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Protein

Hypermethylated in cancer 2 protein

Gene

Hic2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri446 – 468C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Hypermethylated in cancer 2 protein
Short name:
Hic-2
Gene namesi
Name:Hic2
Synonyms:Kiaa1020
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1929869. Hic2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000469461 – 619Hypermethylated in cancer 2 proteinAdd BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei166PhosphoserineBy similarity1
Modified residuei169PhosphoserineBy similarity1
Modified residuei197PhosphoserineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei416PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JLZ6.
PaxDbiQ9JLZ6.
PeptideAtlasiQ9JLZ6.
PRIDEiQ9JLZ6.

PTM databases

iPTMnetiQ9JLZ6.
PhosphoSitePlusiQ9JLZ6.
SwissPalmiQ9JLZ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000050240.
CleanExiMM_HIC2.
GenevisibleiQ9JLZ6. MM.

Interactioni

Subunit structurei

Self-associates. Interacts with HIC1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208374. 1 interactor.
IntActiQ9JLZ6. 1 interactor.
MINTiMINT-4097465.
STRINGi10090.ENSMUSP00000087656.

Structurei

3D structure databases

ProteinModelPortaliQ9JLZ6.
SMRiQ9JLZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 109BTBPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni247 – 249Binding to CtBPBy similarity3

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri446 – 468C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132251.
HOGENOMiHOG000026793.
HOVERGENiHBG079492.
InParanoidiQ9JLZ6.
OMAiRHSARKK.
OrthoDBiEOG091G054Q.
TreeFamiTF333488.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JLZ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSGPLALRW CPWAGHRDMG PDMELPSHSK QLLLQLNQQR AKGFLCDVII
60 70 80 90 100
MVENSIFRAH KNVLAASSIY FKSLVLHDNL INLDTDMVSS TVFQQILDFI
110 120 130 140 150
YTGKLLPSDQ PSEPNFSTLL TAASYLQLPE LAALCRRKLK RAGKPFGPGR
160 170 180 190 200
VGTAGIGRPT RSQRLSTASV IQARFPGLVD VRKGHPAPQE LPQAKGSDDE
210 220 230 240 250
LFLGTSTQES THGLGLGGPA GGEMGLGGCS TSTNGSSGGC EQELGLDLSK
260 270 280 290 300
KSPPLPPTTP GPHLTPEDPA QLSDSQRESP APTSTSALPV GNSASFVELG
310 320 330 340 350
ATPEEPMDVE GAEENHLSLL EGQGGQPRKS LRHSARKKDW NKKEPVAGSP
360 370 380 390 400
FDRRETGSKG SCPGEEGEGT GDRVPNGVLA SSAGGGGPSA SYGEQSFPCK
410 420 430 440 450
EEEENGKDGS EDSGQSGSEG GSGHTGAHYV YRQEGYETVS YGDNVYVCIP
460 470 480 490 500
CAKGFPSSEQ LNAHVETHTE EELFIKEEGA YETGSGGAEE EAEDLSTPSA
510 520 530 540 550
AYTADSRPFK CSVCEKTYKD PATLRQHEKT HWLTRPFPCN ICGKMFTQRG
560 570 580 590 600
TMTRHMRSHL GLKPFACDEC GMRFTRQYRL TEHMRVHSGE KPYECQLCGG
610
KFTQQRNLIS HLRMHTSPS
Length:619
Mass (Da):66,766
Last modified:June 28, 2011 - v4
Checksum:iAA7E58CC3BA8AB39
GO
Isoform 2 (identifier: Q9JLZ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     544-619: KMFTQRGTMT...SHLRMHTSPS → SEPTPSCPLQSSGMSGNLQQSQR

Note: No experimental confirmation available.
Show »
Length:566
Mass (Da):60,187
Checksum:i7E7110E46948CAF7
GO

Sequence cautioni

The sequence BAC98076 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI30631 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti354 – 355RE → AA in AAF28801 (Ref. 5) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010499544 – 619KMFTQ…HTSPS → SEPTPSCPLQSSGMSGNLQQ SQR in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ868292 mRNA. Translation: CAI30631.1. Sequence problems.
AK084975 mRNA. Translation: BAC39326.1.
AK145386 mRNA. Translation: BAE26404.1.
AK156332 mRNA. Translation: BAE33679.1.
AK157276 mRNA. Translation: BAE34025.1.
AK129266 mRNA. Translation: BAC98076.1. Different initiation.
BC065124 mRNA. Translation: AAH65124.1.
AF117382 mRNA. Translation: AAF28801.1.
CCDSiCCDS27999.1. [Q9JLZ6-1]
RefSeqiNP_849253.2. NM_178922.3. [Q9JLZ6-1]
UniGeneiMm.261602.
Mm.470636.

Genome annotation databases

EnsembliENSMUST00000090190; ENSMUSP00000087656; ENSMUSG00000050240. [Q9JLZ6-1]
ENSMUST00000115698; ENSMUSP00000111362; ENSMUSG00000050240. [Q9JLZ6-2]
GeneIDi58180.
KEGGimmu:58180.
UCSCiuc007yko.1. mouse. [Q9JLZ6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ868292 mRNA. Translation: CAI30631.1. Sequence problems.
AK084975 mRNA. Translation: BAC39326.1.
AK145386 mRNA. Translation: BAE26404.1.
AK156332 mRNA. Translation: BAE33679.1.
AK157276 mRNA. Translation: BAE34025.1.
AK129266 mRNA. Translation: BAC98076.1. Different initiation.
BC065124 mRNA. Translation: AAH65124.1.
AF117382 mRNA. Translation: AAF28801.1.
CCDSiCCDS27999.1. [Q9JLZ6-1]
RefSeqiNP_849253.2. NM_178922.3. [Q9JLZ6-1]
UniGeneiMm.261602.
Mm.470636.

3D structure databases

ProteinModelPortaliQ9JLZ6.
SMRiQ9JLZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208374. 1 interactor.
IntActiQ9JLZ6. 1 interactor.
MINTiMINT-4097465.
STRINGi10090.ENSMUSP00000087656.

PTM databases

iPTMnetiQ9JLZ6.
PhosphoSitePlusiQ9JLZ6.
SwissPalmiQ9JLZ6.

Proteomic databases

EPDiQ9JLZ6.
PaxDbiQ9JLZ6.
PeptideAtlasiQ9JLZ6.
PRIDEiQ9JLZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090190; ENSMUSP00000087656; ENSMUSG00000050240. [Q9JLZ6-1]
ENSMUST00000115698; ENSMUSP00000111362; ENSMUSG00000050240. [Q9JLZ6-2]
GeneIDi58180.
KEGGimmu:58180.
UCSCiuc007yko.1. mouse. [Q9JLZ6-1]

Organism-specific databases

CTDi23119.
MGIiMGI:1929869. Hic2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132251.
HOGENOMiHOG000026793.
HOVERGENiHBG079492.
InParanoidiQ9JLZ6.
OMAiRHSARKK.
OrthoDBiEOG091G054Q.
TreeFamiTF333488.

Miscellaneous databases

ChiTaRSiHic2. mouse.
PROiQ9JLZ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050240.
CleanExiMM_HIC2.
GenevisibleiQ9JLZ6. MM.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHIC2_MOUSE
AccessioniPrimary (citable) accession number: Q9JLZ6
Secondary accession number(s): Q3U030
, Q3ULP4, Q5K036, Q8BSZ9, Q8C3T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: June 28, 2011
Last modified: November 2, 2016
This is version 145 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.