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Protein

Peptidoglycan recognition protein 1

Gene

Pglyrp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. May function in intracellular killing of bacteria (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • defense response to bacterium Source: UniProtKB-KW
  • immune response Source: RGD
  • innate immune response Source: UniProtKB-KW
  • peptidoglycan catabolic process Source: InterPro
  • regulation of circadian sleep/wake cycle, sleep Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan recognition protein 1
Alternative name(s):
Peptidoglycan recognition protein short
Short name:
PGRP-S
Gene namesi
Name:Pglyrp1
Synonyms:Pglyrp, Pgrp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621429. Pglyrp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 183166Peptidoglycan recognition protein 1PRO_0000023903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi18 ↔ 142By similarity
Disulfide bondi34 ↔ 79By similarity
Disulfide bondi55 ↔ 61By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9JLN4.
PRIDEiQ9JLN4.

PTM databases

iPTMnetiQ9JLN4.
PhosphoSiteiQ9JLN4.

Expressioni

Tissue specificityi

Expressed in all regions of the brain.

Inductioni

By sleep deprivation in the brain stem and in the hypothalamus.

Interactioni

Protein-protein interaction databases

IntActiQ9JLN4. 1 interaction.
STRINGi10116.ENSRNOP00000018233.

Structurei

3D structure databases

ProteinModelPortaliQ9JLN4.
SMRiQ9JLN4. Positions 17-182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYTD. Eukaryota.
ENOG4111PQD. LUCA.
HOGENOMiHOG000267017.
HOVERGENiHBG007406.
InParanoidiQ9JLN4.
KOiK01446.
PhylomeDBiQ9JLN4.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFAWAPFPA LLGLADSCCF VVPRSEWKAL PSECSKGLKK PVRYVVISHT
60 70 80 90 100
AGSFCSSPDS CEQQARNVQL YQMKQLGWCD VAYNFLIGED GHVYEGRGWT
110 120 130 140 150
IKGDHTGPIW NPMSIGITFM GDYSHRVPAK RALRAALNLL KCGVSEGFLR
160 170 180
SNYEVKGHRD VQSTLSPGDQ LYEIIQSWDH YRE
Length:183
Mass (Da):20,591
Last modified:October 1, 2000 - v1
Checksum:i5B9C1B7AA8A2EC21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154114 mRNA. Translation: AAF73252.1.
RefSeqiNP_445825.1. NM_053373.1.
UniGeneiRn.2834.

Genome annotation databases

GeneIDi84387.
KEGGirno:84387.
UCSCiRGD:621429. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154114 mRNA. Translation: AAF73252.1.
RefSeqiNP_445825.1. NM_053373.1.
UniGeneiRn.2834.

3D structure databases

ProteinModelPortaliQ9JLN4.
SMRiQ9JLN4. Positions 17-182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JLN4. 1 interaction.
STRINGi10116.ENSRNOP00000018233.

PTM databases

iPTMnetiQ9JLN4.
PhosphoSiteiQ9JLN4.

Proteomic databases

PaxDbiQ9JLN4.
PRIDEiQ9JLN4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84387.
KEGGirno:84387.
UCSCiRGD:621429. rat.

Organism-specific databases

CTDi8993.
RGDi621429. Pglyrp1.

Phylogenomic databases

eggNOGiENOG410IYTD. Eukaryota.
ENOG4111PQD. LUCA.
HOGENOMiHOG000267017.
HOVERGENiHBG007406.
InParanoidiQ9JLN4.
KOiK01446.
PhylomeDBiQ9JLN4.

Miscellaneous databases

PROiQ9JLN4.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The cloning of a rat peptidoglycan recognition protein (PGRP) and its induction in brain by sleep deprivation."
    Rehman A., Taishi P., Fang J., Majde J.A., Krueger J.M.
    Cytokine 13:8-17(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Spleen.
  2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPGRP1_RAT
AccessioniPrimary (citable) accession number: Q9JLN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.