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Protein

Erythroid membrane-associated protein

Gene

Ermap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possible role as a cell-adhesion or receptor molecule of erythroid cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Erythroid membrane-associated protein
Gene namesi
Name:Ermap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1349816. Ermap.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 246ExtracellularSequence analysisAdd BLAST217
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 566CytoplasmicSequence analysisAdd BLAST299

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000022608930 – 566Erythroid membrane-associated proteinAdd BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 123PROSITE-ProRule annotation
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei509PhosphoserineCombined sources1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JLN5.
PRIDEiQ9JLN5.

PTM databases

iPTMnetiQ9JLN5.
PhosphoSitePlusiQ9JLN5.

Expressioni

Tissue specificityi

Expressed in spleen and bone marrow.1 Publication

Developmental stagei

First detected at E.11. Expressed in fetal liver at E12.5 and E13.5.1 Publication

Gene expression databases

CleanExiMM_ERMAP.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000123426.

Structurei

3D structure databases

ProteinModelPortaliQ9JLN5.
SMRiQ9JLN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 139Ig-like V-typeAdd BLAST110
Domaini311 – 509B30.2/SPRYPROSITE-ProRule annotationAdd BLAST199

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
HOGENOMiHOG000197761.
HOVERGENiHBG050747.
InParanoidiQ9JLN5.
KOiK06712.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin_SPRY.
IPR013320. ConA-like_dom.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR006574. PRY.
IPR003877. SPRY_dom.
PfamiView protein in Pfam
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JLN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERPSPCGSW LVGCLFTIAV FQPPVQVLGD AGKVYIAPLR DTANLPCPLF
60 70 80 90 100
LWPNMVLSEM RWYRPGHLPR TQAVHVFRDG QDRDEDLMPE YKGRTALVRD
110 120 130 140 150
AHKESYILQI SNVRLEDRGL YQCQVWVGNS SREDNVTLQV AVLGSDPYIH
160 170 180 190 200
VKGYDAGWIE LLCQSVGWFP KPWTEWRDTT GRALLSLSEV HSLDENGLFR
210 220 230 240 250
TAVSSRIRDN ALGNVSCTIH NEALGQEKTT AMIIGAPERG SLSSPAVALS
260 270 280 290 300
VVLPVLGLLI LLGIWLICKQ KKSKEKLLYE QAMEVENLLE DHAKEKGRLH
310 320 330 340 350
KALKKLRSEL KLKRAAANAG WRRARLHFVA VTLDPDTAHP KLILSEDRRC
360 370 380 390 400
VRLGDRKRPV PDNPERFDFV VSVLGSEYFT TGCHYWEVYV GEKTKWILGV
410 420 430 440 450
CSESVSRKGK VTASPANGHW LVRQSRGNEY EALTSPQTSF RLKESPKCVG
460 470 480 490 500
IFLDYEAGII SFYNVTDKSH IFTFTHSFSS PLRPFFEPCL HDEGKNTAPL
510 520 530 540 550
IICTELQKSE ESIVPKQEGK DRANGDVSLK MNPSLLSPQG SELFLLNDTW
560
PSNLGPALKG LKVPSL
Length:566
Mass (Da):63,512
Last modified:March 7, 2006 - v2
Checksum:i0017069E16D5D112
GO
Isoform 2 (identifier: Q9JLN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-147: VWVGNSSREDNVTLQVAVLGSDP → EFPYTGAQNLHRTKKPLLPLMTN
     148-566: Missing.

Note: No experimental confirmation available.
Show »
Length:147
Mass (Da):16,910
Checksum:iD94BAFF1D0ED3D94
GO
Isoform 3 (identifier: Q9JLN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-143: Missing.

Note: No experimental confirmation available.
Show »
Length:564
Mass (Da):63,300
Checksum:i5A46DF790035C6C3
GO

Sequence cautioni

Q9JLN5: The sequence AAF31162 differs from that shown. Reason: Erroneous initiation.Curated
Q9JLN5: The sequence AAH63257 differs from that shown. Reason: Erroneous initiation.Curated
Q9JLN5: The sequence BAE23390 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91Y → S in AAF31162 (PubMed:10721728).Curated1
Sequence conflicti180T → A in AAF31162 (PubMed:10721728).Curated1
Sequence conflicti221N → I in AAF31162 (PubMed:10721728).Curated1
Sequence conflicti287N → S in AAF31162 (PubMed:10721728).Curated1
Sequence conflicti374L → P in AAF31162 (PubMed:10721728).Curated1
Sequence conflicti462F → L in BAC25788 (PubMed:16141072).Curated1
Sequence conflicti541S → C in AAF31162 (PubMed:10721728).Curated1
Sequence conflicti554L → F in AAF31162 (PubMed:10721728).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017425125 – 147VWVGN…LGSDP → EFPYTGAQNLHRTKKPLLPL MTN in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_017426142 – 143Missing in isoform 3. 1 Publication2
Alternative sequenceiVSP_017427148 – 566Missing in isoform 2. 1 PublicationAdd BLAST419

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153906 mRNA. Translation: AAF31162.1. Different initiation.
AK028170 mRNA. Translation: BAC25788.1.
AK137510 mRNA. Translation: BAE23390.1. Different initiation.
BC063257 mRNA. Translation: AAH63257.1. Different initiation.
RefSeqiNP_038876.2. NM_013848.2.
UniGeneiMm.290753.

Genome annotation databases

GeneIDi27028.
KEGGimmu:27028.
UCSCiuc008ulh.2. mouse. [Q9JLN5-2]
uc012dke.1. mouse. [Q9JLN5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiERMAP_MOUSE
AccessioniPrimary (citable) accession number: Q9JLN5
Secondary accession number(s): Q3UV82, Q6P4T5, Q8CEH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: October 25, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families