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Protein

Zinc finger MYM-type protein 3

Gene

Zmym3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri334 – 36835MYM-type 1Add
BLAST
Zinc fingeri380 – 42445MYM-type 2Add
BLAST
Zinc fingeri431 – 46636MYM-type 3Add
BLAST
Zinc fingeri479 – 51335MYM-type 4Add
BLAST
Zinc fingeri523 – 56139MYM-type 5Add
BLAST
Zinc fingeri569 – 60638MYM-type 6Add
BLAST
Zinc fingeri614 – 64835MYM-type 7Add
BLAST
Zinc fingeri655 – 69440MYM-type 8Add
BLAST
Zinc fingeri701 – 73535MYM-type 9Add
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MYM-type protein 3
Alternative name(s):
DXHXS6673E protein
Zinc finger protein 261
Gene namesi
Name:Zmym3
Synonyms:Kiaa0385, Zfp261, Znf261
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1927231. Zmym3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13701370Zinc finger MYM-type protein 3PRO_0000191379Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei265 – 2651PhosphoserineCombined sources
Modified residuei269 – 2691PhosphoserineCombined sources
Modified residuei818 – 8181PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JLM4.
MaxQBiQ9JLM4.
PaxDbiQ9JLM4.
PRIDEiQ9JLM4.

PTM databases

iPTMnetiQ9JLM4.
PhosphoSiteiQ9JLM4.

Expressioni

Tissue specificityi

Ubiquitously expressed in all embryonic stages and adult tissues.1 Publication

Gene expression databases

BgeeiQ9JLM4.
CleanExiMM_ZMYM3.
ExpressionAtlasiQ9JLM4. baseline and differential.
GenevisibleiQ9JLM4. MM.

Interactioni

Subunit structurei

May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068197.

Structurei

3D structure databases

ProteinModelPortaliQ9JLM4.
SMRiQ9JLM4. Positions 310-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 9 MYM-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri334 – 36835MYM-type 1Add
BLAST
Zinc fingeri380 – 42445MYM-type 2Add
BLAST
Zinc fingeri431 – 46636MYM-type 3Add
BLAST
Zinc fingeri479 – 51335MYM-type 4Add
BLAST
Zinc fingeri523 – 56139MYM-type 5Add
BLAST
Zinc fingeri569 – 60638MYM-type 6Add
BLAST
Zinc fingeri614 – 64835MYM-type 7Add
BLAST
Zinc fingeri655 – 69440MYM-type 8Add
BLAST
Zinc fingeri701 – 73535MYM-type 9Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IE8I. Eukaryota.
ENOG410XQR6. LUCA.
GeneTreeiENSGT00550000074408.
HOGENOMiHOG000293258.
HOVERGENiHBG057545.
InParanoidiQ9JLM4.
OMAiGSQTEEW.
OrthoDBiEOG7JT6VN.
PhylomeDBiQ9JLM4.
TreeFamiTF336988.

Family and domain databases

InterProiIPR021893. DUF3504.
IPR011017. TRASH_dom.
IPR010507. Znf_MYM.
[Graphical view]
PfamiPF12012. DUF3504. 1 hit.
PF06467. zf-FCS. 9 hits.
[Graphical view]
SMARTiSM00746. TRASH. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JLM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSDFPSPF DPLTLPEKPL AGDLPVDMEF GEDLLESQTA PSRGWAPPGP
60 70 80 90 100
SPSSGALDLL DTPSGLEKDP GGVLDGATEL LGLGGLLYKA PSPPEVDHGP
110 120 130 140 150
EGTLAWDSGE QTLEPGPGCQ TPEVMPPDPG AGASPPSPEG LLEPLAPDSP
160 170 180 190 200
IILESPHIEE EIPPLATRRR GSPGQEEEHT QGQPQSPNAP PSPSVGETLG
210 220 230 240 250
DGINSSQSKP GVCTPTAHPS LPGDGLTGKE IEKPPERVQK RSERVRRAEP
260 270 280 290 300
PKPEVVDSTE SIPVSDEDSD AMVDDPNDED FVPFRPRRSP RMSLRSSMAQ
310 320 330 340 350
RAGRSSMGTK MSCAHCRTPL QKGQTAYQRK GLPQLFCSSS CLTTYSKKPL
360 370 380 390 400
GRKTCTFCKK EIWNTKDSVV VQTGPGGSFH EFCTSVCLSL YEAQQQRPIP
410 420 430 440 450
QSGDPADATR CSICQKTGEV LHEVSNGSVV HRLCSDSCFS KFRANKGLKT
460 470 480 490 500
NCCDQCGAYI YARPGGLGPE LLFHDGQQKR FCNTTCLGAY KKKNTRVYPC
510 520 530 540 550
VWCKTLCKNF EMLSHVDRNG KTSLFCSLCC TTSYKVKQAG LTGPPRPCSF
560 570 580 590 600
CRRSLSDPCY YNKVDRTVYQ FCSPSCWTKF QHTSPEGGIH LSCHYCHSLF
610 620 630 640 650
SGKPEVLEWQ DQVFQFCCRD CCEDFKRLRG VVSQCEHCRQ EKLLHEKLRF
660 670 680 690 700
SGVEKSFCSE GCVLLYKQDF TKKLGLCCIT CTYCSQTCQR GVTEQLDGST
710 720 730 740 750
WDFCSEDCKT KYLLWYCKAA RCHACKRQGK LLETIHWRGQ IRHFCNQQCL
760 770 780 790 800
LRFYSQQNQP NLDTQSGPES LLNSQSSESK PQTPSQTKVE NNHTVRTPDE
810 820 830 840 850
NGNLGKTPVK RATPSVPTPP PPPPPATPRK NKAAMCKPLM QNRGVSCKAE
860 870 880 890 900
MKSKGSQTEE WKPQVIVLPI PVPIFVPVPM HLYCQKVPVP FSMPIPVPVP
910 920 930 940 950
MFLPTTLEST EKIVETIEEL KVKIPSNPLE ADILAMAEMI AEAEELDKAS
960 970 980 990 1000
SDLCDLVSNQ SAEGLLEDCD LFGTARDDVL AMAVKMANVL DEPGQDLEAD
1010 1020 1030 1040 1050
FPKNPLDINP SVDFLFDCGL VGPEDVSTEQ DLPRAMRKGQ KRLMLSESCS
1060 1070 1080 1090 1100
RDSLSSQPSC TGLNYSYGVN AWKCWVQSKY ANGETSKGDE LRFGPKPMRI
1110 1120 1130 1140 1150
KEDILACSAA ELNYGLAQFV REITRPNGER YEPDSIYYLC LGIQQYLLEN
1160 1170 1180 1190 1200
NRMVNIFTDL YYLTFVQELN KSLSTWQPTL LPNNTVFSRV EEEHLWECKQ
1210 1220 1230 1240 1250
LGVYSPFVLL NTLMFFNTKF FGLQTAEEHM QLSFTNVVRQ SRKCTTPRGT
1260 1270 1280 1290 1300
TKVVSIRYYA PVRQRKGRDT GPGKRKREDE TILEQRENRM NPLRCPVKFY
1310 1320 1330 1340 1350
EFYLSKCPES LRTRNDVFYL QPERSCIAES PLWYSVIPMD RSMLESMLNR
1360 1370
ILAVREIYEE LGRPGEEDLD
Length:1,370
Mass (Da):152,879
Last modified:October 1, 2000 - v1
Checksum:iE9270E68366E46F1
GO

Sequence cautioni

The sequence BAC65550.3 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2392Missing in BAC65550 (PubMed:12693553).Curated
Sequence conflicti493 – 4953KNT → VGP in BAC65550 (PubMed:12693553).Curated
Sequence conflicti719 – 73517AARCH…LLETI → VRRVNRAERRQQGDELW in BAC65550 (PubMed:12693553).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156605 mRNA. Translation: AAF37800.1.
AK122268 Transcribed RNA. Translation: BAC65550.3. Different initiation.
CCDSiCCDS30315.1.
RefSeqiNP_062805.1. NM_019831.3.
XP_006528226.1. XM_006528163.2.
XP_006528227.1. XM_006528164.1.
XP_006528228.1. XM_006528165.2.
XP_006528229.1. XM_006528166.2.
UniGeneiMm.23458.

Genome annotation databases

EnsembliENSMUST00000063577; ENSMUSP00000068197; ENSMUSG00000031310.
GeneIDi56364.
KEGGimmu:56364.
UCSCiuc009txm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156605 mRNA. Translation: AAF37800.1.
AK122268 Transcribed RNA. Translation: BAC65550.3. Different initiation.
CCDSiCCDS30315.1.
RefSeqiNP_062805.1. NM_019831.3.
XP_006528226.1. XM_006528163.2.
XP_006528227.1. XM_006528164.1.
XP_006528228.1. XM_006528165.2.
XP_006528229.1. XM_006528166.2.
UniGeneiMm.23458.

3D structure databases

ProteinModelPortaliQ9JLM4.
SMRiQ9JLM4. Positions 310-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068197.

PTM databases

iPTMnetiQ9JLM4.
PhosphoSiteiQ9JLM4.

Proteomic databases

EPDiQ9JLM4.
MaxQBiQ9JLM4.
PaxDbiQ9JLM4.
PRIDEiQ9JLM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063577; ENSMUSP00000068197; ENSMUSG00000031310.
GeneIDi56364.
KEGGimmu:56364.
UCSCiuc009txm.2. mouse.

Organism-specific databases

CTDi9203.
MGIiMGI:1927231. Zmym3.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IE8I. Eukaryota.
ENOG410XQR6. LUCA.
GeneTreeiENSGT00550000074408.
HOGENOMiHOG000293258.
HOVERGENiHBG057545.
InParanoidiQ9JLM4.
OMAiGSQTEEW.
OrthoDBiEOG7JT6VN.
PhylomeDBiQ9JLM4.
TreeFamiTF336988.

Miscellaneous databases

NextBioi312398.
PROiQ9JLM4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JLM4.
CleanExiMM_ZMYM3.
ExpressionAtlasiQ9JLM4. baseline and differential.
GenevisibleiQ9JLM4. MM.

Family and domain databases

InterProiIPR021893. DUF3504.
IPR011017. TRASH_dom.
IPR010507. Znf_MYM.
[Graphical view]
PfamiPF12012. DUF3504. 1 hit.
PF06467. zf-FCS. 9 hits.
[Graphical view]
SMARTiSM00746. TRASH. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DXS6673E encodes a predominantly nuclear protein, and its mouse ortholog DXHXS6673E is alternatively spliced in a developmental- and tissue-specific manner."
    Scheer M.P., van der Maarel S.M., Kuebart S., Schulz A., Wirth J., Schweiger S., Ropers H.-H., Nothwang H.G.
    Genomics 63:123-132(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-265 AND SER-269, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney and Testis.

Entry informationi

Entry nameiZMYM3_MOUSE
AccessioniPrimary (citable) accession number: Q9JLM4
Secondary accession number(s): Q80U17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.