Sfrp4

Functionⁱ

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis (By similarity). May also act as a regulator of adult uterine morphology and function (PubMed:12063187). May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (PubMed:12960062). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity).2 PublicationsBy similarity

GO - Molecular functionⁱ

G-protein coupled receptor activity Source: GO_Central
Wnt-activated receptor activity Source: GO_Central
Wnt-protein binding
Source: RGD
Inferred from physical interactionⁱ
- 18567805

Complete GO annotation...

GO - Biological processⁱ

bone morphogenesis Source: UniProtKB
cell differentiation Source: UniProtKB-KW
decidualization
Source: RGD
Inferred from expression patternⁱ
- 12063187
female pregnancy
Source: RGD
Inferred from expression patternⁱ
- 16540541
mammary gland involution
Source: RGD
Inferred from expression patternⁱ
- 9409757
negative regulation of canonical Wnt signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 12952927
negative regulation of cell proliferation
Source: RGD
Inferred from direct assayⁱ
- 18567805
negative regulation of JNK cascade
Source: RGD
Inferred from direct assayⁱ
- 18567805
negative regulation of non-canonical Wnt signaling pathway Source: UniProtKB
non-canonical Wnt signaling pathway Source: GO_Central
regulation of BMP signaling pathway Source: UniProtKB
response to estradiol
Source: RGD
Inferred from expression patternⁱ
- 12063187
response to glucocorticoid
Source: RGD
Inferred from expression patternⁱ
- 16540541
response to peptide hormone
Source: RGD
Inferred from expression patternⁱ
- 12960062
Wnt signaling pathway
Source: RGD
Traceable author statementⁱ
- 12063187

Complete GO annotation...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Differentiation, Wnt signaling pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Secreted frizzled-related protein 4 Short name: sFRP-4 Alternative name(s): DDC-4 protein
Gene namesⁱ	Name:Sfrp4 Synonyms:Ddc4, Frp
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	621075. Sfrp4.

RGDⁱ

621075. Sfrp4.

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST		18
ChainⁱPRO_0000032553	19 – 348	Secreted frizzled-related protein 4Add BLAST		330

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	24 ↔ 85	By similarity
Disulfide bondⁱ	32 ↔ 78	By similarity
Glycosylationⁱ	38	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	68	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	69 ↔ 108	By similarity
Disulfide bondⁱ	97 ↔ 136	By similarity
Disulfide bondⁱ	101 ↔ 125	By similarity
Glycosylationⁱ	116	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	194	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	240	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q9JLS4.

PaxDbⁱ

Q9JLS4.

Expressionⁱ

Tissue specificityⁱ

Expressed in the involuting mammary gland, ovarian corpus luteum and prostate. In ovaries, low levels found in granulosa cells. High levels in corpora lutea of pregnant animals.1 Publication

Developmental stageⁱ

Expressed from day 9 of pregnant uterus. Highest level at day 12, specifically in the decidua and weakly, in the myometrium. Levels decline thereafter.1 Publication

Inductionⁱ

Up-regulated 48 hours after estrogen treatment mainly in the uterine endometrial stroma (PubMed:12063187). Induced in ovarian granulosa cells after 12 hours treatment with chorionic gonadotrophin (CG). Further up-regulated in corpora lutea by the luteotrophic hormone PRL (PubMed:12960062).2 Publications

Interactionⁱ

GO - Molecular functionⁱ

Wnt-protein binding
Source: RGD
Inferred from physical interactionⁱ
- 18567805

Complete GO annotation...

Protein-protein interaction databases

IntActⁱ	Q9JLS4. 1 interactor.
STRINGⁱ	10116.ENSRNOP00000025645.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9JLS4.
SMRⁱ	Q9JLS4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	19 – 139	FZPROSITE-ProRule annotationAdd BLAST		121
Domainⁱ	178 – 296	NTRPROSITE-ProRule annotationAdd BLAST		119

Domainⁱ

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesⁱ

Belongs to the secreted frizzled-related protein (sFRP) family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3577. Eukaryota. ENOG410XRC8. LUCA.
HOGENOMⁱ	HOG000231879.
HOVERGENⁱ	HBG070536.
InParanoidⁱ	Q9JLS4.
KEGG Orthology (KO) More...KOⁱ	K02185.
PhylomeDBⁱ	Q9JLS4.

Family and domain databases

InterProⁱ	View protein in InterPro IPR015526. Frizzled/SFRP. IPR020067. Frizzled_dom. IPR001134. Netrin_domain. IPR018933. Netrin_module_non-TIMP. IPR026560. SFRP4. IPR008993. TIMP-like_OB-fold.
PANTHERⁱ	PTHR11309. PTHR11309. 1 hit. PTHR11309:SF99. PTHR11309:SF99. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01392. Fz. 1 hit. PF01759. NTR. 1 hit.
SMARTⁱ	View protein in SMART SM00643. C345C. 1 hit. SM00063. FRI. 1 hit.
SUPFAMⁱ	SSF50242. SSF50242. 1 hit. SSF63501. SSF63501. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50038. FZ. 1 hit. PS50189. NTR. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9JLS4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLSILVALC LCVRLALGVR GAPCEAVRIP MCRHMPWNIT RMPNHLHHST 
        60         70         80         90        100
QENAILAIEQ YEELVDVNCS SVLRFFLCAM YAPICTLEFL HDPIKPCKSV 
       110        120        130        140        150
CQRARDDCEP LMKMYNHSWP ESLACDELPV YDRGVCISPE AIVTDLPEDV 
       160        170        180        190        200
KWIDITPDMM VQERSFDADC KHLSPDRCKC KKVKPTLATY LSKNYSYVIH 
       210        220        230        240        250
AKIKAVQRSG CNEVTTVVDV KEIFKSSSPI PRTQVPLITN SSCQCPHILP 
       260        270        280        290        300
HQDVLIMCYE RRSRMMLLEN CLVEKWRDQL SRRSTQWEER LQEQQRTTQD 
       310        320        330        340 
KKQIASRTSR SNPPKPKGRS PASKPASPKK NIKARSAPKK SNPKKSTS

Length:348

Mass (Da):39,762

Last modified:March 15, 2005 - v2

Checksum:ⁱ08A0F0E3B80561CF

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	12 – 13	CV → WL in AAF66480 (PubMed:11485313).Curated	2
Sequence conflictⁱ	12 – 13	CV → WL in AAF66481 (PubMed:11485313).Curated	2
Sequence conflictⁱ	59	E → G in AAF66480 (PubMed:11485313).Curated	1
Sequence conflictⁱ	74	R → S in AAF66480 (PubMed:11485313).Curated	1
Sequence conflictⁱ	74	R → S in AAF66481 (PubMed:11485313).Curated	1
Sequence conflictⁱ	101	C → S in AAF66481 (PubMed:11485313).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF012891 mRNA. Translation: AAB65431.1. AF140346 mRNA. Translation: AAF66480.1. AF140347 Genomic DNA. Translation: AAF66481.1.
PIRⁱ	JC7735.
NCBI Reference Sequences More...RefSeqⁱ	NP_445996.1. NM_053544.1.
UniGeneⁱ	Rn.10788.

Genome annotation databases

GeneIDⁱ	89803.
KEGGⁱ	rno:89803.
UCSC genome browser More...UCSCⁱ	RGD:621075. rat.

Similar proteinsⁱ

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9JLS4	Q9Z1N6 A0A1Y7VK98 S9XZX5 UPI0003F18C67 UPI0005406909 A0A1A6GDQ1 UPI0002C424D4 UPI0004ECFEE8 A0A1U7Q7I6 G3V8G7 +28	Mus musculus (Mouse) Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus) Chrysochloris asiatica (Cape golden mole) Loxodonta africana (African elephant) Neotoma lepida (Desert woodrat) Trichechus manatus latirostris (Florida manatee) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Mesocricetus auratus (Golden hamster) Rattus norvegicus (Rat) Jaculus jaculus (Lesser Egyptian jerboa) And more	351	UniRef90_Q9Z1N6	Cluster: Secreted frizzled-related sequence protein 4	39

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9JLS4	Q6FHJ7 UPI000020EDC2 UPI00046BB673 UPI0008F4D2AD K7CC23 G3S0Y7 K7CKY8 F7GWG0 G7MLG9 G7P2C5 +139	Homo sapiens (Human) Pan paniscus (Pygmy chimpanzee) (Bonobo) Eptesicus fuscus (Big brown bat) (Vespertilio fuscus) Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Macaca mulatta (Rhesus macaque) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Callithrix jacchus (White-tufted-ear marmoset) Bos mutus (wild yak) Chelonia mydas (Green sea-turtle) (Chelonia agassizi) And more	346	UniRef50_Q6FHJ7	Cluster: Secreted frizzled-related protein 4	150

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF012891 mRNA. Translation: AAB65431.1. AF140346 mRNA. Translation: AAF66480.1. AF140347 Genomic DNA. Translation: AAF66481.1.
PIRⁱ	JC7735.
NCBI Reference Sequences More...RefSeqⁱ	NP_445996.1. NM_053544.1.
UniGeneⁱ	Rn.10788.

3D structure databases

ProteinModelPortalⁱ	Q9JLS4.
SMRⁱ	Q9JLS4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q9JLS4. 1 interactor.
STRINGⁱ	10116.ENSRNOP00000025645.

Proteomic databases

PaxDbⁱ	Q9JLS4.

PaxDbⁱ

Q9JLS4.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	89803.
KEGGⁱ	rno:89803.
UCSC genome browser More...UCSCⁱ	RGD:621075. rat.

Organism-specific databases

CTDⁱ	6424.
Rat genome database More...RGDⁱ	621075. Sfrp4.

Phylogenomic databases

eggNOGⁱ	KOG3577. Eukaryota. ENOG410XRC8. LUCA.
HOGENOMⁱ	HOG000231879.
HOVERGENⁱ	HBG070536.
InParanoidⁱ	Q9JLS4.
KEGG Orthology (KO) More...KOⁱ	K02185.
PhylomeDBⁱ	Q9JLS4.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9JLS4.

PROⁱ

PR:Q9JLS4.

Family and domain databases

InterProⁱ	View protein in InterPro IPR015526. Frizzled/SFRP. IPR020067. Frizzled_dom. IPR001134. Netrin_domain. IPR018933. Netrin_module_non-TIMP. IPR026560. SFRP4. IPR008993. TIMP-like_OB-fold.
PANTHERⁱ	PTHR11309. PTHR11309. 1 hit. PTHR11309:SF99. PTHR11309:SF99. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01392. Fz. 1 hit. PF01759. NTR. 1 hit.
SMARTⁱ	View protein in SMART SM00643. C345C. 1 hit. SM00063. FRI. 1 hit.
SUPFAMⁱ	SSF50242. SSF50242. 1 hit. SSF63501. SSF63501. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50038. FZ. 1 hit. PS50189. NTR. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SFRP4_RAT
Accessionⁱ	Q9JLS4Primary (citable) accession number: Q9JLS4 Secondary accession number(s): O35222, Q9JLS5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
	Last sequence update:	March 15, 2005
	Last modified:	August 30, 2017
	This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

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Proteomes

Annotation systems

Supporting data

UniProtKB - Q9JLS4 (SFRP4_RAT)

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Secreted frizzled-related protein 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