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Q9JLJ5 (ELOV1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Elongation of very long chain fatty acids protein 1

EC=2.3.1.199
Alternative name(s):
3-keto acyl-CoA synthase Elovl1
ELOVL fatty acid elongase 1
Short name=ELOVL FA elongase 1
Very-long-chain 3-oxoacyl-CoA synthase 1
Gene names
Name:Elovl1
Synonyms:Ssc1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids (VLCFAs). Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. Ref.1 Ref.4

Catalytic activity

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Potential.

Tissue specificity

Expressed in a broad variety of tissues. Highly expressed in stomach, lung, kidney, skin and intestine. Moderately expressed in white adipose tissue, liver, spleen, brain, brown adipose tissue, heart and muscle. Weakly expressed in testis. Ref.1

Domain

The di-lysine motif may confer endoplasmic reticulum localization By similarity.

Sequence similarities

Belongs to the ELO family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Elongation of very long chain fatty acids protein 1
PRO_0000207537

Regions

Transmembrane23 – 4321Helical; Potential
Transmembrane61 – 8121Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane203 – 22321Helical; Potential
Transmembrane231 – 25121Helical; Potential
Motif275 – 2795Di-lysine motif Potential

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Experimental info

Sequence conflict78 – 792YE → MR in BAB22975. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9JLJ5 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: CA5A1CF55FDB2F76

FASTA27932,678
        10         20         30         40         50         60 
MEAVVNLYHE LMKHADPRIQ SYPLMGSPLL ITSILLTYVY FILSLGPRIM ANRKPFQLRG 

        70         80         90        100        110        120 
FMIVYNFSLV ILSLYIVYEF LMSGWLSTYT WRCDPIDFSN SPEALRMVRV AWLFMLSKVI 

       130        140        150        160        170        180 
ELMDTVIFIL RKKDGQVTFL HVFHHSVLPW SWWWGIKIAP GGMGSFHAMI NSSVHVVMYL 

       190        200        210        220        230        240 
YYGLSALGPV AQPYLWWKKH MTAIQLIQFV LVSLHISQYY FMPSCNYQYP IIIHLIWMYG 

       250        260        270 
TIFFILFSNF WYHSYTKGKR LPRAVQQNGA PATTKVKAN 

« Hide

References

« Hide 'large scale' references
[1]"Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids."
Tvrdik P., Westerberg R., Silve S., Asadi A., Jakobsson A., Cannon B., Loison G., Jacobsson A.
J. Cell Biol. 149:707-718(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Strain: BALB/c.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-279.
Strain: C57BL/6J.
Tissue: Embryo.
[4]"Fatty acid transport protein 4 (FATP4) prevents light-induced degeneration of cone and rod photoreceptors by inhibiting RPE65 isomerase."
Li S., Lee J., Zhou Y., Gordon W.C., Hill J.M., Bazan N.G., Miner J.H., Jin M.
J. Neurosci. 33:3178-3189(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF170907 mRNA. Translation: AAF72572.1.
BC006735 mRNA. Translation: AAH06735.1.
AK003743 mRNA. Translation: BAB22975.1.
CCDSCCDS18549.1.
RefSeqNP_001034264.1. NM_001039175.2.
NP_001034265.1. NM_001039176.2.
NP_062295.1. NM_019422.3.
XP_006503296.1. XM_006503233.1.
UniGeneMm.282096.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000064816.

PTM databases

PhosphoSiteQ9JLJ5.

Proteomic databases

MaxQBQ9JLJ5.
PaxDbQ9JLJ5.
PRIDEQ9JLJ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000006557; ENSMUSP00000006557; ENSMUSG00000006390.
ENSMUST00000067896; ENSMUSP00000064816; ENSMUSG00000006390.
ENSMUST00000167636; ENSMUSP00000126685; ENSMUSG00000006390.
GeneID54325.
KEGGmmu:54325.
UCSCuc008ujz.1. mouse.

Organism-specific databases

CTD64834.
MGIMGI:1858959. Elovl1.

Phylogenomic databases

eggNOGNOG305096.
GeneTreeENSGT00740000115027.
HOGENOMHOG000038120.
HOVERGENHBG051468.
InParanoidQ9JLJ5.
KOK10247.
OMAWGVKIAP.
OrthoDBEOG7Z3F4V.
PhylomeDBQ9JLJ5.
TreeFamTF323454.

Gene expression databases

ArrayExpressQ9JLJ5.
BgeeQ9JLJ5.
GenevestigatorQ9JLJ5.

Family and domain databases

InterProIPR002076. GNS1_SUR4.
[Graphical view]
PANTHERPTHR11157. PTHR11157. 1 hit.
PfamPF01151. ELO. 1 hit.
[Graphical view]
PROSITEPS01188. ELO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio311104.
PROQ9JLJ5.
SOURCESearch...

Entry information

Entry nameELOV1_MOUSE
AccessionPrimary (citable) accession number: Q9JLJ5
Secondary accession number(s): Q9D1B2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot