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Q9JLZ6

- HIC2_MOUSE

UniProt

Q9JLZ6 - HIC2_MOUSE

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Protein

Hypermethylated in cancer 2 protein

Gene

Hic2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Transcriptional repressor.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri446 – 46823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Hypermethylated in cancer 2 protein
Short name:
Hic-2
Gene namesi
Name:Hic2
Synonyms:Kiaa1020
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1929869. Hic2.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Hypermethylated in cancer 2 proteinPRO_0000046946Add
BLAST

Proteomic databases

MaxQBiQ9JLZ6.
PaxDbiQ9JLZ6.
PRIDEiQ9JLZ6.

PTM databases

PhosphoSiteiQ9JLZ6.

Expressioni

Gene expression databases

BgeeiQ9JLZ6.
CleanExiMM_HIC2.
GenevestigatoriQ9JLZ6.

Interactioni

Subunit structurei

Self-associates. Interacts with HIC1 By similarity.By similarity

Protein-protein interaction databases

IntActiQ9JLZ6. 1 interaction.
MINTiMINT-4097465.

Structurei

3D structure databases

ProteinModelPortaliQ9JLZ6.
SMRiQ9JLZ6. Positions 23-135, 446-617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 10964BTBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni247 – 2493Binding to CtBPBy similarity

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri446 – 46823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119356.
HOGENOMiHOG000026793.
HOVERGENiHBG079492.
InParanoidiQ9JLZ6.
OMAiIMVENSI.
OrthoDBiEOG7T1R9Z.
TreeFamiTF333488.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9JLZ6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSGPLALRW CPWAGHRDMG PDMELPSHSK QLLLQLNQQR AKGFLCDVII
60 70 80 90 100
MVENSIFRAH KNVLAASSIY FKSLVLHDNL INLDTDMVSS TVFQQILDFI
110 120 130 140 150
YTGKLLPSDQ PSEPNFSTLL TAASYLQLPE LAALCRRKLK RAGKPFGPGR
160 170 180 190 200
VGTAGIGRPT RSQRLSTASV IQARFPGLVD VRKGHPAPQE LPQAKGSDDE
210 220 230 240 250
LFLGTSTQES THGLGLGGPA GGEMGLGGCS TSTNGSSGGC EQELGLDLSK
260 270 280 290 300
KSPPLPPTTP GPHLTPEDPA QLSDSQRESP APTSTSALPV GNSASFVELG
310 320 330 340 350
ATPEEPMDVE GAEENHLSLL EGQGGQPRKS LRHSARKKDW NKKEPVAGSP
360 370 380 390 400
FDRRETGSKG SCPGEEGEGT GDRVPNGVLA SSAGGGGPSA SYGEQSFPCK
410 420 430 440 450
EEEENGKDGS EDSGQSGSEG GSGHTGAHYV YRQEGYETVS YGDNVYVCIP
460 470 480 490 500
CAKGFPSSEQ LNAHVETHTE EELFIKEEGA YETGSGGAEE EAEDLSTPSA
510 520 530 540 550
AYTADSRPFK CSVCEKTYKD PATLRQHEKT HWLTRPFPCN ICGKMFTQRG
560 570 580 590 600
TMTRHMRSHL GLKPFACDEC GMRFTRQYRL TEHMRVHSGE KPYECQLCGG
610
KFTQQRNLIS HLRMHTSPS
Length:619
Mass (Da):66,766
Last modified:June 28, 2011 - v4
Checksum:iAA7E58CC3BA8AB39
GO
Isoform 2 (identifier: Q9JLZ6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     544-619: KMFTQRGTMT...SHLRMHTSPS → SEPTPSCPLQSSGMSGNLQQSQR

Note: No experimental confirmation available.

