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Protein

Zinc finger MYM-type protein 3

Gene

Zmym3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri334 – 368MYM-type 1Add BLAST35
Zinc fingeri380 – 424MYM-type 2Add BLAST45
Zinc fingeri431 – 466MYM-type 3Add BLAST36
Zinc fingeri479 – 513MYM-type 4Add BLAST35
Zinc fingeri523 – 561MYM-type 5Add BLAST39
Zinc fingeri569 – 606MYM-type 6Add BLAST38
Zinc fingeri614 – 648MYM-type 7Add BLAST35
Zinc fingeri655 – 694MYM-type 8Add BLAST40
Zinc fingeri701 – 735MYM-type 9Add BLAST35

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MYM-type protein 3
Alternative name(s):
DXHXS6673E protein
Zinc finger protein 261
Gene namesi
Name:Zmym3
Synonyms:Kiaa0385, Zfp261, Znf261
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1927231. Zmym3.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913791 – 1370Zinc finger MYM-type protein 3Add BLAST1370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei265PhosphoserineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei797PhosphothreonineBy similarity1
Modified residuei818PhosphothreonineBy similarity1
Modified residuei827PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JLM4.
MaxQBiQ9JLM4.
PaxDbiQ9JLM4.
PRIDEiQ9JLM4.

PTM databases

iPTMnetiQ9JLM4.
PhosphoSitePlusiQ9JLM4.

Expressioni

Tissue specificityi

Ubiquitously expressed in all embryonic stages and adult tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000031310.
CleanExiMM_ZMYM3.
ExpressionAtlasiQ9JLM4. baseline and differential.
GenevisibleiQ9JLM4. MM.

Interactioni

Subunit structurei

May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GTF2IRD1Q9UHL93EBI-12517169,EBI-372530From Homo sapiens.

Protein-protein interaction databases

IntActiQ9JLM4. 1 interactor.
STRINGi10090.ENSMUSP00000068197.

Structurei

3D structure databases

ProteinModelPortaliQ9JLM4.
SMRiQ9JLM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri334 – 368MYM-type 1Add BLAST35
Zinc fingeri380 – 424MYM-type 2Add BLAST45
Zinc fingeri431 – 466MYM-type 3Add BLAST36
Zinc fingeri479 – 513MYM-type 4Add BLAST35
Zinc fingeri523 – 561MYM-type 5Add BLAST39
Zinc fingeri569 – 606MYM-type 6Add BLAST38
Zinc fingeri614 – 648MYM-type 7Add BLAST35
Zinc fingeri655 – 694MYM-type 8Add BLAST40
Zinc fingeri701 – 735MYM-type 9Add BLAST35

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IE8I. Eukaryota.
ENOG410XQR6. LUCA.
GeneTreeiENSGT00550000074408.
HOGENOMiHOG000293258.
HOVERGENiHBG057545.
InParanoidiQ9JLM4.
OMAiFDCGLVG.
OrthoDBiEOG091G00KQ.
PhylomeDBiQ9JLM4.
TreeFamiTF336988.

Family and domain databases

InterProiView protein in InterPro
IPR021893. DUF3504.
IPR011017. TRASH_dom.
IPR010507. Znf_MYM.
PfamiView protein in Pfam
PF12012. DUF3504. 1 hit.
PF06467. zf-FCS. 9 hits.
SMARTiView protein in SMART
SM00746. TRASH. 10 hits.

Sequencei

Sequence statusi: Complete.

