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Protein

Short transient receptor potential channel 4-associated protein

Gene

Trpc4ap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC (By similarity). Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca2+ storage reduction in response to CHRM1.By similarity2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • hair follicle maturation Source: MGI
  • protein ubiquitination Source: UniProtKB
  • ubiquitin-dependent protein catabolic process Source: UniProtKB

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-3295583 TRP channels
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 4-associated protein
Short name:
Trp4-associated protein
Short name:
Trpc4-associated protein
Alternative name(s):
Protein TAP1
Rabex-5/Rin2-interacting protein
TNF-receptor ubiquitous scaffolding/signaling protein
Short name:
Protein TRUSS
Gene namesi
Name:Trpc4ap
Synonyms:Trrp4ap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1930751 Trpc4ap

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000726422 – 797Short transient receptor potential channel 4-associated proteinAdd BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9JLV2
PaxDbiQ9JLV2
PRIDEiQ9JLV2

PTM databases

iPTMnetiQ9JLV2
PhosphoSitePlusiQ9JLV2

Expressioni

Tissue specificityi

Widely expressed, with high levels in heart, liver and testis.

Gene expression databases

BgeeiENSMUSG00000038324
ExpressionAtlasiQ9JLV2 baseline and differential
GenevisibleiQ9JLV2 MM

Interactioni

Subunit structurei

Component of the DCX(TRUSS) E3 ubiquitin ligase complex, at least composed of CUL4A, DDB1, TRPC4AP/TRUSS and RBX1. Interacts directly with DDB1 (By similarity). Interacts with MYC (By similarity). Constitutively associated with TNFRSF1A. Directly interacts with TRADD, TRAF2, CHUK, IKBKB and IKBKG. Interacts with TRPC1, TRPC4 and TRPC5.By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037574

Structurei

3D structure databases

SMRiQ9JLV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 400Interaction with TNFRSF1AAdd BLAST399

Phylogenomic databases

eggNOGiENOG410IH9D Eukaryota
ENOG410ZAXR LUCA
GeneTreeiENSGT00390000018330
HOGENOMiHOG000231794
HOVERGENiHBG059886
InParanoidiQ9JLV2
KOiK11796
OMAiILNNFHS
OrthoDBiEOG091G02AE
TreeFamiTF329145

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR022162 TRPC4AP
PfamiView protein in Pfam
PF12463 DUF3689, 1 hit
SUPFAMiSSF48371 SSF48371, 4 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JLV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAPAAAGA GASRGRRLAA TAAAWGGWGG RPRPGNILLQ LRQGQLTGRG
60 70 80 90 100
LVRAVQFTET FLTERDKLSK WSGIPQLLLK LYATSHLHSD FVECQSILKE
110 120 130 140 150
ISPLLSMEAM AFVTEDRKFT QEATYPNTYI FDLFGGVDLL VEILMRPTIS
160 170 180 190 200
IRGQKLKISD EMSKDCLSIL YNTCVCTEGV TKRLAEKNDF VIFLFTLMTS
210 220 230 240 250
KKTFLQTATL IEDILGVKKE MIRLDEVPNL SSLVSNFDQQ QLANFCRILA
260 270 280 290 300
VTISEMDTGN DDKHTLLAKN AQQKKSLSLG PSAAEINQAA LLSIPGFVER
310 320 330 340 350
LCKLATRKVS ESTGTASFLQ ELEEWYTWLD NALVLDALMR VANEESEHNQ
360 370 380 390 400
APTVFPSLGT SEEGGLPHTS ARAQLPQSMK IMHEIMYKLE VLYVLCVLLM
410 420 430 440 450
GRQRNQVHRM IAEFKLIPGL NNLFDKLIWR KHSASALVLH GHNQNCDCSP
460 470 480 490 500
DITLKIQFLR LLQSFSDHHE NKYLLLNNQE LNELSAISLK ANIPEVEAVL
510 520 530 540 550
NTDRSLVCDG KRGLLTRLLQ VMKKEPAESS FRFWQARAVE SFLRGTTSYA
560 570 580 590 600
DQMFLLKRGL LEHILYCIVD SECKSRDVLQ SYFDLLGELM KFNVDAFKRF
610 620 630 640 650
NKYINTDAKF QVFLKQINSS LVDSNMLVRC VTLSLDRFEN QVDMKVAEVL
660 670 680 690 700
SECRLLAYIS QVPTQMSFLF RLINIIHVQT LTQENVSCLN TSLVILMLAR
710 720 730 740 750
RKERLPLYLR LLQRMEHSKK YPGFLLNNFH NLLRFWQQHY LHKDKDSTCL
760 770 780 790
ENSSCISFSY WKETVSILLN PDRQSPSALV SYIEEPYMDI DRDFTEE
Length:797
Mass (Da):90,727
Last modified:November 15, 2002 - v2
Checksum:i8BC3453A7658A234
GO
Isoform 2 (identifier: Q9JLV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-358: Missing.

Show »
Length:789
Mass (Da):89,914
Checksum:i92D659B52F87206E
GO

Sequence cautioni

The sequence AAL08422 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11 – 14GASR → LPYW in AAF36513 (Ref. 2) Curated4
Sequence conflicti158I → L in AAF36513 (Ref. 2) Curated1
Sequence conflicti193F → L in AAF36513 (Ref. 2) Curated1
Sequence conflicti359G → S in AAM46938 (PubMed:14585990).Curated1
Sequence conflicti532R → K in AAM46938 (PubMed:14585990).Curated1
Sequence conflicti769L → V in AAL08422 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003983351 – 358Missing in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF509881 mRNA Translation: AAM46938.1
AF130458 mRNA Translation: AAF36513.1
BC003931 mRNA Translation: AAH03931.1
BC033274 mRNA Translation: AAH33274.1
BC057330 mRNA Translation: AAH57330.1
AF093589 mRNA Translation: AAL08422.1 Different initiation.
CCDSiCCDS16952.1 [Q9JLV2-2]
CCDS50769.1 [Q9JLV2-1]
RefSeqiNP_001156924.1, NM_001163452.1 [Q9JLV2-1]
NP_062802.2, NM_019828.2 [Q9JLV2-2]
UniGeneiMm.234944
Mm.268304
Mm.469980

Genome annotation databases

EnsembliENSMUST00000041059; ENSMUSP00000037574; ENSMUSG00000038324 [Q9JLV2-1]
ENSMUST00000103140; ENSMUSP00000099429; ENSMUSG00000038324 [Q9JLV2-2]
GeneIDi56407
KEGGimmu:56407
UCSCiuc008nlc.2 mouse [Q9JLV2-1]
uc012che.1 mouse [Q9JLV2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTP4AP_MOUSE
AccessioniPrimary (citable) accession number: Q9JLV2
Secondary accession number(s): Q920J6, Q99L03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: March 28, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health