Show »
Length:566
Mass (Da):60,187
Checksum:i7E7110E46948CAF7
GO

Sequence cautioni

The sequence CAI30631.1 differs from that shown. Reason: Probable cloning artifact.
The sequence BAC98076.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti354 – 3552RE → AA in AAF28801. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei544 – 61976KMFTQ…HTSPS → SEPTPSCPLQSSGMSGNLQQ SQR in isoform 2. 1 PublicationVSP_010499Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ868292 mRNA. Translation: CAI30631.1. Sequence problems.
AK084975 mRNA. Translation: BAC39326.1.
AK145386 mRNA. Translation: BAE26404.1.
AK156332 mRNA. Translation: BAE33679.1.
AK157276 mRNA. Translation: BAE34025.1.
AK129266 mRNA. Translation: BAC98076.1. Different initiation.
BC065124 mRNA. Translation: AAH65124.1.
AF117382 mRNA. Translation: AAF28801.1.
CCDSiCCDS27999.1. [Q9JLZ6-1]
RefSeqiNP_849253.2. NM_178922.3. [Q9JLZ6-1]
UniGeneiMm.261602.
Mm.470636.

Genome annotation databases

EnsembliENSMUST00000090190; ENSMUSP00000087656; ENSMUSG00000050240. [Q9JLZ6-1]
ENSMUST00000115698; ENSMUSP00000111362; ENSMUSG00000050240. [Q9JLZ6-2]
GeneIDi58180.
KEGGimmu:58180.
UCSCiuc007yko.1. mouse. [Q9JLZ6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ868292 mRNA. Translation: CAI30631.1 . Sequence problems.
AK084975 mRNA. Translation: BAC39326.1 .
AK145386 mRNA. Translation: BAE26404.1 .
AK156332 mRNA. Translation: BAE33679.1 .
AK157276 mRNA. Translation: BAE34025.1 .
AK129266 mRNA. Translation: BAC98076.1 . Different initiation.
BC065124 mRNA. Translation: AAH65124.1 .
AF117382 mRNA. Translation: AAF28801.1 .
CCDSi CCDS27999.1. [Q9JLZ6-1 ]
RefSeqi NP_849253.2. NM_178922.3. [Q9JLZ6-1 ]
UniGenei Mm.261602.
Mm.470636.

3D structure databases

ProteinModelPortali Q9JLZ6.
SMRi Q9JLZ6. Positions 23-135, 446-617.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9JLZ6. 1 interaction.
MINTi MINT-4097465.

PTM databases

PhosphoSitei Q9JLZ6.

Proteomic databases

MaxQBi Q9JLZ6.
PaxDbi Q9JLZ6.
PRIDEi Q9JLZ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000090190 ; ENSMUSP00000087656 ; ENSMUSG00000050240 . [Q9JLZ6-1 ]
ENSMUST00000115698 ; ENSMUSP00000111362 ; ENSMUSG00000050240 . [Q9JLZ6-2 ]
GeneIDi 58180.
KEGGi mmu:58180.
UCSCi uc007yko.1. mouse. [Q9JLZ6-1 ]

Organism-specific databases

CTDi 23119.
MGIi MGI:1929869. Hic2.
Rougei Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000119356.
HOGENOMi HOG000026793.
HOVERGENi HBG079492.
InParanoidi Q9JLZ6.
OMAi IMVENSI.
OrthoDBi EOG7T1R9Z.
TreeFami TF333488.

Miscellaneous databases

NextBioi 314131.
PROi Q9JLZ6.
SOURCEi Search...

Gene expression databases

Bgeei Q9JLZ6.
CleanExi MM_HIC2.
Genevestigatori Q9JLZ6.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and expression analysis of the murine Hic2 gene."
    Terzic A., Graw J.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C3H.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Embryo, Lung and Spleen.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryonic tail.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  5. "Hic2, a novel homolog of Hic1 and gammaFBP."
    Grimm C., Graw J.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 354-619 (ISOFORM 1).
    Strain: Swiss Webster.
    Tissue: Embryo.

Entry informationi

Entry nameiHIC2_MOUSE
AccessioniPrimary (citable) accession number: Q9JLZ6
Secondary accession number(s): Q3U030
, Q3ULP4, Q5K036, Q8BSZ9, Q8C3T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 125 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3