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Q9JLL3

- TNR19_MOUSE

UniProt

Q9JLL3 - TNR19_MOUSE

Protein

Tumor necrosis factor receptor superfamily member 19

Gene

Tnfrsf19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Can mediate activation of c-Jun and NF-kappa-B. May promote caspase-independent cell death By similarity. Isoform 2 and isoform 3 may act as decoy receptors.By similarity

    GO - Biological processi

    1. hair follicle development Source: MGI
    2. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 19
    Alternative name(s):
    TRADE
    Toxicity and JNK inducer
    Gene namesi
    Name:Tnfrsf19
    Synonyms:Taj, Troy
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1352474. Tnfrsf19.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 416387Tumor necrosis factor receptor superfamily member 19PRO_0000034598Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 46PROSITE-ProRule annotation
    Disulfide bondi49 ↔ 62PROSITE-ProRule annotation
    Disulfide bondi52 ↔ 72PROSITE-ProRule annotation
    Disulfide bondi75 ↔ 89PROSITE-ProRule annotation
    Disulfide bondi92 ↔ 106PROSITE-ProRule annotation
    Disulfide bondi95 ↔ 114PROSITE-ProRule annotation
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi117 ↔ 135PROSITE-ProRule annotation
    Disulfide bondi138 ↔ 149PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9JLL3.

    PTM databases

    PhosphoSiteiQ9JLL3.

    Expressioni

    Tissue specificityi

    Highly expressed in adult brain, and in embryos from day 11-17, but not earlier. Detected in embryonic brain and epithelium, and at lower levels in adult heart, lung and liver. In neonatal mice, mainly in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. Isoform 3 was found in embryonic day 17.5 skin but not in brain and liver.

    Gene expression databases

    BgeeiQ9JLL3.
    GenevestigatoriQ9JLL3.

    Interactioni

    Subunit structurei

    Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.By similarity

    Protein-protein interaction databases

    BioGridi205900. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JLL3.
    SMRiQ9JLL3. Positions 33-138.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 170141ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini192 – 416225CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati33 – 7240TNFR-Cys 1Add
    BLAST
    Repeati74 – 11441TNFR-Cys 2Add
    BLAST
    Repeati116 – 14934TNFR-Cys 3; truncatedAdd
    BLAST

    Sequence similaritiesi

    Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47237.
    GeneTreeiENSGT00730000110978.
    HOVERGENiHBG069143.
    InParanoidiQ80T13.
    KOiK05155.
    OMAiICGEFSD.
    OrthoDBiEOG7Z3F4G.
    TreeFamiTF331385.

    Family and domain databases

    InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR022342. TNFR_19.
    [Graphical view]
    PRINTSiPR01969. TNFACTORR19.
    SMARTiSM00208. TNFR. 2 hits.
    [Graphical view]
    PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9JLL3-1) [UniParc]FASTAAdd to Basket

    Also known as: TAJ-alphaL

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALKVLPLHR TVLFAAILFL LHLACKVSCE TGDCRQQEFK DRSGNCVLCK    50
    QCGPGMELSK ECGFGYGEDA QCVPCRPHRF KEDWGFQKCK PCADCALVNR 100
    FQRANCSHTS DAVCGDCLPG FYRKTKLVGF QDMECVPCGD PPPPYEPHCT 150
    SKVNLVKISS TVSSPRDTAL AAVICSALAT VLLALLILCV IYCKRQFMEK 200
    KPSWSLRSQD IQYNGSELSC FDQPRLRHCA HRACCQYHRD SAPMYGPVHL 250
    IPSLCCEEAR SSARAVLGCG LRSPTTLQER NPASVGDTMP AFFGSVSRSI 300
    CAEFSDAWPL MQNPLGGDSS LCDSYPELTG EDTNSLNPEN ESAASLDSSG 350
    GQDLAGTAAL ESSGNVSEST DSPRHGDTGT VWEQTLAQDA QRTPSQGGWE 400
    DRENLNLAMP TAFQDA 416
    Length:416
    Mass (Da):45,265
    Last modified:July 27, 2011 - v2
    Checksum:i9BDC7C7A2D6A9C47
    GO
    Isoform 2 (identifier: Q9JLL3-2) [UniParc]FASTAAdd to Basket

    Also known as: TAJ-beta1

    The sequence of this isoform differs from the canonical sequence as follows:
         150-150: T → E
         151-416: Missing.

    Show »
    Length:150
    Mass (Da):16,728
    Checksum:i4A1B2E93AEF7FF43
    GO
    Isoform 3 (identifier: Q9JLL3-3) [UniParc]FASTAAdd to Basket

    Also known as: TAJ-alphaS, dTROY

    The sequence of this isoform differs from the canonical sequence as follows:
         204-214: WSLRSQDIQYN → CKLPSLCLTVK
         215-416: Missing.

    Show »
    Length:214
    Mass (Da):23,564
    Checksum:iECC63981C37482B8
    GO
    Isoform 4 (identifier: Q9JLL3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         340-348: NESAASLDS → MLCFRFRDL
         349-416: Missing.

