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Protein
Submitted name:

Protein kinase C, zeta

Gene

Prkcz

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein serine/threonine kinase activity Source: Ensembl

GO - Biological processi

  1. microtubule cytoskeleton organization Source: Ensembl
  2. negative regulation of insulin receptor signaling pathway Source: Ensembl
  3. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  4. negative regulation of protein complex assembly Source: Ensembl
  5. neuron projection extension Source: Ensembl
  6. peptidyl-serine phosphorylation Source: Ensembl
  7. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  8. positive regulation of interleukin-10 secretion Source: Ensembl
  9. positive regulation of interleukin-13 secretion Source: Ensembl
  10. positive regulation of interleukin-4 production Source: Ensembl
  11. positive regulation of interleukin-5 secretion Source: Ensembl
  12. positive regulation of T-helper 2 cell cytokine production Source: Ensembl
  13. positive regulation of T-helper 2 cell differentiation Source: Ensembl
  14. protein localization to plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Protein kinase C, zetaImported
Gene namesi
Name:PrkczImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi3399. Prkcz.

Subcellular locationi

GO - Cellular componenti

  1. apical cortex Source: Ensembl
  2. apical plasma membrane Source: Ensembl
  3. axon hillock Source: Ensembl
  4. extracellular vesicular exosome Source: Ensembl
  5. microtubule organizing center Source: Ensembl
  6. myelin sheath abaxonal region Source: Ensembl
  7. nuclear envelope Source: Ensembl
  8. nuclear matrix Source: Ensembl
  9. protein complex Source: Ensembl
  10. tight junction Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ9JLP6. baseline.
GenevestigatoriQ9JLP6.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG104837.

Family and domain databases

InterProiIPR000270. OPR_PB1.
IPR012233. PKC.
[Graphical view]
PANTHERiPTHR24357:SF60. PTHR24357:SF60. 1 hit.
PfamiPF00564. PB1. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9JLP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSRTDPKMD RSGGRVRLKA HYGGDILITS VDPTTTFQDL CEEVRDMCGL
60 70 80 90 100
HQQHPLTLKW VDSEGDPCTV SSQMELEEAF RLACQGRDEV LIIHVFPSIP
110 120 130 140
EQPGMPCPGE DKSIYRRGAR RWRKLYRANG HLFQAKRFNR
Length:140
Mass (Da):16,070
Last modified:September 30, 2000 - v1
Checksum:i51E6B242AB4DE92F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei140 – 1401Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH009282 Genomic DNA. Translation: AAF68171.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH009282 Genomic DNA. Translation: AAF68171.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi3399. Prkcz.

Phylogenomic databases

HOVERGENiHBG104837.

Gene expression databases

ExpressionAtlasiQ9JLP6. baseline.
GenevestigatoriQ9JLP6.

Family and domain databases

InterProiIPR000270. OPR_PB1.
IPR012233. PKC.
[Graphical view]
PANTHERiPTHR24357:SF60. PTHR24357:SF60. 1 hit.
PfamiPF00564. PB1. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The Rat Protein Kinase C Zeta Gene Contains Alternative Promoters for Generation of Dual Transcripts with 5'-end Heterogeneity."
    Marshall B.S., Powell C.T.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.

Entry informationi

Entry nameiQ9JLP6_RAT
AccessioniPrimary (citable) accession number: Q9JLP6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 30, 2000
Last sequence update: September 30, 2000
Last modified: March 31, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.