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Protein

BH3-interacting domain death agonist

Gene

Bid

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-RNO-111447 Activation of BAD and translocation to mitochondria
R-RNO-111452 Activation and oligomerization of BAK protein
R-RNO-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-RNO-114294 Activation, translocation and oligomerization of BAX
R-RNO-75108 Activation, myristolyation of BID and translocation to mitochondria

Names & Taxonomyi

Protein namesi
Recommended name:
BH3-interacting domain death agonist
Alternative name(s):
p22 BID
Short name:
BID
Cleaved into the following 3 chains:
Alternative name(s):
p15 BID
Alternative name(s):
p13 BID
Alternative name(s):
p11 BID
Gene namesi
Name:Bid
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620160 Bid

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002233691 – 196BH3-interacting domain death agonistAdd BLAST196
ChainiPRO_000022337061 – 196BH3-interacting domain death agonist p15By similarityAdd BLAST136
ChainiPRO_000022337177 – 196BH3-interacting domain death agonist p13By similarityAdd BLAST120
ChainiPRO_0000223372100 – 196BH3-interacting domain death agonist p11By similarityAdd BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei79PhosphoserineCombined sources1

Post-translational modificationi

TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.By similarity
p15 BID is ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei60 – 61CleavageBy similarity2
Sitei76 – 77CleavageBy similarity2
Sitei99 – 100CleavageBy similarity2

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9JLT6
PRIDEiQ9JLT6

PTM databases

iPTMnetiQ9JLT6
PhosphoSitePlusiQ9JLT6

Expressioni

Gene expression databases

BgeeiENSRNOG00000012439
ExpressionAtlasiQ9JLT6 baseline and differential
GenevisibleiQ9JLT6 RN

Interactioni

Subunit structurei

Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2. p15 BID interacts with ITCH.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9JLT6, 1 interactor
MINTiQ9JLT6
STRINGi10116.ENSRNOP00000016776

Structurei

3D structure databases

ProteinModelPortaliQ9JLT6
SMRiQ9JLT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi87 – 101BH3By similarityAdd BLAST15

Domaini

Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.

Phylogenomic databases

eggNOGiENOG410IVZ7 Eukaryota
ENOG410ZF8F LUCA
GeneTreeiENSGT00390000002868
HOGENOMiHOG000010016
HOVERGENiHBG001703
InParanoidiQ9JLT6
KOiK04726
OMAiRDVFRTT
OrthoDBiEOG091G0LRX
PhylomeDBiQ9JLT6
TreeFamiTF102047

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR020728 Bcl2_BH3_motif_CS
IPR010479 BID
IPR036834 Blc2-like_sf
PANTHERiPTHR35447 PTHR35447, 1 hit
PfamiView protein in Pfam
PF06393 BID, 1 hit
PIRSFiPIRSF038018 BID, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS01259 BH3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSEVSNGSG LGAEHITNLL VFGFLRNNDR DFHQELEVLG QELPVQVYLE
60 70 80 90 100
GDREDELQTD GSRASRSFYH GRIEPDSESQ DEVIHNIARH LAQAGDELDH
110 120 130 140 150
SIQPTLVRQL AAQFMNGSLS EEDKRNCLAK ALDEVKTSFP RDMENDKAML
160 170 180 190
IMTMLLAKKV ASHAPSLLRD VFRTTVNFIN QNLFSYVRDL VRNEMD
Length:196
Mass (Da):22,249
Last modified:February 21, 2006 - v2
Checksum:iC5F6AD2F5D9B52E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176V → A in AAF61422 (Ref. 2) Curated1
Sequence conflicti185S → F in AAF61422 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF259503 mRNA Translation: AAF71759.1
AF136282 mRNA Translation: AAF61422.1
RefSeqiNP_073175.1, NM_022684.1
XP_017448369.1, XM_017592880.1
UniGeneiRn.31142

Genome annotation databases

EnsembliENSRNOT00000016776; ENSRNOP00000016776; ENSRNOG00000012439
GeneIDi64625
KEGGirno:64625
UCSCiRGD:620160 rat

Similar proteinsi

Entry informationi

Entry nameiBID_RAT
AccessioniPrimary (citable) accession number: Q9JLT6
Secondary accession number(s): Q9JK60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 21, 2006
Last modified: May 23, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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