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Protein

ARF GTPase-activating protein GIT2

Gene

Git2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase-activating protein for the ADP ribosylation factor family.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 34C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • protein-containing complex binding Source: MGI

GO - Biological processi

  • behavioral response to pain Source: MGI

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ARF GTPase-activating protein GIT2
Short name:
ARF GAP GIT2
Alternative name(s):
Cool-interacting tyrosine-phosphorylated protein 2
Short name:
CAT-2
Short name:
CAT2
G protein-coupled receptor kinase-interactor 2
GRK-interacting protein 2
Gene namesi
Name:Git2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1347053 Git2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000742041 – 708ARF GTPase-activating protein GIT2Add BLAST708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei393PhosphoserineCombined sources1
Modified residuei396PhosphoserineCombined sources1
Modified residuei400PhosphothreonineCombined sources1
Modified residuei508PhosphoserineBy similarity1
Modified residuei511PhosphoserineCombined sources1
Modified residuei519PhosphoserineCombined sources1
Modified residuei536PhosphothreonineCombined sources1
Modified residuei563PhosphoserineCombined sources1

Post-translational modificationi

Tyrosine phosphorylated when coexpressed in cells with PTK2/FAK1 and SRC.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JLQ2
MaxQBiQ9JLQ2
PaxDbiQ9JLQ2
PeptideAtlasiQ9JLQ2
PRIDEiQ9JLQ2

PTM databases

iPTMnetiQ9JLQ2
PhosphoSitePlusiQ9JLQ2

Miscellaneous databases

PMAP-CutDBiQ9JLQ2

Expressioni

Gene expression databases

BgeeiENSMUSG00000041890
CleanExiMM_GIT2
ExpressionAtlasiQ9JLQ2 baseline and differential
GenevisibleiQ9JLQ2 MM

Interactioni

Subunit structurei

Interacts with G protein-coupled receptor kinases. Associates with PXN. Also interacts with PIX exchange factors. Identified in a complex with ARHGEF6 and BIN2 (By similarity). Interacts with TGFB1I1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Arhgef7Q9ES286EBI-642860,EBI-642580

Protein-protein interaction databases

BioGridi204983, 4 interactors
IntActiQ9JLQ2, 5 interactors
MINTiQ9JLQ2
STRINGi10090.ENSMUSP00000107803

Structurei

3D structure databases

ProteinModelPortaliQ9JLQ2
SMRiQ9JLQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 124Arf-GAPPROSITE-ProRule annotationAdd BLAST124
Repeati132 – 161ANK 1Add BLAST30
Repeati166 – 195ANK 2Add BLAST30
Repeati199 – 228ANK 3Add BLAST30

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 34C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0818 Eukaryota
ENOG410XR8U LUCA
GeneTreeiENSGT00920000149085
HOGENOMiHOG000232135
HOVERGENiHBG012506
InParanoidiQ9JLQ2
KOiK12487
TreeFamiTF317762

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR022018 GIT1_C
IPR013724 GIT_SHD
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01412 ArfGap, 1 hit
PF12205 GIT1_C, 1 hit
PF08518 GIT_SHD, 2 hits
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00105 ArfGap, 1 hit
SM00555 GIT, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50115 ARFGAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JLQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRLRSSDV CADCNGPDPS WASVNRGTFI CDECCSVHRS LGRHISQVRH
60 70 80 90 100
LKHTAWPPTL LQMVETLYNN GANSIWEHSL LDPASIMSGR RKANPQDKVH
110 120 130 140 150
PNKAEFIRAK YQMLAFVHRL PCREDDSVTA KDLSKQLHSS VRTGNLETCL
160 170 180 190 200
RLLSLGAQAN FFHPEKGSTP LHVASKAGQI LQAELLAVYG ADPGTQDSSG
210 220 230 240 250
KTPVDYARQG GHHELAERLI EIQYELTDRL AFYLCGRKPD HKSGQHFLIP
260 270 280 290 300
QRADSLDLSE LAKAAKKKLQ SLSNHLFEEL AMDVYDEVDR RETDAVWLAT
310 320 330 340 350
QNHSTLVTET TVVPFLPVNP EYSSTRNQGR QKLARFNAHE FATLVIDILS
360 370 380 390 400
DAKRRQQGSP LSRSKDNVEL ILRTVSTQHS TESQDNDQPD YDSVASDEDT
410 420 430 440 450
DVETRASKAN RQKLQTLQSE NSSLRRQATA SACQVQTGSD HKDTASHSSL
460 470 480 490 500
KRRPSARGSR PMSMYETGSG QKPYLPMGEA SHPEESRTRL QPFPTHIGRS
510 520 530 540 550
ALVTSSSSLP SFPSTLSWSR DESARRASRL EKQNSTPESD YDNTACDPEP
560 570 580 590 600
DDTGSTRKGR QRSMLWQGDG LLPDTAEPHS VPSPTLPSTE DVIRKTEQIT
610 620 630 640 650
KNIQELLRAA QENKHDSYIP CSERIHVAVT EMAALFPKKP KSDTVRTSLR
660 670 680 690 700
LLTSSAYRLQ SECRKALPGD SSLPTDVQLV TQQVIQCAYD IAKAAKQLVT

ITTKENSS
Length:708
Mass (Da):78,766
Last modified:July 27, 2011 - v2
Checksum:iB84F4F684182D8CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188V → E in AAF61633 (PubMed:10428811).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148693 mRNA Translation: AAF61633.1
AC087330 Genomic DNA No translation available.
CCDSiCCDS19570.2
RefSeqiNP_062808.3, NM_019834.3
UniGeneiMm.195632

Genome annotation databases

EnsembliENSMUST00000112185; ENSMUSP00000107803; ENSMUSG00000041890
GeneIDi26431
KEGGimmu:26431
UCSCiuc008yzz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGIT2_MOUSE
AccessioniPrimary (citable) accession number: Q9JLQ2
Secondary accession number(s): E9QPU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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