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Q9JLZ6

- HIC2_MOUSE

UniProt

Q9JLZ6 - HIC2_MOUSE

Protein

Hypermethylated in cancer 2 protein

Gene

Hic2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 4 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Transcriptional repressor.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri446 – 46823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri509 – 53123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri537 – 55923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri565 – 58723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri593 – 61523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hypermethylated in cancer 2 protein
    Short name:
    Hic-2
    Gene namesi
    Name:Hic2
    Synonyms:Kiaa1020
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1929869. Hic2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. focal adhesion Source: Ensembl
    2. nucleus Source: UniProtKB
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 619619Hypermethylated in cancer 2 proteinPRO_0000046946Add
    BLAST

    Proteomic databases

    PaxDbiQ9JLZ6.
    PRIDEiQ9JLZ6.

    PTM databases

    PhosphoSiteiQ9JLZ6.

    Expressioni

    Gene expression databases

    BgeeiQ9JLZ6.
    CleanExiMM_HIC2.
    GenevestigatoriQ9JLZ6.

    Interactioni

    Subunit structurei

    Self-associates. Interacts with HIC1 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9JLZ6. 1 interaction.
    MINTiMINT-4097465.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JLZ6.
    SMRiQ9JLZ6. Positions 23-135, 446-617.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 10964BTBPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni247 – 2493Binding to CtBPBy similarity

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri446 – 46823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri509 – 53123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri537 – 55923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri565 – 58723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri593 – 61523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117308.
    HOGENOMiHOG000026793.
    HOVERGENiHBG079492.
    InParanoidiQ9JLZ6.
    OMAiIMVENSI.
    OrthoDBiEOG7T1R9Z.
    TreeFamiTF333488.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9JLZ6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVSGPLALRW CPWAGHRDMG PDMELPSHSK QLLLQLNQQR AKGFLCDVII    50
    MVENSIFRAH KNVLAASSIY FKSLVLHDNL INLDTDMVSS TVFQQILDFI 100
    YTGKLLPSDQ PSEPNFSTLL TAASYLQLPE LAALCRRKLK RAGKPFGPGR 150
    VGTAGIGRPT RSQRLSTASV IQARFPGLVD VRKGHPAPQE LPQAKGSDDE 200
    LFLGTSTQES THGLGLGGPA GGEMGLGGCS TSTNGSSGGC EQELGLDLSK 250
    KSPPLPPTTP GPHLTPEDPA QLSDSQRESP APTSTSALPV GNSASFVELG 300
    ATPEEPMDVE GAEENHLSLL EGQGGQPRKS LRHSARKKDW NKKEPVAGSP 350
    FDRRETGSKG SCPGEEGEGT GDRVPNGVLA SSAGGGGPSA SYGEQSFPCK 400
    EEEENGKDGS EDSGQSGSEG GSGHTGAHYV YRQEGYETVS YGDNVYVCIP 450
    CAKGFPSSEQ LNAHVETHTE EELFIKEEGA YETGSGGAEE EAEDLSTPSA 500
    AYTADSRPFK CSVCEKTYKD PATLRQHEKT HWLTRPFPCN ICGKMFTQRG 550
    TMTRHMRSHL GLKPFACDEC GMRFTRQYRL TEHMRVHSGE KPYECQLCGG 600
    KFTQQRNLIS HLRMHTSPS 619
    Length:619
    Mass (Da):66,766
    Last modified:June 28, 2011 - v4
    Checksum:iAA7E58CC3BA8AB39
    GO
    Isoform 2 (identifier: Q9JLZ6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         544-619: KMFTQRGTMT...SHLRMHTSPS → SEPTPSCPLQSSGMSGNLQQSQR

    Note: No experimental confirmation available.

    Show »
    Length:566
    Mass (Da):60,187
    Checksum:i7E7110E46948CAF7
    GO

    Sequence cautioni

    The sequence CAI30631.1 differs from that shown. Reason: Probable cloning artifact.
    The sequence BAC98076.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti354 – 3552RE → AA in AAF28801. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei544 – 61976KMFTQ…HTSPS → SEPTPSCPLQSSGMSGNLQQ SQR in isoform 2. 1 PublicationVSP_010499Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ868292 mRNA. Translation: CAI30631.1. Sequence problems.
    AK084975 mRNA. Translation: BAC39326.1.
    AK145386 mRNA. Translation: BAE26404.1.
    AK156332 mRNA. Translation: BAE33679.1.
    AK157276 mRNA. Translation: BAE34025.1.
    AK129266 mRNA. Translation: BAC98076.1. Different initiation.
    BC065124 mRNA. Translation: AAH65124.1.
    AF117382 mRNA. Translation: AAF28801.1.
    CCDSiCCDS27999.1. [Q9JLZ6-1]
    RefSeqiNP_849253.2. NM_178922.3. [Q9JLZ6-1]
    UniGeneiMm.261602.
    Mm.470636.

    Genome annotation databases

    EnsembliENSMUST00000090190; ENSMUSP00000087656; ENSMUSG00000050240. [Q9JLZ6-1]
    ENSMUST00000115698; ENSMUSP00000111362; ENSMUSG00000050240. [Q9JLZ6-2]
    GeneIDi58180.
    KEGGimmu:58180.
    UCSCiuc007yko.1. mouse. [Q9JLZ6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ868292 mRNA. Translation: CAI30631.1 . Sequence problems.
    AK084975 mRNA. Translation: BAC39326.1 .
    AK145386 mRNA. Translation: BAE26404.1 .
    AK156332 mRNA. Translation: BAE33679.1 .
    AK157276 mRNA. Translation: BAE34025.1 .
    AK129266 mRNA. Translation: BAC98076.1 . Different initiation.
    BC065124 mRNA. Translation: AAH65124.1 .
    AF117382 mRNA. Translation: AAF28801.1 .
    CCDSi CCDS27999.1. [Q9JLZ6-1 ]
    RefSeqi NP_849253.2. NM_178922.3. [Q9JLZ6-1 ]
    UniGenei Mm.261602.
    Mm.470636.

    3D structure databases

    ProteinModelPortali Q9JLZ6.
    SMRi Q9JLZ6. Positions 23-135, 446-617.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9JLZ6. 1 interaction.
    MINTi MINT-4097465.

    PTM databases

    PhosphoSitei Q9JLZ6.

    Proteomic databases

    PaxDbi Q9JLZ6.
    PRIDEi Q9JLZ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000090190 ; ENSMUSP00000087656 ; ENSMUSG00000050240 . [Q9JLZ6-1 ]
    ENSMUST00000115698 ; ENSMUSP00000111362 ; ENSMUSG00000050240 . [Q9JLZ6-2 ]
    GeneIDi 58180.
    KEGGi mmu:58180.
    UCSCi uc007yko.1. mouse. [Q9JLZ6-1 ]

    Organism-specific databases

    CTDi 23119.
    MGIi MGI:1929869. Hic2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117308.
    HOGENOMi HOG000026793.
    HOVERGENi HBG079492.
    InParanoidi Q9JLZ6.
    OMAi IMVENSI.
    OrthoDBi EOG7T1R9Z.
    TreeFami TF333488.

    Miscellaneous databases

    NextBioi 314131.
    PROi Q9JLZ6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JLZ6.
    CleanExi MM_HIC2.
    Genevestigatori Q9JLZ6.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and expression analysis of the murine Hic2 gene."
      Terzic A., Graw J.
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C3H.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J and NOD.
      Tissue: Embryo, Lung and Spleen.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Embryonic tail.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.
    5. "Hic2, a novel homolog of Hic1 and gammaFBP."
      Grimm C., Graw J.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 354-619 (ISOFORM 1).
      Strain: Swiss Webster.
      Tissue: Embryo.

    Entry informationi

    Entry nameiHIC2_MOUSE
    AccessioniPrimary (citable) accession number: Q9JLZ6
    Secondary accession number(s): Q3U030
    , Q3ULP4, Q5K036, Q8BSZ9, Q8C3T5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 124 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3