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Protein

Retinal homeobox protein Rx

Gene

Rax

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi137 – 196HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal homeobox protein Rx
Alternative name(s):
Retina and anterior neural fold homeobox protein
Gene namesi
Name:Rax
Synonyms:Rx
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620371. Rax.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000134931 – 342Retinal homeobox protein RxAdd BLAST342

Proteomic databases

PaxDbiQ9JLT7.
PRIDEiQ9JLT7.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022785.

Structurei

3D structure databases

ProteinModelPortaliQ9JLT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 40Octapeptide motif8
Motifi319 – 332OARPROSITE-ProRule annotationAdd BLAST14
Motifi325 – 329Nuclear localization signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi276 – 279Poly-Pro4

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000231518.
HOVERGENiHBG021349.
InParanoidiQ9JLT7.
KOiK09332.
PhylomeDBiQ9JLT7.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
IPR032967. Rx.
[Graphical view]
PANTHERiPTHR24329:SF302. PTHR24329:SF302. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform Long (identifier: Q9JLT7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHLPGCPPAM ADGSFSLAGH LLRSPGGSTS RLHSIEAILG FTKEDGILDT
60 70 80 90 100
FPAERSSRGS KERDPRLGAR SACPKAPAGG SESSPPAAPG LVPEFEATRP
110 120 130 140 150
CYPKEQGEAR PSPGLPVGPA AGDSKLSEEE EPPKKKHRRN RTTFTTYQLH
160 170 180 190 200
ELERAFEKSH YPDVYSREEL AGKVNLPEVR VQVWFQNRRA KWRRQEKLEV
210 220 230 240 250
SSMKLQDSPL LSFSRSPPSS ALAPLGGPGS GSGPPGSALP LEPWLGPPLP
260 270 280 290 300
GGGATALQSL PGFGPPGQGL PASYTPPPPF LNSAPLGPGL QQLGPPPAYP
310 320 330 340
CAPAFGDKFS LEEAYPRNSS IAALRLKAKE HIQAIGKPWQ AL
Length:342
Mass (Da):36,337
Last modified:October 1, 2000 - v1
Checksum:i03CD1F495EE64EC3
GO
Isoform Short (identifier: Q9JLT7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Show »
Length:333
Mass (Da):35,433
Checksum:i2EC25BCC77B35356
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0188061 – 9Missing in isoform Short. Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320225, AF320224 Genomic DNA. Translation: AAK07422.1.
AF320225, AF320224 Genomic DNA. Translation: AAK07423.1.
AF135839 mRNA. Translation: AAF61631.1.
RefSeqiNP_446130.1. NM_053678.1. [Q9JLT7-1]
UniGeneiRn.87955.

Genome annotation databases

GeneIDi114213.
KEGGirno:114213.
UCSCiRGD:620371. rat. [Q9JLT7-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320225, AF320224 Genomic DNA. Translation: AAK07422.1.
AF320225, AF320224 Genomic DNA. Translation: AAK07423.1.
AF135839 mRNA. Translation: AAF61631.1.
RefSeqiNP_446130.1. NM_053678.1. [Q9JLT7-1]
UniGeneiRn.87955.

3D structure databases

ProteinModelPortaliQ9JLT7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022785.

Proteomic databases

PaxDbiQ9JLT7.
PRIDEiQ9JLT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114213.
KEGGirno:114213.
UCSCiRGD:620371. rat. [Q9JLT7-1]

Organism-specific databases

CTDi30062.
RGDi620371. Rax.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000231518.
HOVERGENiHBG021349.
InParanoidiQ9JLT7.
KOiK09332.
PhylomeDBiQ9JLT7.

Miscellaneous databases

PROiQ9JLT7.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
IPR032967. Rx.
[Graphical view]
PANTHERiPTHR24329:SF302. PTHR24329:SF302. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRX_RAT
AccessioniPrimary (citable) accession number: Q9JLT7
Secondary accession number(s): Q99PA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: October 5, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.