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Q9JLL3

- TNR19_MOUSE

UniProt

Q9JLL3 - TNR19_MOUSE

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Protein

Tumor necrosis factor receptor superfamily member 19

Gene

Tnfrsf19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Can mediate activation of c-Jun and NF-kappa-B. May promote caspase-independent cell death (By similarity). Isoform 2 and isoform 3 may act as decoy receptors.By similarity

GO - Biological processi

  1. hair follicle development Source: MGI
  2. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 19
Alternative name(s):
TRADE
Toxicity and JNK inducer
Gene namesi
Name:Tnfrsf19
Synonyms:Taj, Troy
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1352474. Tnfrsf19.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 170141ExtracellularSequence AnalysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence AnalysisAdd
BLAST
Topological domaini192 – 416225CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 416387Tumor necrosis factor receptor superfamily member 19PRO_0000034598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 46PROSITE-ProRule annotation
Disulfide bondi49 ↔ 62PROSITE-ProRule annotation
Disulfide bondi52 ↔ 72PROSITE-ProRule annotation
Disulfide bondi75 ↔ 89PROSITE-ProRule annotation
Disulfide bondi92 ↔ 106PROSITE-ProRule annotation
Disulfide bondi95 ↔ 114PROSITE-ProRule annotation
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi117 ↔ 135PROSITE-ProRule annotation
Disulfide bondi138 ↔ 149PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9JLL3.

PTM databases

PhosphoSiteiQ9JLL3.

Expressioni

Tissue specificityi

Highly expressed in adult brain, and in embryos from day 11-17, but not earlier. Detected in embryonic brain and epithelium, and at lower levels in adult heart, lung and liver. In neonatal mice, mainly in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. Isoform 3 was found in embryonic day 17.5 skin but not in brain and liver.

Gene expression databases

BgeeiQ9JLL3.
GenevestigatoriQ9JLL3.

Interactioni

Subunit structurei

Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.By similarity

Protein-protein interaction databases

BioGridi205900. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9JLL3.
SMRiQ9JLL3. Positions 33-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati33 – 7240TNFR-Cys 1Add
BLAST
Repeati74 – 11441TNFR-Cys 2Add
BLAST
Repeati116 – 14934TNFR-Cys 3; truncatedAdd
BLAST

Sequence similaritiesi

Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47237.
GeneTreeiENSGT00730000110978.
HOVERGENiHBG069143.
InParanoidiQ9JLL3.
KOiK05155.
OMAiICGEFSD.
OrthoDBiEOG7Z3F4G.
TreeFamiTF331385.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022342. TNFR_19.
[Graphical view]
PRINTSiPR01969. TNFACTORR19.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9JLL3-1) [UniParc]FASTAAdd to Basket

Also known as: TAJ-alphaL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALKVLPLHR TVLFAAILFL LHLACKVSCE TGDCRQQEFK DRSGNCVLCK
60 70 80 90 100
QCGPGMELSK ECGFGYGEDA QCVPCRPHRF KEDWGFQKCK PCADCALVNR
110 120 130 140 150
FQRANCSHTS DAVCGDCLPG FYRKTKLVGF QDMECVPCGD PPPPYEPHCT
160 170 180 190 200
SKVNLVKISS TVSSPRDTAL AAVICSALAT VLLALLILCV IYCKRQFMEK
210 220 230 240 250
KPSWSLRSQD IQYNGSELSC FDQPRLRHCA HRACCQYHRD SAPMYGPVHL
260 270 280 290 300
IPSLCCEEAR SSARAVLGCG LRSPTTLQER NPASVGDTMP AFFGSVSRSI
310 320 330 340 350
CAEFSDAWPL MQNPLGGDSS LCDSYPELTG EDTNSLNPEN ESAASLDSSG
360 370 380 390 400
GQDLAGTAAL ESSGNVSEST DSPRHGDTGT VWEQTLAQDA QRTPSQGGWE
410
DRENLNLAMP TAFQDA
Length:416
Mass (Da):45,265
Last modified:July 27, 2011 - v2
Checksum:i9BDC7C7A2D6A9C47
GO
Isoform 2 (identifier: Q9JLL3-2) [UniParc]FASTAAdd to Basket

Also known as: TAJ-beta1

The sequence of this isoform differs from the canonical sequence as follows:
     150-150: T → E
     151-416: Missing.

Show »
Length:150
Mass (Da):16,728
Checksum:i4A1B2E93AEF7FF43
GO
Isoform 3 (identifier: Q9JLL3-3) [UniParc]FASTAAdd to Basket

Also known as: TAJ-alphaS, dTROY

The sequence of this isoform differs from the canonical sequence as follows:
     204-214: WSLRSQDIQYN → CKLPSLCLTVK
     215-416: Missing.

Show »
Length:214
Mass (Da):23,564
Checksum:iECC63981C37482B8
GO
Isoform 4 (identifier: Q9JLL3-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-348: NESAASLDS → MLCFRFRDL
     349-416: Missing.

Show »
Length:348
Mass (Da):38,471
Checksum:i08A8273AA5280FFD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311T → A in AAF19795. (PubMed:10585776)Curated
Sequence conflicti208 – 2081S → P in AAF19795. (PubMed:10585776)Curated
Sequence conflicti287 – 2871D → N in AAF19795. (PubMed:10585776)Curated
Sequence conflicti287 – 2871D → N in AAF71825. (PubMed:10809768)Curated
Sequence conflicti343 – 3431A → T in AAF71825. (PubMed:10809768)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei150 – 1501T → E in isoform 2. 1 PublicationVSP_006513
Alternative sequencei151 – 416266Missing in isoform 2. 1 PublicationVSP_006514Add
BLAST
Alternative sequencei204 – 21411WSLRSQDIQYN → CKLPSLCLTVK in isoform 3. 3 PublicationsVSP_006515Add
BLAST
Alternative sequencei215 – 416202Missing in isoform 3. 3 PublicationsVSP_006516Add
BLAST
Alternative sequencei340 – 3489NESAASLDS → MLCFRFRDL in isoform 4. 1 PublicationVSP_006517
Alternative sequencei349 – 41668Missing in isoform 4. 1 PublicationVSP_006518Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173166 mRNA. Translation: AAF19795.1.
AF167552 mRNA. Translation: AAF71825.1.
AF167554 mRNA. Translation: AAF71827.1.
AF167553 mRNA. Translation: AAF71826.1.
AB040432 mRNA. Translation: BAB03267.1.
AB040433 mRNA. Translation: BAB03268.1.
AF247000 mRNA. Translation: AAK28397.1.
AK028146 mRNA. Translation: BAC25774.1.
BC030062 mRNA. Translation: AAH30062.1.
CCDSiCCDS36941.1. [Q9JLL3-1]
RefSeqiNP_001157627.1. NM_001164155.1. [Q9JLL3-1]
NP_038897.4. NM_013869.5. [Q9JLL3-1]
UniGeneiMm.281356.

Genome annotation databases

EnsembliENSMUST00000111234; ENSMUSP00000106865; ENSMUSG00000060548. [Q9JLL3-1]
ENSMUST00000111236; ENSMUSP00000106867; ENSMUSG00000060548. [Q9JLL3-1]
GeneIDi29820.
KEGGimmu:29820.
UCSCiuc007ufi.2. mouse. [Q9JLL3-1]
uc007ufl.2. mouse. [Q9JLL3-3]
uc007ufn.2. mouse. [Q9JLL3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173166 mRNA. Translation: AAF19795.1 .
AF167552 mRNA. Translation: AAF71825.1 .
AF167554 mRNA. Translation: AAF71827.1 .
AF167553 mRNA. Translation: AAF71826.1 .
AB040432 mRNA. Translation: BAB03267.1 .
AB040433 mRNA. Translation: BAB03268.1 .
AF247000 mRNA. Translation: AAK28397.1 .
AK028146 mRNA. Translation: BAC25774.1 .
BC030062 mRNA. Translation: AAH30062.1 .
CCDSi CCDS36941.1. [Q9JLL3-1 ]
RefSeqi NP_001157627.1. NM_001164155.1. [Q9JLL3-1 ]
NP_038897.4. NM_013869.5. [Q9JLL3-1 ]
UniGenei Mm.281356.

3D structure databases

ProteinModelPortali Q9JLL3.
SMRi Q9JLL3. Positions 33-138.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 205900. 1 interaction.

PTM databases

PhosphoSitei Q9JLL3.

Proteomic databases

PRIDEi Q9JLL3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000111234 ; ENSMUSP00000106865 ; ENSMUSG00000060548 . [Q9JLL3-1 ]
ENSMUST00000111236 ; ENSMUSP00000106867 ; ENSMUSG00000060548 . [Q9JLL3-1 ]
GeneIDi 29820.
KEGGi mmu:29820.
UCSCi uc007ufi.2. mouse. [Q9JLL3-1 ]
uc007ufl.2. mouse. [Q9JLL3-3 ]
uc007ufn.2. mouse. [Q9JLL3-2 ]

Organism-specific databases

CTDi 55504.
MGIi MGI:1352474. Tnfrsf19.

Phylogenomic databases

eggNOGi NOG47237.
GeneTreei ENSGT00730000110978.
HOVERGENi HBG069143.
InParanoidi Q9JLL3.
KOi K05155.
OMAi ICGEFSD.
OrthoDBi EOG7Z3F4G.
TreeFami TF331385.

Miscellaneous databases

NextBioi 306994.
PROi Q9JLL3.
SOURCEi Search...

Gene expression databases

Bgeei Q9JLL3.
Genevestigatori Q9JLL3.

Family and domain databases

InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022342. TNFR_19.
[Graphical view ]
PRINTSi PR01969. TNFACTORR19.
SMARTi SM00208. TNFR. 2 hits.
[Graphical view ]
PROSITEi PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily."
    Hu S., Tamada K., Ni J., Vincenz C., Chen L.
    Genomics 62:103-107(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
  2. "TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death."
    Eby M.T., Jasmin A., Kumar A., Sharma K., Chaudhary P.M.
    J. Biol. Chem. 275:15336-15342(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Embryo and Spleen.
  3. "TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles."
    Kojima T., Morikawa Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Senba E., Kitamura T.
    J. Biol. Chem. 275:20742-20747(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain.
  4. "TRADE, a novel TNF receptor family member associated with death signaling."
    Chaudhary D., Long A.J.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Tongue.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: Czech II.
    Tissue: Lung.

Entry informationi

Entry nameiTNR19_MOUSE
AccessioniPrimary (citable) accession number: Q9JLL3
Secondary accession number(s): Q80T13
, Q812G3, Q9JHF1, Q9JJH6, Q9JLL2, Q9QXW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3