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Q9JLN5

- ERMAP_MOUSE

UniProt

Q9JLN5 - ERMAP_MOUSE

Protein

Erythroid membrane-associated protein

Gene

Ermap

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Possible role as a cell-adhesion or receptor molecule of erythroid cells.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Erythroid membrane-associated protein
    Gene namesi
    Name:Ermap
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1349816. Ermap.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytoplasmic vesicle Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 566537Erythroid membrane-associated proteinPRO_0000226089Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 ↔ 123PROSITE-ProRule annotation
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9JLN5.

    PTM databases

    PhosphoSiteiQ9JLN5.

    Expressioni

    Tissue specificityi

    Expressed in spleen and bone marrow.1 Publication

    Developmental stagei

    First detected at E.11. Expressed in fetal liver at E12.5 and E13.5.1 Publication

    Gene expression databases

    ArrayExpressiQ9JLN5.
    BgeeiQ9JLN5.
    CleanExiMM_ERMAP.
    GenevestigatoriQ9JLN5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JLN5.
    SMRiQ9JLN5. Positions 24-236, 324-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 246217ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini268 – 566299CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei247 – 26721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 139110Ig-like V-typeAdd
    BLAST
    Domaini311 – 509199B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320971.
    HOGENOMiHOG000197761.
    HOVERGENiHBG050747.
    InParanoidiQ9JLN5.
    KOiK06712.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view]
    PfamiPF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00406. IGv. 1 hit.
    SM00589. PRY. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9JLN5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MERPSPCGSW LVGCLFTIAV FQPPVQVLGD AGKVYIAPLR DTANLPCPLF    50
    LWPNMVLSEM RWYRPGHLPR TQAVHVFRDG QDRDEDLMPE YKGRTALVRD 100
    AHKESYILQI SNVRLEDRGL YQCQVWVGNS SREDNVTLQV AVLGSDPYIH 150
    VKGYDAGWIE LLCQSVGWFP KPWTEWRDTT GRALLSLSEV HSLDENGLFR 200
    TAVSSRIRDN ALGNVSCTIH NEALGQEKTT AMIIGAPERG SLSSPAVALS 250
    VVLPVLGLLI LLGIWLICKQ KKSKEKLLYE QAMEVENLLE DHAKEKGRLH 300
    KALKKLRSEL KLKRAAANAG WRRARLHFVA VTLDPDTAHP KLILSEDRRC 350
    VRLGDRKRPV PDNPERFDFV VSVLGSEYFT TGCHYWEVYV GEKTKWILGV 400
    CSESVSRKGK VTASPANGHW LVRQSRGNEY EALTSPQTSF RLKESPKCVG 450
    IFLDYEAGII SFYNVTDKSH IFTFTHSFSS PLRPFFEPCL HDEGKNTAPL 500
    IICTELQKSE ESIVPKQEGK DRANGDVSLK MNPSLLSPQG SELFLLNDTW 550
    PSNLGPALKG LKVPSL 566
    Length:566
    Mass (Da):63,512
    Last modified:March 7, 2006 - v2
    Checksum:i0017069E16D5D112
    GO
    Isoform 2 (identifier: Q9JLN5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         125-147: VWVGNSSREDNVTLQVAVLGSDP → EFPYTGAQNLHRTKKPLLPLMTN
         148-566: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:147
    Mass (Da):16,910
    Checksum:iD94BAFF1D0ED3D94
    GO
    Isoform 3 (identifier: Q9JLN5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         142-143: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:564
    Mass (Da):63,300
    Checksum:i5A46DF790035C6C3
    GO

    Sequence cautioni

    The sequence AAF31162.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH63257.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAE23390.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 911Y → S in AAF31162. (PubMed:10721728)Curated
    Sequence conflicti180 – 1801T → A in AAF31162. (PubMed:10721728)Curated
    Sequence conflicti221 – 2211N → I in AAF31162. (PubMed:10721728)Curated
    Sequence conflicti287 – 2871N → S in AAF31162. (PubMed:10721728)Curated
    Sequence conflicti374 – 3741L → P in AAF31162. (PubMed:10721728)Curated
    Sequence conflicti462 – 4621F → L in BAC25788. (PubMed:16141072)Curated
    Sequence conflicti541 – 5411S → C in AAF31162. (PubMed:10721728)Curated
    Sequence conflicti554 – 5541L → F in AAF31162. (PubMed:10721728)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei125 – 14723VWVGN…LGSDP → EFPYTGAQNLHRTKKPLLPL MTN in isoform 2. 1 PublicationVSP_017425Add
    BLAST
    Alternative sequencei142 – 1432Missing in isoform 3. 1 PublicationVSP_017426
    Alternative sequencei148 – 566419Missing in isoform 2. 1 PublicationVSP_017427Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF153906 mRNA. Translation: AAF31162.1. Different initiation.
    AK028170 mRNA. Translation: BAC25788.1.
    AK137510 mRNA. Translation: BAE23390.1. Different initiation.
    BC063257 mRNA. Translation: AAH63257.1. Different initiation.
    RefSeqiNP_038876.2. NM_013848.2.
    UniGeneiMm.290753.

    Genome annotation databases

    GeneIDi27028.
    KEGGimmu:27028.
    UCSCiuc008ulh.2. mouse. [Q9JLN5-2]
    uc012dke.1. mouse. [Q9JLN5-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF153906 mRNA. Translation: AAF31162.1 . Different initiation.
    AK028170 mRNA. Translation: BAC25788.1 .
    AK137510 mRNA. Translation: BAE23390.1 . Different initiation.
    BC063257 mRNA. Translation: AAH63257.1 . Different initiation.
    RefSeqi NP_038876.2. NM_013848.2.
    UniGenei Mm.290753.

    3D structure databases

    ProteinModelPortali Q9JLN5.
    SMRi Q9JLN5. Positions 24-236, 324-503.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9JLN5.

    Proteomic databases

    PRIDEi Q9JLN5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 27028.
    KEGGi mmu:27028.
    UCSCi uc008ulh.2. mouse. [Q9JLN5-2 ]
    uc012dke.1. mouse. [Q9JLN5-3 ]

    Organism-specific databases

    CTDi 114625.
    MGIi MGI:1349816. Ermap.

    Phylogenomic databases

    eggNOGi NOG320971.
    HOGENOMi HOG000197761.
    HOVERGENi HBG050747.
    InParanoidi Q9JLN5.
    KOi K06712.

    Miscellaneous databases

    NextBioi 304957.
    PROi Q9JLN5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JLN5.
    Bgeei Q9JLN5.
    CleanExi MM_ERMAP.
    Genevestigatori Q9JLN5.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view ]
    Pfami PF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00406. IGv. 1 hit.
    SM00589. PRY. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane protein."
      Ye T.-Z., Gordon C.T., Lai Y.-H., Fujiwara Y., Peters L.L., Perkins A.C., Chui D.H.K.
      Gene 242:337-345(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Strain: C57BL/6J.
      Tissue: Erythroid cell.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 323-566 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Bone and Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiERMAP_MOUSE
    AccessioniPrimary (citable) accession number: Q9JLN5
    Secondary accession number(s): Q3UV82, Q6P4T5, Q8CEH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3