Q9JLT5 (Q9JLT5_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
WFS1 EMBL AAF61423.1

Gene names

Name:

Wfs1 EMBL AAF61423.1 RGD 68954

Organism

Rattus norvegicus (Rat) EMBL AAF61423.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	890 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	ER-associated protein catabolic process Inferred from sequence or structural similarity. Source: BHF-UCL endoplasmic reticulum calcium ion homeostasis Inferred from sequence or structural similarity. Source: BHF-UCL endoplasmic reticulum unfolded protein response Inferred from sequence or structural similarity. Source: BHF-UCL glucose homeostasis Inferred from sequence or structural similarity. Source: BHF-UCL kidney development Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of neuron apoptotic process Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity. Source: BHF-UCL olfactory behavior Inferred from expression pattern PubMed 11958857. Source: RGD polyubiquitinated misfolded protein transport Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of calcium ion transport Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of growth Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of protein ubiquitination Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of proteolysis Inferred from sequence or structural similarity. Source: BHF-UCL protein stabilization Inferred from sequence or structural similarity. Source: BHF-UCL renal water homeostasis Inferred from sequence or structural similarity. Source: BHF-UCL sensory perception of sound Inferred from sequence or structural similarity. Source: BHF-UCL visual perception Inferred from sequence or structural similarity. Source: BHF-UCL
Cellular_component	dendrite Inferred from direct assay Ref.1. Source: BHF-UCL integral to endoplasmic reticulum membrane Inferred from sequence or structural similarity. Source: BHF-UCL
Molecular_function	ATPase binding Inferred from sequence or structural similarity. Source: BHF-UCL activating transcription factor binding Inferred from sequence or structural similarity. Source: BHF-UCL calcium-dependent protein binding Inferred from mutant phenotype PubMed 19292454. Source: RGD calmodulin binding Inferred from mutant phenotype PubMed 19292454. Source: RGD transporter activity Inferred from sequence or structural similarity. Source: BHF-UCL ubiquitin protein ligase binding Inferred from sequence or structural similarity. Source: BHF-UCL
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9JLT5 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 657BE51019D9065B	FASTA	890	100,533
	10 20 30 40 50 60 MSSGTPPPSP SGPPPPPAPQ PQARARLNAT TSLEQDKIEP PRAPRPQPDS SAGRSAGEAT 70 80 90 100 110 120 TPEPRAPHAS SREGTDKAGP MKADVEIPFE EILEKAKAGD PKAQTEVGKH YLRLANDADE 130 140 150 160 170 180 ELNSCSAVAW LILAAKQGRR EAVKLLRRCL ADRKGITSEN EAEVKQLSSE TDLERAVRKA 190 200 210 220 230 240 ALVMYWKLNP KKKKQVAVSE LLENVGQVNE QDGGAQPGPV PKSLQKQRRM LERLVSSESK 250 260 270 280 290 300 NYIALDDFVE LTKKYAKGII PNNLFLQDED EDEDELSGKS PEDLPLRQKV VKYPLHAIME 310 320 330 340 350 360 IKEYLIDVAS KAGMHWLSTI VPTHHINALI FFFIISNLTI DFFAFFIPLV VFYLSFVSMV 370 380 390 400 410 420 ICTLKVFQDS KAWENFRTLT DLLLRFEPNL DVEQAEVNFG WNHLEPYIHF LLSVVFVIFS 430 440 450 460 470 480 FPLASKDCIP CSELAVVSAF FTVTSYMSLS SSAEPYTRRA LVTEVAAGLL SLLPTMPVDW 490 500 510 520 530 540 PFLKALGQTF FTVPIGHFII LNVSLPCLLY VYLFYLFFRM AQLRNFKGTY CYLVPYLVCF 550 560 570 580 590 600 MWCELSVVIL LQSTGLGLVR ASIGYFLFLF ALPILVAGLA LMGTVQFARW FLSLDLTKIM 610 620 630 640 650 660 VTTVICSVPL LFRWWTKANF SVVGMVKSLT RSSIVKLILV WLTAILLFCW FYVYRSEGMK 670 680 690 700 710 720 VYNSTLTWQQ YGFLCGPRAW KETNMARTQI LCSHLEGHRV TWTGRFKYVR VTEIDNSAES 730 740 750 760 770 780 AINMLPFFLG DWMRCLYGEA YPSCSSGNTS TAEEELCRLK QLAKHPCHIK KFDRYKFEIT 790 800 810 820 830 840 VGMPFGTNGN RGHEEDDITK DIVLRASSEF KDVLLNLRQG SLIEFSTILE GRLGSKWPVF 850 860 870 880 890 ELKAISCLNC MTQLSPARRH VKIEQDWRST VHGALKFAFD FFFFPFLSAA

References

[1]	"WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain." Takeda K., Inoue H., Tanizawa Y., Matsuzaki Y., Oba J., Watanabe Y., Shinoda K., Oka Y. Hum. Mol. Genet. 10:477-484(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Pancreas EMBL AAF61423.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF136378 mRNA. Translation: AAF61423.1.
IPI	IPI00204055.
RefSeq	NP_114011.1. NM_031823.1.
UniGene	Rn.229139.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000032218. Q9JLT5.
PTM databases
PhosphoSite	Q9JLT5.
Proteomic databases
PaxDb	Q9JLT5.
PRIDE	Q9JLT5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	83725.
KEGG	rno:83725.
Organism-specific databases
CTD	7466.
RGD	68954. Wfs1.
Phylogenomic databases
eggNOG	NOG82472.
HOGENOM	HOG000132944.
HOVERGEN	HBG014957.
InParanoid	Q9JLT5.
KO	K14020.
OrthoDB	EOG44BB1V.
Gene expression databases
ArrayExpress	Q9JLT5.
Genevestigator	Q9JLT5.
Family and domain databases
InterPro	IPR026208. Wolframin. IPR026209. Wolframin_fam. [Graphical view]
PANTHER	PTHR13098. PTHR13098. 1 hit.
PRINTS	PR02060. WOLFFAMILY. PR02061. WOLFRAMIN.
ProtoNet	Search...
Other
NextBio	616309.

Entry information

Entry name

Q9JLT5_RAT

Accession

Primary (citable) accession number: Q9JLT5

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)