Sfrp4

Functionⁱ

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity).By similarity

GO - Molecular functionⁱ

G-protein coupled receptor activity Source: GO_Central
Wnt-activated receptor activity Source: GO_Central
Wnt-protein binding
Source: RGD
Inferred from physical interactionⁱ
- 18567805

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
decidualization
Source: RGD
Inferred from expression patternⁱ
- 12063187
female pregnancy
Source: RGD
Inferred from expression patternⁱ
- 16540541
mammary gland involution
Source: RGD
Inferred from expression patternⁱ
- 9409757
negative regulation of canonical Wnt signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 12952927
negative regulation of cell proliferation
Source: RGD
Inferred from direct assayⁱ
- 18567805
negative regulation of JNK cascade
Source: RGD
Inferred from direct assayⁱ
- 18567805
non-canonical Wnt signaling pathway Source: GO_Central
response to estradiol
Source: RGD
Inferred from expression patternⁱ
- 12063187
response to glucocorticoid
Source: RGD
Inferred from expression patternⁱ
- 16540541
response to peptide hormone
Source: RGD
Inferred from expression patternⁱ
- 12960062
Wnt signaling pathway
Source: RGD
Traceable author statementⁱ
- 12063187

Complete GO annotation...

Keywords - Molecular functionⁱ

Developmental protein

Keywords - Biological processⁱ

Differentiation, Wnt signaling pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Secreted frizzled-related protein 4 Short name: sFRP-4 Alternative name(s): DDC-4 protein
Gene namesⁱ	Name:Sfrp4 Synonyms:Ddc4, Frp
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

RGDⁱ	621075. Sfrp4.

Subcellular locationⁱ

Secreted By similarity

GO - Cellular componentⁱ

cytoplasm
Source: RGD
Inferred from direct assayⁱ
- 12960062
extracellular space
Source: RGD
Inferred from direct assayⁱ
- 12960062
integral component of membrane Source: GO_Central

Complete GO annotation...

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Signal peptideⁱ	1 – 18	18	Sequence analysis			Add BLAST
Chainⁱ	19 – 348	330	Secreted frizzled-related protein 4		PRO_0000032553	Add BLAST

Amino acid modifications

Feature key	Position(s)	Length	Description
Disulfide bondⁱ	24 ↔ 85		By similarity
Disulfide bondⁱ	32 ↔ 78		By similarity
Glycosylationⁱ	38 – 38	1	N-linked (GlcNAc...)Sequence analysis
Glycosylationⁱ	68 – 68	1	N-linked (GlcNAc...)Sequence analysis
Disulfide bondⁱ	69 ↔ 108		By similarity
Disulfide bondⁱ	97 ↔ 136		By similarity
Disulfide bondⁱ	101 ↔ 125		By similarity
Glycosylationⁱ	116 – 116	1	N-linked (GlcNAc...)Sequence analysis
Glycosylationⁱ	194 – 194	1	N-linked (GlcNAc...)Sequence analysis
Glycosylationⁱ	240 – 240	1	N-linked (GlcNAc...)Sequence analysis

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q9JLS4.
PRIDEⁱ	Q9JLS4.

Expressionⁱ

Tissue specificityⁱ

Expressed in the involuting mammary gland, ovarian corpus luteum and prostate. In ovaries, low levels found in granulosa cells. High levels in corpora lutea of pregnant animals.1 Publication

Developmental stageⁱ

Expressed from day 9 of pregnant uterus. Highest level at day 12, specifically in the decidua and weakly, in the myometrium. Levels decline thereafter.1 Publication

Inductionⁱ

Up-regulated 48 hours after estrogen treatment mainly in the uterine endometrial stroma. Induced in ovarian granulosa cells after 12 hours treatment with chorionic gonadotrophin (CG). Further up-regulated in corpora lutea by the luteotrophic hormone PRL.1 Publication

Interactionⁱ

GO - Molecular functionⁱ

Wnt-protein binding
Source: RGD
Inferred from physical interactionⁱ
- 18567805

Protein-protein interaction databases

IntActⁱ	Q9JLS4. 1 interaction.
STRINGⁱ	10116.ENSRNOP00000025645.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9JLS4.
SMRⁱ	Q9JLS4. Positions 22-144.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Domainⁱ	19 – 139	121	FZPROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00090			Add BLAST
Domainⁱ	178 – 296	119	NTRPROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00295			Add BLAST

Domainⁱ

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesⁱ

Belongs to the secreted frizzled-related protein (sFRP) family.Curated

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

Contains 1 NTR domain.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3577. Eukaryota. ENOG410XRC8. LUCA.
HOGENOMⁱ	HOG000231879.
HOVERGENⁱ	HBG070536.
InParanoidⁱ	Q9JLS4.
KOⁱ	K02185.
PhylomeDBⁱ	Q9JLS4.

