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Protein

Protein transport protein Sec61 subunit alpha isoform 2

Gene

Sec61a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).By similarity

GO - Molecular functioni

  • ribosome binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit alpha isoform 2
Short name:
Sec61 alpha-2
Gene namesi
Name:Sec61a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1931071. Sec61a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3332CytoplasmicSequence analysisAdd
BLAST
Transmembranei34 – 5320HelicalSequence analysisAdd
BLAST
Topological domaini54 – 7623LumenalSequence analysisAdd
BLAST
Transmembranei77 – 9620HelicalSequence analysisAdd
BLAST
Topological domaini97 – 11721CytoplasmicSequence analysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence analysisAdd
BLAST
Topological domaini139 – 1446LumenalSequence analysis
Transmembranei145 – 16521HelicalSequence analysisAdd
BLAST
Topological domaini166 – 1727CytoplasmicSequence analysis
Transmembranei173 – 19321HelicalSequence analysisAdd
BLAST
Topological domaini194 – 24047LumenalSequence analysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence analysisAdd
BLAST
Topological domaini262 – 28827CytoplasmicSequence analysisAdd
BLAST
Transmembranei289 – 30921HelicalSequence analysisAdd
BLAST
Topological domaini310 – 35445LumenalSequence analysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence analysisAdd
BLAST
Topological domaini376 – 42045CytoplasmicSequence analysisAdd
BLAST
Transmembranei421 – 44121HelicalSequence analysisAdd
BLAST
Topological domaini442 – 4454LumenalSequence analysis
Transmembranei446 – 46217HelicalSequence analysisAdd
BLAST
Topological domaini463 – 47614CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 476475Protein transport protein Sec61 subunit alpha isoform 2PRO_0000131796Add
BLAST

Proteomic databases

EPDiQ9JLR1.
MaxQBiQ9JLR1.
PaxDbiQ9JLR1.
PRIDEiQ9JLR1.

PTM databases

iPTMnetiQ9JLR1.
PhosphoSiteiQ9JLR1.

Expressioni

Gene expression databases

BgeeiQ9JLR1.
CleanExiMM_SEC61A2.
ExpressionAtlasiQ9JLR1. baseline and differential.
GenevisibleiQ9JLR1. MM.

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100046.

Structurei

3D structure databases

ProteinModelPortaliQ9JLR1.
SMRiQ9JLR1. Positions 25-476.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1373. Eukaryota.
COG0201. LUCA.
GeneTreeiENSGT00390000003721.
HOGENOMiHOG000231249.
HOVERGENiHBG055271.
InParanoidiQ9JLR1.
KOiK10956.
OMAiRYIPYVT.
OrthoDBiEOG7BGHKH.
PhylomeDBiQ9JLR1.
TreeFamiTF300348.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIKFLEVIK PFCAVLPEIQ KPERKIQFRE KVLWTAITLF IFLVCCQIPL
60 70 80 90 100
FGIMSSDSAD PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII
110 120 130 140 150
EVGDTPKDRA LFNGAQKLFG MIITIGQAIV YVMTGMYGDP AEMGAGICLL
160 170 180 190 200
IIIQLFVAGL IVLLLDELLQ KGYGLGSGIS LFIATNICET IVWKAFSPTT
210 220 230 240 250
INTGRGTEFE GAVIALFHLL ATRTDKVRAL REAFYRQNLP NLMNLIATVF
260 270 280 290 300
VFAVVIYFQG FRVDLPIKSA RYRGQYSSYP IKLFYTSNIP IILQSALVSN
310 320 330 340 350
LYVISQMLSV RFSGNFLVNL LGQWADVSGG GPARSYPVGG LCYYLSPPES
360 370 380 390 400
MGAIFEDPVH VVVYIIFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV
410 420 430 440 450
MRGHRDTSMV HELNRYIPTA AAFGGLCIGA LSVLADFLGA IGSGTGILLA
460 470
VTIIYQYFEI FVKEQAEVGG MGALFF
Length:476
Mass (Da):52,248
Last modified:January 23, 2007 - v3
Checksum:i87CC8E7D366C2C37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145254 mRNA. Translation: AAF66696.1.
AF222748 mRNA. Translation: AAG44253.1.
AK077701 mRNA. Translation: BAC36967.1.
BC005458 mRNA. Translation: AAH05458.1.
CCDSiCCDS15668.1.
RefSeqiNP_067280.1. NM_021305.3.
UniGeneiMm.21435.

Genome annotation databases

EnsembliENSMUST00000102981; ENSMUSP00000100046; ENSMUSG00000025816.
GeneIDi57743.
KEGGimmu:57743.
UCSCiuc008ifx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145254 mRNA. Translation: AAF66696.1.
AF222748 mRNA. Translation: AAG44253.1.
AK077701 mRNA. Translation: BAC36967.1.
BC005458 mRNA. Translation: AAH05458.1.
CCDSiCCDS15668.1.
RefSeqiNP_067280.1. NM_021305.3.
UniGeneiMm.21435.

3D structure databases

ProteinModelPortaliQ9JLR1.
SMRiQ9JLR1. Positions 25-476.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100046.

PTM databases

iPTMnetiQ9JLR1.
PhosphoSiteiQ9JLR1.

Proteomic databases

EPDiQ9JLR1.
MaxQBiQ9JLR1.
PaxDbiQ9JLR1.
PRIDEiQ9JLR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102981; ENSMUSP00000100046; ENSMUSG00000025816.
GeneIDi57743.
KEGGimmu:57743.
UCSCiuc008ifx.1. mouse.

Organism-specific databases

CTDi55176.
MGIiMGI:1931071. Sec61a2.

Phylogenomic databases

eggNOGiKOG1373. Eukaryota.
COG0201. LUCA.
GeneTreeiENSGT00390000003721.
HOGENOMiHOG000231249.
HOVERGENiHBG055271.
InParanoidiQ9JLR1.
KOiK10956.
OMAiRYIPYVT.
OrthoDBiEOG7BGHKH.
PhylomeDBiQ9JLR1.
TreeFamiTF300348.

Enzyme and pathway databases

ReactomeiR-MMU-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

ChiTaRSiSec61a2. mouse.
PROiQ9JLR1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JLR1.
CleanExiMM_SEC61A2.
ExpressionAtlasiQ9JLR1. baseline and differential.
GenevisibleiQ9JLR1. MM.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sec61 alpha isoforms."
    Finke K., Prehn S., Hartmann E.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiS61A2_MOUSE
AccessioniPrimary (citable) accession number: Q9JLR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.