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Q9JLX8

- Q9JLX8_RAT

UniProt

Q9JLX8 - Q9JLX8_RAT

Protein
Submitted name:

Preproendothelin-1

Gene

Edn1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Biological processi

    1. body fluid secretion Source: Ensembl
    2. calcium-mediated signaling Source: Ensembl
    3. cartilage development Source: Ensembl
    4. dorsal/ventral pattern formation Source: Ensembl
    5. glucose transport Source: Ensembl
    6. heart development Source: Ensembl
    7. inositol phosphate-mediated signaling Source: Ensembl
    8. in utero embryonic development Source: Ensembl
    9. middle ear morphogenesis Source: Ensembl
    10. negative regulation of cAMP biosynthetic process Source: Ensembl
    11. negative regulation of cellular protein metabolic process Source: Ensembl
    12. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
    13. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    14. neural crest cell development Source: Ensembl
    15. nitric oxide transport Source: Ensembl
    16. patterning of blood vessels Source: Ensembl
    17. peptide hormone secretion Source: Ensembl
    18. phosphatidylinositol 3-kinase signaling Source: Ensembl
    19. phospholipase D-activating G-protein coupled receptor signaling pathway Source: Ensembl
    20. positive regulation of cardiac muscle hypertrophy Source: Ensembl
    21. positive regulation of cell migration Source: Ensembl
    22. positive regulation of cell size Source: Ensembl
    23. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
    24. positive regulation of heart rate Source: Ensembl
    25. positive regulation of hormone secretion Source: Ensembl
    26. positive regulation of JUN kinase activity Source: Ensembl
    27. positive regulation of mitosis Source: Ensembl
    28. positive regulation of prostaglandin-endoperoxide synthase activity Source: Ensembl
    29. positive regulation of receptor biosynthetic process Source: Ensembl
    30. positive regulation of renal sodium excretion Source: Ensembl
    31. positive regulation of sarcomere organization Source: Ensembl
    32. positive regulation of smooth muscle cell proliferation Source: Ensembl
    33. positive regulation of urine volume Source: Ensembl
    34. prostaglandin biosynthetic process Source: Ensembl
    35. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    36. protein kinase C deactivation Source: Ensembl
    37. regulation of pH Source: Ensembl
    38. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
    39. regulation of vasoconstriction Source: InterPro
    40. respiratory gaseous exchange Source: Ensembl
    41. response to hypoxia Source: Ensembl
    42. rhythmic excitation Source: Ensembl
    43. vein smooth muscle contraction Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Preproendothelin-1Imported
    Gene namesi
    Name:Edn1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi2532. Edn1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ9JLX8.
    GenevestigatoriQ9JLX8.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG051441.
    InParanoidiQ9JLX8.

    Family and domain databases

    InterProiIPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view]
    SMARTiSM00272. END. 1 hit.
    [Graphical view]
    PROSITEiPS00270. ENDOTHELIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9JLX8-1 [UniParc]FASTAAdd to Basket

    « Hide

    RSKRSLKDLL PTKTTDQGNR CQCAHQKDKK CWNFCQADKE LRAQSTMQKG    50
    VKDFKKGKPC PKLGKKCIYQ QLVEGRKLRR LEAISNSIKT SFRVAKLKAE 100
    LYRDQ 105
    Length:105
    Mass (Da):12,202
    Last modified:October 1, 2000 - v1
    Checksum:iCE368E686F828573
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei105 – 1051Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF122903 mRNA. Translation: AAF31762.1.
    UniGeneiRn.10918.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF122903 mRNA. Translation: AAF31762.1 .
    UniGenei Rn.10918.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 2532. Edn1.

    Phylogenomic databases

    HOVERGENi HBG051441.
    InParanoidi Q9JLX8.

    Gene expression databases

    ArrayExpressi Q9JLX8.
    Genevestigatori Q9JLX8.

    Family and domain databases

    InterProi IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view ]
    SMARTi SM00272. END. 1 hit.
    [Graphical view ]
    PROSITEi PS00270. ENDOTHELIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Increased Local Expression of ET-1 Enhances a-agonist Induced Contraction of Rat Aorta After Prolonged Hypoxia In Vivo."
      Toporsian M., Auer G., Zacour M., Cernacek P., Ward M.E.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.

    Entry informationi

    Entry nameiQ9JLX8_RAT
    AccessioniPrimary (citable) accession number: Q9JLX8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)