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Protein

Natural killer cell receptor 2B4

Gene

Cd244

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Modulate other receptor-ligand interactions to enhance leukocyte activation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Natural killer cell receptor 2B4
Alternative name(s):
NK cell type I receptor protein 2B4
Short name:
NKR2B4
Non-MHC restricted killing associated
CD_antigen: CD244
Gene namesi
Name:Cd244
Synonyms:2b4, Nmrk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68400 Cd244

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 223ExtracellularSequence analysisAdd BLAST204
Transmembranei224 – 247HelicalSequence analysisAdd BLAST24
Topological domaini248 – 311CytoplasmicSequence analysisAdd BLAST64

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001467020 – 311Natural killer cell receptor 2B4Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 118By similarity
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi153 ↔ 195Sequence analysis
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JLM2
PRIDEiQ9JLM2

Interactioni

Subunit structurei

Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006266

Structurei

3D structure databases

ProteinModelPortaliQ9JLM2
SMRiQ9JLM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 128Ig-like 1Add BLAST107
Domaini131 – 215Ig-like 2Add BLAST85

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKYZ Eukaryota
ENOG410Y74Q LUCA
HOGENOMiHOG000111481
HOVERGENiHBG050850
InParanoidiQ9JLM2
KOiK06582
PhylomeDBiQ9JLM2

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR024304 NK_rcpt_2B4
IPR024303 NK_rcpt_2B4_Ig_dom
PANTHERiPTHR12080:SF56 PTHR12080:SF56, 1 hit
PfamiView protein in Pfam
PF11465 Receptor_2B4, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQQTVLLSL FLLLRAHQGQ DCADSSEEVL GVSGKPVRLR PSNIQAKHVS
60 70 80 90 100
IEWKKKTGHQ QTPQIVTWDT TDNKNFNMCC SDIYGFESEN FALSIKSAKL
110 120 130 140 150
NDSGHYLLEI TNQRGIVCTK NFQMLIFDPV ETPHLTVQGT LWANGTCQLS
160 170 180 190 200
LSCFVPKDDN VSYALYRGSM LISNQRYGTH WENRTDASSL HTYTCNVSNK
210 220 230 240 250
ASWANHTLTS PQSCQSVPSK FNYLPFMVSI GILVKFFHGA IDCFCVWNRK
260 270 280 290 300
RKQSQSIAKE SLTIHEYVKN AQVSRDQRGH FRASGSSSDV RGDERGQRES
310
DRRLFQFINR S
Length:311
Mass (Da):35,300
Last modified:October 1, 2000 - v1
Checksum:i5A527D22D2565772
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46A → T in AAF71161 (PubMed:10803843).Curated1
Sequence conflicti177 – 204YGTHW…KASWA → IQLSALCGIHRYPRQIFSWG HRLLLCVE in AAF71161 (PubMed:10803843).CuratedAdd BLAST28
Sequence conflicti205 – 311Missing in AAF71161 (PubMed:10803843).CuratedAdd BLAST107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156988 mRNA Translation: AAF71161.1
AF156989 mRNA Translation: AAF71162.1
RefSeqiNP_071595.1, NM_022259.1
UniGeneiRn.113760
Rn.53994

Genome annotation databases

GeneIDi64025
KEGGirno:64025
UCSCiRGD:68400 rat

Similar proteinsi

Entry informationi

Entry nameiCD244_RAT
AccessioniPrimary (citable) accession number: Q9JLM2
Secondary accession number(s): Q9JLM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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