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Protein

HIG1 domain family member 1A, mitochondrial

Gene

Higd1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity).By similarity

GO - Biological processi

  • cellular response to glucose starvation Source: MGI
  • cellular response to hypoxia Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of release of cytochrome c from mitochondria Source: MGI
  • oxidation-reduction process Source: UniProtKB-KW
  • positive regulation of protein serine/threonine kinase activity Source: MGI

Keywordsi

Biological processElectron transport, Respiratory chain, Stress response, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
HIG1 domain family member 1A, mitochondrial
Alternative name(s):
Hypoxia-inducible gene 1 protein
Gene namesi
Name:Higd1a
Synonyms:Hig1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1930666 Higd1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei69 – 89HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002157712 – 95HIG1 domain family member 1A, mitochondrialAdd BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei8PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9JLR9
MaxQBiQ9JLR9
PaxDbiQ9JLR9
PRIDEiQ9JLR9

PTM databases

iPTMnetiQ9JLR9
PhosphoSitePlusiQ9JLR9

Expressioni

Inductioni

By hypoxia.

Gene expression databases

BgeeiENSMUSG00000038412
CleanExiMM_HIGD1A
ExpressionAtlasiQ9JLR9 baseline and differential
GenevisibleiQ9JLR9 MM

Interactioni

Subunit structurei

Associates with cytochrome c oxidase (COX, complex IV); proposed complex component. Also associates with respiratory chain supercomplexes (By similarity).By similarity

Protein-protein interaction databases

BioGridi207883, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ9JLR9
SMRiQ9JLR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 93HIG1PROSITE-ProRule annotationAdd BLAST92

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4431 Eukaryota
ENOG41121ET LUCA
GeneTreeiENSGT00530000063398
HOGENOMiHOG000234513
HOVERGENiHBG054361
InParanoidiQ9JLR9
OMAiGYSMYQE
OrthoDBiEOG091G166Q
PhylomeDBiQ9JLR9
TreeFamiTF314628

Family and domain databases

InterProiView protein in InterPro
IPR007667 Hypoxia_induced_domain
PfamiView protein in Pfam
PF04588 HIG_1_N, 1 hit
PROSITEiView protein in PROSITE
PS51503 HIG1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTNTDLSLS SYDEGQGSKF IRKAKETPFV PIGMAGFAAI VAYGLYKLKS
60 70 80 90
RGNTKMSIHL IHMRVAAQGF VVGAMTLGMG YSMYQEFWAN PKPKP
Length:95
Mass (Da):10,425
Last modified:October 1, 2000 - v1
Checksum:iB94465D57AB0E3E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141312 mRNA Translation: AAF25721.1
AY028386 mRNA Translation: AAK21982.1
AK004166 mRNA Translation: BAB23202.1
AK008756 mRNA Translation: BAB25877.1
AK018360 mRNA Translation: BAB31176.1
BC021594 mRNA Translation: AAH21594.1
BC090259 mRNA Translation: AAH90259.1
CCDSiCCDS40812.1
RefSeqiNP_062788.1, NM_019814.4
XP_006512264.1, XM_006512201.1
UniGeneiMm.347915
Mm.391698

Genome annotation databases

EnsembliENSMUST00000060251; ENSMUSP00000054881; ENSMUSG00000038412
ENSMUST00000213124; ENSMUSP00000149531; ENSMUSG00000038412
ENSMUST00000215300; ENSMUSP00000150726; ENSMUSG00000038412
GeneIDi56295
KEGGimmu:56295
UCSCiuc009seb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHIG1A_MOUSE
AccessioniPrimary (citable) accession number: Q9JLR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health