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Protein

Trehalase

Gene

Treh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.

Catalytic activityi

Alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei165SubstrateBy similarity1
Binding sitei209SubstrateBy similarity1
Binding sitei316Substrate; via carbonyl oxygenBy similarity1
Active sitei318Proton donor/acceptorBy similarity1
Active sitei511Proton donor/acceptorBy similarity1
Binding sitei526SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH37. Glycoside Hydrolase Family 37.

Names & Taxonomyi

Protein namesi
Recommended name:
Trehalase (EC:3.2.1.28)
Alternative name(s):
Alpha,alpha-trehalase
Alpha,alpha-trehalose glucohydrolase
Gene namesi
Name:Treh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1926230. Treh.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • brush border Source: MGI
  • extracellular exosome Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001205321 – 553TrehalaseAdd BLAST533
PropeptideiPRO_0000012054554 – 576Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi258N-linked (GlcNAc...)Sequence analysis1
Glycosylationi366N-linked (GlcNAc...)Sequence analysis1
Lipidationi553GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ9JLT2.
PaxDbiQ9JLT2.
PeptideAtlasiQ9JLT2.
PRIDEiQ9JLT2.

PTM databases

iPTMnetiQ9JLT2.
PhosphoSitePlusiQ9JLT2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032098.
CleanExiMM_TREH.
ExpressionAtlasiQ9JLT2. baseline and differential.
GenevisibleiQ9JLT2. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034609.

Structurei

3D structure databases

ProteinModelPortaliQ9JLT2.
SMRiQ9JLT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni172 – 173Substrate bindingBy similarity2
Regioni218 – 220Substrate bindingBy similarity3
Regioni283 – 285Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the glycosyl hydrolase 37 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0602. Eukaryota.
COG1626. LUCA.
GeneTreeiENSGT00390000006949.
HOGENOMiHOG000215465.
HOVERGENiHBG014956.
InParanoidiQ9JLT2.
KOiK01194.
OMAiWAGQLHQ.
OrthoDBiEOG091G0341.
PhylomeDBiQ9JLT2.
TreeFamiTF314239.

Family and domain databases

InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR001661. Glyco_hydro_37.
IPR018232. Glyco_hydro_37_CS.
[Graphical view]
PANTHERiPTHR23403. PTHR23403. 1 hit.
PfamiPF01204. Trehalase. 1 hit.
[Graphical view]
PRINTSiPR00744. GLHYDRLASE37.
SUPFAMiSSF48208. SSF48208. 1 hit.
PROSITEiPS00927. TREHALASE_1. 1 hit.
PS00928. TREHALASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWELHLLLL LGLGLRSQEA LPPPCESQIY CHGELLHQVQ MAQLYQDDKQ
60 70 80 90 100
FVDMSLATSP DEVLQKFSEL ATVHNHSIPK EQLQEFVQSH FQPVGQELQS
110 120 130 140 150
WTPEDWKDSP QFLQKISDAN LRVWAEELHK IWKKLGKKMK AEVLSYPERS
160 170 180 190 200
SLIYSKHPFI VPGGRFVEFY YWDSYWVMEG LLLSEMASTV KGMLQNFLDL
210 220 230 240 250
VKTYGHIPNG GRIYYLQRSQ PPLLTLMMDR YVAHTKDVAF LQENIGTLAS
260 270 280 290 300
ELDFWTVNRT VSVVSGGQSY VLNRYYVPYG GPRPESYRKD AELANSVPEG
310 320 330 340 350
DRETLWAELK AGAESGWDFS SRWLVGGPDP DLLSSIRTSK MVPADLNAFL
360 370 380 390 400
CQAEELMSNF YSRLGNDTEA TKYRNLRAQR LAAMEAVLWD EQKGAWFDYD
410 420 430 440 450
LEKGKKNLEF YPSNLSPLWA GCFSDPSVAD KALKYLEDSK ILTYQYGIPT
460 470 480 490 500
SLRNTGQQWD FPNAWAPLQD LVIRGLAKSA SPRTQEVAFQ LAQNWIKTNF
510 520 530 540 550
KVYSQKSAMF EKYDISNGGH PGGGGEYEVQ EGFGWTNGLA LMLLDRYGDQ
560 570
LTSGTQLASL GPHCLVAALL LSLLLQ
Length:576
Mass (Da):65,401
Last modified:October 1, 2000 - v1
Checksum:i53CDA6A10511520E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82Q → R in AAK97631 (PubMed:11404018).Curated1
Sequence conflicti416S → T in AAK97631 (PubMed:11404018).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136944 mRNA. Translation: AAF61430.1.
AK008912 mRNA. Translation: BAB25963.1.
AF404760 Genomic DNA. Translation: AAK97631.1.
CCDSiCCDS23117.1.
RefSeqiNP_067456.1. NM_021481.3.
UniGeneiMm.45380.

Genome annotation databases

EnsembliENSMUST00000034609; ENSMUSP00000034609; ENSMUSG00000032098.
GeneIDi58866.
KEGGimmu:58866.
UCSCiuc009pec.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136944 mRNA. Translation: AAF61430.1.
AK008912 mRNA. Translation: BAB25963.1.
AF404760 Genomic DNA. Translation: AAK97631.1.
CCDSiCCDS23117.1.
RefSeqiNP_067456.1. NM_021481.3.
UniGeneiMm.45380.

3D structure databases

ProteinModelPortaliQ9JLT2.
SMRiQ9JLT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034609.

Protein family/group databases

CAZyiGH37. Glycoside Hydrolase Family 37.

PTM databases

iPTMnetiQ9JLT2.
PhosphoSitePlusiQ9JLT2.

Proteomic databases

MaxQBiQ9JLT2.
PaxDbiQ9JLT2.
PeptideAtlasiQ9JLT2.
PRIDEiQ9JLT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034609; ENSMUSP00000034609; ENSMUSG00000032098.
GeneIDi58866.
KEGGimmu:58866.
UCSCiuc009pec.2. mouse.

Organism-specific databases

CTDi11181.
MGIiMGI:1926230. Treh.

Phylogenomic databases

eggNOGiKOG0602. Eukaryota.
COG1626. LUCA.
GeneTreeiENSGT00390000006949.
HOGENOMiHOG000215465.
HOVERGENiHBG014956.
InParanoidiQ9JLT2.
KOiK01194.
OMAiWAGQLHQ.
OrthoDBiEOG091G0341.
PhylomeDBiQ9JLT2.
TreeFamiTF314239.

Miscellaneous databases

PROiQ9JLT2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032098.
CleanExiMM_TREH.
ExpressionAtlasiQ9JLT2. baseline and differential.
GenevisibleiQ9JLT2. MM.

Family and domain databases

InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR001661. Glyco_hydro_37.
IPR018232. Glyco_hydro_37_CS.
[Graphical view]
PANTHERiPTHR23403. PTHR23403. 1 hit.
PfamiPF01204. Trehalase. 1 hit.
[Graphical view]
PRINTSiPR00744. GLHYDRLASE37.
SUPFAMiSSF48208. SSF48208. 1 hit.
PROSITEiPS00927. TREHALASE_1. 1 hit.
PS00928. TREHALASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTREA_MOUSE
AccessioniPrimary (citable) accession number: Q9JLT2
Secondary accession number(s): Q91ZS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.