Family and domain databases

Gene3Dⁱ	1.10.2000.10. 1 hit.
InterProⁱ	IPR015526. Frizzled/SFRP. IPR020067. Frizzled_dom. IPR001134. Netrin_domain. IPR018933. Netrin_module_non-TIMP. IPR026560. SFRP4. IPR008993. TIMP-like_OB-fold. [Graphical view]
PANTHERⁱ	PTHR11309. PTHR11309. 1 hit. PTHR11309:SF7. PTHR11309:SF7. 1 hit.
Pfamⁱ	PF01392. Fz. 1 hit. PF01759. NTR. 1 hit. [Graphical view]
SMARTⁱ	SM00643. C345C. 1 hit. SM00063. FRI. 1 hit. [Graphical view]
SUPFAMⁱ	SSF50242. SSF50242. 1 hit. SSF63501. SSF63501. 1 hit.
PROSITEⁱ	PS50038. FZ. 1 hit. PS50189. NTR. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9JLS4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLSILVALC LCVRLALGVR GAPCEAVRIP MCRHMPWNIT RMPNHLHHST 
        60         70         80         90        100
QENAILAIEQ YEELVDVNCS SVLRFFLCAM YAPICTLEFL HDPIKPCKSV 
       110        120        130        140        150
CQRARDDCEP LMKMYNHSWP ESLACDELPV YDRGVCISPE AIVTDLPEDV 
       160        170        180        190        200
KWIDITPDMM VQERSFDADC KHLSPDRCKC KKVKPTLATY LSKNYSYVIH 
       210        220        230        240        250
AKIKAVQRSG CNEVTTVVDV KEIFKSSSPI PRTQVPLITN SSCQCPHILP 
       260        270        280        290        300
HQDVLIMCYE RRSRMMLLEN CLVEKWRDQL SRRSTQWEER LQEQQRTTQD 
       310        320        330        340 
KKQIASRTSR SNPPKPKGRS PASKPASPKK NIKARSAPKK SNPKKSTS

Length:348

Mass (Da):39,762

Last modified:March 15, 2005 - v2

Checksum:ⁱ08A0F0E3B80561CF

GO

Experimental Info

Feature key	Position(s)	Length	Description
Sequence conflictⁱ	12 – 13	2	CV → WL in AAF66480 (PubMed:11485313).Curated
Sequence conflictⁱ	12 – 13	2	CV → WL in AAF66481 (PubMed:11485313).Curated
Sequence conflictⁱ	59 – 59	1	E → G in AAF66480 (PubMed:11485313).Curated
Sequence conflictⁱ	74 – 74	1	R → S in AAF66480 (PubMed:11485313).Curated
Sequence conflictⁱ	74 – 74	1	R → S in AAF66481 (PubMed:11485313).Curated
Sequence conflictⁱ	101 – 101	1	C → S in AAF66481 (PubMed:11485313).Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF012891 mRNA. Translation: AAB65431.1. AF140346 mRNA. Translation: AAF66480.1. AF140347 Genomic DNA. Translation: AAF66481.1.
PIRⁱ	JC7735.
RefSeqⁱ	NP_445996.1. NM_053544.1.
UniGeneⁱ	Rn.10788.

Genome annotation databases

GeneIDⁱ	89803.
KEGGⁱ	rno:89803.
UCSCⁱ	RGD:621075. rat.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF012891 mRNA. Translation: AAB65431.1. AF140346 mRNA. Translation: AAF66480.1. AF140347 Genomic DNA. Translation: AAF66481.1.
PIRⁱ	JC7735.
RefSeqⁱ	NP_445996.1. NM_053544.1.
UniGeneⁱ	Rn.10788.

3D structure databases

ProteinModelPortalⁱ	Q9JLS4.
SMRⁱ	Q9JLS4. Positions 22-144.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q9JLS4. 1 interaction.
STRINGⁱ	10116.ENSRNOP00000025645.

Proteomic databases

PaxDbⁱ	Q9JLS4.
PRIDEⁱ	Q9JLS4.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	89803.
KEGGⁱ	rno:89803.
UCSCⁱ	RGD:621075. rat.

Organism-specific databases

CTDⁱ	6424.
RGDⁱ	621075. Sfrp4.

Phylogenomic databases

eggNOGⁱ	KOG3577. Eukaryota. ENOG410XRC8. LUCA.
HOGENOMⁱ	HOG000231879.
HOVERGENⁱ	HBG070536.
InParanoidⁱ	Q9JLS4.
KOⁱ	K02185.
PhylomeDBⁱ	Q9JLS4.

Miscellaneous databases

PROⁱ	Q9JLS4.

PROⁱ

Q9JLS4.

Family and domain databases

Gene3Dⁱ	1.10.2000.10. 1 hit.
InterProⁱ	IPR015526. Frizzled/SFRP. IPR020067. Frizzled_dom. IPR001134. Netrin_domain. IPR018933. Netrin_module_non-TIMP. IPR026560. SFRP4. IPR008993. TIMP-like_OB-fold. [Graphical view]
PANTHERⁱ	PTHR11309. PTHR11309. 1 hit. PTHR11309:SF7. PTHR11309:SF7. 1 hit.
Pfamⁱ	PF01392. Fz. 1 hit. PF01759. NTR. 1 hit. [Graphical view]
SMARTⁱ	SM00643. C345C. 1 hit. SM00063. FRI. 1 hit. [Graphical view]
SUPFAMⁱ	SSF50242. SSF50242. 1 hit. SSF63501. SSF63501. 1 hit.
PROSITEⁱ	PS50038. FZ. 1 hit. PS50189. NTR. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

SFRP4_RAT

Accessionⁱ

Primary (citable) accession number: Q9JLS4
Secondary accession number(s): O35222, Q9JLS5

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	July 6, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9JLS4 (SFRP4_RAT)

UniProt

Q9JLS4 - SFRP4_RAT

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Secreted frizzled-related protein 4

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