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Q9JLV1

- BAG3_MOUSE

UniProt

Q9JLV1 - BAG3_MOUSE

Protein

BAG family molecular chaperone regulator 3

Gene

Bag3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. protein complex binding Source: MGI

    GO - Biological processi

    1. brain development Source: Ensembl
    2. cellular response to mechanical stimulus Source: MGI
    3. extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
    4. extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
    5. negative regulation of striated muscle cell apoptotic process Source: MGI
    6. protein stabilization Source: MGI
    7. spinal cord development Source: Ensembl

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BAG family molecular chaperone regulator 3
    Short name:
    BAG-3
    Alternative name(s):
    Bcl-2-associated athanogene 3
    Bcl-2-binding protein Bis
    Gene namesi
    Name:Bag3
    Synonyms:Bis
    ORF Names:MNCb-2243
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1352493. Bag3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: MGI
    2. neuron projection Source: Ensembl
    3. plasma membrane Source: Ensembl
    4. Z disc Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 577576BAG family molecular chaperone regulator 3PRO_0000088869Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei204 – 2041PhosphoserineBy similarity
    Modified residuei280 – 2801PhosphoserineBy similarity
    Modified residuei281 – 2811PhosphoserineBy similarity
    Modified residuei285 – 2851PhosphoserineBy similarity
    Modified residuei291 – 2911PhosphothreonineBy similarity
    Modified residuei297 – 2971Phosphoserine1 Publication
    Modified residuei382 – 3821PhosphoserineBy similarity
    Modified residuei390 – 3901Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9JLV1.
    PaxDbiQ9JLV1.
    PRIDEiQ9JLV1.

    PTM databases

    PhosphoSiteiQ9JLV1.

    Expressioni

    Gene expression databases

    BgeeiQ9JLV1.
    CleanExiMM_BAG3.
    GenevestigatoriQ9JLV1.

    Interactioni

    Subunit structurei

    Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to Bcl-2 and PLC-gamma By similarity. Interacts with DNAJB6 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EBNA-LPQ8AZK72EBI-309231,EBI-1185167From a different organism.

    Protein-protein interaction databases

    BioGridi205891. 6 interactions.
    IntActiQ9JLV1. 4 interactions.
    MINTiMINT-4124913.

    Structurei

    Secondary structure

    1
    577
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi417 – 4204
    Helixi425 – 44521
    Beta strandi451 – 4533
    Helixi454 – 47118
    Helixi479 – 50325

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1UK5NMR-A406-503[»]
    ProteinModelPortaliQ9JLV1.
    SMRiQ9JLV1. Positions 18-57, 401-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9JLV1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 5635WW 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini126 – 15732WW 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini426 – 50378BAGPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi186 – 1938Poly-Ser

    Sequence similaritiesi

    Contains 1 BAG domain.PROSITE-ProRule annotation
    Contains 2 WW domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG238690.
    GeneTreeiENSGT00530000063256.
    HOGENOMiHOG000050234.
    HOVERGENiHBG003419.
    InParanoidiQ9CQL3.
    KOiK09557.
    OMAiVYPQLRP.
    OrthoDBiEOG75B85S.
    TreeFamiTF102013.

    Family and domain databases

    Gene3Di1.20.58.120. 1 hit.
    InterProiIPR003103. BAG_domain.
    IPR001202. WW_dom.
    [Graphical view]
    PfamiPF02179. BAG. 1 hit.
    PF00397. WW. 1 hit.
    [Graphical view]
    SMARTiSM00264. BAG. 1 hit.
    SM00456. WW. 1 hit.
    [Graphical view]
    SUPFAMiSSF51045. SSF51045. 1 hit.
    PROSITEiPS51035. BAG. 1 hit.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JLV1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAATQSPMM QMASGNGASD RDPLPPGWEI KIDPQTGWPF FVDHNSRTTT    50
    WNDPRVPPEG PKDTASSANG PSRDGSRLLP IREGHPIYPQ LRPGYIPIPV 100
    LHEGSENRQP HLFHAYSQPG VQRFRTEAAA ATPQRSQSPL RGGMTEAAQT 150
    DKQCGQMPAT ATTAAAQPPT AHGPERSQSP AASDCSSSSS SASLPSSGRS 200
    SLGSHQLPRG YIPIPVIHEQ NITRPAAQPS FHQAQKTHYP AQQGEYQPQQ 250
    PVYHKIQGDD WEPRPLRAAS PFRSPVRGAS SREGSPARSG TPVHCPSPIR 300
    VHTVVDRPQP MTHREPPPVT QPENKPESKP GPAGPDLPPG HIPIQVIRRE 350
    ADSKPVSQKS PPPAEKVEVK VSSAPIPCPS PSPAPSAVPS PPKNVAAEQK 400
    AAPSPAPAEP AAPKSGEAET PPKHPGVLKV EAILEKVQGL EQAVDSFEGK 450
    KTDKKYLMIE EYLTKELLAL DSVDPEGRAD VRQARRDGVR KVQTILEKLE 500
    QKAIDVPGQV QVYELQPSNL EAEQPLQEIM GAVVADKDKK GPENKDPQTE 550
    SQQLEAKAAT PPNPSNPADS AGNLVAP 577
    Length:577
    Mass (Da):61,860
    Last modified:July 27, 2011 - v2
    Checksum:i7BBF296A4A2EF7E3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti74 – 741D → N in AAF26840. (PubMed:10597216)Curated
    Sequence conflicti527 – 5271Q → P in AAF26840. (PubMed:10597216)Curated
    Sequence conflicti539 – 5391K → E in BAA95066. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF130471 mRNA. Translation: AAF26840.1.
    AB041583 mRNA. Translation: BAA95066.1.
    AK007414 mRNA. Translation: BAB25024.1.
    AK016510 mRNA. Translation: BAB30278.1.
    AK036675 mRNA. Translation: BAC29531.1.
    CH466531 Genomic DNA. Translation: EDL17651.1.
    CCDSiCCDS21898.1.
    RefSeqiNP_038891.4. NM_013863.5.
    UniGeneiMm.84073.

