Q9JLX8 (Q9JLX8_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Preproendothelin-1 EMBL AAF31762.1

Gene names

Name:

Edn1 RGD 2532

Organism

Rattus norvegicus (Rat) EMBL AAF31762.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	105 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	body fluid secretion Inferred from electronic annotation. Source: Compara calcium-mediated signaling Inferred from electronic annotation. Source: Compara cartilage development Inferred from electronic annotation. Source: Compara dorsal/ventral pattern formation Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Inferred from electronic annotation. Source: Compara glucose transport Inferred from electronic annotation. Source: Compara heart development Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara inositol phosphate-mediated signaling Inferred from electronic annotation. Source: Compara middle ear morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of cAMP biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of cellular protein metabolic process Inferred from electronic annotation. Source: Compara negative regulation of nitric-oxide synthase biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara neural crest cell development Inferred from electronic annotation. Source: Compara nitric oxide transport Inferred from electronic annotation. Source: Compara patterning of blood vessels Inferred from electronic annotation. Source: Compara peptide hormone secretion Inferred from electronic annotation. Source: Compara phosphatidylinositol 3-kinase cascade Inferred from electronic annotation. Source: Compara phospholipase D-activating G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of JUN kinase activity Inferred from electronic annotation. Source: Compara positive regulation of cardiac muscle hypertrophy Inferred from electronic annotation. Source: Compara positive regulation of cell migration Inferred from electronic annotation. Source: Compara positive regulation of cell size Inferred from electronic annotation. Source: Compara positive regulation of heart rate Inferred from electronic annotation. Source: Compara positive regulation of hormone secretion Inferred from electronic annotation. Source: Compara positive regulation of mitosis Inferred from electronic annotation. Source: Compara positive regulation of prostaglandin-endoperoxide synthase activity Inferred from electronic annotation. Source: Compara positive regulation of receptor biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of renal sodium excretion Inferred from electronic annotation. Source: Compara positive regulation of sarcomere organization Inferred from electronic annotation. Source: Compara positive regulation of smooth muscle cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of urine volume Inferred from electronic annotation. Source: Compara prostaglandin biosynthetic process Inferred from electronic annotation. Source: Compara protein kinase C deactivation Inferred from electronic annotation. Source: Compara protein kinase C-activating G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara regulation of pH Inferred from electronic annotation. Source: Compara regulation of systemic arterial blood pressure by endothelin Inferred from electronic annotation. Source: Compara regulation of vasoconstriction Inferred from electronic annotation. Source: InterPro respiratory gaseous exchange Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara rhythmic excitation Inferred from electronic annotation. Source: Compara vein smooth muscle contraction Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAF31762.1
	Non-terminal residue	105	1	EMBL AAF31762.1

Sequences

	Sequence		Length	Mass (Da)
	Q9JLX8 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: CE368E686F828573	FASTA	105	12,202
	10 20 30 40 50 60 RSKRSLKDLL PTKTTDQGNR CQCAHQKDKK CWNFCQADKE LRAQSTMQKG VKDFKKGKPC 70 80 90 100 PKLGKKCIYQ QLVEGRKLRR LEAISNSIKT SFRVAKLKAE LYRDQ

References

[1]	"Increased Local Expression of ET-1 Enhances a-agonist Induced Contraction of Rat Aorta After Prolonged Hypoxia In Vivo." Toporsian M., Auer G., Zacour M., Cernacek P., Ward M.E. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL AAF31762.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF122903 mRNA. Translation: AAF31762.1.
IPI	IPI00206210.
UniGene	Rn.10918.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9JLX8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
RGD	2532. Edn1.
Phylogenomic databases
HOVERGEN	HBG051441.
InParanoid	Q9JLX8.
Gene expression databases
ArrayExpress	Q9JLX8.
Genevestigator	Q9JLX8.
Family and domain databases
InterPro	IPR019764. Endothelin_toxin_CS. IPR001928. Endothln-like_toxin. [Graphical view]
SMART	SM00272. END. 1 hit. [Graphical view]
PROSITE	PS00270. ENDOTHELIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9JLX8_RAT

Accession

Primary (citable) accession number: Q9JLX8

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	October 3, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)