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Protein

Trehalase

Gene

Treh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.

Catalytic activityi

Alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei165SubstrateBy similarity1
Binding sitei209SubstrateBy similarity1
Binding sitei316Substrate; via carbonyl oxygenBy similarity1
Active sitei318Proton donor/acceptorBy similarity1
Active sitei511Proton donor/acceptorBy similarity1
Binding sitei526SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH37 Glycoside Hydrolase Family 37

Names & Taxonomyi

Protein namesi
Recommended name:
Trehalase (EC:3.2.1.28)
Alternative name(s):
Alpha,alpha-trehalase
Alpha,alpha-trehalose glucohydrolase
Gene namesi
Name:Treh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1926230 Treh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001205321 – 553TrehalaseAdd BLAST533
PropeptideiPRO_0000012054554 – 576Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi366N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi553GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ9JLT2
PaxDbiQ9JLT2
PeptideAtlasiQ9JLT2
PRIDEiQ9JLT2

PTM databases

iPTMnetiQ9JLT2
PhosphoSitePlusiQ9JLT2

Expressioni

Gene expression databases

BgeeiENSMUSG00000032098
CleanExiMM_TREH
ExpressionAtlasiQ9JLT2 baseline and differential
GenevisibleiQ9JLT2 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034609

Structurei

3D structure databases

ProteinModelPortaliQ9JLT2
SMRiQ9JLT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni172 – 173Substrate bindingBy similarity2
Regioni218 – 220Substrate bindingBy similarity3
Regioni283 – 285Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the glycosyl hydrolase 37 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0602 Eukaryota
COG1626 LUCA
GeneTreeiENSGT00390000006949
HOGENOMiHOG000215465
HOVERGENiHBG014956
InParanoidiQ9JLT2
KOiK01194
OMAiKYDISNG
OrthoDBiEOG091G0341
PhylomeDBiQ9JLT2
TreeFamiTF314239

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR001661 Glyco_hydro_37
IPR018232 Glyco_hydro_37_CS
PANTHERiPTHR23403 PTHR23403, 1 hit
PfamiView protein in Pfam
PF01204 Trehalase, 1 hit
PRINTSiPR00744 GLHYDRLASE37
SUPFAMiSSF48208 SSF48208, 1 hit
PROSITEiView protein in PROSITE
PS00927 TREHALASE_1, 1 hit
PS00928 TREHALASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWELHLLLL LGLGLRSQEA LPPPCESQIY CHGELLHQVQ MAQLYQDDKQ
60 70 80 90 100
FVDMSLATSP DEVLQKFSEL ATVHNHSIPK EQLQEFVQSH FQPVGQELQS
110 120 130 140 150
WTPEDWKDSP QFLQKISDAN LRVWAEELHK IWKKLGKKMK AEVLSYPERS
160 170 180 190 200
SLIYSKHPFI VPGGRFVEFY YWDSYWVMEG LLLSEMASTV KGMLQNFLDL
210 220 230 240 250
VKTYGHIPNG GRIYYLQRSQ PPLLTLMMDR YVAHTKDVAF LQENIGTLAS
260 270 280 290 300
ELDFWTVNRT VSVVSGGQSY VLNRYYVPYG GPRPESYRKD AELANSVPEG
310 320 330 340 350
DRETLWAELK AGAESGWDFS SRWLVGGPDP DLLSSIRTSK MVPADLNAFL
360 370 380 390 400
CQAEELMSNF YSRLGNDTEA TKYRNLRAQR LAAMEAVLWD EQKGAWFDYD
410 420 430 440 450
LEKGKKNLEF YPSNLSPLWA GCFSDPSVAD KALKYLEDSK ILTYQYGIPT
460 470 480 490 500
SLRNTGQQWD FPNAWAPLQD LVIRGLAKSA SPRTQEVAFQ LAQNWIKTNF
510 520 530 540 550
KVYSQKSAMF EKYDISNGGH PGGGGEYEVQ EGFGWTNGLA LMLLDRYGDQ
560 570
LTSGTQLASL GPHCLVAALL LSLLLQ
Length:576
Mass (Da):65,401
Last modified:October 1, 2000 - v1
Checksum:i53CDA6A10511520E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82Q → R in AAK97631 (PubMed:11404018).Curated1
Sequence conflicti416S → T in AAK97631 (PubMed:11404018).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136944 mRNA Translation: AAF61430.1
AK008912 mRNA Translation: BAB25963.1
AF404760 Genomic DNA Translation: AAK97631.1
CCDSiCCDS23117.1
RefSeqiNP_067456.1, NM_021481.3
UniGeneiMm.45380

Genome annotation databases

EnsembliENSMUST00000034609; ENSMUSP00000034609; ENSMUSG00000032098
GeneIDi58866
KEGGimmu:58866
UCSCiuc009pec.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTREA_MOUSE
AccessioniPrimary (citable) accession number: Q9JLT2
Secondary accession number(s): Q91ZS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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