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Q9JLY7

- DUS14_MOUSE

UniProt

Q9JLY7 - DUS14_MOUSE

Protein

Dual specificity protein phosphatase 14

Gene

Dusp14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei111 – 1111Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: InterPro
    2. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    3. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptidyl-tyrosine dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 14 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    Mitogen-activated protein kinase phosphatase 6
    Short name:
    MAP kinase phosphatase 6
    Short name:
    MKP-6
    Gene namesi
    Name:Dusp14
    Synonyms:Mkp6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1927168. Dusp14.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Dual specificity protein phosphatase 14PRO_0000094823Add
    BLAST

    Proteomic databases

    PaxDbiQ9JLY7.
    PRIDEiQ9JLY7.

    PTM databases

    PhosphoSiteiQ9JLY7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9JLY7.
    BgeeiQ9JLY7.
    CleanExiMM_DUSP14.
    GenevestigatoriQ9JLY7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JLY7.
    SMRiQ9JLY7. Positions 24-191.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini91 – 15666Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00750000117525.
    HOGENOMiHOG000233766.
    HOVERGENiHBG051422.
    InParanoidiQ9JLY7.
    KOiK14165.
    OMAiRSQGFFH.
    OrthoDBiEOG7PK90H.
    PhylomeDBiQ9JLY7.
    TreeFamiTF316009.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR020420. Atypical_DUSP_famB.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    PR01910. ADSPHPHTASEB.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JLY7-1 [UniParc]FASTAAdd to Basket

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    MSSRGHSTLP RTLMAPRMIS EGDIGGIAQI TSSLFLGRAS VASNWHLLQA    50
    RGITCVINAT IEIPNFNWPQ FEYVKVPLAD IPHAPIRLYF DTVADKIHSV 100
    SKKHGATLVH CAAGVSRSAT LCIAYLMKFH NLCLLEAYNW VKARRPVIRP 150
    NLGFWRQLID YESQLFGKSS VKMVQTPYGI IPDVYEKESR HLMPYWGI 198
    Length:198
    Mass (Da):22,311
    Last modified:January 23, 2002 - v2
    Checksum:i5C2B4210E886DFCF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti38 – 381R → K in AAF28862. (PubMed:11123293)Curated
    Sequence conflicti150 – 1501P → H in AAF28862. (PubMed:11123293)Curated
    Sequence conflicti160 – 1601D → E in AAF28862. (PubMed:11123293)Curated
    Sequence conflicti163 – 1631S → R in AAF28862. (PubMed:11123293)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF120113 mRNA. Translation: AAF28862.1.
    AK009744 mRNA. Translation: BAB26474.1.
    BC002130 mRNA. Translation: AAH02130.1.
    CCDSiCCDS25182.1.
    RefSeqiNP_062793.2. NM_019819.3.
    XP_006533859.1. XM_006533796.1.
    XP_006533860.1. XM_006533797.1.
    XP_006533861.1. XM_006533798.1.
    XP_006533862.1. XM_006533799.1.
    UniGeneiMm.240885.
    Mm.475342.

    Genome annotation databases

    EnsembliENSMUST00000018792; ENSMUSP00000018792; ENSMUSG00000018648.
    ENSMUST00000100705; ENSMUSP00000098271; ENSMUSG00000018648.
    ENSMUST00000108101; ENSMUSP00000103736; ENSMUSG00000018648.
    ENSMUST00000164891; ENSMUSP00000130624; ENSMUSG00000018648.
    GeneIDi56405.
    KEGGimmu:56405.
    UCSCiuc007kqc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF120113 mRNA. Translation: AAF28862.1 .
    AK009744 mRNA. Translation: BAB26474.1 .
    BC002130 mRNA. Translation: AAH02130.1 .
    CCDSi CCDS25182.1.
    RefSeqi NP_062793.2. NM_019819.3.
    XP_006533859.1. XM_006533796.1.
    XP_006533860.1. XM_006533797.1.
    XP_006533861.1. XM_006533798.1.
    XP_006533862.1. XM_006533799.1.
    UniGenei Mm.240885.
    Mm.475342.

    3D structure databases

    ProteinModelPortali Q9JLY7.
    SMRi Q9JLY7. Positions 24-191.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9JLY7.

    Proteomic databases

    PaxDbi Q9JLY7.
    PRIDEi Q9JLY7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018792 ; ENSMUSP00000018792 ; ENSMUSG00000018648 .
    ENSMUST00000100705 ; ENSMUSP00000098271 ; ENSMUSG00000018648 .
    ENSMUST00000108101 ; ENSMUSP00000103736 ; ENSMUSG00000018648 .
    ENSMUST00000164891 ; ENSMUSP00000130624 ; ENSMUSG00000018648 .
    GeneIDi 56405.
    KEGGi mmu:56405.
    UCSCi uc007kqc.1. mouse.

    Organism-specific databases

    CTDi 11072.
    MGIi MGI:1927168. Dusp14.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00750000117525.
    HOGENOMi HOG000233766.
    HOVERGENi HBG051422.
    InParanoidi Q9JLY7.
    KOi K14165.
    OMAi RSQGFFH.
    OrthoDBi EOG7PK90H.
    PhylomeDBi Q9JLY7.
    TreeFami TF316009.

    Miscellaneous databases

    ChiTaRSi DUSP14. mouse.
    NextBioi 312530.
    PROi Q9JLY7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JLY7.
    Bgeei Q9JLY7.
    CleanExi MM_DUSP14.
    Genevestigatori Q9JLY7.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR020420. Atypical_DUSP_famB.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    PR01910. ADSPHPHTASEB.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6."
      Marti F., Krause A., Post N.H., Lyddane C., Dupont B., Sadelain M., King P.D.
      J. Immunol. 166:197-206(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Tongue.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiDUS14_MOUSE
    AccessioniPrimary (citable) accession number: Q9JLY7
    Secondary accession number(s): Q9D715
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3