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Q9JLL0

- CRIM1_MOUSE

UniProt

Q9JLL0 - CRIM1_MOUSE

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Protein

Cysteine-rich motor neuron 1 protein

Gene
Crim1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface By similarity.

GO - Molecular functioni

  1. PDZ domain binding Source: MGI
  2. serine-type endopeptidase inhibitor activity Source: InterPro

GO - Biological processi

  1. regulation of cell growth Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich motor neuron 1 protein
Short name:
CRIM-1
Gene namesi
Name:Crim1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1354756. Crim1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 940906Extracellular Reviewed predictionAdd
BLAST
Transmembranei941 – 96121Helical; Reviewed predictionAdd
BLAST
Topological domaini962 – 103776Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 Reviewed predictionAdd
BLAST
Chaini35 – 10371003Cysteine-rich motor neuron 1 proteinPRO_0000021002Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi330 – 3301N-linked (GlcNAc...) Reviewed prediction
Modified residuei1036 – 10361Phosphothreonine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JLL0.
PRIDEiQ9JLL0.

PTM databases

PhosphoSiteiQ9JLL0.

Expressioni

Tissue specificityi

Expressed during embryonic development in brain, kidney, spinal chord, testis, lens, vibrissae, pinna, tooth primordia and in specific regions of the CNS. Expressed in adult lens. Displays male-specific expression in the fetal gonads with the strongest expression in the Sertoli cells of developing testis.3 Publications

Developmental stagei

Detected in embryo at 11.5 dpc to 17.7 dpc with a maximum between 12.5 and 13.5 dpc.2 Publications

Gene expression databases

ArrayExpressiQ9JLL0.
BgeeiQ9JLL0.
GenevestigatoriQ9JLL0.

Interactioni

Subunit structurei

Interacts with BMP4 and BMP7 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024876.

Structurei

3D structure databases

ProteinModelPortaliQ9JLL0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 11278IGFBP N-terminalAdd
BLAST
Domaini334 – 39158VWFC 1Add
BLAST
Domaini401 – 45757VWFC 2Add
BLAST
Domaini469 – 49830Antistasin-like 1Add
BLAST
Domaini505 – 53228Antistasin-like 2Add
BLAST
Domaini539 – 56426Antistasin-like 3Add
BLAST
Domaini567 – 59226Antistasin-like 4Add
BLAST
Domaini606 – 66358VWFC 3Add
BLAST
Domaini677 – 73559VWFC 4Add
BLAST
Domaini751 – 80959VWFC 5Add
BLAST
Domaini817 – 87458VWFC 6Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi314 – 3163Cell attachment site Reviewed prediction

Sequence similaritiesi

Contains 6 VWFC domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283828.
GeneTreeiENSGT00730000111018.
HOGENOMiHOG000063671.
HOVERGENiHBG081345.
InParanoidiQ9JLL0.
OMAiWREDDCT.
OrthoDBiEOG71P2D4.
PhylomeDBiQ9JLL0.
TreeFamiTF106451.

Family and domain databases

Gene3Di2.10.22.10. 3 hits.
InterProiIPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_C.
[Graphical view]
PfamiPF02822. Antistasin. 4 hits.
PF00093. VWC. 6 hits.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEiPS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLL0-1 [UniParc]FASTAAdd to Basket

« Hide

MYLVAGGRGL AGCGHLSVSL LGLLLLLARS GTRALVCLPC DESKCEEPRS     50
CPGSIVQGVC GCCYMCARQR NESCGGAYGL HGACDRGLRC VIRPPLNGDS 100
ITEYEVGVCE DEDWDDDQLI GFEPCNENLI SGCNIINGKC ECGTIRTCNN 150
PFEFPRKDMC LSALKRIEEE KPDCSKARCE VRFSPRCPED SILIEGYAPP 200
GECCPLPSRC VCDPAGCLRK VCQPGYLNIL VSKASGKPGE CCDLYECKPV 250
FSVDCSTVEC PPVQQAVCPL DSYETQVRLT ADGCCTLPAR CECLSGLCGF 300
PVCEVGSTPR IVSRGDGTPG KCCDVFECVN ETKPACVFNS VEYYDGDMFR 350
MDNCRFCRCQ GGVSICFTAQ CGELNCERYY VPEGECCPVC EDPIYPLNNP 400
AGCYANGQIR AHGDRWREDD CTFCQCINGE PHCVATACGQ SCMHPVKVPG 450
ECCPVCEEPT YITIDPPACG ELSNCSLKEK DCVYGFKLDH NGCRTCQCKI 500
REELCLGLKR ACTLDCPFGF LTDVHNCELC QCRPRPKKCR PTMCDKFCPL 550
GFLKNKHGCD ICRCKKCPEL PCSKICPLGF QQDSHGCLIC KCREVPPSAG 600
PPVLSGTCLS MDGHHHKNEE SWHDGCRECY CHNGKEMCAL ITCPVPACGN 650
PTIRSGQCCP SCTDDFVVQK PELSTPSICH APGGEYFVEG ETWNIDSCTQ 700
CTCHSGRVLC ETEVCPPLLC QNPSRTQDSC CPQCTDDPPQ PSTSHNESVP 750
SYCRNDEGDI FLAAESWKPD ACTSCVCVDS AISCYSESCP SVACERPVLR 800
KGQCCPYCLE DTIPKKVVCH FSGKTYADEE RWDIDSCTHC YCLQGQTLCS 850
TVSCPPLPCA EPIKVEGSCC PMCPEMYVPE PTNVPIEKKN HRGEIDLEVP 900
MWPTPSENDI IHLPRDMGHL QVDYRDNNRL HPGEDSSLDS IVSVVVPIII 950
CLSIIIAFLL INQKKQWVPL LCWYRTPTKP SSLNNQLVSV DCKKGTRVQV 1000
DGPQRMLRIA EPDARFSGFY SMQKQNHLQA DNFYQTV 1037
Length:1,037
Mass (Da):114,066
Last modified:December 12, 2006 - v2
Checksum:iC41948C0A2B66EA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC100348 mRNA. Translation: AAI00349.1.
AF168680 mRNA. Translation: AAF34410.1.
CCDSiCCDS28976.1.
RefSeqiNP_056615.1. NM_015800.3.
UniGeneiMm.311912.

Genome annotation databases

EnsembliENSMUST00000112498; ENSMUSP00000108117; ENSMUSG00000024074.
GeneIDi50766.
KEGGimmu:50766.
UCSCiuc008dou.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC100348 mRNA. Translation: AAI00349.1 .
AF168680 mRNA. Translation: AAF34410.1 .
CCDSi CCDS28976.1.
RefSeqi NP_056615.1. NM_015800.3.
UniGenei Mm.311912.

3D structure databases

ProteinModelPortali Q9JLL0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000024876.

PTM databases

PhosphoSitei Q9JLL0.

Proteomic databases

PaxDbi Q9JLL0.
PRIDEi Q9JLL0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000112498 ; ENSMUSP00000108117 ; ENSMUSG00000024074 .
GeneIDi 50766.
KEGGi mmu:50766.
UCSCi uc008dou.2. mouse.

Organism-specific databases

CTDi 51232.
MGIi MGI:1354756. Crim1.

Phylogenomic databases

eggNOGi NOG283828.
GeneTreei ENSGT00730000111018.
HOGENOMi HOG000063671.
HOVERGENi HBG081345.
InParanoidi Q9JLL0.
OMAi WREDDCT.
OrthoDBi EOG71P2D4.
PhylomeDBi Q9JLL0.
TreeFami TF106451.

Miscellaneous databases

ChiTaRSi CRIM1. mouse.
NextBioi 307671.
PROi Q9JLL0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JLL0.
Bgeei Q9JLL0.
Genevestigatori Q9JLL0.

Family and domain databases

Gene3Di 2.10.22.10. 3 hits.
InterProi IPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF02822. Antistasin. 4 hits.
PF00093. VWC. 6 hits.
[Graphical view ]
SMARTi SM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEi PS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis."
    Kolle G.V., Georgas K., Holmes G.P., Little M.H., Yamada T.
    Mech. Dev. 90:181-193(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-1037, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  3. "Characterisation of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern."
    Georgas K., Bowles J., Yamada T., Koopman P., Little M.H.
    Dev. Dyn. 219:582-587(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  4. "Expression of Crim1 during murine ocular development."
    Lovicu F.J., Kolle G.V., Yamada T., Little M.H., McAvoy J.W.
    Mech. Dev. 94:261-265(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCRIM1_MOUSE
AccessioniPrimary (citable) accession number: Q9JLL0
Secondary accession number(s): Q497W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 12, 2006
Last modified: July 9, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi