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Protein

Cysteine-rich motor neuron 1 protein

Gene

Crim1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface (By similarity).By similarity

GO - Molecular functioni

  1. PDZ domain binding Source: MGI
  2. serine-type endopeptidase inhibitor activity Source: InterPro

GO - Biological processi

  1. regulation of cell growth Source: InterPro
Complete GO annotation...

Protein family/group databases

MEROPSiI15.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich motor neuron 1 protein
Short name:
CRIM-1
Gene namesi
Name:Crim1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1354756. Crim1.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 940906ExtracellularSequence AnalysisAdd
BLAST
Transmembranei941 – 96121HelicalSequence AnalysisAdd
BLAST
Topological domaini962 – 103776CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 10371003Cysteine-rich motor neuron 1 proteinPRO_0000021002Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
Modified residuei1036 – 10361PhosphothreonineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9JLL0.
PaxDbiQ9JLL0.
PRIDEiQ9JLL0.

PTM databases

PhosphoSiteiQ9JLL0.

Expressioni

Tissue specificityi

Expressed during embryonic development in brain, kidney, spinal chord, testis, lens, vibrissae, pinna, tooth primordia and in specific regions of the CNS. Expressed in adult lens. Displays male-specific expression in the fetal gonads with the strongest expression in the Sertoli cells of developing testis.3 Publications

Developmental stagei

Detected in embryo at 11.5 dpc to 17.7 dpc with a maximum between 12.5 and 13.5 dpc.2 Publications

Gene expression databases

BgeeiQ9JLL0.
ExpressionAtlasiQ9JLL0. baseline and differential.
GenevestigatoriQ9JLL0.

Interactioni

Subunit structurei

Interacts with BMP4 and BMP7.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024876.

Structurei

3D structure databases

ProteinModelPortaliQ9JLL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 11278IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini334 – 39158VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini401 – 45757VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini469 – 49830Antistasin-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini505 – 53228Antistasin-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini539 – 56426Antistasin-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini567 – 59226Antistasin-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini606 – 66358VWFC 3PROSITE-ProRule annotationAdd
BLAST
Domaini677 – 73559VWFC 4PROSITE-ProRule annotationAdd
BLAST
Domaini751 – 80959VWFC 5PROSITE-ProRule annotationAdd
BLAST
Domaini817 – 87458VWFC 6PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi314 – 3163Cell attachment siteSequence Analysis

Sequence similaritiesi

Contains 4 antistasin-like domains.PROSITE-ProRule annotation
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 6 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283828.
GeneTreeiENSGT00780000122012.
HOGENOMiHOG000063671.
HOVERGENiHBG081345.
InParanoidiQ9JLL0.
OMAiWREDDCT.
OrthoDBiEOG71P2D4.
PhylomeDBiQ9JLL0.
TreeFamiTF106451.

Family and domain databases

Gene3Di2.10.22.10. 3 hits.
InterProiIPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_C.
[Graphical view]
PfamiPF02822. Antistasin. 4 hits.
PF00093. VWC. 6 hits.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEiPS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLVAGGRGL AGCGHLSVSL LGLLLLLARS GTRALVCLPC DESKCEEPRS
60 70 80 90 100
CPGSIVQGVC GCCYMCARQR NESCGGAYGL HGACDRGLRC VIRPPLNGDS
110 120 130 140 150
ITEYEVGVCE DEDWDDDQLI GFEPCNENLI SGCNIINGKC ECGTIRTCNN
160 170 180 190 200
PFEFPRKDMC LSALKRIEEE KPDCSKARCE VRFSPRCPED SILIEGYAPP
210 220 230 240 250
GECCPLPSRC VCDPAGCLRK VCQPGYLNIL VSKASGKPGE CCDLYECKPV
260 270 280 290 300
FSVDCSTVEC PPVQQAVCPL DSYETQVRLT ADGCCTLPAR CECLSGLCGF
310 320 330 340 350
PVCEVGSTPR IVSRGDGTPG KCCDVFECVN ETKPACVFNS VEYYDGDMFR
360 370 380 390 400
MDNCRFCRCQ GGVSICFTAQ CGELNCERYY VPEGECCPVC EDPIYPLNNP
410 420 430 440 450
AGCYANGQIR AHGDRWREDD CTFCQCINGE PHCVATACGQ SCMHPVKVPG
460 470 480 490 500
ECCPVCEEPT YITIDPPACG ELSNCSLKEK DCVYGFKLDH NGCRTCQCKI
510 520 530 540 550
REELCLGLKR ACTLDCPFGF LTDVHNCELC QCRPRPKKCR PTMCDKFCPL
560 570 580 590 600
GFLKNKHGCD ICRCKKCPEL PCSKICPLGF QQDSHGCLIC KCREVPPSAG
610 620 630 640 650
PPVLSGTCLS MDGHHHKNEE SWHDGCRECY CHNGKEMCAL ITCPVPACGN
660 670 680 690 700
PTIRSGQCCP SCTDDFVVQK PELSTPSICH APGGEYFVEG ETWNIDSCTQ
710 720 730 740 750
CTCHSGRVLC ETEVCPPLLC QNPSRTQDSC CPQCTDDPPQ PSTSHNESVP
760 770 780 790 800
SYCRNDEGDI FLAAESWKPD ACTSCVCVDS AISCYSESCP SVACERPVLR
810 820 830 840 850
KGQCCPYCLE DTIPKKVVCH FSGKTYADEE RWDIDSCTHC YCLQGQTLCS
860 870 880 890 900
TVSCPPLPCA EPIKVEGSCC PMCPEMYVPE PTNVPIEKKN HRGEIDLEVP
910 920 930 940 950
MWPTPSENDI IHLPRDMGHL QVDYRDNNRL HPGEDSSLDS IVSVVVPIII
960 970 980 990 1000
CLSIIIAFLL INQKKQWVPL LCWYRTPTKP SSLNNQLVSV DCKKGTRVQV
1010 1020 1030
DGPQRMLRIA EPDARFSGFY SMQKQNHLQA DNFYQTV
Length:1,037
Mass (Da):114,066
Last modified:December 12, 2006 - v2
Checksum:iC41948C0A2B66EA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100348 mRNA. Translation: AAI00349.1.
AF168680 mRNA. Translation: AAF34410.1.
CCDSiCCDS28976.1.
RefSeqiNP_056615.1. NM_015800.3.
UniGeneiMm.311912.

Genome annotation databases

EnsembliENSMUST00000112498; ENSMUSP00000108117; ENSMUSG00000024074.
GeneIDi50766.
KEGGimmu:50766.
UCSCiuc008dou.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100348 mRNA. Translation: AAI00349.1.
AF168680 mRNA. Translation: AAF34410.1.
CCDSiCCDS28976.1.
RefSeqiNP_056615.1. NM_015800.3.
UniGeneiMm.311912.

3D structure databases

ProteinModelPortaliQ9JLL0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024876.

Protein family/group databases

MEROPSiI15.011.

PTM databases

PhosphoSiteiQ9JLL0.

Proteomic databases

MaxQBiQ9JLL0.
PaxDbiQ9JLL0.
PRIDEiQ9JLL0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112498; ENSMUSP00000108117; ENSMUSG00000024074.
GeneIDi50766.
KEGGimmu:50766.
UCSCiuc008dou.2. mouse.

Organism-specific databases

CTDi51232.
MGIiMGI:1354756. Crim1.

Phylogenomic databases

eggNOGiNOG283828.
GeneTreeiENSGT00780000122012.
HOGENOMiHOG000063671.
HOVERGENiHBG081345.
InParanoidiQ9JLL0.
OMAiWREDDCT.
OrthoDBiEOG71P2D4.
PhylomeDBiQ9JLL0.
TreeFamiTF106451.

Miscellaneous databases

ChiTaRSiCrim1. mouse.
NextBioi307671.
PROiQ9JLL0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JLL0.
ExpressionAtlasiQ9JLL0. baseline and differential.
GenevestigatoriQ9JLL0.

Family and domain databases

Gene3Di2.10.22.10. 3 hits.
InterProiIPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_C.
[Graphical view]
PfamiPF02822. Antistasin. 4 hits.
PF00093. VWC. 6 hits.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEiPS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis."
    Kolle G.V., Georgas K., Holmes G.P., Little M.H., Yamada T.
    Mech. Dev. 90:181-193(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-1037, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  3. "Characterisation of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern."
    Georgas K., Bowles J., Yamada T., Koopman P., Little M.H.
    Dev. Dyn. 219:582-587(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  4. "Expression of Crim1 during murine ocular development."
    Lovicu F.J., Kolle G.V., Yamada T., Little M.H., McAvoy J.W.
    Mech. Dev. 94:261-265(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCRIM1_MOUSE
AccessioniPrimary (citable) accession number: Q9JLL0
Secondary accession number(s): Q497W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 12, 2006
Last modified: March 4, 2015
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.