    Show »
    Length:348
    Mass (Da):38,471
    Checksum:i08A8273AA5280FFD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311T → A in AAF19795. (PubMed:10585776)Curated
    Sequence conflicti208 – 2081S → P in AAF19795. (PubMed:10585776)Curated
    Sequence conflicti287 – 2871D → N in AAF19795. (PubMed:10585776)Curated
    Sequence conflicti287 – 2871D → N in AAF71825. (PubMed:10809768)Curated
    Sequence conflicti343 – 3431A → T in AAF71825. (PubMed:10809768)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei150 – 1501T → E in isoform 2. 1 PublicationVSP_006513
    Alternative sequencei151 – 416266Missing in isoform 2. 1 PublicationVSP_006514Add
    BLAST
    Alternative sequencei204 – 21411WSLRSQDIQYN → CKLPSLCLTVK in isoform 3. 3 PublicationsVSP_006515Add
    BLAST
    Alternative sequencei215 – 416202Missing in isoform 3. 3 PublicationsVSP_006516Add
    BLAST
    Alternative sequencei340 – 3489NESAASLDS → MLCFRFRDL in isoform 4. 1 PublicationVSP_006517
    Alternative sequencei349 – 41668Missing in isoform 4. 1 PublicationVSP_006518Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF173166 mRNA. Translation: AAF19795.1.
    AF167552 mRNA. Translation: AAF71825.1.
    AF167554 mRNA. Translation: AAF71827.1.
    AF167553 mRNA. Translation: AAF71826.1.
    AB040432 mRNA. Translation: BAB03267.1.
    AB040433 mRNA. Translation: BAB03268.1.
    AF247000 mRNA. Translation: AAK28397.1.
    AK028146 mRNA. Translation: BAC25774.1.
    BC030062 mRNA. Translation: AAH30062.1.
    CCDSiCCDS36941.1. [Q9JLL3-1]
    RefSeqiNP_001157627.1. NM_001164155.1. [Q9JLL3-1]
    NP_038897.4. NM_013869.5. [Q9JLL3-1]
    UniGeneiMm.281356.

    Genome annotation databases

    EnsembliENSMUST00000111234; ENSMUSP00000106865; ENSMUSG00000060548. [Q9JLL3-1]
    ENSMUST00000111236; ENSMUSP00000106867; ENSMUSG00000060548. [Q9JLL3-1]
    GeneIDi29820.
    KEGGimmu:29820.
    UCSCiuc007ufi.2. mouse. [Q9JLL3-1]
    uc007ufl.2. mouse. [Q9JLL3-3]
    uc007ufn.2. mouse. [Q9JLL3-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF173166 mRNA. Translation: AAF19795.1 .
    AF167552 mRNA. Translation: AAF71825.1 .
    AF167554 mRNA. Translation: AAF71827.1 .
    AF167553 mRNA. Translation: AAF71826.1 .
    AB040432 mRNA. Translation: BAB03267.1 .
    AB040433 mRNA. Translation: BAB03268.1 .
    AF247000 mRNA. Translation: AAK28397.1 .
    AK028146 mRNA. Translation: BAC25774.1 .
    BC030062 mRNA. Translation: AAH30062.1 .
    CCDSi CCDS36941.1. [Q9JLL3-1 ]
    RefSeqi NP_001157627.1. NM_001164155.1. [Q9JLL3-1 ]
    NP_038897.4. NM_013869.5. [Q9JLL3-1 ]
    UniGenei Mm.281356.

    3D structure databases

    ProteinModelPortali Q9JLL3.
    SMRi Q9JLL3. Positions 33-138.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 205900. 1 interaction.

    PTM databases

    PhosphoSitei Q9JLL3.

    Proteomic databases

    PRIDEi Q9JLL3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000111234 ; ENSMUSP00000106865 ; ENSMUSG00000060548 . [Q9JLL3-1 ]
    ENSMUST00000111236 ; ENSMUSP00000106867 ; ENSMUSG00000060548 . [Q9JLL3-1 ]
    GeneIDi 29820.
    KEGGi mmu:29820.
    UCSCi uc007ufi.2. mouse. [Q9JLL3-1 ]
    uc007ufl.2. mouse. [Q9JLL3-3 ]
    uc007ufn.2. mouse. [Q9JLL3-2 ]

    Organism-specific databases

    CTDi 55504.
    MGIi MGI:1352474. Tnfrsf19.

    Phylogenomic databases

    eggNOGi NOG47237.
    GeneTreei ENSGT00730000110978.
    HOVERGENi HBG069143.
    InParanoidi Q80T13.
    KOi K05155.
    OMAi ICGEFSD.
    OrthoDBi EOG7Z3F4G.
    TreeFami TF331385.

    Miscellaneous databases

    NextBioi 306994.
    PROi Q9JLL3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JLL3.
    Genevestigatori Q9JLL3.

    Family and domain databases

    InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR022342. TNFR_19.
    [Graphical view ]
    PRINTSi PR01969. TNFACTORR19.
    SMARTi SM00208. TNFR. 2 hits.
    [Graphical view ]
    PROSITEi PS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily."
      Hu S., Tamada K., Ni J., Vincenz C., Chen L.
      Genomics 62:103-107(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    2. "TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death."
      Eby M.T., Jasmin A., Kumar A., Sharma K., Chaudhary P.M.
      J. Biol. Chem. 275:15336-15342(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Embryo and Spleen.
    3. "TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles."
      Kojima T., Morikawa Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Senba E., Kitamura T.
      J. Biol. Chem. 275:20742-20747(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain.
    4. "TRADE, a novel TNF receptor family member associated with death signaling."
      Chaudhary D., Long A.J.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Tongue.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: Czech II.
      Tissue: Lung.

    Entry informationi

    Entry nameiTNR19_MOUSE
    AccessioniPrimary (citable) accession number: Q9JLL3
    Secondary accession number(s): Q80T13
    , Q812G3, Q9JHF1, Q9JJH6, Q9JLL2, Q9QXW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3