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Q9JM01

- CDKL3_RAT

UniProt

Q9JM01 - CDKL3_RAT

Protein

Cyclin-dependent kinase-like 3

Gene

Cdkl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei125 – 1251Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. dendrite extension Source: MGI
    2. negative regulation of axon extension Source: MGI
    3. positive regulation of dendrite morphogenesis Source: MGI

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase-like 3 (EC:2.7.11.22)
    Alternative name(s):
    Serine/threonine protein kinase NKIATRE
    Gene namesi
    Name:Cdkl3
    Synonyms:Nkiatre
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi619874. Cdkl3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 593593Cyclin-dependent kinase-like 3PRO_0000085823Add
    BLAST

    Proteomic databases

    PaxDbiQ9JM01.
    PRIDEiQ9JM01.

    PTM databases

    PhosphoSiteiQ9JM01.

    Expressioni

    Tissue specificityi

    Highly expressed in brain, and to a lower extent in heart and testis.1 Publication

    Gene expression databases

    GenevestigatoriQ9JM01.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000060584.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JM01.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 286283Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi45 – 517[NKR]KIAxRE

    Domaini

    The [NKR]KIAxRE motif seems to be a cyclin-binding region.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00650000093115.
    HOGENOMiHOG000233024.
    HOVERGENiHBG080204.
    KOiK08824.
    OMAiCKHKNTG.
    OrthoDBiEOG7992PS.
    PhylomeDBiQ9JM01.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9JM01-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEMYETLGKV GEGSYGTVMK CKHKDTGRIV AIKIFYEKPE KSVNKIATRE    50
    IKFLKQFRHE NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK 100
    RLRKYLFQIL RAIEYLHNNN IIHRDIKPEN ILVSQSGITK LCDFGFARTL 150
    AAPGDVYTDY VATRWYRAPE LVLKDTTYGK PVDIWALGCM IIEMATGNPY 200
    LPSSSDLDLL HKIVLKVGNL TPHLHNIFSK SPIFAGVVLP QVQHPKNARK 250
    KYPKLNGLLA DIVHACLQID PAERISSTDL LHHDYFTRDG FIEKFIPELR 300
    AKLLQEAKVN SFIKPKENFK ENEPVRDEKK PVFTNPLLYG NPTLYGKEVD 350
    RDKRAKELKV RVIKAKGGKG DVPDLKKTES EGEHRQQGTA EDTHPTSLDR 400
    KPSVSELTNP VHPSANSDTV KEDPHSGGCM IMPPINLTSS NLLAANPSSN 450
    LSHPNSRLTE RTKKRRTSSQ TIGQTLSNSR QEDTGPTQVQ TEKGAFNERT 500
    GQNDQIASGN KRKLNFSKCD RKEFHFPELP FTIQAKEMKG MEVKQIKVLK 550
    RESKKTDSPK IPTLLSMDSN QEKQEVFNIF PGWCKRGNLN WPS 593
    Length:593
    Mass (Da):67,553
    Last modified:November 22, 2005 - v2
    Checksum:i40F8C846EA421E0B
    GO
    Isoform 2 (identifier: Q9JM01-2) [UniParc]FASTAAdd to Basket

    Also known as: NKIATRE alpha, p57 alpha isoform

    The sequence of this isoform differs from the canonical sequence as follows:
         504-505: DQ → AK
         506-593: Missing.

    Note: Found in the nucleus and cytoplasm.

    Show »
    Length:505
    Mass (Da):57,243
    Checksum:i89747921FF2CE683
    GO
    Isoform 3 (identifier: Q9JM01-3) [UniParc]FASTAAdd to Basket

    Also known as: NKIATRE beta, p52 beta isoform

    The sequence of this isoform differs from the canonical sequence as follows:
         458-593: Missing.

    Note: Found in the cytoplasm.

    Show »
    Length:457
    Mass (Da):51,895
    Checksum:i99D0782794099CDA
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei458 – 593136Missing in isoform 3. 1 PublicationVSP_016158Add
    BLAST
    Alternative sequencei504 – 5052DQ → AK in isoform 2. 1 PublicationVSP_016159
    Alternative sequencei506 – 59388Missing in isoform 2. 1 PublicationVSP_016160Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF112183 mRNA. Translation: AAF34870.1.
    AF112184 mRNA. Translation: AAF34871.1.
    AABR03073386 Genomic DNA. No translation available.
    AABR03074822 Genomic DNA. No translation available.
    AABR03073552 Genomic DNA. No translation available.
    RefSeqiNP_068540.1. NM_021772.2. [Q9JM01-3]
    UniGeneiRn.154405.
    Rn.229441.

    Genome annotation databases

    EnsembliENSRNOT00000059040; ENSRNOP00000055819; ENSRNOG00000005097. [Q9JM01-1]
    GeneIDi60396.
    KEGGirno:60396.
    UCSCiRGD:619874. rat. [Q9JM01-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF112183 mRNA. Translation: AAF34870.1 .
    AF112184 mRNA. Translation: AAF34871.1 .
    AABR03073386 Genomic DNA. No translation available.
    AABR03074822 Genomic DNA. No translation available.
    AABR03073552 Genomic DNA. No translation available.
    RefSeqi NP_068540.1. NM_021772.2. [Q9JM01-3 ]
    UniGenei Rn.154405.
    Rn.229441.

    3D structure databases

    ProteinModelPortali Q9JM01.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000060584.

    PTM databases

    PhosphoSitei Q9JM01.

    Proteomic databases

    PaxDbi Q9JM01.
    PRIDEi Q9JM01.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000059040 ; ENSRNOP00000055819 ; ENSRNOG00000005097 . [Q9JM01-1 ]
    GeneIDi 60396.
    KEGGi rno:60396.
    UCSCi RGD:619874. rat. [Q9JM01-1 ]

    Organism-specific databases

    CTDi 51265.
    RGDi 619874. Cdkl3.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00650000093115.
    HOGENOMi HOG000233024.
    HOVERGENi HBG080204.
    KOi K08824.
    OMAi CKHKNTG.
    OrthoDBi EOG7992PS.
    PhylomeDBi Q9JM01.

    Miscellaneous databases

    NextBioi 612104.
    PROi Q9JM01.

    Gene expression databases

    Genevestigatori Q9JM01.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NKIATRE is a novel conserved cdc2-related kinase."
      Haq R., Randall S., Midmer M., Yee K., Zanke B.
      Genomics 71:131-141(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Brain and Jejunum.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.

    Entry informationi

    Entry nameiCDKL3_RAT
    AccessioniPrimary (citable) accession number: Q9JM01
    Secondary accession number(s): Q9JM02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3