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Q9JLX8

- Q9JLX8_RAT

UniProt

Q9JLX8 - Q9JLX8_RAT

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Protein
Submitted name:

Preproendothelin-1

Gene

Edn1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. body fluid secretion Source: Ensembl
  2. calcium-mediated signaling Source: Ensembl
  3. cartilage development Source: Ensembl
  4. dorsal/ventral pattern formation Source: Ensembl
  5. glucose transport Source: Ensembl
  6. heart development Source: Ensembl
  7. inositol phosphate-mediated signaling Source: Ensembl
  8. in utero embryonic development Source: Ensembl
  9. middle ear morphogenesis Source: Ensembl
  10. negative regulation of cAMP biosynthetic process Source: Ensembl
  11. negative regulation of cellular protein metabolic process Source: Ensembl
  12. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  13. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  14. neural crest cell development Source: Ensembl
  15. nitric oxide transport Source: Ensembl
  16. patterning of blood vessels Source: Ensembl
  17. peptide hormone secretion Source: Ensembl
  18. phosphatidylinositol 3-kinase signaling Source: Ensembl
  19. phospholipase D-activating G-protein coupled receptor signaling pathway Source: Ensembl
  20. positive regulation of cardiac muscle hypertrophy Source: Ensembl
  21. positive regulation of cell migration Source: Ensembl
  22. positive regulation of cell size Source: Ensembl
  23. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  24. positive regulation of heart rate Source: Ensembl
  25. positive regulation of hormone secretion Source: Ensembl
  26. positive regulation of JUN kinase activity Source: Ensembl
  27. positive regulation of mitosis Source: Ensembl
  28. positive regulation of prostaglandin-endoperoxide synthase activity Source: Ensembl
  29. positive regulation of receptor biosynthetic process Source: Ensembl
  30. positive regulation of renal sodium excretion Source: Ensembl
  31. positive regulation of sarcomere organization Source: Ensembl
  32. positive regulation of smooth muscle cell proliferation Source: Ensembl
  33. positive regulation of urine volume Source: Ensembl
  34. prostaglandin biosynthetic process Source: Ensembl
  35. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  36. protein kinase C deactivation Source: Ensembl
  37. regulation of pH Source: Ensembl
  38. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
  39. regulation of vasoconstriction Source: InterPro
  40. respiratory gaseous exchange Source: Ensembl
  41. response to hypoxia Source: Ensembl
  42. rhythmic excitation Source: Ensembl
  43. vein smooth muscle contraction Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Preproendothelin-1Imported
Gene namesi
Name:Edn1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2532. Edn1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ9JLX8. baseline and differential.
GenevestigatoriQ9JLX8.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG051441.

Family and domain databases

InterProiIPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
SMARTiSM00272. END. 1 hit.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9JLX8-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
RSKRSLKDLL PTKTTDQGNR CQCAHQKDKK CWNFCQADKE LRAQSTMQKG
60 70 80 90 100
VKDFKKGKPC PKLGKKCIYQ QLVEGRKLRR LEAISNSIKT SFRVAKLKAE

LYRDQ
Length:105
Mass (Da):12,202
Last modified:October 1, 2000 - v1
Checksum:iCE368E686F828573
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei105 – 1051Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF122903 mRNA. Translation: AAF31762.1.
UniGeneiRn.10918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF122903 mRNA. Translation: AAF31762.1 .
UniGenei Rn.10918.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 2532. Edn1.

Phylogenomic databases

HOVERGENi HBG051441.

Gene expression databases

ExpressionAtlasi Q9JLX8. baseline and differential.
Genevestigatori Q9JLX8.

Family and domain databases

InterProi IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view ]
SMARTi SM00272. END. 1 hit.
[Graphical view ]
PROSITEi PS00270. ENDOTHELIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Increased Local Expression of ET-1 Enhances a-agonist Induced Contraction of Rat Aorta After Prolonged Hypoxia In Vivo."
    Toporsian M., Auer G., Zacour M., Cernacek P., Ward M.E.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.

Entry informationi

Entry nameiQ9JLX8_RAT
AccessioniPrimary (citable) accession number: Q9JLX8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)