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Protein

Calcium-binding protein 5

Gene

Cabp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials. Involved in the transmission of light signals.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi41 – 521PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi118 – 1292PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi155 – 1663PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 5
Short name:
CaBP5
Gene namesi
Name:Cabp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1352746. Cabp5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

No morphologic changes, but 50% reduction of the sensitivity of retinal ganglion cell light responses.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000735251 – 173Calcium-binding protein 5Add BLAST173

Proteomic databases

PaxDbiQ9JLK3.
PRIDEiQ9JLK3.

Expressioni

Tissue specificityi

Expressed in retina and in the inner hair cells (IHC) of the cochlea.2 Publications

Gene expression databases

BgeeiENSMUSG00000005649.
CleanExiMM_CABP5.
ExpressionAtlasiQ9JLK3. baseline and differential.
GenevisibleiQ9JLK3. MM.

Interactioni

Subunit structurei

Interacts with CACNA1C (via C-terminal CDB motif) in a calcium-dependent manner.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005791.

Structurei

3D structure databases

ProteinModelPortaliQ9JLK3.
SMRiQ9JLK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 63EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini64 – 99EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini105 – 140EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini142 – 173EF-hand 4PROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ9JLK3.
PhylomeDBiQ9JLK3.
TreeFamiTF334804.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JLK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFPMGPACI FLRKGIAEKQ RERPLGQDEL DELREAFLEF DKDQDGFISY
60 70 80 90 100
KDLGNLMRTM GYMPTEMELT ELGQQIRMNL GGRVDFEDFV ELMTPKLLAE
110 120 130 140 150
TAGMIGVQEM RDAFKEFDAN GDGEITLAEL QQAMQRLLGE KLTPREIAEV
160 170
VQEADINGDG TVDFEEFVKM MSR
Length:173
Mass (Da):19,730
Last modified:October 1, 2000 - v1
Checksum:i96D14CC81C8BFEE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169161 mRNA. Translation: AAF25795.1.
BC018253 mRNA. Translation: AAH18253.1.
CCDSiCCDS20831.1.
RefSeqiNP_038905.1. NM_013877.3.
UniGeneiMm.103669.

Genome annotation databases

EnsembliENSMUST00000005791; ENSMUSP00000005791; ENSMUSG00000005649.
GeneIDi29865.
KEGGimmu:29865.
UCSCiuc009ffv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169161 mRNA. Translation: AAF25795.1.
BC018253 mRNA. Translation: AAH18253.1.
CCDSiCCDS20831.1.
RefSeqiNP_038905.1. NM_013877.3.
UniGeneiMm.103669.

3D structure databases

ProteinModelPortaliQ9JLK3.
SMRiQ9JLK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005791.

Proteomic databases

PaxDbiQ9JLK3.
PRIDEiQ9JLK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005791; ENSMUSP00000005791; ENSMUSG00000005649.
GeneIDi29865.
KEGGimmu:29865.
UCSCiuc009ffv.1. mouse.

Organism-specific databases

CTDi56344.
MGIiMGI:1352746. Cabp5.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ9JLK3.
PhylomeDBiQ9JLK3.
TreeFamiTF334804.

Miscellaneous databases

PROiQ9JLK3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005649.
CleanExiMM_CABP5.
ExpressionAtlasiQ9JLK3. baseline and differential.
GenevisibleiQ9JLK3. MM.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCABP5_MOUSE
AccessioniPrimary (citable) accession number: Q9JLK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.