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Q9JLJ3

- AL9A1_RAT

UniProt

Q9JLJ3 - AL9A1_RAT

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Protein
4-trimethylaminobutyraldehyde dehydrogenase
Gene
Aldh9a1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine.1 Publication

Catalytic activityi

4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH.
An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei254 – 2541 Reviewed prediction
Active sitei288 – 2881 Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi232 – 2376NAD By similarity

GO - Molecular functioni

  1. 4-trimethylammoniobutyraldehyde dehydrogenase activity Source: RGD
  2. NAD binding Source: RGD
  3. aldehyde dehydrogenase (NAD) activity Source: RGD
  4. amine binding Source: RGD
  5. aminobutyraldehyde dehydrogenase activity Source: RGD
  6. protein homodimerization activity Source: RGD

GO - Biological processi

  1. carnitine biosynthetic process Source: RGD
  2. cellular aldehyde metabolic process Source: Ensembl
  3. kidney development Source: RGD
  4. liver development Source: RGD
  5. neurotransmitter biosynthetic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14430.
SABIO-RKQ9JLJ3.
UniPathwayiUPA00118.

Names & Taxonomyi

Protein namesi
Recommended name:
4-trimethylaminobutyraldehyde dehydrogenase (EC:1.2.1.47)
Short name:
TMABADH
Alternative name(s):
Aldehyde dehydrogenase family 9 member A1 (EC:1.2.1.3)
Gene namesi
Name:Aldh9a1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi68409. Aldh9a1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RGD
  2. mitochondrion Source: Ensembl
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 4944934-trimethylaminobutyraldehyde dehydrogenase
PRO_0000056489Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei30 – 301N6-acetyllysine; alternate By similarity
Modified residuei30 – 301N6-succinyllysine; alternate By similarity
Modified residuei59 – 591N6-succinyllysine By similarity
Modified residuei298 – 2981N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9JLJ3.
PRIDEiQ9JLJ3.

PTM databases

PhosphoSiteiQ9JLJ3.

Expressioni

Gene expression databases

GenevestigatoriQ9JLJ3.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

IntActiQ9JLJ3. 1 interaction.
MINTiMINT-4580055.

Structurei

3D structure databases

ProteinModelPortaliQ9JLJ3.
SMRiQ9JLJ3. Positions 2-492.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00720000108597.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ9JLJ3.
KOiK00149.
OrthoDBiEOG7327P4.
PhylomeDBiQ9JLJ3.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLJ3-1 [UniParc]FASTAAdd to Basket

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MSTGTFVVSQ PLNYRGGARV EPVDASGTEK AFEPATGREI ATFKCSGEKE    50
VNLAVENAKA AFKIWSKKSG LERCQVLLEA ARIIKERRDE IAIMETINNG 100
KSIFEARLDV DTSWQCLEYY AGLAASMAGE HIQLPGGSFG YTRREPLGVC 150
LGIGAWNYPF QIACWKSAPA LACGNAMIFK PSPFTPVSAL LLAEIYTKAG 200
APNGLFNVVQ GGAATGQFLC QHRDVAKVSF TGSVPTGMKI MEMAAKGIKP 250
ITLELGGKSP LIIFSDCNMK NAVKGALLAN FLTQGQVCCN GTRVFVQKEI 300
ADAFTKEVVR QTQRIKIGDP LLEDTRMGPL INAPHLERVL GFVRSAKEQG 350
ATVLCGGEPY APEDPKLKHG YYMTPCILTN CTDDMTCVKE EIFGPVMSIL 400
TFETEAEVLE RANDTTFGLA AGVFTRDIQR AHRVAAELQA GTCYINNYNV 450
SPVELPFGGY KKSGFGRENG RVTIEYYSQL KTVCVEMGDV ESAF 494
Length:494
Mass (Da):53,653
Last modified:October 1, 2000 - v1
Checksum:iE417BD52D7DF567C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti493 – 4942AF → PFENQ in AAH74019. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF170918 mRNA. Translation: AAF43598.1.
BC074019 mRNA. Translation: AAH74019.1.
RefSeqiNP_071609.2. NM_022273.2.
UniGeneiRn.98155.

Genome annotation databases

EnsembliENSRNOT00000005611; ENSRNOP00000005611; ENSRNOG00000004027.
GeneIDi64040.
KEGGirno:64040.
UCSCiRGD:68409. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF170918 mRNA. Translation: AAF43598.1 .
BC074019 mRNA. Translation: AAH74019.1 .
RefSeqi NP_071609.2. NM_022273.2.
UniGenei Rn.98155.

3D structure databases

ProteinModelPortali Q9JLJ3.
SMRi Q9JLJ3. Positions 2-492.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9JLJ3. 1 interaction.
MINTi MINT-4580055.

PTM databases

PhosphoSitei Q9JLJ3.

Proteomic databases

PaxDbi Q9JLJ3.
PRIDEi Q9JLJ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000005611 ; ENSRNOP00000005611 ; ENSRNOG00000004027 .
GeneIDi 64040.
KEGGi rno:64040.
UCSCi RGD:68409. rat.

Organism-specific databases

CTDi 223.
RGDi 68409. Aldh9a1.

Phylogenomic databases

eggNOGi COG1012.
GeneTreei ENSGT00720000108597.
HOGENOMi HOG000271505.
HOVERGENi HBG000097.
InParanoidi Q9JLJ3.
KOi K00149.
OrthoDBi EOG7327P4.
PhylomeDBi Q9JLJ3.

Enzyme and pathway databases

UniPathwayi UPA00118 .
BioCyci MetaCyc:MONOMER-14430.
SABIO-RK Q9JLJ3.

Miscellaneous databases

NextBioi 612685.
PROi Q9JLJ3.

Gene expression databases

Genevestigatori Q9JLJ3.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis."
    Vaz F.M., Fouchier S.W., Ofman R., Sommer M., Wanders R.J.A.
    J. Biol. Chem. 275:7390-7394(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, FUNCTION, CHARACTERIZATION.
    Strain: Wistar.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. Lubec G., Afjehi-Sadat L., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 50-59; 199-223; 275-293 AND 412-426, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain and Spinal cord.

Entry informationi

Entry nameiAL9A1_RAT
AccessioniPrimary (citable) accession number: Q9JLJ3
Secondary accession number(s): Q6GMM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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