Q9JLM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSDFPSPF DPLTLPEKPL AGDLPVDMEF GEDLLESQTA PSRGWAPPGP
60 70 80 90 100
SPSSGALDLL DTPSGLEKDP GGVLDGATEL LGLGGLLYKA PSPPEVDHGP
110 120 130 140 150
EGTLAWDSGE QTLEPGPGCQ TPEVMPPDPG AGASPPSPEG LLEPLAPDSP
160 170 180 190 200
IILESPHIEE EIPPLATRRR GSPGQEEEHT QGQPQSPNAP PSPSVGETLG
210 220 230 240 250
DGINSSQSKP GVCTPTAHPS LPGDGLTGKE IEKPPERVQK RSERVRRAEP
260 270 280 290 300
PKPEVVDSTE SIPVSDEDSD AMVDDPNDED FVPFRPRRSP RMSLRSSMAQ
310 320 330 340 350
RAGRSSMGTK MSCAHCRTPL QKGQTAYQRK GLPQLFCSSS CLTTYSKKPL
360 370 380 390 400
GRKTCTFCKK EIWNTKDSVV VQTGPGGSFH EFCTSVCLSL YEAQQQRPIP
410 420 430 440 450
QSGDPADATR CSICQKTGEV LHEVSNGSVV HRLCSDSCFS KFRANKGLKT
460 470 480 490 500
NCCDQCGAYI YARPGGLGPE LLFHDGQQKR FCNTTCLGAY KKKNTRVYPC
510 520 530 540 550
VWCKTLCKNF EMLSHVDRNG KTSLFCSLCC TTSYKVKQAG LTGPPRPCSF
560 570 580 590 600
CRRSLSDPCY YNKVDRTVYQ FCSPSCWTKF QHTSPEGGIH LSCHYCHSLF
610 620 630 640 650
SGKPEVLEWQ DQVFQFCCRD CCEDFKRLRG VVSQCEHCRQ EKLLHEKLRF
660 670 680 690 700
SGVEKSFCSE GCVLLYKQDF TKKLGLCCIT CTYCSQTCQR GVTEQLDGST
710 720 730 740 750
WDFCSEDCKT KYLLWYCKAA RCHACKRQGK LLETIHWRGQ IRHFCNQQCL
760 770 780 790 800
LRFYSQQNQP NLDTQSGPES LLNSQSSESK PQTPSQTKVE NNHTVRTPDE
810 820 830 840 850
NGNLGKTPVK RATPSVPTPP PPPPPATPRK NKAAMCKPLM QNRGVSCKAE
860 870 880 890 900
MKSKGSQTEE WKPQVIVLPI PVPIFVPVPM HLYCQKVPVP FSMPIPVPVP
910 920 930 940 950
MFLPTTLEST EKIVETIEEL KVKIPSNPLE ADILAMAEMI AEAEELDKAS
960 970 980 990 1000
SDLCDLVSNQ SAEGLLEDCD LFGTARDDVL AMAVKMANVL DEPGQDLEAD
1010 1020 1030 1040 1050
FPKNPLDINP SVDFLFDCGL VGPEDVSTEQ DLPRAMRKGQ KRLMLSESCS
1060 1070 1080 1090 1100
RDSLSSQPSC TGLNYSYGVN AWKCWVQSKY ANGETSKGDE LRFGPKPMRI
1110 1120 1130 1140 1150
KEDILACSAA ELNYGLAQFV REITRPNGER YEPDSIYYLC LGIQQYLLEN
1160 1170 1180 1190 1200
NRMVNIFTDL YYLTFVQELN KSLSTWQPTL LPNNTVFSRV EEEHLWECKQ
1210 1220 1230 1240 1250
LGVYSPFVLL NTLMFFNTKF FGLQTAEEHM QLSFTNVVRQ SRKCTTPRGT
1260 1270 1280 1290 1300
TKVVSIRYYA PVRQRKGRDT GPGKRKREDE TILEQRENRM NPLRCPVKFY
1310 1320 1330 1340 1350
EFYLSKCPES LRTRNDVFYL QPERSCIAES PLWYSVIPMD RSMLESMLNR
1360 1370
ILAVREIYEE LGRPGEEDLD
Length:1,370
Mass (Da):152,879
Last modified:October 1, 2000 - v1
Checksum:iE9270E68366E46F1
GO

Sequence cautioni

The sequence BAC65550 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238 – 239Missing in BAC65550 (PubMed:12693553).Curated2
Sequence conflicti493 – 495KNT → VGP in BAC65550 (PubMed:12693553).Curated3
Sequence conflicti719 – 735AARCH…LLETI → VRRVNRAERRQQGDELW in BAC65550 (PubMed:12693553).CuratedAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156605 mRNA. Translation: AAF37800.1.
AK122268 Transcribed RNA. Translation: BAC65550.3. Different initiation.
CCDSiCCDS30315.1.
RefSeqiNP_062805.1. NM_019831.3.
XP_006528226.1. XM_006528163.3.
XP_006528227.1. XM_006528164.2.
XP_006528228.1. XM_006528165.3.
XP_006528229.1. XM_006528166.3.
UniGeneiMm.23458.

Genome annotation databases

EnsembliENSMUST00000063577; ENSMUSP00000068197; ENSMUSG00000031310.
GeneIDi56364.
KEGGimmu:56364.
UCSCiuc009txm.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZMYM3_MOUSE
AccessioniPrimary (citable) accession number: Q9JLM4
Secondary accession number(s): Q80U17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 1, 2000
Last modified: June 7, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot