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Protein

Ventral anterior homeobox 2

Gene

Vax2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi102 – 161HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation, Wnt signaling pathway

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ventral anterior homeobox 2
Gene namesi
Name:Vax2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621133. Vax2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493531 – 292Ventral anterior homeobox 2Add BLAST292

Proteomic databases

PaxDbiQ9JLZ9.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018128.

Structurei

3D structure databases

ProteinModelPortaliQ9JLZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMX homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0843. Eukaryota.
ENOG4111SRW. LUCA.
HOGENOMiHOG000049217.
HOVERGENiHBG007558.
InParanoidiQ9JLZ9.
KOiK09318.
PhylomeDBiQ9JLZ9.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR033021. Vax2.
[Graphical view]
PANTHERiPTHR24339:SF34. PTHR24339:SF34. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JLZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDGGAERDR GPKRREEPGG RSGCRGEHRG AEDLRADTGS TSPREIAGTS
60 70 80 90 100
ASSPAGSRES GGDSDGQQAL GETDHCRRIL VRDAKGTIRE IVLPKGLDLD
110 120 130 140 150
RPKRTRTSFT AEQLYRLEME FQRCQYVVGR ERTELARQLN LSETQVKVWF
160 170 180 190 200
QNRRTKQKKD QSRDLEKRAS SSAFEAFATS NVLRLLEQGR LLSVPRAPSL
210 220 230 240 250
LALSPGLPGL TAGHRGTSLG DPRNSSQRLN PMPSASASSP LPPPLPAVCF
260 270 280 290
SAAPLLDLPA SYKLGSSAFE PYSRLEQQKV GSPGQSDKKA DI
Length:292
Mass (Da):31,706
Last modified:October 1, 2000 - v1
Checksum:i5D1C12BB470682A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113516 mRNA. Translation: AAF25691.1.
RefSeqiNP_072159.1. NM_022637.1.
UniGeneiRn.48765.

Genome annotation databases

GeneIDi64572.
KEGGirno:64572.
UCSCiRGD:621133. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113516 mRNA. Translation: AAF25691.1.
RefSeqiNP_072159.1. NM_022637.1.
UniGeneiRn.48765.

3D structure databases

ProteinModelPortaliQ9JLZ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018128.

Proteomic databases

PaxDbiQ9JLZ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64572.
KEGGirno:64572.
UCSCiRGD:621133. rat.

Organism-specific databases

CTDi25806.
RGDi621133. Vax2.

Phylogenomic databases

eggNOGiKOG0843. Eukaryota.
ENOG4111SRW. LUCA.
HOGENOMiHOG000049217.
HOVERGENiHBG007558.
InParanoidiQ9JLZ9.
KOiK09318.
PhylomeDBiQ9JLZ9.

Miscellaneous databases

PROiQ9JLZ9.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR033021. Vax2.
[Graphical view]
PANTHERiPTHR24339:SF34. PTHR24339:SF34. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVAX2_RAT
AccessioniPrimary (citable) accession number: Q9JLZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.