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Q9JLJ5

- ELOV1_MOUSE

UniProt

Q9JLJ5 - ELOV1_MOUSE

Protein

Elongation of very long chain fatty acids protein 1

Gene

Elovl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids (VLCFAs). Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.2 Publications

    Catalytic activityi

    A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.

    GO - Molecular functioni

    1. fatty acid elongase activity Source: Ensembl

    GO - Biological processi

    1. fatty acid elongation, monounsaturated fatty acid Source: UniProtKB
    2. fatty acid elongation, saturated fatty acid Source: UniProtKB
    3. sphingolipid biosynthetic process Source: UniProtKB
    4. very long-chain fatty acid biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation of very long chain fatty acids protein 1 (EC:2.3.1.199)
    Alternative name(s):
    3-keto acyl-CoA synthase Elovl1
    ELOVL fatty acid elongase 1
    Short name:
    ELOVL FA elongase 1
    Very-long-chain 3-oxoacyl-CoA synthase 1
    Gene namesi
    Name:Elovl1
    Synonyms:Ssc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1858959. Elovl1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Elongation of very long chain fatty acids protein 1PRO_0000207537Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9JLJ5.
    PaxDbiQ9JLJ5.
    PRIDEiQ9JLJ5.

    PTM databases

    PhosphoSiteiQ9JLJ5.

    Expressioni

    Tissue specificityi

    Expressed in a broad variety of tissues. Highly expressed in stomach, lung, kidney, skin and intestine. Moderately expressed in white adipose tissue, liver, spleen, brain, brown adipose tissue, heart and muscle. Weakly expressed in testis.1 Publication

    Gene expression databases

    ArrayExpressiQ9JLJ5.
    BgeeiQ9JLJ5.
    GenevestigatoriQ9JLJ5.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000064816.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei231 – 25121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi275 – 2795Di-lysine motifSequence Analysis

    Domaini

    The di-lysine motif may confer endoplasmic reticulum localization.By similarity

    Sequence similaritiesi

    Belongs to the ELO family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG305096.
    GeneTreeiENSGT00740000115027.
    HOGENOMiHOG000038120.
    HOVERGENiHBG051468.
    InParanoidiQ9JLJ5.
    KOiK10247.
    OMAiWGVKIAP.
    OrthoDBiEOG7Z3F4V.
    PhylomeDBiQ9JLJ5.
    TreeFamiTF323454.

    Family and domain databases

    InterProiIPR002076. GNS1_SUR4.
    [Graphical view]
    PANTHERiPTHR11157. PTHR11157. 1 hit.
    PfamiPF01151. ELO. 1 hit.
    [Graphical view]
    PROSITEiPS01188. ELO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JLJ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAVVNLYHE LMKHADPRIQ SYPLMGSPLL ITSILLTYVY FILSLGPRIM    50
    ANRKPFQLRG FMIVYNFSLV ILSLYIVYEF LMSGWLSTYT WRCDPIDFSN 100
    SPEALRMVRV AWLFMLSKVI ELMDTVIFIL RKKDGQVTFL HVFHHSVLPW 150
    SWWWGIKIAP GGMGSFHAMI NSSVHVVMYL YYGLSALGPV AQPYLWWKKH 200
    MTAIQLIQFV LVSLHISQYY FMPSCNYQYP IIIHLIWMYG TIFFILFSNF 250
    WYHSYTKGKR LPRAVQQNGA PATTKVKAN 279
    Length:279
    Mass (Da):32,678
    Last modified:October 1, 2000 - v1
    Checksum:iCA5A1CF55FDB2F76
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti78 – 792YE → MR in BAB22975. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF170907 mRNA. Translation: AAF72572.1.
    BC006735 mRNA. Translation: AAH06735.1.
    AK003743 mRNA. Translation: BAB22975.1.
    CCDSiCCDS18549.1.
    RefSeqiNP_001034264.1. NM_001039175.2.
    NP_001034265.1. NM_001039176.2.
    NP_062295.1. NM_019422.3.
    XP_006503296.1. XM_006503233.1.
    UniGeneiMm.282096.

    Genome annotation databases

    EnsembliENSMUST00000006557; ENSMUSP00000006557; ENSMUSG00000006390.
    ENSMUST00000067896; ENSMUSP00000064816; ENSMUSG00000006390.
    ENSMUST00000167636; ENSMUSP00000126685; ENSMUSG00000006390.
    GeneIDi54325.
    KEGGimmu:54325.
    UCSCiuc008ujz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF170907 mRNA. Translation: AAF72572.1 .
    BC006735 mRNA. Translation: AAH06735.1 .
    AK003743 mRNA. Translation: BAB22975.1 .
    CCDSi CCDS18549.1.
    RefSeqi NP_001034264.1. NM_001039175.2.
    NP_001034265.1. NM_001039176.2.
    NP_062295.1. NM_019422.3.
    XP_006503296.1. XM_006503233.1.
    UniGenei Mm.282096.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000064816.

    PTM databases

    PhosphoSitei Q9JLJ5.

    Proteomic databases

    MaxQBi Q9JLJ5.
    PaxDbi Q9JLJ5.
    PRIDEi Q9JLJ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006557 ; ENSMUSP00000006557 ; ENSMUSG00000006390 .
    ENSMUST00000067896 ; ENSMUSP00000064816 ; ENSMUSG00000006390 .
    ENSMUST00000167636 ; ENSMUSP00000126685 ; ENSMUSG00000006390 .
    GeneIDi 54325.
    KEGGi mmu:54325.
    UCSCi uc008ujz.1. mouse.

    Organism-specific databases

    CTDi 64834.
    MGIi MGI:1858959. Elovl1.

    Phylogenomic databases

    eggNOGi NOG305096.
    GeneTreei ENSGT00740000115027.
    HOGENOMi HOG000038120.
    HOVERGENi HBG051468.
    InParanoidi Q9JLJ5.
    KOi K10247.
    OMAi WGVKIAP.
    OrthoDBi EOG7Z3F4V.
    PhylomeDBi Q9JLJ5.
    TreeFami TF323454.

    Miscellaneous databases

    NextBioi 311104.
    PROi Q9JLJ5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JLJ5.
    Bgeei Q9JLJ5.
    Genevestigatori Q9JLJ5.

    Family and domain databases

    InterProi IPR002076. GNS1_SUR4.
    [Graphical view ]
    PANTHERi PTHR11157. PTHR11157. 1 hit.
    Pfami PF01151. ELO. 1 hit.
    [Graphical view ]
    PROSITEi PS01188. ELO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids."
      Tvrdik P., Westerberg R., Silve S., Asadi A., Jakobsson A., Cannon B., Loison G., Jacobsson A.
      J. Cell Biol. 149:707-718(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-279.
      Strain: C57BL/6J.
      Tissue: Embryo.
    4. "Fatty acid transport protein 4 (FATP4) prevents light-induced degeneration of cone and rod photoreceptors by inhibiting RPE65 isomerase."
      Li S., Lee J., Zhou Y., Gordon W.C., Hill J.M., Bazan N.G., Miner J.H., Jin M.
      J. Neurosci. 33:3178-3189(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiELOV1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JLJ5
    Secondary accession number(s): Q9D1B2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3