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Q9JLL0

- CRIM1_MOUSE

UniProt

Q9JLL0 - CRIM1_MOUSE

Protein

Cysteine-rich motor neuron 1 protein

Gene

Crim1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface By similarity.By similarity

    GO - Molecular functioni

    1. PDZ domain binding Source: MGI
    2. serine-type endopeptidase inhibitor activity Source: InterPro

    GO - Biological processi

    1. regulation of cell growth Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine-rich motor neuron 1 protein
    Short name:
    CRIM-1
    Gene namesi
    Name:Crim1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1354756. Crim1.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. extracellular region Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 10371003Cysteine-rich motor neuron 1 proteinPRO_0000021002Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1036 – 10361PhosphothreonineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9JLL0.
    PRIDEiQ9JLL0.

    PTM databases

    PhosphoSiteiQ9JLL0.

    Expressioni

    Tissue specificityi

    Expressed during embryonic development in brain, kidney, spinal chord, testis, lens, vibrissae, pinna, tooth primordia and in specific regions of the CNS. Expressed in adult lens. Displays male-specific expression in the fetal gonads with the strongest expression in the Sertoli cells of developing testis.3 Publications

    Developmental stagei

    Detected in embryo at 11.5 dpc to 17.7 dpc with a maximum between 12.5 and 13.5 dpc.2 Publications

    Gene expression databases

    ArrayExpressiQ9JLL0.
    BgeeiQ9JLL0.
    GenevestigatoriQ9JLL0.

    Interactioni

    Subunit structurei

    Interacts with BMP4 and BMP7.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000024876.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JLL0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini35 – 940906ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini962 – 103776CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei941 – 96121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 11278IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini334 – 39158VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini401 – 45757VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini469 – 49830Antistasin-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini505 – 53228Antistasin-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini539 – 56426Antistasin-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini567 – 59226Antistasin-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini606 – 66358VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini677 – 73559VWFC 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini751 – 80959VWFC 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini817 – 87458VWFC 6PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi314 – 3163Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Contains 4 antistasin-like domains.PROSITE-ProRule annotation
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 6 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG283828.
    GeneTreeiENSGT00730000111018.
    HOGENOMiHOG000063671.
    HOVERGENiHBG081345.
    InParanoidiQ9JLL0.
    OMAiWREDDCT.
    OrthoDBiEOG71P2D4.
    PhylomeDBiQ9JLL0.
    TreeFamiTF106451.

    Family and domain databases

    Gene3Di2.10.22.10. 3 hits.
    InterProiIPR004094. Antistasin-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011061. Hirudin/antistatin.
    IPR000867. IGFBP-like.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF02822. Antistasin. 4 hits.
    PF00093. VWC. 6 hits.
    [Graphical view]
    SMARTiSM00121. IB. 1 hit.
    SM00214. VWC. 6 hits.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF57262. SSF57262. 3 hits.
    PROSITEiPS51252. ANTISTASIN. 4 hits.
    PS51323. IGFBP_N_2. 1 hit.
    PS01208. VWFC_1. 6 hits.
    PS50184. VWFC_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JLL0-1 [UniParc]FASTAAdd to Basket

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    MYLVAGGRGL AGCGHLSVSL LGLLLLLARS GTRALVCLPC DESKCEEPRS     50
    CPGSIVQGVC GCCYMCARQR NESCGGAYGL HGACDRGLRC VIRPPLNGDS 100
    ITEYEVGVCE DEDWDDDQLI GFEPCNENLI SGCNIINGKC ECGTIRTCNN 150
    PFEFPRKDMC LSALKRIEEE KPDCSKARCE VRFSPRCPED SILIEGYAPP 200
    GECCPLPSRC VCDPAGCLRK VCQPGYLNIL VSKASGKPGE CCDLYECKPV 250
    FSVDCSTVEC PPVQQAVCPL DSYETQVRLT ADGCCTLPAR CECLSGLCGF 300
    PVCEVGSTPR IVSRGDGTPG KCCDVFECVN ETKPACVFNS VEYYDGDMFR 350
    MDNCRFCRCQ GGVSICFTAQ CGELNCERYY VPEGECCPVC EDPIYPLNNP 400
    AGCYANGQIR AHGDRWREDD CTFCQCINGE PHCVATACGQ SCMHPVKVPG 450
    ECCPVCEEPT YITIDPPACG ELSNCSLKEK DCVYGFKLDH NGCRTCQCKI 500
    REELCLGLKR ACTLDCPFGF LTDVHNCELC QCRPRPKKCR PTMCDKFCPL 550
    GFLKNKHGCD ICRCKKCPEL PCSKICPLGF QQDSHGCLIC KCREVPPSAG 600
    PPVLSGTCLS MDGHHHKNEE SWHDGCRECY CHNGKEMCAL ITCPVPACGN 650
    PTIRSGQCCP SCTDDFVVQK PELSTPSICH APGGEYFVEG ETWNIDSCTQ 700
    CTCHSGRVLC ETEVCPPLLC QNPSRTQDSC CPQCTDDPPQ PSTSHNESVP 750
    SYCRNDEGDI FLAAESWKPD ACTSCVCVDS AISCYSESCP SVACERPVLR 800
    KGQCCPYCLE DTIPKKVVCH FSGKTYADEE RWDIDSCTHC YCLQGQTLCS 850
    TVSCPPLPCA EPIKVEGSCC PMCPEMYVPE PTNVPIEKKN HRGEIDLEVP 900
    MWPTPSENDI IHLPRDMGHL QVDYRDNNRL HPGEDSSLDS IVSVVVPIII 950
    CLSIIIAFLL INQKKQWVPL LCWYRTPTKP SSLNNQLVSV DCKKGTRVQV 1000
    DGPQRMLRIA EPDARFSGFY SMQKQNHLQA DNFYQTV 1037
    Length:1,037
    Mass (Da):114,066
    Last modified:December 12, 2006 - v2
    Checksum:iC41948C0A2B66EA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC100348 mRNA. Translation: AAI00349.1.
    AF168680 mRNA. Translation: AAF34410.1.
    CCDSiCCDS28976.1.
    RefSeqiNP_056615.1. NM_015800.3.
    UniGeneiMm.311912.

    Genome annotation databases

    EnsembliENSMUST00000112498; ENSMUSP00000108117; ENSMUSG00000024074.
    GeneIDi50766.
    KEGGimmu:50766.
    UCSCiuc008dou.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC100348 mRNA. Translation: AAI00349.1 .
    AF168680 mRNA. Translation: AAF34410.1 .
    CCDSi CCDS28976.1.
    RefSeqi NP_056615.1. NM_015800.3.
    UniGenei Mm.311912.

    3D structure databases

    ProteinModelPortali Q9JLL0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000024876.

    PTM databases

    PhosphoSitei Q9JLL0.

    Proteomic databases

    PaxDbi Q9JLL0.
    PRIDEi Q9JLL0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000112498 ; ENSMUSP00000108117 ; ENSMUSG00000024074 .
    GeneIDi 50766.
    KEGGi mmu:50766.
    UCSCi uc008dou.2. mouse.

    Organism-specific databases

    CTDi 51232.
    MGIi MGI:1354756. Crim1.

    Phylogenomic databases

    eggNOGi NOG283828.
    GeneTreei ENSGT00730000111018.
    HOGENOMi HOG000063671.
    HOVERGENi HBG081345.
    InParanoidi Q9JLL0.
    OMAi WREDDCT.
    OrthoDBi EOG71P2D4.
    PhylomeDBi Q9JLL0.
    TreeFami TF106451.

    Miscellaneous databases

    ChiTaRSi CRIM1. mouse.
    NextBioi 307671.
    PROi Q9JLL0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JLL0.
    Bgeei Q9JLL0.
    Genevestigatori Q9JLL0.

    Family and domain databases

    Gene3Di 2.10.22.10. 3 hits.
    InterProi IPR004094. Antistasin-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011061. Hirudin/antistatin.
    IPR000867. IGFBP-like.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF02822. Antistasin. 4 hits.
    PF00093. VWC. 6 hits.
    [Graphical view ]
    SMARTi SM00121. IB. 1 hit.
    SM00214. VWC. 6 hits.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF57262. SSF57262. 3 hits.
    PROSITEi PS51252. ANTISTASIN. 4 hits.
    PS51323. IGFBP_N_2. 1 hit.
    PS01208. VWFC_1. 6 hits.
    PS50184. VWFC_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    2. "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis."
      Kolle G.V., Georgas K., Holmes G.P., Little M.H., Yamada T.
      Mech. Dev. 90:181-193(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-1037, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    3. "Characterisation of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern."
      Georgas K., Bowles J., Yamada T., Koopman P., Little M.H.
      Dev. Dyn. 219:582-587(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    4. "Expression of Crim1 during murine ocular development."
      Lovicu F.J., Kolle G.V., Yamada T., Little M.H., McAvoy J.W.
      Mech. Dev. 94:261-265(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCRIM1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JLL0
    Secondary accession number(s): Q497W4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3