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Protein

Suppressor of cytokine signaling 6

Gene

Socs6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity).By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Growth regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-1433559. Regulation of KIT signaling.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 6
Short name:
SOCS-6
Alternative name(s):
Cytokine-inducible SH2 protein 4
Short name:
CIS-4
Suppressor of cytokine signaling 4
Short name:
SOCS-4
Gene namesi
Name:Socs6
Synonyms:Cis4, Cish4, Socs4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1924885. Socs6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Suppressor of cytokine signaling 6PRO_0000181252Add
BLAST

Proteomic databases

MaxQBiQ9JLY0.
PaxDbiQ9JLY0.
PeptideAtlasiQ9JLY0.
PRIDEiQ9JLY0.

PTM databases

iPTMnetiQ9JLY0.
PhosphoSiteiQ9JLY0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000056153.
CleanExiMM_SOCS4.
MM_SOCS6.
ExpressionAtlasiQ9JLY0. baseline and differential.
GenevisibleiQ9JLY0. MM.

Interactioni

Subunit structurei

Interacts with KIT (phosphorylated) (By similarity). Interacts with RBCK1. Interacts with phosphorylated IRS4. Interacts with PIM3.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RBCK1Q9BYM85EBI-8500205,EBI-2340624From a different organism.

Protein-protein interaction databases

BioGridi207682. 8 interactions.
IntActiQ9JLY0. 3 interactions.
MINTiMINT-2577134.
STRINGi10090.ENSMUSP00000064929.

Structurei

3D structure databases

ProteinModelPortaliQ9JLY0.
SMRiQ9JLY0. Positions 365-533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini382 – 489108SH2PROSITE-ProRule annotationAdd
BLAST
Domaini484 – 53350SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566. Eukaryota.
ENOG4111V4J. LUCA.
GeneTreeiENSGT00760000119136.
HOGENOMiHOG000027792.
HOVERGENiHBG057479.
InParanoidiQ9JLY0.
KOiK04699.
OMAiTRWEAEG.
OrthoDBiEOG091G0EP6.
TreeFamiTF321368.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR028421. SOCS6.
IPR001496. SOCS_box.
[Graphical view]
PANTHERiPTHR24369:SF83. PTHR24369:SF83. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JLY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKISLKTFR KSFNLSKSKD ETEFMVVQPQ SLAGDFVKDD SLFGSCYGKD
60 70 80 90 100
MASCDIGSED EKGKNRSKSE SLMGTLKRRL SAKQKTKGKG GTASTDEDTF
110 120 130 140 150
SSASAPGGLK DVRAPRPIRS TSLRSHHYSP TPWPLRPTSS EETCIKMEMR
160 170 180 190 200
VKALVHAASP GPVNGVRKDL RELQPRELRD LQPEPRPESR CSPSSPGDLS
210 220 230 240 250
LHLEEHVPVV IGLMSQDYLQ YTVPLDDGMC PLEGPRSCCL DTSSPMEVSA
260 270 280 290 300
VPLPGASGAF SEDDSHVDQD LVVGPEILVD SSVNNLLIGT TGVMLQSPRG
310 320 330 340 350
GHDDAPPLSP LLPPMQNNPI QRNFSGLSGP DLHMAESVRC HLNFDPNSAP
360 370 380 390 400
GVARVYDSVQ SSGPMVVTSL TEELKKLAKQ GWYWGPITRW EAEGKLANVP
410 420 430 440 450
DGSFLVRDSS DDRYLLSLSF RSHGKTLHTR IEHSNGRFSF YEQPDVEGHT
460 470 480 490 500
SIVDLIEHSI RDSENGAFCY SRSRLPGSAT YPVRLTNPVS RFMQVRSLQY
510 520 530
LCRFVIRQYT RIDLIQKLPL PNKMKDYLQE KHY
Length:533
Mass (Da):59,077
Last modified:July 27, 2011 - v2
Checksum:iF779C6519DB0A17B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101R → T in AAF28872 (Ref. 1) Curated
Sequence conflicti92 – 921T → S in AAF28872 (Ref. 1) Curated
Sequence conflicti149 – 1524MRVK → IASE in AAF28872 (Ref. 1) Curated
Sequence conflicti308 – 3081L → I in BAB31956 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121907 mRNA. Translation: AAF28872.1.
AK019993 mRNA. Translation: BAB31956.1.
AK028665 mRNA. Translation: BAC26055.1.
AK028701 mRNA. Translation: BAC26074.1.
AK031164 mRNA. Translation: BAC27287.1.
AK044946 mRNA. Translation: BAC32154.1.
AK142069 mRNA. Translation: BAE24930.1.
AK156591 mRNA. Translation: BAE33770.1.
CH466632 Genomic DNA. Translation: EDL00645.1.
CH466632 Genomic DNA. Translation: EDL00646.1.
BC017597 mRNA. Translation: AAH17597.1.
BC094443 mRNA. Translation: AAH94443.1.
CCDSiCCDS29389.1.
RefSeqiNP_061291.2. NM_018821.4.
XP_006526576.1. XM_006526513.2.
XP_011245391.1. XM_011247089.1.
XP_011245392.1. XM_011247090.1.
UniGeneiMm.476577.
Mm.91920.

Genome annotation databases

EnsembliENSMUST00000070116; ENSMUSP00000064929; ENSMUSG00000056153.
ENSMUST00000123826; ENSMUSP00000114993; ENSMUSG00000056153.
ENSMUST00000125362; ENSMUSP00000118764; ENSMUSG00000056153.
GeneIDi54607.
KEGGimmu:54607.
UCSCiuc008fvf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121907 mRNA. Translation: AAF28872.1.
AK019993 mRNA. Translation: BAB31956.1.
AK028665 mRNA. Translation: BAC26055.1.
AK028701 mRNA. Translation: BAC26074.1.
AK031164 mRNA. Translation: BAC27287.1.
AK044946 mRNA. Translation: BAC32154.1.
AK142069 mRNA. Translation: BAE24930.1.
AK156591 mRNA. Translation: BAE33770.1.
CH466632 Genomic DNA. Translation: EDL00645.1.
CH466632 Genomic DNA. Translation: EDL00646.1.
BC017597 mRNA. Translation: AAH17597.1.
BC094443 mRNA. Translation: AAH94443.1.
CCDSiCCDS29389.1.
RefSeqiNP_061291.2. NM_018821.4.
XP_006526576.1. XM_006526513.2.
XP_011245391.1. XM_011247089.1.
XP_011245392.1. XM_011247090.1.
UniGeneiMm.476577.
Mm.91920.

3D structure databases

ProteinModelPortaliQ9JLY0.
SMRiQ9JLY0. Positions 365-533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207682. 8 interactions.
IntActiQ9JLY0. 3 interactions.
MINTiMINT-2577134.
STRINGi10090.ENSMUSP00000064929.

PTM databases

iPTMnetiQ9JLY0.
PhosphoSiteiQ9JLY0.

Proteomic databases

MaxQBiQ9JLY0.
PaxDbiQ9JLY0.
PeptideAtlasiQ9JLY0.
PRIDEiQ9JLY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070116; ENSMUSP00000064929; ENSMUSG00000056153.
ENSMUST00000123826; ENSMUSP00000114993; ENSMUSG00000056153.
ENSMUST00000125362; ENSMUSP00000118764; ENSMUSG00000056153.
GeneIDi54607.
KEGGimmu:54607.
UCSCiuc008fvf.1. mouse.

Organism-specific databases

CTDi9306.
MGIiMGI:1924885. Socs6.

Phylogenomic databases

eggNOGiKOG4566. Eukaryota.
ENOG4111V4J. LUCA.
GeneTreeiENSGT00760000119136.
HOGENOMiHOG000027792.
HOVERGENiHBG057479.
InParanoidiQ9JLY0.
KOiK04699.
OMAiTRWEAEG.
OrthoDBiEOG091G0EP6.
TreeFamiTF321368.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-MMU-1433559. Regulation of KIT signaling.

Miscellaneous databases

PROiQ9JLY0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056153.
CleanExiMM_SOCS4.
MM_SOCS6.
ExpressionAtlasiQ9JLY0. baseline and differential.
GenevisibleiQ9JLY0. MM.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR028421. SOCS6.
IPR001496. SOCS_box.
[Graphical view]
PANTHERiPTHR24369:SF83. PTHR24369:SF83. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSOCS6_MOUSE
AccessioniPrimary (citable) accession number: Q9JLY0
Secondary accession number(s): Q8VEN5, Q9D2A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.