    Genome annotation databases

    EnsembliENSMUST00000033136; ENSMUSP00000033136; ENSMUSG00000030847.
    GeneIDi29810.
    KEGGimmu:29810.
    UCSCiuc009jzb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF130471 mRNA. Translation: AAF26840.1 .
    AB041583 mRNA. Translation: BAA95066.1 .
    AK007414 mRNA. Translation: BAB25024.1 .
    AK016510 mRNA. Translation: BAB30278.1 .
    AK036675 mRNA. Translation: BAC29531.1 .
    CH466531 Genomic DNA. Translation: EDL17651.1 .
    CCDSi CCDS21898.1.
    RefSeqi NP_038891.4. NM_013863.5.
    UniGenei Mm.84073.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1UK5 NMR - A 406-503 [» ]
    ProteinModelPortali Q9JLV1.
    SMRi Q9JLV1. Positions 18-57, 401-503.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 205891. 6 interactions.
    IntActi Q9JLV1. 4 interactions.
    MINTi MINT-4124913.

    PTM databases

    PhosphoSitei Q9JLV1.

    Proteomic databases

    MaxQBi Q9JLV1.
    PaxDbi Q9JLV1.
    PRIDEi Q9JLV1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033136 ; ENSMUSP00000033136 ; ENSMUSG00000030847 .
    GeneIDi 29810.
    KEGGi mmu:29810.
    UCSCi uc009jzb.2. mouse.

    Organism-specific databases

    CTDi 9531.
    MGIi MGI:1352493. Bag3.

    Phylogenomic databases

    eggNOGi NOG238690.
    GeneTreei ENSGT00530000063256.
    HOGENOMi HOG000050234.
    HOVERGENi HBG003419.
    InParanoidi Q9CQL3.
    KOi K09557.
    OMAi VYPQLRP.
    OrthoDBi EOG75B85S.
    TreeFami TF102013.

    Miscellaneous databases

    EvolutionaryTracei Q9JLV1.
    NextBioi 306958.
    PROi Q9JLV1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JLV1.
    CleanExi MM_BAG3.
    Genevestigatori Q9JLV1.

    Family and domain databases

    Gene3Di 1.20.58.120. 1 hit.
    InterProi IPR003103. BAG_domain.
    IPR001202. WW_dom.
    [Graphical view ]
    Pfami PF02179. BAG. 1 hit.
    PF00397. WW. 1 hit.
    [Graphical view ]
    SMARTi SM00264. BAG. 1 hit.
    SM00456. WW. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51045. SSF51045. 1 hit.
    PROSITEi PS51035. BAG. 1 hit.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death."
      Lee J.H., Takahashi T., Yasuhara N., Inazawa J., Kamada S., Tsujimoto Y.
      Oncogene 18:6183-6190(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
      Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone, Pancreas and Testis.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-297 AND SER-390, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "Solution structure of the murine BAG domain of Bcl2-associated athanogene 3."
      RIKEN structural genomics initiative (RSGI)
      Submitted (FEB-2004) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 404-503.

    Entry informationi

    Entry nameiBAG3_MOUSE
    AccessioniPrimary (citable) accession number: Q9JLV1
    Secondary accession number(s): Q9CQL3, Q9JJC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3