##gff-version 3 Q9JLN9 UniProtKB Chain 1 2549 . . . ID=PRO_0000088809;Note=Serine/threonine-protein kinase mTOR Q9JLN9 UniProtKB Repeat 16 53 . . . Note=HEAT 1 Q9JLN9 UniProtKB Repeat 55 99 . . . Note=HEAT 2 Q9JLN9 UniProtKB Repeat 100 137 . . . Note=HEAT 3 Q9JLN9 UniProtKB Repeat 138 179 . . . Note=HEAT 4 Q9JLN9 UniProtKB Repeat 180 220 . . . Note=HEAT 5 Q9JLN9 UniProtKB Repeat 222 276 . . . Note=HEAT 6 Q9JLN9 UniProtKB Repeat 277 313 . . . Note=HEAT 7 Q9JLN9 UniProtKB Repeat 314 364 . . . Note=HEAT 8 Q9JLN9 UniProtKB Repeat 365 409 . . . Note=HEAT 9 Q9JLN9 UniProtKB Repeat 410 445 . . . Note=HEAT 10 Q9JLN9 UniProtKB Repeat 446 494 . . . Note=HEAT 11 Q9JLN9 UniProtKB Repeat 495 529 . . . Note=HEAT 12 Q9JLN9 UniProtKB Repeat 530 563 . . . Note=HEAT 13 Q9JLN9 UniProtKB Repeat 564 596 . . . Note=HEAT 14 Q9JLN9 UniProtKB Repeat 597 636 . . . Note=HEAT 15 Q9JLN9 UniProtKB Repeat 637 683 . . . Note=HEAT 16 Q9JLN9 UniProtKB Repeat 686 724 . . . Note=HEAT 17 Q9JLN9 UniProtKB Repeat 727 766 . . . Note=HEAT 18 Q9JLN9 UniProtKB Repeat 769 811 . . . Note=HEAT 19 Q9JLN9 UniProtKB Repeat 814 853 . . . Note=HEAT 20 Q9JLN9 UniProtKB Repeat 857 893 . . . Note=HEAT 21 Q9JLN9 UniProtKB Repeat 894 942 . . . Note=HEAT 22 Q9JLN9 UniProtKB Repeat 943 988 . . . Note=HEAT 23 Q9JLN9 UniProtKB Repeat 989 1027 . . . Note=HEAT 24 Q9JLN9 UniProtKB Repeat 1029 1068 . . . Note=HEAT 25 Q9JLN9 UniProtKB Repeat 1069 1105 . . . Note=HEAT 26 Q9JLN9 UniProtKB Repeat 1106 1144 . . . Note=HEAT 27 Q9JLN9 UniProtKB Repeat 1145 1188 . . . Note=HEAT 28 Q9JLN9 UniProtKB Repeat 1189 1225 . . . Note=HEAT 29 Q9JLN9 UniProtKB Repeat 1226 1273 . . . Note=HEAT 30 Q9JLN9 UniProtKB Repeat 1274 1311 . . . Note=HEAT 31 Q9JLN9 UniProtKB Repeat 1312 1345 . . . Note=HEAT 32 Q9JLN9 UniProtKB Repeat 1346 1382 . . . Note=TPR 1 Q9JLN9 UniProtKB Domain 1382 1982 . . . Note=FAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00534 Q9JLN9 UniProtKB Repeat 1383 1408 . . . Note=TPR 2 Q9JLN9 UniProtKB Repeat 1409 1442 . . . Note=TPR 3 Q9JLN9 UniProtKB Repeat 1443 1473 . . . Note=TPR 4 Q9JLN9 UniProtKB Repeat 1474 1507 . . . Note=TPR 5 Q9JLN9 UniProtKB Repeat 1508 1541 . . . Note=TPR 6 Q9JLN9 UniProtKB Repeat 1542 1574 . . . Note=TPR 7 Q9JLN9 UniProtKB Repeat 1575 1614 . . . Note=TPR 8 Q9JLN9 UniProtKB Repeat 1615 1649 . . . Note=TPR 9 Q9JLN9 UniProtKB Repeat 1650 1693 . . . Note=TPR 10 Q9JLN9 UniProtKB Repeat 1694 1731 . . . Note=TPR 11 Q9JLN9 UniProtKB Repeat 1732 1786 . . . Note=TPR 12 Q9JLN9 UniProtKB Repeat 1787 1846 . . . Note=TPR 13 Q9JLN9 UniProtKB Repeat 1898 1930 . . . Note=TPR 14 Q9JLN9 UniProtKB Repeat 1931 1970 . . . Note=TPR 15 Q9JLN9 UniProtKB Repeat 1971 2005 . . . Note=TPR 16 Q9JLN9 UniProtKB Domain 2156 2469 . . . Note=PI3K/PI4K catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269 Q9JLN9 UniProtKB Domain 2517 2549 . . . Note=FATC;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00534,ECO:0000255|PROSITE-ProRule:PRU00535 Q9JLN9 UniProtKB Region 1 651 . . . Note=Interaction with NBN;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Region 1825 1867 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9JLN9 UniProtKB Region 2012 2144 . . . Note=Sufficient for interaction with the FKBP1A/rapamycin complex;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7809080;Dbxref=PMID:7809080 Q9JLN9 UniProtKB Region 2162 2168 . . . Note=G-loop;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269 Q9JLN9 UniProtKB Region 2258 2296 . . . Note=Interaction with MLST8;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Region 2335 2343 . . . Note=Catalytic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269 Q9JLN9 UniProtKB Region 2355 2380 . . . Note=Activation loop;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269 Q9JLN9 UniProtKB Binding site 2165 2165 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Binding site 2167 2167 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Binding site 2185 2185 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Binding site 2187 2187 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Binding site 2190 2190 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Binding site 2225 2225 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Binding site 2238 2238 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Binding site 2239 2239 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Binding site 2240 2240 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Binding site 2245 2245 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Binding site 2343 2343 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Binding site 2345 2345 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Binding site 2356 2356 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Binding site 2357 2357 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Modified residue 1 1 . . . Note=N-acetylmethionine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Modified residue 567 567 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Modified residue 1162 1162 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Modified residue 1218 1218 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Modified residue 1261 1261 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:19487463,ECO:0007744|PubMed:21183079;Dbxref=PMID:19487463,PMID:21183079 Q9JLN9 UniProtKB Modified residue 2159 2159 . . . Note=Phosphoserine%3B by TBK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29150432;Dbxref=PMID:29150432 Q9JLN9 UniProtKB Modified residue 2164 2164 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Modified residue 2173 2173 . . . Note=Phosphothreonine%3B by PKB/AKT1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Modified residue 2446 2446 . . . Note=Phosphothreonine%3B by RPS6KB1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42345 Q9JLN9 UniProtKB Modified residue 2448 2448 . . . Note=Phosphoserine%3B by RPS6KB1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24187137,ECO:0000269|PubMed:26359501;Dbxref=PMID:24187137,PMID:26359501 Q9JLN9 UniProtKB Modified residue 2478 2478 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17242355,ECO:0007744|PubMed:21183079;Dbxref=PMID:17242355,PMID:21183079 Q9JLN9 UniProtKB Modified residue 2481 2481 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17242355,ECO:0007744|PubMed:21183079;Dbxref=PMID:17242355,PMID:21183079 Q9JLN9 UniProtKB Alternative sequence 236 256 . . . ID=VSP_011909;Note=In isoform 2. HTFEEAEKGFDETLAKEKGMN->VRDGSTQPLAKHFGLESCSWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9JLN9 UniProtKB Alternative sequence 257 2549 . . . ID=VSP_011910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9JLN9 UniProtKB Mutagenesis 2035 2035 . . . Note=Abolishes interaction with the FKBP1A-rapamycin complex. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7809080;Dbxref=PMID:7809080 Q9JLN9 UniProtKB Mutagenesis 2159 2159 . . . Note=Knockin macrophages display reduced mTORC1 activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29150432;Dbxref=PMID:29150432 Q9JLN9 UniProtKB Sequence conflict 33 33 . . . Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9JLN9 UniProtKB Sequence conflict 628 628 . . . Note=R->C;Ontology_term=ECO:0000305;evidence=ECO:0000305