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Q9JM01

- CDKL3_RAT

UniProt

Q9JM01 - CDKL3_RAT

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Protein

Cyclin-dependent kinase-like 3

Gene

Cdkl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei125 – 1251Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. dendrite extension Source: MGI
  2. negative regulation of axon extension Source: MGI
  3. positive regulation of dendrite morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 3 (EC:2.7.11.22)
Alternative name(s):
Serine/threonine protein kinase NKIATRE
Gene namesi
Name:Cdkl3
Synonyms:Nkiatre
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi619874. Cdkl3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Cyclin-dependent kinase-like 3PRO_0000085823Add
BLAST

Proteomic databases

PaxDbiQ9JM01.
PRIDEiQ9JM01.

PTM databases

PhosphoSiteiQ9JM01.

Expressioni

Tissue specificityi

Highly expressed in brain, and to a lower extent in heart and testis.1 Publication

Gene expression databases

GenevestigatoriQ9JM01.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060584.

Structurei

3D structure databases

ProteinModelPortaliQ9JM01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 286283Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 517[NKR]KIAxRE

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119242.
HOGENOMiHOG000233024.
HOVERGENiHBG080204.
InParanoidiQ9JM01.
KOiK08824.
OMAiCKHKNTG.
OrthoDBiEOG7992PS.
PhylomeDBiQ9JM01.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9JM01-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMYETLGKV GEGSYGTVMK CKHKDTGRIV AIKIFYEKPE KSVNKIATRE
60 70 80 90 100
IKFLKQFRHE NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK
110 120 130 140 150
RLRKYLFQIL RAIEYLHNNN IIHRDIKPEN ILVSQSGITK LCDFGFARTL
160 170 180 190 200
AAPGDVYTDY VATRWYRAPE LVLKDTTYGK PVDIWALGCM IIEMATGNPY
210 220 230 240 250
LPSSSDLDLL HKIVLKVGNL TPHLHNIFSK SPIFAGVVLP QVQHPKNARK
260 270 280 290 300
KYPKLNGLLA DIVHACLQID PAERISSTDL LHHDYFTRDG FIEKFIPELR
310 320 330 340 350
AKLLQEAKVN SFIKPKENFK ENEPVRDEKK PVFTNPLLYG NPTLYGKEVD
360 370 380 390 400
RDKRAKELKV RVIKAKGGKG DVPDLKKTES EGEHRQQGTA EDTHPTSLDR
410 420 430 440 450
KPSVSELTNP VHPSANSDTV KEDPHSGGCM IMPPINLTSS NLLAANPSSN
460 470 480 490 500
LSHPNSRLTE RTKKRRTSSQ TIGQTLSNSR QEDTGPTQVQ TEKGAFNERT
510 520 530 540 550
GQNDQIASGN KRKLNFSKCD RKEFHFPELP FTIQAKEMKG MEVKQIKVLK
560 570 580 590
RESKKTDSPK IPTLLSMDSN QEKQEVFNIF PGWCKRGNLN WPS
Length:593
Mass (Da):67,553
Last modified:November 22, 2005 - v2
Checksum:i40F8C846EA421E0B
GO
Isoform 2 (identifier: Q9JM01-2) [UniParc]FASTAAdd to Basket

Also known as: NKIATRE alpha, p57 alpha isoform

The sequence of this isoform differs from the canonical sequence as follows:
     504-505: DQ → AK
     506-593: Missing.

Note: Found in the nucleus and cytoplasm.

Show »
Length:505
Mass (Da):57,243
Checksum:i89747921FF2CE683
GO
Isoform 3 (identifier: Q9JM01-3) [UniParc]FASTAAdd to Basket

Also known as: NKIATRE beta, p52 beta isoform

The sequence of this isoform differs from the canonical sequence as follows:
     458-593: Missing.

Note: Found in the cytoplasm.

Show »
Length:457
Mass (Da):51,895
Checksum:i99D0782794099CDA
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei458 – 593136Missing in isoform 3. 1 PublicationVSP_016158Add
BLAST
Alternative sequencei504 – 5052DQ → AK in isoform 2. 1 PublicationVSP_016159
Alternative sequencei506 – 59388Missing in isoform 2. 1 PublicationVSP_016160Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF112183 mRNA. Translation: AAF34870.1.
AF112184 mRNA. Translation: AAF34871.1.
AABR03073386 Genomic DNA. No translation available.
AABR03074822 Genomic DNA. No translation available.
AABR03073552 Genomic DNA. No translation available.
RefSeqiNP_068540.1. NM_021772.2. [Q9JM01-3]
UniGeneiRn.154405.
Rn.229441.

Genome annotation databases

EnsembliENSRNOT00000059040; ENSRNOP00000055819; ENSRNOG00000005097. [Q9JM01-1]
GeneIDi60396.
KEGGirno:60396.
UCSCiRGD:619874. rat. [Q9JM01-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF112183 mRNA. Translation: AAF34870.1 .
AF112184 mRNA. Translation: AAF34871.1 .
AABR03073386 Genomic DNA. No translation available.
AABR03074822 Genomic DNA. No translation available.
AABR03073552 Genomic DNA. No translation available.
RefSeqi NP_068540.1. NM_021772.2. [Q9JM01-3 ]
UniGenei Rn.154405.
Rn.229441.

3D structure databases

ProteinModelPortali Q9JM01.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000060584.

PTM databases

PhosphoSitei Q9JM01.

Proteomic databases

PaxDbi Q9JM01.
PRIDEi Q9JM01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000059040 ; ENSRNOP00000055819 ; ENSRNOG00000005097 . [Q9JM01-1 ]
GeneIDi 60396.
KEGGi rno:60396.
UCSCi RGD:619874. rat. [Q9JM01-1 ]

Organism-specific databases

CTDi 51265.
RGDi 619874. Cdkl3.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119242.
HOGENOMi HOG000233024.
HOVERGENi HBG080204.
InParanoidi Q9JM01.
KOi K08824.
OMAi CKHKNTG.
OrthoDBi EOG7992PS.
PhylomeDBi Q9JM01.

Miscellaneous databases

NextBioi 612104.
PROi Q9JM01.

Gene expression databases

Genevestigatori Q9JM01.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NKIATRE is a novel conserved cdc2-related kinase."
    Haq R., Randall S., Midmer M., Yee K., Zanke B.
    Genomics 71:131-141(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Brain and Jejunum.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiCDKL3_RAT
AccessioniPrimary (citable) accession number: Q9JM01
Secondary accession number(s): Q9JM02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3