Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9JLL0 (CRIM1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine-rich motor neuron 1 protein

Short name=CRIM-1
Gene names
Name:Crim1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1037 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface By similarity.

Subunit structure

Interacts with BMP4 and BMP7 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Expressed during embryonic development in brain, kidney, spinal chord, testis, lens, vibrissae, pinna, tooth primordia and in specific regions of the CNS. Expressed in adult lens. Displays male-specific expression in the fetal gonads with the strongest expression in the Sertoli cells of developing testis. Ref.2 Ref.3 Ref.4

Developmental stage

Detected in embryo at 11.5 dpc to 17.7 dpc with a maximum between 12.5 and 13.5 dpc. Ref.2 Ref.3

Sequence similarities

Contains 4 antistasin-like domains.

Contains 1 IGFBP N-terminal domain.

Contains 6 VWFC domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 10371003Cysteine-rich motor neuron 1 protein
PRO_0000021002

Regions

Topological domain35 – 940906Extracellular Potential
Transmembrane941 – 96121Helical; Potential
Topological domain962 – 103776Cytoplasmic Potential
Domain35 – 11278IGFBP N-terminal
Domain334 – 39158VWFC 1
Domain401 – 45757VWFC 2
Domain469 – 49830Antistasin-like 1
Domain505 – 53228Antistasin-like 2
Domain539 – 56426Antistasin-like 3
Domain567 – 59226Antistasin-like 4
Domain606 – 66358VWFC 3
Domain677 – 73559VWFC 4
Domain751 – 80959VWFC 5
Domain817 – 87458VWFC 6
Motif314 – 3163Cell attachment site Potential

Amino acid modifications

Modified residue10361Phosphothreonine By similarity
Glycosylation3301N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9JLL0 [UniParc].

Last modified December 12, 2006. Version 2.
Checksum: C41948C0A2B66EA3

FASTA1,037114,066
        10         20         30         40         50         60 
MYLVAGGRGL AGCGHLSVSL LGLLLLLARS GTRALVCLPC DESKCEEPRS CPGSIVQGVC 

        70         80         90        100        110        120 
GCCYMCARQR NESCGGAYGL HGACDRGLRC VIRPPLNGDS ITEYEVGVCE DEDWDDDQLI 

       130        140        150        160        170        180 
GFEPCNENLI SGCNIINGKC ECGTIRTCNN PFEFPRKDMC LSALKRIEEE KPDCSKARCE 

       190        200        210        220        230        240 
VRFSPRCPED SILIEGYAPP GECCPLPSRC VCDPAGCLRK VCQPGYLNIL VSKASGKPGE 

       250        260        270        280        290        300 
CCDLYECKPV FSVDCSTVEC PPVQQAVCPL DSYETQVRLT ADGCCTLPAR CECLSGLCGF 

       310        320        330        340        350        360 
PVCEVGSTPR IVSRGDGTPG KCCDVFECVN ETKPACVFNS VEYYDGDMFR MDNCRFCRCQ 

       370        380        390        400        410        420 
GGVSICFTAQ CGELNCERYY VPEGECCPVC EDPIYPLNNP AGCYANGQIR AHGDRWREDD 

       430        440        450        460        470        480 
CTFCQCINGE PHCVATACGQ SCMHPVKVPG ECCPVCEEPT YITIDPPACG ELSNCSLKEK 

       490        500        510        520        530        540 
DCVYGFKLDH NGCRTCQCKI REELCLGLKR ACTLDCPFGF LTDVHNCELC QCRPRPKKCR 

       550        560        570        580        590        600 
PTMCDKFCPL GFLKNKHGCD ICRCKKCPEL PCSKICPLGF QQDSHGCLIC KCREVPPSAG 

       610        620        630        640        650        660 
PPVLSGTCLS MDGHHHKNEE SWHDGCRECY CHNGKEMCAL ITCPVPACGN PTIRSGQCCP 

       670        680        690        700        710        720 
SCTDDFVVQK PELSTPSICH APGGEYFVEG ETWNIDSCTQ CTCHSGRVLC ETEVCPPLLC 

       730        740        750        760        770        780 
QNPSRTQDSC CPQCTDDPPQ PSTSHNESVP SYCRNDEGDI FLAAESWKPD ACTSCVCVDS 

       790        800        810        820        830        840 
AISCYSESCP SVACERPVLR KGQCCPYCLE DTIPKKVVCH FSGKTYADEE RWDIDSCTHC 

       850        860        870        880        890        900 
YCLQGQTLCS TVSCPPLPCA EPIKVEGSCC PMCPEMYVPE PTNVPIEKKN HRGEIDLEVP 

       910        920        930        940        950        960 
MWPTPSENDI IHLPRDMGHL QVDYRDNNRL HPGEDSSLDS IVSVVVPIII CLSIIIAFLL 

       970        980        990       1000       1010       1020 
INQKKQWVPL LCWYRTPTKP SSLNNQLVSV DCKKGTRVQV DGPQRMLRIA EPDARFSGFY 

      1030 
SMQKQNHLQA DNFYQTV 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[2]"CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis."
Kolle G.V., Georgas K., Holmes G.P., Little M.H., Yamada T.
Mech. Dev. 90:181-193(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-1037, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[3]"Characterisation of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern."
Georgas K., Bowles J., Yamada T., Koopman P., Little M.H.
Dev. Dyn. 219:582-587(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[4]"Expression of Crim1 during murine ocular development."
Lovicu F.J., Kolle G.V., Yamada T., Little M.H., McAvoy J.W.
Mech. Dev. 94:261-265(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC100348 mRNA. Translation: AAI00349.1.
AF168680 mRNA. Translation: AAF34410.1.
CCDSCCDS28976.1.
RefSeqNP_056615.1. NM_015800.3.
UniGeneMm.311912.

3D structure databases

ProteinModelPortalQ9JLL0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000024876.

PTM databases

PhosphoSiteQ9JLL0.

Proteomic databases

PaxDbQ9JLL0.
PRIDEQ9JLL0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000112498; ENSMUSP00000108117; ENSMUSG00000024074.
GeneID50766.
KEGGmmu:50766.
UCSCuc008dou.2. mouse.

Organism-specific databases

CTD51232.
MGIMGI:1354756. Crim1.

Phylogenomic databases

eggNOGNOG283828.
GeneTreeENSGT00730000111018.
HOGENOMHOG000063671.
HOVERGENHBG081345.
InParanoidQ9JLL0.
OMAWREDDCT.
OrthoDBEOG71P2D4.
PhylomeDBQ9JLL0.
TreeFamTF106451.

Gene expression databases

ArrayExpressQ9JLL0.
BgeeQ9JLL0.
GenevestigatorQ9JLL0.

Family and domain databases

Gene3D2.10.22.10. 3 hits.
InterProIPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_C.
[Graphical view]
PfamPF02822. Antistasin. 4 hits.
PF00093. VWC. 6 hits.
[Graphical view]
SMARTSM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEPS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCRIM1. mouse.
NextBio307671.
PROQ9JLL0.
SOURCESearch...

Entry information

Entry nameCRIM1_MOUSE
AccessionPrimary (citable) accession number: Q9JLL0
Secondary accession number(s): Q497W4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 12, 2006
Last modified: July 9, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot