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Q9JLL3

- TNR19_MOUSE

UniProt

Q9JLL3 - TNR19_MOUSE

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Protein
Tumor necrosis factor receptor superfamily member 19
Gene
Tnfrsf19, Taj, Troy
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Can mediate activation of c-Jun and NF-kappa-B. May promote caspase-independent cell death By similarity. Isoform 2 and isoform 3 may act as decoy receptors.

GO - Biological processi

  1. hair follicle development Source: MGI
  2. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 19
Alternative name(s):
TRADE
Toxicity and JNK inducer
Gene namesi
Name:Tnfrsf19
Synonyms:Taj, Troy
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1352474. Tnfrsf19.

Subcellular locationi

Isoform 2 : Secreted Inferred

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 170141Extracellular Reviewed prediction
Add
BLAST
Transmembranei171 – 19121Helical; Reviewed prediction
Add
BLAST
Topological domaini192 – 416225Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Chaini30 – 416387Tumor necrosis factor receptor superfamily member 19
PRO_0000034598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 46 By similarity
Disulfide bondi49 ↔ 62 By similarity
Disulfide bondi52 ↔ 72 By similarity
Disulfide bondi75 ↔ 89 By similarity
Disulfide bondi92 ↔ 106 By similarity
Disulfide bondi95 ↔ 114 By similarity
Glycosylationi105 – 1051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi117 ↔ 135 By similarity
Disulfide bondi138 ↔ 149 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9JLL3.

PTM databases

PhosphoSiteiQ9JLL3.

Expressioni

Tissue specificityi

Highly expressed in adult brain, and in embryos from day 11-17, but not earlier. Detected in embryonic brain and epithelium, and at lower levels in adult heart, lung and liver. In neonatal mice, mainly in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. Isoform 3 was found in embryonic day 17.5 skin but not in brain and liver.

Gene expression databases

BgeeiQ9JLL3.
GenevestigatoriQ9JLL3.

Interactioni

Subunit structurei

Associates with TRAF1, TRAF2, TRAF3 and TRAF5 By similarity. Interacts with LINGO1 By similarity.

Protein-protein interaction databases

BioGridi205900. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9JLL3.
SMRiQ9JLL3. Positions 33-138.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati33 – 7240TNFR-Cys 1
Add
BLAST
Repeati74 – 11441TNFR-Cys 2
Add
BLAST
Repeati116 – 14934TNFR-Cys 3; truncated
Add
BLAST

Sequence similaritiesi

Contains 3 TNFR-Cys repeats.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47237.
GeneTreeiENSGT00730000110978.
HOVERGENiHBG069143.
InParanoidiQ80T13.
KOiK05155.
OMAiICGEFSD.
OrthoDBiEOG7Z3F4G.
TreeFamiTF331385.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022342. TNFR_19.
[Graphical view]
PRINTSiPR01969. TNFACTORR19.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9JLL3-1) [UniParc]FASTAAdd to Basket

Also known as: TAJ-alphaL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALKVLPLHR TVLFAAILFL LHLACKVSCE TGDCRQQEFK DRSGNCVLCK    50
QCGPGMELSK ECGFGYGEDA QCVPCRPHRF KEDWGFQKCK PCADCALVNR 100
FQRANCSHTS DAVCGDCLPG FYRKTKLVGF QDMECVPCGD PPPPYEPHCT 150
SKVNLVKISS TVSSPRDTAL AAVICSALAT VLLALLILCV IYCKRQFMEK 200
KPSWSLRSQD IQYNGSELSC FDQPRLRHCA HRACCQYHRD SAPMYGPVHL 250
IPSLCCEEAR SSARAVLGCG LRSPTTLQER NPASVGDTMP AFFGSVSRSI 300
CAEFSDAWPL MQNPLGGDSS LCDSYPELTG EDTNSLNPEN ESAASLDSSG 350
GQDLAGTAAL ESSGNVSEST DSPRHGDTGT VWEQTLAQDA QRTPSQGGWE 400
DRENLNLAMP TAFQDA 416
Length:416
Mass (Da):45,265
Last modified:July 27, 2011 - v2
Checksum:i9BDC7C7A2D6A9C47
GO
Isoform 2 (identifier: Q9JLL3-2) [UniParc]FASTAAdd to Basket

Also known as: TAJ-beta1

The sequence of this isoform differs from the canonical sequence as follows:
     150-150: T → E
     151-416: Missing.

Show »
Length:150
Mass (Da):16,728
Checksum:i4A1B2E93AEF7FF43
GO
Isoform 3 (identifier: Q9JLL3-3) [UniParc]FASTAAdd to Basket

Also known as: TAJ-alphaS, dTROY

The sequence of this isoform differs from the canonical sequence as follows:
     204-214: WSLRSQDIQYN → CKLPSLCLTVK
     215-416: Missing.

Show »
Length:214
Mass (Da):23,564
Checksum:iECC63981C37482B8
GO
Isoform 4 (identifier: Q9JLL3-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-348: NESAASLDS → MLCFRFRDL
     349-416: Missing.

Show »
Length:348
Mass (Da):38,471
Checksum:i08A8273AA5280FFD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei150 – 1501T → E in isoform 2.
VSP_006513
Alternative sequencei151 – 416266Missing in isoform 2.
VSP_006514Add
BLAST
Alternative sequencei204 – 21411WSLRSQDIQYN → CKLPSLCLTVK in isoform 3.
VSP_006515Add
BLAST
Alternative sequencei215 – 416202Missing in isoform 3.
VSP_006516Add
BLAST
Alternative sequencei340 – 3489NESAASLDS → MLCFRFRDL in isoform 4.
VSP_006517
Alternative sequencei349 – 41668Missing in isoform 4.
VSP_006518Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311T → A in AAF19795. 1 Publication
Sequence conflicti208 – 2081S → P in AAF19795. 1 Publication
Sequence conflicti287 – 2871D → N in AAF19795. 1 Publication
Sequence conflicti287 – 2871D → N in AAF71825. 1 Publication
Sequence conflicti343 – 3431A → T in AAF71825. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF173166 mRNA. Translation: AAF19795.1.
AF167552 mRNA. Translation: AAF71825.1.
AF167554 mRNA. Translation: AAF71827.1.
AF167553 mRNA. Translation: AAF71826.1.
AB040432 mRNA. Translation: BAB03267.1.
AB040433 mRNA. Translation: BAB03268.1.
AF247000 mRNA. Translation: AAK28397.1.
AK028146 mRNA. Translation: BAC25774.1.
BC030062 mRNA. Translation: AAH30062.1.
CCDSiCCDS36941.1. [Q9JLL3-1]
RefSeqiNP_001157627.1. NM_001164155.1. [Q9JLL3-1]
NP_038897.4. NM_013869.5. [Q9JLL3-1]
UniGeneiMm.281356.

Genome annotation databases

EnsembliENSMUST00000111234; ENSMUSP00000106865; ENSMUSG00000060548. [Q9JLL3-1]
ENSMUST00000111236; ENSMUSP00000106867; ENSMUSG00000060548. [Q9JLL3-1]
GeneIDi29820.
KEGGimmu:29820.
UCSCiuc007ufi.2. mouse. [Q9JLL3-1]
uc007ufl.2. mouse. [Q9JLL3-3]
uc007ufn.2. mouse. [Q9JLL3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF173166 mRNA. Translation: AAF19795.1 .
AF167552 mRNA. Translation: AAF71825.1 .
AF167554 mRNA. Translation: AAF71827.1 .
AF167553 mRNA. Translation: AAF71826.1 .
AB040432 mRNA. Translation: BAB03267.1 .
AB040433 mRNA. Translation: BAB03268.1 .
AF247000 mRNA. Translation: AAK28397.1 .
AK028146 mRNA. Translation: BAC25774.1 .
BC030062 mRNA. Translation: AAH30062.1 .
CCDSi CCDS36941.1. [Q9JLL3-1 ]
RefSeqi NP_001157627.1. NM_001164155.1. [Q9JLL3-1 ]
NP_038897.4. NM_013869.5. [Q9JLL3-1 ]
UniGenei Mm.281356.

3D structure databases

ProteinModelPortali Q9JLL3.
SMRi Q9JLL3. Positions 33-138.
ModBasei Search...

Protein-protein interaction databases

BioGridi 205900. 1 interaction.

PTM databases

PhosphoSitei Q9JLL3.

Proteomic databases

PRIDEi Q9JLL3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000111234 ; ENSMUSP00000106865 ; ENSMUSG00000060548 . [Q9JLL3-1 ]
ENSMUST00000111236 ; ENSMUSP00000106867 ; ENSMUSG00000060548 . [Q9JLL3-1 ]
GeneIDi 29820.
KEGGi mmu:29820.
UCSCi uc007ufi.2. mouse. [Q9JLL3-1 ]
uc007ufl.2. mouse. [Q9JLL3-3 ]
uc007ufn.2. mouse. [Q9JLL3-2 ]

Organism-specific databases

CTDi 55504.
MGIi MGI:1352474. Tnfrsf19.

Phylogenomic databases

eggNOGi NOG47237.
GeneTreei ENSGT00730000110978.
HOVERGENi HBG069143.
InParanoidi Q80T13.
KOi K05155.
OMAi ICGEFSD.
OrthoDBi EOG7Z3F4G.
TreeFami TF331385.

Miscellaneous databases

NextBioi 306994.
PROi Q9JLL3.
SOURCEi Search...

Gene expression databases

Bgeei Q9JLL3.
Genevestigatori Q9JLL3.

Family and domain databases

InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022342. TNFR_19.
[Graphical view ]
PRINTSi PR01969. TNFACTORR19.
SMARTi SM00208. TNFR. 2 hits.
[Graphical view ]
PROSITEi PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily."
    Hu S., Tamada K., Ni J., Vincenz C., Chen L.
    Genomics 62:103-107(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
  2. "TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death."
    Eby M.T., Jasmin A., Kumar A., Sharma K., Chaudhary P.M.
    J. Biol. Chem. 275:15336-15342(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Embryo and Spleen.
  3. "TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles."
    Kojima T., Morikawa Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Senba E., Kitamura T.
    J. Biol. Chem. 275:20742-20747(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain.
  4. "TRADE, a novel TNF receptor family member associated with death signaling."
    Chaudhary D., Long A.J.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Tongue.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: Czech II.
    Tissue: Lung.

Entry informationi

Entry nameiTNR19_MOUSE
AccessioniPrimary (citable) accession number: Q9JLL3
Secondary accession number(s): Q80T13
, Q812G3, Q9JHF1, Q9JJH6, Q9JLL2, Q9QXW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi