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Protein

BAG family molecular chaperone regulator 3

Gene

Bag3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 3
Short name:
BAG-3
Alternative name(s):
Bcl-2-associated athanogene 3
Bcl-2-binding protein Bis
Gene namesi
Name:Bag3
Synonyms:Bis
ORF Names:MNCb-2243
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1352493 Bag3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000888692 – 577BAG family molecular chaperone regulator 3Add BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei138PhosphoserineCombined sources1
Modified residuei141Omega-N-methylarginineCombined sources1
Modified residuei179PhosphoserineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei267Omega-N-methylarginineCombined sources1
Modified residuei280PhosphoserineBy similarity1
Modified residuei281PhosphoserineBy similarity1
Modified residuei285PhosphoserineBy similarity1
Modified residuei291PhosphothreonineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei380PhosphoserineCombined sources1
Modified residuei382PhosphoserineCombined sources1
Modified residuei390PhosphoserineCombined sources1
Cross-linki450Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki450Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9JLV1
PaxDbiQ9JLV1
PRIDEiQ9JLV1

PTM databases

iPTMnetiQ9JLV1
PhosphoSitePlusiQ9JLV1
SwissPalmiQ9JLV1

Expressioni

Gene expression databases

BgeeiENSMUSG00000030847
CleanExiMM_BAG3
GenevisibleiQ9JLV1 MM

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP70/HSC70 chaperones. Interacts with BCL2. Interacts with phospholipase C-gamma proteins. Interacts with DNAJB6. Interacts (via BAG domain) with HSF1; this interaction occurs in normal and heat-shocked cells. Interacts with HSPA8 (via NBD), HSPA1A (via NBD) and HSPA1B (via NBD). Interacts (via WW domain 1) with SYNPO2 (via PPPY motif).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EBNA-LPQ8AZK72EBI-309231,EBI-1185167From Epstein-Barr virus (strain B95-8).

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205891, 7 interactors
IntActiQ9JLV1, 6 interactors
MINTiQ9JLV1
STRINGi10090.ENSMUSP00000033136

Structurei

Secondary structure

1577
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi417 – 420Combined sources4
Helixi425 – 445Combined sources21
Beta strandi451 – 453Combined sources3
Helixi454 – 471Combined sources18
Helixi479 – 503Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UK5NMR-A406-503[»]
ProteinModelPortaliQ9JLV1
SMRiQ9JLV1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9JLV1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 56WW 1PROSITE-ProRule annotationAdd BLAST35
Domaini126 – 157WW 2PROSITE-ProRule annotationAdd BLAST32
Domaini426 – 503BAGPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi186 – 193Poly-Ser8

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0940 Eukaryota
KOG4361 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00530000063256
HOGENOMiHOG000050234
HOVERGENiHBG003419
InParanoidiQ9JLV1
KOiK09557
OMAiQTGWPFF
OrthoDBiEOG091G08LY
TreeFamiTF102013

Family and domain databases

CDDicd00201 WW, 1 hit
Gene3Di1.20.58.120, 1 hit
InterProiView protein in InterPro
IPR036533 BAG_dom_sf
IPR003103 BAG_domain
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF02179 BAG, 1 hit
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00264 BAG, 1 hit
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
SSF63491 SSF63491, 1 hit
PROSITEiView protein in PROSITE
PS51035 BAG, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAATQSPMM QMASGNGASD RDPLPPGWEI KIDPQTGWPF FVDHNSRTTT
60 70 80 90 100
WNDPRVPPEG PKDTASSANG PSRDGSRLLP IREGHPIYPQ LRPGYIPIPV
110 120 130 140 150
LHEGSENRQP HLFHAYSQPG VQRFRTEAAA ATPQRSQSPL RGGMTEAAQT
160 170 180 190 200
DKQCGQMPAT ATTAAAQPPT AHGPERSQSP AASDCSSSSS SASLPSSGRS
210 220 230 240 250
SLGSHQLPRG YIPIPVIHEQ NITRPAAQPS FHQAQKTHYP AQQGEYQPQQ
260 270 280 290 300
PVYHKIQGDD WEPRPLRAAS PFRSPVRGAS SREGSPARSG TPVHCPSPIR
310 320 330 340 350
VHTVVDRPQP MTHREPPPVT QPENKPESKP GPAGPDLPPG HIPIQVIRRE
360 370 380 390 400
ADSKPVSQKS PPPAEKVEVK VSSAPIPCPS PSPAPSAVPS PPKNVAAEQK
410 420 430 440 450
AAPSPAPAEP AAPKSGEAET PPKHPGVLKV EAILEKVQGL EQAVDSFEGK
460 470 480 490 500
KTDKKYLMIE EYLTKELLAL DSVDPEGRAD VRQARRDGVR KVQTILEKLE
510 520 530 540 550
QKAIDVPGQV QVYELQPSNL EAEQPLQEIM GAVVADKDKK GPENKDPQTE
560 570
SQQLEAKAAT PPNPSNPADS AGNLVAP
Length:577
Mass (Da):61,860
Last modified:July 27, 2011 - v2
Checksum:i7BBF296A4A2EF7E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74D → N in AAF26840 (PubMed:10597216).Curated1
Sequence conflicti527Q → P in AAF26840 (PubMed:10597216).Curated1
Sequence conflicti539K → E in BAA95066 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130471 mRNA Translation: AAF26840.1
AB041583 mRNA Translation: BAA95066.1
AK007414 mRNA Translation: BAB25024.1
AK016510 mRNA Translation: BAB30278.1
AK036675 mRNA Translation: BAC29531.1
CH466531 Genomic DNA Translation: EDL17651.1
CCDSiCCDS21898.1
RefSeqiNP_038891.4, NM_013863.5
UniGeneiMm.84073

Genome annotation databases

EnsembliENSMUST00000033136; ENSMUSP00000033136; ENSMUSG00000030847
GeneIDi29810
KEGGimmu:29810
UCSCiuc009jzb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiBAG3_MOUSE
AccessioniPrimary (citable) accession number: Q9JLV1
Secondary accession number(s): Q9CQL3, Q9JJC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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