Q9JLL3 (TNR19_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tumor necrosis factor receptor superfamily member 19

Alternative name(s):
TRADE
Toxicity and JNK inducer

Gene names

Name:	Tnfrsf19
Synonyms:	Taj, Troy

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Can mediate activation of c-Jun and NF-kappa-B. May promote caspase-independent cell death By similarity. Isoform 2 and isoform 3 may act as decoy receptors.
Subunit structure	Associates with TRAF1, TRAF2, TRAF3 and TRAF5 By similarity. Interacts with LINGO1 By similarity.
Subcellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein Probable. Isoform 3: Cell membrane; Single-pass type I membrane protein Probable. Isoform 4: Cell membrane; Single-pass type I membrane protein Probable. Isoform 2: Secreted Probable.
Tissue specificity	Highly expressed in adult brain, and in embryos from day 11-17, but not earlier. Detected in embryonic brain and epithelium, and at lower levels in adult heart, lung and liver. In neonatal mice, mainly in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. Isoform 3 was found in embryonic day 17.5 skin but not in brain and liver.
Sequence similarities	Contains 3 TNFR-Cys repeats.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	hair follicle development Inferred from genetic interaction PubMed 18689798. Source: MGI positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from direct assay Ref.3. Source: MGI
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9JLL3-1)

Also known as: TAJ-alphaL;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9JLL3-2)

Also known as: TAJ-beta1;

The sequence of this isoform differs from the canonical sequence as follows:
     150-150: T → E
     151-416: Missing.

Isoform 3 (identifier: Q9JLL3-3)

Also known as: TAJ-alphaS; dTROY;

The sequence of this isoform differs from the canonical sequence as follows:
     204-214: WSLRSQDIQYN → CKLPSLCLTVK
     215-416: Missing.

