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Protein

Natural killer cell receptor 2B4

Gene

Cd244

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Modulate other receptor-ligand interactions to enhance leukocyte activation.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Natural killer cell receptor 2B4
Alternative name(s):
NK cell type I receptor protein 2B4
Short name:
NKR2B4
Non-MHC restricted killing associated
CD_antigen: CD244
Gene namesi
Name:Cd244
Synonyms:2b4, Nmrk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68400. Cd244.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 223204ExtracellularSequence analysisAdd
BLAST
Transmembranei224 – 24724HelicalSequence analysisAdd
BLAST
Topological domaini248 – 31164CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 311292Natural killer cell receptor 2B4PRO_0000014670Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 118By similarity
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence analysis
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi153 ↔ 195Sequence analysis
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence analysis
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence analysis
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence analysis
Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JLM2.
PRIDEiQ9JLM2.

Interactioni

Subunit structurei

Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006266.

Structurei

3D structure databases

ProteinModelPortaliQ9JLM2.
SMRiQ9JLM2. Positions 21-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 128107Ig-like 1Add
BLAST
Domaini131 – 21585Ig-like 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKYZ. Eukaryota.
ENOG410Y74Q. LUCA.
HOGENOMiHOG000111481.
HOVERGENiHBG050850.
InParanoidiQ9JLM2.
KOiK06582.
PhylomeDBiQ9JLM2.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR024304. NK_rcpt_2B4.
IPR024303. NK_rcpt_2B4_Ig_dom.
[Graphical view]
PANTHERiPTHR12080:SF56. PTHR12080:SF56. 1 hit.
PfamiPF11465. Receptor_2B4. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQQTVLLSL FLLLRAHQGQ DCADSSEEVL GVSGKPVRLR PSNIQAKHVS
60 70 80 90 100
IEWKKKTGHQ QTPQIVTWDT TDNKNFNMCC SDIYGFESEN FALSIKSAKL
110 120 130 140 150
NDSGHYLLEI TNQRGIVCTK NFQMLIFDPV ETPHLTVQGT LWANGTCQLS
160 170 180 190 200
LSCFVPKDDN VSYALYRGSM LISNQRYGTH WENRTDASSL HTYTCNVSNK
210 220 230 240 250
ASWANHTLTS PQSCQSVPSK FNYLPFMVSI GILVKFFHGA IDCFCVWNRK
260 270 280 290 300
RKQSQSIAKE SLTIHEYVKN AQVSRDQRGH FRASGSSSDV RGDERGQRES
310
DRRLFQFINR S
Length:311
Mass (Da):35,300
Last modified:October 1, 2000 - v1
Checksum:i5A527D22D2565772
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461A → T in AAF71161 (PubMed:10803843).Curated
Sequence conflicti177 – 20428YGTHW…KASWA → IQLSALCGIHRYPRQIFSWG HRLLLCVE in AAF71161 (PubMed:10803843).CuratedAdd
BLAST
Sequence conflicti205 – 311107Missing in AAF71161 (PubMed:10803843).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156988 mRNA. Translation: AAF71161.1.
AF156989 mRNA. Translation: AAF71162.1.
RefSeqiNP_071595.1. NM_022259.1.
UniGeneiRn.113760.
Rn.53994.

Genome annotation databases

GeneIDi64025.
KEGGirno:64025.
UCSCiRGD:68400. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156988 mRNA. Translation: AAF71161.1.
AF156989 mRNA. Translation: AAF71162.1.
RefSeqiNP_071595.1. NM_022259.1.
UniGeneiRn.113760.
Rn.53994.

3D structure databases

ProteinModelPortaliQ9JLM2.
SMRiQ9JLM2. Positions 21-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006266.

Proteomic databases

PaxDbiQ9JLM2.
PRIDEiQ9JLM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64025.
KEGGirno:64025.
UCSCiRGD:68400. rat.

Organism-specific databases

CTDi51744.
RGDi68400. Cd244.

Phylogenomic databases

eggNOGiENOG410IKYZ. Eukaryota.
ENOG410Y74Q. LUCA.
HOGENOMiHOG000111481.
HOVERGENiHBG050850.
InParanoidiQ9JLM2.
KOiK06582.
PhylomeDBiQ9JLM2.

Miscellaneous databases

NextBioi612631.
PROiQ9JLM2.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR024304. NK_rcpt_2B4.
IPR024303. NK_rcpt_2B4_Ig_dom.
[Graphical view]
PANTHERiPTHR12080:SF56. PTHR12080:SF56. 1 hit.
PfamiPF11465. Receptor_2B4. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of transmembrane and soluble forms of a novel rat natural killer cell receptor related to 2B4."
    Kumaresan P.R., Stepp S.E., Bennett M., Kumar V., Mathew P.A.
    Immunogenetics 51:306-313(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCD244_RAT
AccessioniPrimary (citable) accession number: Q9JLM2
Secondary accession number(s): Q9JLM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.