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Protein

Retinal homeobox protein Rx

Gene

Rax

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi137 – 196HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal homeobox protein Rx
Alternative name(s):
Retina and anterior neural fold homeobox protein
Gene namesi
Name:Rax
Synonyms:Rx
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620371 Rax

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000134931 – 342Retinal homeobox protein RxAdd BLAST342

Proteomic databases

PaxDbiQ9JLT7
PRIDEiQ9JLT7

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022785

Structurei

3D structure databases

ProteinModelPortaliQ9JLT7
SMRiQ9JLT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 40Octapeptide motif8
Motifi319 – 332OARPROSITE-ProRule annotationAdd BLAST14
Motifi325 – 329Nuclear localization signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi276 – 279Poly-Pro4

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
HOGENOMiHOG000231518
HOVERGENiHBG021349
InParanoidiQ9JLT7
KOiK09332
PhylomeDBiQ9JLT7

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform Long (identifier: Q9JLT7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHLPGCPPAM ADGSFSLAGH LLRSPGGSTS RLHSIEAILG FTKEDGILDT
60 70 80 90 100
FPAERSSRGS KERDPRLGAR SACPKAPAGG SESSPPAAPG LVPEFEATRP
110 120 130 140 150
CYPKEQGEAR PSPGLPVGPA AGDSKLSEEE EPPKKKHRRN RTTFTTYQLH
160 170 180 190 200
ELERAFEKSH YPDVYSREEL AGKVNLPEVR VQVWFQNRRA KWRRQEKLEV
210 220 230 240 250
SSMKLQDSPL LSFSRSPPSS ALAPLGGPGS GSGPPGSALP LEPWLGPPLP
260 270 280 290 300
GGGATALQSL PGFGPPGQGL PASYTPPPPF LNSAPLGPGL QQLGPPPAYP
310 320 330 340
CAPAFGDKFS LEEAYPRNSS IAALRLKAKE HIQAIGKPWQ AL
Length:342
Mass (Da):36,337
Last modified:October 1, 2000 - v1
Checksum:i03CD1F495EE64EC3
GO
Isoform Short (identifier: Q9JLT7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Show »
Length:333
Mass (Da):35,433
Checksum:i2EC25BCC77B35356
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0188061 – 9Missing in isoform Short. Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320225, AF320224 Genomic DNA Translation: AAK07422.1
AF320225, AF320224 Genomic DNA Translation: AAK07423.1
AF135839 mRNA Translation: AAF61631.1
RefSeqiNP_446130.1, NM_053678.1 [Q9JLT7-1]
UniGeneiRn.87955

Genome annotation databases

GeneIDi114213
KEGGirno:114213
UCSCiRGD:620371 rat [Q9JLT7-1]

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiRX_RAT
AccessioniPrimary (citable) accession number: Q9JLT7
Secondary accession number(s): Q99PA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health