Isoform 4 (identifier: Q9JLL3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     340-348: NESAASLDS → MLCFRFRDL
     349-416: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 416	387	Tumor necrosis factor receptor superfamily member 19		PRO_0000034598
Regions
	Topological domain	30 – 170	141	Extracellular Potential
	Transmembrane	171 – 191	21	Helical; Potential
	Topological domain	192 – 416	225	Cytoplasmic Potential
	Repeat	33 – 72	40	TNFR-Cys 1
	Repeat	74 – 114	41	TNFR-Cys 2
	Repeat	116 – 149	34	TNFR-Cys 3; truncated
Amino acid modifications
	Glycosylation	105	1	N-linked (GlcNAc...) Potential
	Disulfide bond	34 ↔ 46		By similarity
	Disulfide bond	49 ↔ 62		By similarity
	Disulfide bond	52 ↔ 72		By similarity
	Disulfide bond	75 ↔ 89		By similarity
	Disulfide bond	92 ↔ 106		By similarity
	Disulfide bond	95 ↔ 114		By similarity
	Disulfide bond	117 ↔ 135		By similarity
	Disulfide bond	138 ↔ 149		By similarity
Natural variations
	Alternative sequence	150	1	T → E in isoform 2.		VSP_006513
	Alternative sequence	151 – 416	266	Missing in isoform 2.		VSP_006514
	Alternative sequence	204 – 214	11	WSLRSQDIQYN → CKLPSLCLTVK in isoform 3.		VSP_006515
	Alternative sequence	215 – 416	202	Missing in isoform 3.		VSP_006516
	Alternative sequence	340 – 348	9	NESAASLDS → MLCFRFRDL in isoform 4.		VSP_006517
	Alternative sequence	349 – 416	68	Missing in isoform 4.		VSP_006518
Experimental info
	Sequence conflict	31	1	T → A in AAF19795. Ref.1
	Sequence conflict	208	1	S → P in AAF19795. Ref.1
	Sequence conflict	287	1	D → N in AAF19795. Ref.1
	Sequence conflict	287	1	D → N in AAF71825. Ref.2
	Sequence conflict	343	1	A → T in AAF71825. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (TAJ-alphaL) [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 9BDC7C7A2D6A9C47	FASTA	416	45,265
	10 20 30 40 50 60 MALKVLPLHR TVLFAAILFL LHLACKVSCE TGDCRQQEFK DRSGNCVLCK QCGPGMELSK 70 80 90 100 110 120 ECGFGYGEDA QCVPCRPHRF KEDWGFQKCK PCADCALVNR FQRANCSHTS DAVCGDCLPG 130 140 150 160 170 180 FYRKTKLVGF QDMECVPCGD PPPPYEPHCT SKVNLVKISS TVSSPRDTAL AAVICSALAT 190 200 210 220 230 240 VLLALLILCV IYCKRQFMEK KPSWSLRSQD IQYNGSELSC FDQPRLRHCA HRACCQYHRD 250 260 270 280 290 300 SAPMYGPVHL IPSLCCEEAR SSARAVLGCG LRSPTTLQER NPASVGDTMP AFFGSVSRSI 310 320 330 340 350 360 CAEFSDAWPL MQNPLGGDSS LCDSYPELTG EDTNSLNPEN ESAASLDSSG GQDLAGTAAL 370 380 390 400 410 ESSGNVSEST DSPRHGDTGT VWEQTLAQDA QRTPSQGGWE DRENLNLAMP TAFQDA
	Isoform 2 (TAJ-beta1) [UniParc]. Checksum: 4A1B2E93AEF7FF43	FASTA	150	16,728
	10 20 30 40 50 60 MALKVLPLHR TVLFAAILFL LHLACKVSCE TGDCRQQEFK DRSGNCVLCK QCGPGMELSK 70 80 90 100 110 120 ECGFGYGEDA QCVPCRPHRF KEDWGFQKCK PCADCALVNR FQRANCSHTS DAVCGDCLPG 130 140 150 FYRKTKLVGF QDMECVPCGD PPPPYEPHCE
	Isoform 3 (TAJ-alphaS) (dTROY) [UniParc]. Checksum: ECC63981C37482B8	FASTA	214	23,564
	10 20 30 40 50 60 MALKVLPLHR TVLFAAILFL LHLACKVSCE TGDCRQQEFK DRSGNCVLCK QCGPGMELSK 70 80 90 100 110 120 ECGFGYGEDA QCVPCRPHRF KEDWGFQKCK PCADCALVNR FQRANCSHTS DAVCGDCLPG 130 140 150 160 170 180 FYRKTKLVGF QDMECVPCGD PPPPYEPHCT SKVNLVKISS TVSSPRDTAL AAVICSALAT 190 200 210 VLLALLILCV IYCKRQFMEK KPSCKLPSLC LTVK
	Isoform 4 [UniParc]. Checksum: 08A8273AA5280FFD	FASTA	348	38,471
	10 20 30 40 50 60 MALKVLPLHR TVLFAAILFL LHLACKVSCE TGDCRQQEFK DRSGNCVLCK QCGPGMELSK 70 80 90 100 110 120 ECGFGYGEDA QCVPCRPHRF KEDWGFQKCK PCADCALVNR FQRANCSHTS DAVCGDCLPG 130 140 150 160 170 180 FYRKTKLVGF QDMECVPCGD PPPPYEPHCT SKVNLVKISS TVSSPRDTAL AAVICSALAT 190 200 210 220 230 240 VLLALLILCV IYCKRQFMEK KPSWSLRSQD IQYNGSELSC FDQPRLRHCA HRACCQYHRD 250 260 270 280 290 300 SAPMYGPVHL IPSLCCEEAR SSARAVLGCG LRSPTTLQER NPASVGDTMP AFFGSVSRSI 310 320 330 340 CAEFSDAWPL MQNPLGGDSS LCDSYPELTG EDTNSLNPEM LCFRFRDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily." Hu S., Tamada K., Ni J., Vincenz C., Chen L. Genomics 62:103-107(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[2]	"TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death." Eby M.T., Jasmin A., Kumar A., Sharma K., Chaudhary P.M. J. Biol. Chem. 275:15336-15342(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Embryo and Spleen.
[3]	"TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles." Kojima T., Morikawa Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Senba E., Kitamura T. J. Biol. Chem. 275:20742-20747(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3). Tissue: Brain.
[4]	"TRADE, a novel TNF receptor family member associated with death signaling." Chaudhary D., Long A.J. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: C57BL/6.
[5]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Tongue.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Strain: Czech II. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF173166 mRNA. Translation: AAF19795.1. AF167552 mRNA. Translation: AAF71825.1. AF167554 mRNA. Translation: AAF71827.1. AF167553 mRNA. Translation: AAF71826.1. AB040432 mRNA. Translation: BAB03267.1. AB040433 mRNA. Translation: BAB03268.1. AF247000 mRNA. Translation: AAK28397.1. AK028146 mRNA. Translation: BAC25774.1. BC030062 mRNA. Translation: AAH30062.1.
IPI	IPI00340474. IPI00387198. IPI00387201. IPI00399493.
RefSeq	NP_001157627.1. NM_001164155.1. NP_038897.4. NM_013869.5.
UniGene	Mm.281356.
3D structure databases
ProteinModelPortal	Q9JLL3.
SMR	Q9JLL3. Positions 34-169.
ModBase	Search...
PTM databases
PhosphoSite	Q9JLL3.
Proteomic databases
PRIDE	Q9JLL3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000111234; ENSMUSP00000106865; ENSMUSG00000060548. ENSMUST00000111236; ENSMUSP00000106867; ENSMUSG00000060548.
GeneID	29820.
KEGG	mmu:29820.
UCSC	uc007ufl.2. mouse. uc007ufn.2. mouse.
Organism-specific databases
CTD	55504.
MGI	MGI:1352474. Tnfrsf19.
Phylogenomic databases
eggNOG	NOG47237.
GeneTree	ENSGT00530000063330.
HOVERGEN	HBG069143.
InParanoid	Q80T13.
KO	K05155.
OMA	ICGEFSD.
OrthoDB	EOG4RFKTV.
Gene expression databases
Bgee	Q9JLL3.
Genevestigator	Q9JLL3.
GermOnline	ENSMUSG00000060548. Mus musculus.
Family and domain databases
InterPro	IPR001368. TNFR/NGFR_Cys_rich_reg. IPR022342. TNFR_19. [Graphical view]
PRINTS	PR01969. TNFACTORR19.
SMART	SM00208. TNFR. 2 hits. [Graphical view]
PROSITE	PS00652. TNFR_NGFR_1. 2 hits. PS50050. TNFR_NGFR_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	306994.
SOURCE	Search...

Entry information

Entry name

TNR19_MOUSE

Accession

Primary (citable) accession number: Q9JLL3
Secondary accession number(s): Q80T13 , Q812G3, Q9JHF1, Q9JJH6, Q9JLL2, Q9QXW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program