAFAAL
260 270 280 290 300
QDSELFDSSV EAIVNAISQP DAQRYVNTLL KLIPLVLGLQ EQLRQAVQNG
310 320 330 340 350
DMETSHGICR IAVALGENHS RALLDQVEHW QSFLALVNMI MFCTGIPGHY
360 370 380 390 400
PVNETTSSLT LTFWYTLQDD ILSFEAEKQA VYQQVYRPVY FQLVDVLLHK
410 420 430 440 450
AQFPSDEEYG FWSSDEKEQF RIYRVDISDT LMYVYEMLGA ELLSNLYDKL
460 470 480 490 500
GRLLTSSEEP YSWQHTEALL YGFQSIAETI DVNYSDVVPG LIGLIPRISI
510 520 530 540 550
SNVQLADTVM FTIGALSEWL ADHPVMINSV LPLVLHALGN PELSVSSVST
560 570 580 590 600
LKKICRECKY ELPPYAANIV AVSQDVLMKQ IHKTSQCMWL MQALGFLLSA
610 620 630 640 650
LQVEENLKNL HSLISTYIQQ LEKLAEEIPK PSNKLAIVHI LGLLSNLFTT
660 670 680 690 700
LDVSHHEDDH EGPELRKLPV PQGPNPVVVV LQQVFQLIQK VLSKWLSDAQ
710 720 730 740 750
VVEAVCAIFE KSVKTLLDDF APMVPQLCEM LGRMYSTVPQ ASALDLTRQL
760 770 780 790 800
VHIFAHEPAH FPPIEALFLL VTSVTLSLFQ QGPRDHPDIV DSFMQLLAQA
810 820 830 840 850
LKRKPDLFQC ERLDVKAVFQ CAVLALKFPE APTVKASCGF FTELLPRCGE
860 870 880 890 900
IESVGKVVQE DGRMLLIAVL EAIGGQASRS LMDCFADILF ALNKHCFSLL
910 920 930 940 950
SMWIKEALQP PGFPSARLSP EQKDTFSQQI LRERVNKRRV KEMVKEFTLL
960
CRGLHGTDYT ADY
Length:963
Mass (Da):108,187
Last modified:October 1, 2000 - v1
Checksum:i35756A64B1DC9BCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110195 mRNA. Translation: AAF44721.1.
RefSeqiNP_446230.1. NM_053778.1.
UniGeneiRn.14252.

Genome annotation databases

GeneIDi116458.
KEGGirno:116458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110195 mRNA. Translation: AAF44721.1.
RefSeqiNP_446230.1. NM_053778.1.
UniGeneiRn.14252.

3D structure databases

ProteinModelPortaliQ9JM04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026844.

Proteomic databases

PaxDbiQ9JM04.
PRIDEiQ9JM04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116458.
KEGGirno:116458.

Organism-specific databases

CTDi9670.
RGDi620071. Ipo13.

Phylogenomic databases

eggNOGiKOG2022. Eukaryota.
ENOG410XT8Y. LUCA.
HOGENOMiHOG000049153.
HOVERGENiHBG052141.
InParanoidiQ9JM04.
PhylomeDBiQ9JM04.

Miscellaneous databases

NextBioi618970.
PROiQ9JM04.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel karyopherin-beta homolog is developmentally and hormonally regulated in fetal lung."
    Zhang C., Sweezey N.B., Gagnon S., Muskat B., Koehler D., Post M., Kaplan F.
    Am. J. Respir. Cell Mol. Biol. 22:451-459(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
    Strain: Wistar.
    Tissue: Lung.

Entry informationi

Entry nameiIPO13_RAT
AccessioniPrimary (citable) accession number: Q9JM04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.