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Protein

Calcium-binding protein 2

Gene

Cabp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi87 – 98121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi161 – 172122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi198 – 209123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 2
Short name:
CaBP2
Gene namesi
Name:Cabp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1352749. Cabp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 216215Calcium-binding protein 2PRO_0000073518Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiQ9JLK4.
PRIDEiQ9JLK4.

Expressioni

Tissue specificityi

Expressed in retina and in the inner hair cells (IHC) of the cochlea.1 Publication

Gene expression databases

BgeeiQ9JLK4.
CleanExiMM_CABP2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125255.

Structurei

3D structure databases

ProteinModelPortaliQ9JLK4.
SMRiQ9JLK4. Positions 67-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 10936EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini107 – 14236EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini148 – 18336EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini185 – 21632EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ9JLK4.
PhylomeDBiQ9JLK4.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR015754. Ca-bd_2.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR23050:SF21. PTHR23050:SF21. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform L-CaBP2 (identifier: Q9JLK4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNCAKTPWH RGSKERWQWP GSPLGGSRPS PGPRTEEQEG TQGYSVLGSL
60 70 80 90 100
VGPACIFLRP SIAATQLDRE LRPEEIEELQ IAFQEFDRDR DGYIGYRELG
110 120 130 140 150
ACMRTLGYMP TEMELIEISQ QISGGKVDFE DFVELMGPKL LAETADMIGV
160 170 180 190 200
RELRDAFREF DTNGDGCISV GELRAALKAL LGERLSQREV DEILQDIDLN
210
GDGLVDFEEF VRMMSR
Length:216
Mass (Da):24,223
Last modified:January 23, 2007 - v3
Checksum:i416A49E44A7290DD
GO
Isoform S-CaBP2 (identifier: Q9JLK4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-68: Missing.

Show »
Length:163
Mass (Da):18,632
Checksum:iB45813C1DBC0471E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei16 – 6853Missing in isoform S-CaBP2. 1 PublicationVSP_000735Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169157 mRNA. Translation: AAF25791.1.
AF169156 mRNA. Translation: AAF25790.1.
BC107029 mRNA. Translation: AAI07030.1.
RefSeqiNP_001153724.1. NM_001160252.1.
NP_001153725.1. NM_001160253.1.
NP_038906.2. NM_013878.2.
UniGeneiMm.46268.

Genome annotation databases

GeneIDi29866.
KEGGimmu:29866.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169157 mRNA. Translation: AAF25791.1.
AF169156 mRNA. Translation: AAF25790.1.
BC107029 mRNA. Translation: AAI07030.1.
RefSeqiNP_001153724.1. NM_001160252.1.
NP_001153725.1. NM_001160253.1.
NP_038906.2. NM_013878.2.
UniGeneiMm.46268.

3D structure databases

ProteinModelPortaliQ9JLK4.
SMRiQ9JLK4. Positions 67-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125255.

Proteomic databases

PaxDbiQ9JLK4.
PRIDEiQ9JLK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29866.
KEGGimmu:29866.

Organism-specific databases

CTDi51475.
MGIiMGI:1352749. Cabp2.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ9JLK4.
PhylomeDBiQ9JLK4.

Miscellaneous databases

PROiQ9JLK4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JLK4.
CleanExiMM_CABP2.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR015754. Ca-bd_2.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR23050:SF21. PTHR23050:SF21. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin."
    Haeseleer F., Sokal I., Verlinde C.L.M.J., Erdjument-Bromage H., Tempst P., Pronin A.N., Benovic J.L., Fariss R.N., Palczewski K.
    J. Biol. Chem. 275:1247-1260(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS L-CABP2 AND S-CABP2).
    Tissue: Retina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM L-CABP2).
  3. "Ca2+-binding proteins tune Ca2+-feedback to Cav1.3 channels in mouse auditory hair cells."
    Cui G., Meyer A.C., Calin-Jageman I., Neef J., Haeseleer F., Moser T., Lee A.
    J. Physiol. (Lond.) 585:791-803(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCABP2_MOUSE
AccessioniPrimary (citable) accession number: Q9JLK4
Secondary accession number(s): Q3KNX9, Q9JLK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.