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Protein

Cyclin-dependent kinase-like 3

Gene

Cdkl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei125Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • dendrite extension Source: MGI
  • negative regulation of axon extension Source: MGI
  • positive regulation of dendrite morphogenesis Source: MGI
  • protein phosphorylation Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 3 (EC:2.7.11.22)
Alternative name(s):
Serine/threonine protein kinase NKIATRE
Gene namesi
Name:Cdkl3
Synonyms:Nkiatre
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619874. Cdkl3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858231 – 593Cyclin-dependent kinase-like 3Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei158PhosphothreonineCombined sources1
Modified residuei160PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JM01.
PRIDEiQ9JM01.

PTM databases

iPTMnetiQ9JM01.
PhosphoSitePlusiQ9JM01.

Expressioni

Tissue specificityi

Highly expressed in brain, and to a lower extent in heart and testis.1 Publication

Gene expression databases

BgeeiENSRNOG00000054806.
GenevisibleiQ9JM01. RN.

Structurei

3D structure databases

ProteinModelPortaliQ9JM01.
SMRiQ9JM01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST283

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 51[NKR]KIAxRE7

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0593. Eukaryota.
ENOG410XNSW. LUCA.
GeneTreeiENSGT00830000128262.
HOGENOMiHOG000233024.
HOVERGENiHBG080204.
InParanoidiQ9JM01.
KOiK08824.
PhylomeDBiQ9JM01.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JM01-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMYETLGKV GEGSYGTVMK CKHKDTGRIV AIKIFYEKPE KSVNKIATRE
60 70 80 90 100
IKFLKQFRHE NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK
110 120 130 140 150
RLRKYLFQIL RAIEYLHNNN IIHRDIKPEN ILVSQSGITK LCDFGFARTL
160 170 180 190 200
AAPGDVYTDY VATRWYRAPE LVLKDTTYGK PVDIWALGCM IIEMATGNPY
210 220 230 240 250
LPSSSDLDLL HKIVLKVGNL TPHLHNIFSK SPIFAGVVLP QVQHPKNARK
260 270 280 290 300
KYPKLNGLLA DIVHACLQID PAERISSTDL LHHDYFTRDG FIEKFIPELR
310 320 330 340 350
AKLLQEAKVN SFIKPKENFK ENEPVRDEKK PVFTNPLLYG NPTLYGKEVD
360 370 380 390 400
RDKRAKELKV RVIKAKGGKG DVPDLKKTES EGEHRQQGTA EDTHPTSLDR
410 420 430 440 450
KPSVSELTNP VHPSANSDTV KEDPHSGGCM IMPPINLTSS NLLAANPSSN
460 470 480 490 500
LSHPNSRLTE RTKKRRTSSQ TIGQTLSNSR QEDTGPTQVQ TEKGAFNERT
510 520 530 540 550
GQNDQIASGN KRKLNFSKCD RKEFHFPELP FTIQAKEMKG MEVKQIKVLK
560 570 580 590
RESKKTDSPK IPTLLSMDSN QEKQEVFNIF PGWCKRGNLN WPS
Length:593
Mass (Da):67,553
Last modified:November 22, 2005 - v2
Checksum:i40F8C846EA421E0B
GO
Isoform 2 (identifier: Q9JM01-2) [UniParc]FASTAAdd to basket
Also known as: NKIATRE alpha, p57 alpha isoform

The sequence of this isoform differs from the canonical sequence as follows:
     504-505: DQ → AK
     506-593: Missing.

Note: Found in the nucleus and cytoplasm.
Show »
Length:505
Mass (Da):57,243
Checksum:i89747921FF2CE683
GO
Isoform 3 (identifier: Q9JM01-3) [UniParc]FASTAAdd to basket
Also known as: NKIATRE beta, p52 beta isoform

The sequence of this isoform differs from the canonical sequence as follows:
     458-593: Missing.

Note: Found in the cytoplasm.
Show »
Length:457
Mass (Da):51,895
Checksum:i99D0782794099CDA
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016158458 – 593Missing in isoform 3. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_016159504 – 505DQ → AK in isoform 2. 1 Publication2
Alternative sequenceiVSP_016160506 – 593Missing in isoform 2. 1 PublicationAdd BLAST88

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112183 mRNA. Translation: AAF34870.1.
AF112184 mRNA. Translation: AAF34871.1.
AABR03073386 Genomic DNA. No translation available.
AABR03074822 Genomic DNA. No translation available.
AABR03073552 Genomic DNA. No translation available.
RefSeqiNP_068540.1. NM_021772.2. [Q9JM01-3]
UniGeneiRn.154405.
Rn.229441.

Genome annotation databases

EnsembliENSRNOT00000087152; ENSRNOP00000068841; ENSRNOG00000054806. [Q9JM01-1]
GeneIDi60396.
KEGGirno:60396.
UCSCiRGD:619874. rat. [Q9JM01-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCDKL3_RAT
AccessioniPrimary (citable) accession number: Q9JM01
Secondary accession number(s): Q9JM02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 22, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families