Cysteine-rich motor neuron 1 protein precursor

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Q9JLL0 (CRIM1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 85. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cysteine-rich motor neuron 1 protein
Short name=CRIM-1

Gene names

Name:

Crim1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1037 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface By similarity.
Subunit structure	Interacts with BMP4 and BMP7 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Tissue specificity	Expressed during embryonic development in brain, kidney, spinal chord, testis, lens, vibrissae, pinna, tooth primordia and in specific regions of the CNS. Expressed in adult lens. Displays male-specific expression in the fetal gonads with the strongest expression in the Sertoli cells of developing testis. Ref.2 Ref.3 Ref.4
Developmental stage	Detected in embryo at 11.5 dpc to 17.7 dpc with a maximum between 12.5 and 13.5 dpc. Ref.2 Ref.3
Sequence similarities	Contains 4 antistasin-like domains. Contains 1 IGFBP N-terminal domain. Contains 6 VWFC domains.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of catalytic activity Inferred from electronic annotation. Source: GOC regulation of cell growth Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	serine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 34

Potential

Chain

35 – 1037

1003

Cysteine-rich motor neuron 1 protein

PRO_0000021002

Regions

Topological domain

35 – 940

906

Extracellular Potential

Transmembrane

941 – 961

Helical; Potential

Topological domain

962 – 1037

Cytoplasmic Potential

Domain

35 – 112

IGFBP N-terminal

Domain

334 – 391

VWFC 1

Domain

401 – 457

VWFC 2

Domain

469 – 498

Antistasin-like 1

Domain

505 – 532

Antistasin-like 2

Domain

539 – 564

Antistasin-like 3

Domain

567 – 592

Antistasin-like 4

Domain

606 – 663

VWFC 3

Domain

677 – 735

VWFC 4

Domain

751 – 809

VWFC 5

Domain

817 – 874

VWFC 6

Motif

314 – 316

Cell attachment site Potential

Amino acid modifications

Modified residue

1036

Phosphothreonine By similarity

Glycosylation

330

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q9JLL0 [UniParc].

Last modified December 12, 2006. Version 2.
Checksum: C41948C0A2B66EA3
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FASTA

1,037

114,066

        10         20         30         40         50         60 
MYLVAGGRGL AGCGHLSVSL LGLLLLLARS GTRALVCLPC DESKCEEPRS CPGSIVQGVC 

        70         80         90        100        110        120 
GCCYMCARQR NESCGGAYGL HGACDRGLRC VIRPPLNGDS ITEYEVGVCE DEDWDDDQLI 

       130        140        150        160        170        180 
GFEPCNENLI SGCNIINGKC ECGTIRTCNN PFEFPRKDMC LSALKRIEEE KPDCSKARCE 

       190        200        210        220        230        240 
VRFSPRCPED SILIEGYAPP GECCPLPSRC VCDPAGCLRK VCQPGYLNIL VSKASGKPGE 

       250        260        270        280        290        300 
CCDLYECKPV FSVDCSTVEC PPVQQAVCPL DSYETQVRLT ADGCCTLPAR CECLSGLCGF 

       310        320        330        340        350        360 
PVCEVGSTPR IVSRGDGTPG KCCDVFECVN ETKPACVFNS VEYYDGDMFR MDNCRFCRCQ 

       370        380        390        400        410        420 
GGVSICFTAQ CGELNCERYY VPEGECCPVC EDPIYPLNNP AGCYANGQIR AHGDRWREDD 

       430        440        450        460        470        480 
CTFCQCINGE PHCVATACGQ SCMHPVKVPG ECCPVCEEPT YITIDPPACG ELSNCSLKEK 

       490        500        510        520        530        540 
DCVYGFKLDH NGCRTCQCKI REELCLGLKR ACTLDCPFGF LTDVHNCELC QCRPRPKKCR 

       550        560        570        580        590        600 
PTMCDKFCPL GFLKNKHGCD ICRCKKCPEL PCSKICPLGF QQDSHGCLIC KCREVPPSAG 

       610        620        630        640        650        660 
PPVLSGTCLS MDGHHHKNEE SWHDGCRECY CHNGKEMCAL ITCPVPACGN PTIRSGQCCP 

       670        680        690        700        710        720 
SCTDDFVVQK PELSTPSICH APGGEYFVEG ETWNIDSCTQ CTCHSGRVLC ETEVCPPLLC 

       730        740        750        760        770        780 
QNPSRTQDSC CPQCTDDPPQ PSTSHNESVP SYCRNDEGDI FLAAESWKPD ACTSCVCVDS 

       790        800        810        820        830        840 
AISCYSESCP SVACERPVLR KGQCCPYCLE DTIPKKVVCH FSGKTYADEE RWDIDSCTHC 

       850        860        870        880        890        900 
YCLQGQTLCS TVSCPPLPCA EPIKVEGSCC PMCPEMYVPE PTNVPIEKKN HRGEIDLEVP 

       910        920        930        940        950        960 
MWPTPSENDI IHLPRDMGHL QVDYRDNNRL HPGEDSSLDS IVSVVVPIII CLSIIIAFLL 

       970        980        990       1000       1010       1020 
INQKKQWVPL LCWYRTPTKP SSLNNQLVSV DCKKGTRVQV DGPQRMLRIA EPDARFSGFY 

      1030 
SMQKQNHLQA DNFYQTV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[2]	"CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis." Kolle G.V., Georgas K., Holmes G.P., Little M.H., Yamada T. Mech. Dev. 90:181-193(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-1037, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[3]	"Characterisation of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern." Georgas K., Bowles J., Yamada T., Koopman P., Little M.H. Dev. Dyn. 219:582-587(2000) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[4]	"Expression of Crim1 during murine ocular development." Lovicu F.J., Kolle G.V., Yamada T., Little M.H., McAvoy J.W. Mech. Dev. 94:261-265(2000) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC100348 mRNA. Translation: AAI00349.1. AF168680 mRNA. Translation: AAF34410.1.
IPI	IPI00124453.
RefSeq	NP_056615.1. NM_015800.3.
UniGene	Mm.311912.
3D structure databases
ProteinModelPortal	Q9JLL0.
SMR	Q9JLL0. Positions 37-93, 333-393, 400-457, 607-667, 680-739, 757-811, 816-879.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000024876.
PTM databases
PhosphoSite	Q9JLL0.
Proteomic databases
PaxDb	Q9JLL0.
PRIDE	Q9JLL0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000112498; ENSMUSP00000108117; ENSMUSG00000024074.
GeneID	50766.
KEGG	mmu:50766.
UCSC	uc008dou.2. mouse.
Organism-specific databases
CTD	51232.
MGI	MGI:1354756. Crim1.
Phylogenomic databases
eggNOG	NOG283828.
GeneTree	ENSGT00700000104369.
HOGENOM	HOG000063671.
HOVERGEN	HBG081345.
InParanoid	Q9JLL0.
OMA	RWREDDC.
OrthoDB	EOG4JQ3WR.
Gene expression databases
ArrayExpress	Q9JLL0.
Bgee	Q9JLL0.
Genevestigator	Q9JLL0.
GermOnline	ENSMUSG00000024074. Mus musculus.
Family and domain databases
Gene3D	2.10.22.10. 3 hits.
InterPro	IPR000867. IGFBP-like. IPR011061. Prot_inh_I14/15_hirudin/antisn. IPR018112. Prot_inh_I15_antistasin. IPR004094. Prot_inh_I15_antistasin-like. IPR001007. VWF_C. [Graphical view]
Pfam	PF02822. Antistasin. 4 hits. PF00093. VWC. 6 hits. [Graphical view]
SMART	SM00121. IB. 1 hit. SM00214. VWC. 6 hits. [Graphical view]
SUPFAM	SSF57262. Antihaemostatic. 2 hits.
PROSITE	PS51252. ANTISTASIN. 4 hits. PS51323. IGFBP_N_2. 1 hit. PS01208. VWFC_1. 6 hits. PS50184. VWFC_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CRIM1. mouse.
NextBio	307671.
SOURCE	Search...

Entry information

Entry name

CRIM1_MOUSE

Accession

Primary (citable) accession number: Q9JLL0
Secondary accession number(s): Q497W4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	December 12, 2006
Last modified:	April 3, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents