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Q9JLV1 (BAG3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BAG family molecular chaperone regulator 3

Short name=BAG-3
Alternative name(s):
Bcl-2-associated athanogene 3
Bcl-2-binding protein Bis
Gene names
Name:Bag3
Synonyms:Bis
ORF Names:MNCb-2243
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length577 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.

Subunit structure

Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to Bcl-2 and PLC-gamma By similarity. Interacts with DNAJB6 By similarity.

Sequence similarities

Contains 1 BAG domain.

Contains 2 WW domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 577576BAG family molecular chaperone regulator 3
PRO_0000088869

Regions

Domain22 – 5635WW 1
Domain126 – 15732WW 2
Domain426 – 50378BAG
Compositional bias186 – 1938Poly-Ser

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue2041Phosphoserine By similarity
Modified residue2801Phosphoserine By similarity
Modified residue2811Phosphoserine By similarity
Modified residue2851Phosphoserine By similarity
Modified residue2911Phosphothreonine By similarity
Modified residue2971Phosphoserine Ref.5
Modified residue3821Phosphoserine By similarity
Modified residue3901Phosphoserine Ref.5

Experimental info

Sequence conflict741D → N in AAF26840. Ref.1
Sequence conflict5271Q → P in AAF26840. Ref.1
Sequence conflict5391K → E in BAA95066. Ref.2

Secondary structure

.......... 577
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9JLV1 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 7BBF296A4A2EF7E3

FASTA57761,860
        10         20         30         40         50         60 
MSAATQSPMM QMASGNGASD RDPLPPGWEI KIDPQTGWPF FVDHNSRTTT WNDPRVPPEG 

        70         80         90        100        110        120 
PKDTASSANG PSRDGSRLLP IREGHPIYPQ LRPGYIPIPV LHEGSENRQP HLFHAYSQPG 

       130        140        150        160        170        180 
VQRFRTEAAA ATPQRSQSPL RGGMTEAAQT DKQCGQMPAT ATTAAAQPPT AHGPERSQSP 

       190        200        210        220        230        240 
AASDCSSSSS SASLPSSGRS SLGSHQLPRG YIPIPVIHEQ NITRPAAQPS FHQAQKTHYP 

       250        260        270        280        290        300 
AQQGEYQPQQ PVYHKIQGDD WEPRPLRAAS PFRSPVRGAS SREGSPARSG TPVHCPSPIR 

       310        320        330        340        350        360 
VHTVVDRPQP MTHREPPPVT QPENKPESKP GPAGPDLPPG HIPIQVIRRE ADSKPVSQKS 

       370        380        390        400        410        420 
PPPAEKVEVK VSSAPIPCPS PSPAPSAVPS PPKNVAAEQK AAPSPAPAEP AAPKSGEAET 

       430        440        450        460        470        480 
PPKHPGVLKV EAILEKVQGL EQAVDSFEGK KTDKKYLMIE EYLTKELLAL DSVDPEGRAD 

       490        500        510        520        530        540 
VRQARRDGVR KVQTILEKLE QKAIDVPGQV QVYELQPSNL EAEQPLQEIM GAVVADKDKK 

       550        560        570 
GPENKDPQTE SQQLEAKAAT PPNPSNPADS AGNLVAP 

« Hide

References

« Hide 'large scale' references
[1]"Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death."
Lee J.H., Takahashi T., Yasuhara N., Inazawa J., Kamada S., Tsujimoto Y.
Oncogene 18:6183-6190(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone, Pancreas and Testis.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-297 AND SER-390, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[6]"Solution structure of the murine BAG domain of Bcl2-associated athanogene 3."
RIKEN structural genomics initiative (RSGI)
Submitted (FEB-2004) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 404-503.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF130471 mRNA. Translation: AAF26840.1.
AB041583 mRNA. Translation: BAA95066.1.
AK007414 mRNA. Translation: BAB25024.1.
AK016510 mRNA. Translation: BAB30278.1.
AK036675 mRNA. Translation: BAC29531.1.
CH466531 Genomic DNA. Translation: EDL17651.1.
CCDSCCDS21898.1.
RefSeqNP_038891.4. NM_013863.5.
UniGeneMm.84073.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1UK5NMR-A406-503[»]
ProteinModelPortalQ9JLV1.
SMRQ9JLV1. Positions 18-57, 401-503.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid205891. 6 interactions.
IntActQ9JLV1. 4 interactions.
MINTMINT-4124913.

PTM databases

PhosphoSiteQ9JLV1.

Proteomic databases

MaxQBQ9JLV1.
PaxDbQ9JLV1.
PRIDEQ9JLV1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033136; ENSMUSP00000033136; ENSMUSG00000030847.
GeneID29810.
KEGGmmu:29810.
UCSCuc009jzb.2. mouse.

Organism-specific databases

CTD9531.
MGIMGI:1352493. Bag3.

Phylogenomic databases

eggNOGNOG238690.
GeneTreeENSGT00530000063256.
HOGENOMHOG000050234.
HOVERGENHBG003419.
InParanoidQ9CQL3.
KOK09557.
OMAVYPQLRP.
OrthoDBEOG75B85S.
TreeFamTF102013.

Gene expression databases

BgeeQ9JLV1.
CleanExMM_BAG3.
GenevestigatorQ9JLV1.

Family and domain databases

Gene3D1.20.58.120. 1 hit.
InterProIPR003103. BAG_domain.
IPR001202. WW_dom.
[Graphical view]
PfamPF02179. BAG. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTSM00264. BAG. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMSSF51045. SSF51045. 1 hit.
PROSITEPS51035. BAG. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9JLV1.
NextBio306958.
PROQ9JLV1.
SOURCESearch...

Entry information

Entry nameBAG3_MOUSE
AccessionPrimary (citable) accession number: Q9JLV1
Secondary accession number(s): Q9CQL3, Q9JJC7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot