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Protein

HIG1 domain family member 1A, mitochondrial

Gene

Higd1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity).By similarity

GO - Biological processi

  • cellular response to glucose starvation Source: MGI
  • cellular response to hypoxia Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of release of cytochrome c from mitochondria Source: MGI
  • oxidation-reduction process Source: UniProtKB-KW
  • positive regulation of protein serine/threonine kinase activity Source: MGI
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Stress response, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
HIG1 domain family member 1A, mitochondrial
Alternative name(s):
Hypoxia-inducible gene 1 protein
Gene namesi
Name:Higd1a
Synonyms:Hig1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1930666. Higd1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei69 – 89HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: CACAO
  • nucleus Source: CACAO
  • protein complex Source: MGI
  • respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002157712 – 95HIG1 domain family member 1A, mitochondrialAdd BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei8PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9JLR9.
MaxQBiQ9JLR9.
PaxDbiQ9JLR9.
PRIDEiQ9JLR9.

PTM databases

iPTMnetiQ9JLR9.
PhosphoSitePlusiQ9JLR9.

Expressioni

Inductioni

By hypoxia.

Gene expression databases

BgeeiENSMUSG00000038412.
CleanExiMM_HIGD1A.
ExpressionAtlasiQ9JLR9. baseline and differential.
GenevisibleiQ9JLR9. MM.

Interactioni

Subunit structurei

Associates with cytochrome c oxidase (COX, complex IV); proposed complex component. Also associates with respiratory chain supercomplexes (By similarity).By similarity

Protein-protein interaction databases

BioGridi207883. 1 interactor.
STRINGi10090.ENSMUSP00000054881.

Structurei

3D structure databases

ProteinModelPortaliQ9JLR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 93HIG1PROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Contains 1 HIG1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4431. Eukaryota.
ENOG41121ET. LUCA.
GeneTreeiENSGT00530000063398.
HOGENOMiHOG000234513.
HOVERGENiHBG054361.
InParanoidiQ9JLR9.
OMAiREYWAKP.
OrthoDBiEOG091G166Q.
PhylomeDBiQ9JLR9.
TreeFamiTF314628.

Family and domain databases

InterProiIPR007667. Hypoxia_induced_domain.
[Graphical view]
PfamiPF04588. HIG_1_N. 1 hit.
[Graphical view]
PROSITEiPS51503. HIG1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTNTDLSLS SYDEGQGSKF IRKAKETPFV PIGMAGFAAI VAYGLYKLKS
60 70 80 90
RGNTKMSIHL IHMRVAAQGF VVGAMTLGMG YSMYQEFWAN PKPKP
Length:95
Mass (Da):10,425
Last modified:October 1, 2000 - v1
Checksum:iB94465D57AB0E3E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141312 mRNA. Translation: AAF25721.1.
AY028386 mRNA. Translation: AAK21982.1.
AK004166 mRNA. Translation: BAB23202.1.
AK008756 mRNA. Translation: BAB25877.1.
AK018360 mRNA. Translation: BAB31176.1.
BC021594 mRNA. Translation: AAH21594.1.
BC090259 mRNA. Translation: AAH90259.1.
CCDSiCCDS40812.1.
RefSeqiNP_062788.1. NM_019814.4.
XP_006512264.1. XM_006512201.1.
UniGeneiMm.347915.

Genome annotation databases

EnsembliENSMUST00000060251; ENSMUSP00000054881; ENSMUSG00000038412.
GeneIDi56295.
KEGGimmu:56295.
UCSCiuc009seb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141312 mRNA. Translation: AAF25721.1.
AY028386 mRNA. Translation: AAK21982.1.
AK004166 mRNA. Translation: BAB23202.1.
AK008756 mRNA. Translation: BAB25877.1.
AK018360 mRNA. Translation: BAB31176.1.
BC021594 mRNA. Translation: AAH21594.1.
BC090259 mRNA. Translation: AAH90259.1.
CCDSiCCDS40812.1.
RefSeqiNP_062788.1. NM_019814.4.
XP_006512264.1. XM_006512201.1.
UniGeneiMm.347915.

3D structure databases

ProteinModelPortaliQ9JLR9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207883. 1 interactor.
STRINGi10090.ENSMUSP00000054881.

PTM databases

iPTMnetiQ9JLR9.
PhosphoSitePlusiQ9JLR9.

Proteomic databases

EPDiQ9JLR9.
MaxQBiQ9JLR9.
PaxDbiQ9JLR9.
PRIDEiQ9JLR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060251; ENSMUSP00000054881; ENSMUSG00000038412.
GeneIDi56295.
KEGGimmu:56295.
UCSCiuc009seb.2. mouse.

Organism-specific databases

CTDi25994.
MGIiMGI:1930666. Higd1a.

Phylogenomic databases

eggNOGiKOG4431. Eukaryota.
ENOG41121ET. LUCA.
GeneTreeiENSGT00530000063398.
HOGENOMiHOG000234513.
HOVERGENiHBG054361.
InParanoidiQ9JLR9.
OMAiREYWAKP.
OrthoDBiEOG091G166Q.
PhylomeDBiQ9JLR9.
TreeFamiTF314628.

Miscellaneous databases

PROiQ9JLR9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038412.
CleanExiMM_HIGD1A.
ExpressionAtlasiQ9JLR9. baseline and differential.
GenevisibleiQ9JLR9. MM.

Family and domain databases

InterProiIPR007667. Hypoxia_induced_domain.
[Graphical view]
PfamiPF04588. HIG_1_N. 1 hit.
[Graphical view]
PROSITEiPS51503. HIG1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHIG1A_MOUSE
AccessioniPrimary (citable) accession number: Q9JLR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.