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Q9JLL3 (TNR19_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor receptor superfamily member 19
Alternative name(s):
TRADE
Toxicity and JNK inducer
Gene names
Name:Tnfrsf19
Synonyms:Taj, Troy
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Can mediate activation of c-Jun and NF-kappa-B. May promote caspase-independent cell death By similarity. Isoform 2 and isoform 3 may act as decoy receptors.

Subunit structure

Associates with TRAF1, TRAF2, TRAF3 and TRAF5 By similarity. Interacts with LINGO1 By similarity.

Subcellular location

Isoform 1: Cell membrane; Single-pass type I membrane protein Probable.

Isoform 3: Cell membrane; Single-pass type I membrane protein Probable.

Isoform 4: Cell membrane; Single-pass type I membrane protein Probable.

Isoform 2: Secreted Probable.

Tissue specificity

Highly expressed in adult brain, and in embryos from day 11-17, but not earlier. Detected in embryonic brain and epithelium, and at lower levels in adult heart, lung and liver. In neonatal mice, mainly in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. Isoform 3 was found in embryonic day 17.5 skin but not in brain and liver.

Sequence similarities

Contains 3 TNFR-Cys repeats.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9JLL3-1)

Also known as: TAJ-alphaL;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9JLL3-2)

Also known as: TAJ-beta1;

The sequence of this isoform differs from the canonical sequence as follows:
     150-150: T → E
     151-416: Missing.
Isoform 3 (identifier: Q9JLL3-3)

Also known as: TAJ-alphaS; dTROY;

The sequence of this isoform differs from the canonical sequence as follows:
     204-214: WSLRSQDIQYN → CKLPSLCLTVK
     215-416: Missing.
Isoform 4 (identifier: Q9JLL3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     340-348: NESAASLDS → MLCFRFRDL
     349-416: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 416387Tumor necrosis factor receptor superfamily member 19
PRO_0000034598

Regions

Topological domain30 – 170141Extracellular Potential
Transmembrane171 – 19121Helical; Potential
Topological domain192 – 416225Cytoplasmic Potential
Repeat33 – 7240TNFR-Cys 1
Repeat74 – 11441TNFR-Cys 2
Repeat116 – 14934TNFR-Cys 3; truncated

Amino acid modifications

Glycosylation1051N-linked (GlcNAc...) Potential
Disulfide bond34 ↔ 46 By similarity
Disulfide bond49 ↔ 62 By similarity
Disulfide bond52 ↔ 72 By similarity
Disulfide bond75 ↔ 89 By similarity
Disulfide bond92 ↔ 106 By similarity
Disulfide bond95 ↔ 114 By similarity
Disulfide bond117 ↔ 135 By similarity
Disulfide bond138 ↔ 149 By similarity

Natural variations

Alternative sequence1501T → E in isoform 2.
VSP_006513
Alternative sequence151 – 416266Missing in isoform 2.
VSP_006514
Alternative sequence204 – 21411WSLRSQDIQYN → CKLPSLCLTVK in isoform 3.
VSP_006515
Alternative sequence215 – 416202Missing in isoform 3.
VSP_006516
Alternative sequence340 – 3489NESAASLDS → MLCFRFRDL in isoform 4.
VSP_006517
Alternative sequence349 – 41668Missing in isoform 4.
VSP_006518

Experimental info

Sequence conflict311T → A in AAF19795. Ref.1
Sequence conflict2081S → P in AAF19795. Ref.1
Sequence conflict2871D → N in AAF19795. Ref.1
Sequence conflict2871D → N in AAF71825. Ref.2
Sequence conflict3431A → T in AAF71825. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (TAJ-alphaL) [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 9BDC7C7A2D6A9C47

FASTA41645,265
        10         20         30         40         50         60 
MALKVLPLHR TVLFAAILFL LHLACKVSCE TGDCRQQEFK DRSGNCVLCK QCGPGMELSK 

        70         80         90        100        110        120 
ECGFGYGEDA QCVPCRPHRF KEDWGFQKCK PCADCALVNR FQRANCSHTS DAVCGDCLPG 

       130        140        150        160        170        180 
FYRKTKLVGF QDMECVPCGD PPPPYEPHCT SKVNLVKISS TVSSPRDTAL AAVICSALAT 

       190        200        210        220        230        240 
VLLALLILCV IYCKRQFMEK KPSWSLRSQD IQYNGSELSC FDQPRLRHCA HRACCQYHRD 

       250        260        270        280        290        300 
SAPMYGPVHL IPSLCCEEAR SSARAVLGCG LRSPTTLQER NPASVGDTMP AFFGSVSRSI 

       310        320        330        340        350        360 
CAEFSDAWPL MQNPLGGDSS LCDSYPELTG EDTNSLNPEN ESAASLDSSG GQDLAGTAAL 

       370        380        390        400        410 
ESSGNVSEST DSPRHGDTGT VWEQTLAQDA QRTPSQGGWE DRENLNLAMP TAFQDA 

« Hide

Isoform 2 (TAJ-beta1) [UniParc].

Checksum: 4A1B2E93AEF7FF43
Show »

FASTA15016,728
Isoform 3 (TAJ-alphaS) (dTROY) [UniParc].

Checksum: ECC63981C37482B8
Show »

FASTA21423,564
Isoform 4 [UniParc].

Checksum: 08A8273AA5280FFD
Show »

FASTA34838,471

References

« Hide 'large scale' references
[1]"Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily."
Hu S., Tamada K., Ni J., Vincenz C., Chen L.
Genomics 62:103-107(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[2]"TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death."
Eby M.T., Jasmin A., Kumar A., Sharma K., Chaudhary P.M.
J. Biol. Chem. 275:15336-15342(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Embryo and Spleen.
[3]"TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles."
Kojima T., Morikawa Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Senba E., Kitamura T.
J. Biol. Chem. 275:20742-20747(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
Tissue: Brain.
[4]"TRADE, a novel TNF receptor family member associated with death signaling."
Chaudhary D., Long A.J.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: C57BL/6.
[5]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Tongue.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Strain: Czech II.
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF173166 mRNA. Translation: AAF19795.1.
AF167552 mRNA. Translation: AAF71825.1.
AF167554 mRNA. Translation: AAF71827.1.
AF167553 mRNA. Translation: AAF71826.1.
AB040432 mRNA. Translation: BAB03267.1.
AB040433 mRNA. Translation: BAB03268.1.
AF247000 mRNA. Translation: AAK28397.1.
AK028146 mRNA. Translation: BAC25774.1.
BC030062 mRNA. Translation: AAH30062.1.
CCDSCCDS36941.1. [Q9JLL3-1]
RefSeqNP_001157627.1. NM_001164155.1. [Q9JLL3-1]
NP_038897.4. NM_013869.5. [Q9JLL3-1]
UniGeneMm.281356.

3D structure databases

ProteinModelPortalQ9JLL3.
SMRQ9JLL3. Positions 33-138.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid205900. 1 interaction.

PTM databases

PhosphoSiteQ9JLL3.

Proteomic databases

PRIDEQ9JLL3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000111234; ENSMUSP00000106865; ENSMUSG00000060548. [Q9JLL3-1]
ENSMUST00000111236; ENSMUSP00000106867; ENSMUSG00000060548. [Q9JLL3-1]
GeneID29820.
KEGGmmu:29820.
UCSCuc007ufi.2. mouse. [Q9JLL3-1]
uc007ufl.2. mouse. [Q9JLL3-3]
uc007ufn.2. mouse. [Q9JLL3-2]

Organism-specific databases

CTD55504.
MGIMGI:1352474. Tnfrsf19.

Phylogenomic databases

eggNOGNOG47237.
GeneTreeENSGT00730000110978.
HOVERGENHBG069143.
InParanoidQ80T13.
KOK05155.
OMAICGEFSD.
OrthoDBEOG7Z3F4G.
TreeFamTF331385.

Gene expression databases

BgeeQ9JLL3.
GenevestigatorQ9JLL3.

Family and domain databases

InterProIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022342. TNFR_19.
[Graphical view]
PRINTSPR01969. TNFACTORR19.
SMARTSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio306994.
PROQ9JLL3.
SOURCESearch...

Entry information

Entry nameTNR19_MOUSE
AccessionPrimary (citable) accession number: Q9JLL3
Secondary accession number(s): Q80T13 expand/collapse secondary AC list , Q812G3, Q9JHF1, Q9JJH6, Q9JLL2, Q9QXW7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot