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Protein

Ventral anterior homeobox 2

Gene

Vax2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi102 – 161HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ventral anterior homeobox 2
Gene namesi
Name:Vax2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621133 Vax2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493531 – 292Ventral anterior homeobox 2Add BLAST292

Proteomic databases

PaxDbiQ9JLZ9
PRIDEiQ9JLZ9

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018128

Structurei

3D structure databases

ProteinModelPortaliQ9JLZ9
SMRiQ9JLZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMX homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0843 Eukaryota
ENOG4111SRW LUCA
HOGENOMiHOG000049217
HOVERGENiHBG007558
InParanoidiQ9JLZ9
KOiK09318
PhylomeDBiQ9JLZ9

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
IPR033021 Vax2
PANTHERiPTHR24339:SF34 PTHR24339:SF34, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JLZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDGGAERDR GPKRREEPGG RSGCRGEHRG AEDLRADTGS TSPREIAGTS
60 70 80 90 100
ASSPAGSRES GGDSDGQQAL GETDHCRRIL VRDAKGTIRE IVLPKGLDLD
110 120 130 140 150
RPKRTRTSFT AEQLYRLEME FQRCQYVVGR ERTELARQLN LSETQVKVWF
160 170 180 190 200
QNRRTKQKKD QSRDLEKRAS SSAFEAFATS NVLRLLEQGR LLSVPRAPSL
210 220 230 240 250
LALSPGLPGL TAGHRGTSLG DPRNSSQRLN PMPSASASSP LPPPLPAVCF
260 270 280 290
SAAPLLDLPA SYKLGSSAFE PYSRLEQQKV GSPGQSDKKA DI
Length:292
Mass (Da):31,706
Last modified:October 1, 2000 - v1
Checksum:i5D1C12BB470682A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113516 mRNA Translation: AAF25691.1
RefSeqiNP_072159.1, NM_022637.1
UniGeneiRn.48765

Genome annotation databases

GeneIDi64572
KEGGirno:64572
UCSCiRGD:621133 rat

Similar proteinsi

Entry informationi

Entry nameiVAX2_RAT
AccessioniPrimary (citable) accession number: Q9JLZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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