UniProtKB - Q9JLS4 (SFRP4_RAT)
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Protein
Secreted frizzled-related protein 4
Gene
Sfrp4
Organism
Rattus norvegicus (Rat)
Status
Functioni
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis (By similarity). May also act as a regulator of adult uterine morphology and function (PubMed:12063187). May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (PubMed:12960062). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity).2 PublicationsBy similarity
GO - Molecular functioni
- G-protein coupled receptor activity Source: GO_Central
- Wnt-activated receptor activity Source: GO_Central
- Wnt-protein binding Source: RGD
GO - Biological processi
- bone morphogenesis Source: UniProtKB
- cell differentiation Source: UniProtKB-KW
- decidualization Source: RGD
- female pregnancy Source: RGD
- mammary gland involution Source: RGD
- negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
- negative regulation of cell proliferation Source: RGD
- negative regulation of DNA binding transcription factor activity Source: RGD
- negative regulation of JNK cascade Source: RGD
- negative regulation of non-canonical Wnt signaling pathway Source: UniProtKB
- negative regulation of sodium-dependent phosphate transport Source: RGD
- non-canonical Wnt signaling pathway Source: GO_Central
- phosphate ion homeostasis Source: RGD
- positive regulation of apoptotic process Source: RGD
- positive regulation of canonical Wnt signaling pathway Source: RGD
- positive regulation of epidermal cell differentiation Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of keratinocyte apoptotic process Source: RGD
- positive regulation of receptor internalization Source: RGD
- regulation of BMP signaling pathway Source: UniProtKB
- response to estradiol Source: RGD
- response to glucocorticoid Source: RGD
- response to peptide hormone Source: RGD
- Wnt signaling pathway Source: RGD
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Wnt signaling pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Secreted frizzled-related protein 4Short name: sFRP-4 Alternative name(s): DDC-4 protein |
Gene namesi | Name:Sfrp4 Synonyms:Ddc4, Frp |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621075. Sfrp4. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000032553 | 19 – 348 | Secreted frizzled-related protein 4Add BLAST | 330 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 24 ↔ 85 | By similarity | ||
Disulfide bondi | 32 ↔ 78 | By similarity | ||
Glycosylationi | 38 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 68 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 69 ↔ 108 | By similarity | ||
Disulfide bondi | 97 ↔ 136 | By similarity | ||
Disulfide bondi | 101 ↔ 125 | By similarity | ||
Glycosylationi | 116 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 194 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 240 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9JLS4. |
PTM databases
CarbonylDBi | Q9JLS4. |
Expressioni
Tissue specificityi
Expressed in the involuting mammary gland, ovarian corpus luteum and prostate. In ovaries, low levels found in granulosa cells. High levels in corpora lutea of pregnant animals.1 Publication
Developmental stagei
Expressed from day 9 of pregnant uterus. Highest level at day 12, specifically in the decidua and weakly, in the myometrium. Levels decline thereafter.1 Publication
Inductioni
Up-regulated 48 hours after estrogen treatment mainly in the uterine endometrial stroma (PubMed:12063187). Induced in ovarian granulosa cells after 12 hours treatment with chorionic gonadotrophin (CG). Further up-regulated in corpora lutea by the luteotrophic hormone PRL (PubMed:12960062).2 Publications
Interactioni
GO - Molecular functioni
- Wnt-protein binding Source: RGD
Protein-protein interaction databases
IntActi | Q9JLS4. 1 interactor. |
STRINGi | 10116.ENSRNOP00000025645. |
Structurei
3D structure databases
ProteinModelPortali | Q9JLS4. |
SMRi | Q9JLS4. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 139 | FZPROSITE-ProRule annotationAdd BLAST | 121 | |
Domaini | 178 – 296 | NTRPROSITE-ProRule annotationAdd BLAST | 119 |
Domaini
The FZ domain is involved in binding with Wnt ligands.By similarity
Sequence similaritiesi
Belongs to the secreted frizzled-related protein (sFRP) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3577. Eukaryota. ENOG410XRC8. LUCA. |
HOGENOMi | HOG000231879. |
HOVERGENi | HBG070536. |
InParanoidi | Q9JLS4. |
KOi | K02185. |
PhylomeDBi | Q9JLS4. |
Family and domain databases
Gene3Di | 1.10.2000.10. 1 hit. |
InterProi | View protein in InterPro IPR015526. Frizzled/SFRP. IPR020067. Frizzled_dom. IPR036790. Frizzled_dom_sf. IPR001134. Netrin_domain. IPR018933. Netrin_module_non-TIMP. IPR026560. SFRP4. IPR008993. TIMP-like_OB-fold. |
PANTHERi | PTHR11309. PTHR11309. 1 hit. PTHR11309:SF7. PTHR11309:SF7. 1 hit. |
Pfami | View protein in Pfam PF01392. Fz. 1 hit. PF01759. NTR. 1 hit. |
SMARTi | View protein in SMART SM00643. C345C. 1 hit. SM00063. FRI. 1 hit. |
SUPFAMi | SSF50242. SSF50242. 1 hit. SSF63501. SSF63501. 1 hit. |
PROSITEi | View protein in PROSITE PS50038. FZ. 1 hit. PS50189. NTR. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9JLS4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLSILVALC LCVRLALGVR GAPCEAVRIP MCRHMPWNIT RMPNHLHHST
60 70 80 90 100
QENAILAIEQ YEELVDVNCS SVLRFFLCAM YAPICTLEFL HDPIKPCKSV
110 120 130 140 150
CQRARDDCEP LMKMYNHSWP ESLACDELPV YDRGVCISPE AIVTDLPEDV
160 170 180 190 200
KWIDITPDMM VQERSFDADC KHLSPDRCKC KKVKPTLATY LSKNYSYVIH
210 220 230 240 250
AKIKAVQRSG CNEVTTVVDV KEIFKSSSPI PRTQVPLITN SSCQCPHILP
260 270 280 290 300
HQDVLIMCYE RRSRMMLLEN CLVEKWRDQL SRRSTQWEER LQEQQRTTQD
310 320 330 340
KKQIASRTSR SNPPKPKGRS PASKPASPKK NIKARSAPKK SNPKKSTS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 – 13 | CV → WL in AAF66480 (PubMed:11485313).Curated | 2 | |
Sequence conflicti | 12 – 13 | CV → WL in AAF66481 (PubMed:11485313).Curated | 2 | |
Sequence conflicti | 59 | E → G in AAF66480 (PubMed:11485313).Curated | 1 | |
Sequence conflicti | 74 | R → S in AAF66480 (PubMed:11485313).Curated | 1 | |
Sequence conflicti | 74 | R → S in AAF66481 (PubMed:11485313).Curated | 1 | |
Sequence conflicti | 101 | C → S in AAF66481 (PubMed:11485313).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF012891 mRNA. Translation: AAB65431.1. AF140346 mRNA. Translation: AAF66480.1. AF140347 Genomic DNA. Translation: AAF66481.1. |
PIRi | JC7735. |
RefSeqi | NP_445996.1. NM_053544.1. |
UniGenei | Rn.10788. |
Genome annotation databases
GeneIDi | 89803. |
KEGGi | rno:89803. |
UCSCi | RGD:621075. rat. |
Similar proteinsi
Entry informationi
Entry namei | SFRP4_RAT | |
Accessioni | Q9JLS4Primary (citable) accession number: Q9JLS4 Secondary accession number(s): O35222, Q9JLS5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | March 15, 2005 | |
Last modified: | February 28, 2018 | |
This is version 108 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |