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Q9JLZ6 (HIC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hypermethylated in cancer 2 protein

Short name=Hic-2
Gene names
Name:Hic2
Synonyms:Kiaa1020
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length619 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional repressor By similarity.

Subunit structure

Self-associates. Interacts with HIC1 By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.

Contains 1 BTB (POZ) domain.

Contains 5 C2H2-type zinc fingers.

Sequence caution

The sequence BAC98076.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence CAI30631.1 differs from that shown. Reason: Probable cloning artifact.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionRepressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentfocal adhesion

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

plasma membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9JLZ6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9JLZ6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     544-619: KMFTQRGTMT...SHLRMHTSPS → SEPTPSCPLQSSGMSGNLQQSQR
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 619619Hypermethylated in cancer 2 protein
PRO_0000046946

Regions

Domain46 – 10964BTB
Zinc finger446 – 46823C2H2-type 1
Zinc finger509 – 53123C2H2-type 2
Zinc finger537 – 55923C2H2-type 3
Zinc finger565 – 58723C2H2-type 4
Zinc finger593 – 61523C2H2-type 5
Region247 – 2493Binding to CtBP By similarity

Natural variations

Alternative sequence544 – 61976KMFTQ…HTSPS → SEPTPSCPLQSSGMSGNLQQ SQR in isoform 2.
VSP_010499

Experimental info

Sequence conflict354 – 3552RE → AA in AAF28801. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 28, 2011. Version 4.
Checksum: AA7E58CC3BA8AB39

FASTA61966,766
        10         20         30         40         50         60 
MVSGPLALRW CPWAGHRDMG PDMELPSHSK QLLLQLNQQR AKGFLCDVII MVENSIFRAH 

        70         80         90        100        110        120 
KNVLAASSIY FKSLVLHDNL INLDTDMVSS TVFQQILDFI YTGKLLPSDQ PSEPNFSTLL 

       130        140        150        160        170        180 
TAASYLQLPE LAALCRRKLK RAGKPFGPGR VGTAGIGRPT RSQRLSTASV IQARFPGLVD 

       190        200        210        220        230        240 
VRKGHPAPQE LPQAKGSDDE LFLGTSTQES THGLGLGGPA GGEMGLGGCS TSTNGSSGGC 

       250        260        270        280        290        300 
EQELGLDLSK KSPPLPPTTP GPHLTPEDPA QLSDSQRESP APTSTSALPV GNSASFVELG 

       310        320        330        340        350        360 
ATPEEPMDVE GAEENHLSLL EGQGGQPRKS LRHSARKKDW NKKEPVAGSP FDRRETGSKG 

       370        380        390        400        410        420 
SCPGEEGEGT GDRVPNGVLA SSAGGGGPSA SYGEQSFPCK EEEENGKDGS EDSGQSGSEG 

       430        440        450        460        470        480 
GSGHTGAHYV YRQEGYETVS YGDNVYVCIP CAKGFPSSEQ LNAHVETHTE EELFIKEEGA 

       490        500        510        520        530        540 
YETGSGGAEE EAEDLSTPSA AYTADSRPFK CSVCEKTYKD PATLRQHEKT HWLTRPFPCN 

       550        560        570        580        590        600 
ICGKMFTQRG TMTRHMRSHL GLKPFACDEC GMRFTRQYRL TEHMRVHSGE KPYECQLCGG 

       610 
KFTQQRNLIS HLRMHTSPS 

« Hide

Isoform 2 [UniParc].

Checksum: 7E7110E46948CAF7
Show »

FASTA56660,187

References

« Hide 'large scale' references
[1]"Characterization and expression analysis of the murine Hic2 gene."
Terzic A., Graw J.
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: C3H.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J and NOD.
Tissue: Embryo, Lung and Spleen.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Embryonic tail.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Brain.
[5]"Hic2, a novel homolog of Hic1 and gammaFBP."
Grimm C., Graw J.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 354-619 (ISOFORM 1).
Strain: Swiss Webster.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ868292 mRNA. Translation: CAI30631.1. Sequence problems.
AK084975 mRNA. Translation: BAC39326.1.
AK145386 mRNA. Translation: BAE26404.1.
AK156332 mRNA. Translation: BAE33679.1.
AK157276 mRNA. Translation: BAE34025.1.
AK129266 mRNA. Translation: BAC98076.1. Different initiation.
BC065124 mRNA. Translation: AAH65124.1.
AF117382 mRNA. Translation: AAF28801.1.
RefSeqNP_849253.2. NM_178922.3.
UniGeneMm.261602.
Mm.470636.

3D structure databases

ProteinModelPortalQ9JLZ6.
SMRQ9JLZ6. Positions 23-135, 395-618.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9JLZ6. 1 interaction.
MINTMINT-4097465.

PTM databases

PhosphoSiteQ9JLZ6.

Proteomic databases

PaxDbQ9JLZ6.
PRIDEQ9JLZ6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000090190; ENSMUSP00000087656; ENSMUSG00000050240. [Q9JLZ6-1]
ENSMUST00000115698; ENSMUSP00000111362; ENSMUSG00000050240. [Q9JLZ6-2]
GeneID58180.
KEGGmmu:58180.
UCSCuc007yko.1. mouse. [Q9JLZ6-1]

Organism-specific databases

CTD23119.
MGIMGI:1929869. Hic2.
RougeSearch...

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00750000117308.
HOGENOMHOG000026793.
HOVERGENHBG079492.
InParanoidQ9JLZ6.
OMAIMVENSI.
OrthoDBEOG7T1R9Z.
TreeFamTF333488.

Gene expression databases

BgeeQ9JLZ6.
CleanExMM_HIC2.
GenevestigatorQ9JLZ6.

Family and domain databases

Gene3D3.30.160.60. 5 hits.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
PROSITEPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio314131.
PROQ9JLZ6.
SOURCESearch...

Entry information

Entry nameHIC2_MOUSE
AccessionPrimary (citable) accession number: Q9JLZ6
Secondary accession number(s): Q3U030 expand/collapse secondary AC list , Q3ULP4, Q5K036, Q8BSZ9, Q8C3T5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 120 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot