Reviewed, UniProtKB/Swiss-Prot Q9JLJ2 (AL9A1_MOUSE)

Names and origin

Protein names

Recommended name:
    4-trimethylaminobutyraldehyde dehydrogenase
      Short name=TMABADH
    EC=1.2.1.47
Alternative name(s):
    Aldehyde dehydrogenase family 9 member A1
    EC=1.2.1.3

Gene names

Name:

Aldh9a1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	494 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine By similarity.
Catalytic activity	4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH. An aldehyde + NAD+ + H2O = an acid + NADH.
Pathway	Amine and polyamine biosynthesis; carnitine biosynthesis.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	carnitine metabolic process Ref.1 Inferred from direct assay. Source: MGI oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Ref.1 Inferred from direct assay. Source: MGI mitochondrion Inferred from direct assay. Source: MGI
Molecular function	4-trimethylammoniobutyraldehyde dehydrogenase activity Inferred from electronic annotation. Source: EC aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 494	493	4-trimethylaminobutyraldehyde dehydrogenase		PRO_0000056486
Regions
	Nucleotide binding	232 – 237	6	NAD By similarity
Sites
	Active site	254	1	Potential
	Active site	288	1	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
	Modified residue	298	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9JLJ2-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: CBB27755330E0A23	FASTA	494	53,515
	10 20 30 40 50 60 MSTGTFVVSQ PLNYRGGARV EPVDASGTEK AFEPATGRVI ATFACSGEKE VNLAVENAKA 70 80 90 100 110 120 AFKLWSKKSG LERCQVLLEA ARIIKERKDE IATVETINNG KSIFEARLDV DTCWQCLEYY 130 140 150 160 170 180 AGLAASMAGE HIQLPGGSFG YTRREPLGVC VGIGAWNYPF QIACWKSAPA LACGNAMIFK 190 200 210 220 230 240 PSPFTPVSAL LLAEIYTKAG APPGLFNVVQ GGAATGQFLC HHREVAKISF TGSVPTGVKI 250 260 270 280 290 300 MEMSAKGVKP ITLELGGKSP LIIFSDCNME NAVKGALMAN FLTQGQVCCN GTRVFVQKEI 310 320 330 340 350 360 ADKFINEVVK QTQKIKLGDP LLEDTRMGPL INAPHLERVL GFVKLAKEQG ATVLCGGEVY 370 380 390 400 410 420 VPEDPKLKHG YYMTPCILTN CRDDMTCVKE EIFGPVMSIL TFGTEAEVLE RANDTTFGLA 430 440 450 460 470 480 AGVFTRDIQR AHRVAAELQA GTCYINNYNV SPVELPFGGY KKSGFGRENG RVTIEYYSQL 490 KTVCVEMGDV ESAF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis." Vaz F.M., Fouchier S.W., Ofman R., Sommer M., Wanders R.J.A. J. Biol. Chem. 275:7390-7394(2000) [PubMed: 10702312] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
[3]	Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 39-59; 74-82; 88-101; 228-239; 247-274; 317-338; 348-366; 412-426 AND 472-494, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF170919 mRNA. Translation: AAF43599.1. BC003297 mRNA. Translation: AAH03297.1.
IPI	IPI00124372.
RefSeq	NP_064377.2.
UniGene	Mm.330055 Mm.474999
3D structure databases
SMR	Q9JLJ2. Positions 2-492.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9JLJ2.
PTM databases
PhosphoSite	Q9JLJ2.
2-D gel databases
REPRODUCTION-2DPAGE	Q9JLJ2.
Proteomic databases
PRIDE	Q9JLJ2.
Genome annotation databases
Ensembl	ENSMUST00000028004; ENSMUSP00000028004; ENSMUSG00000026687; Mus musculus. [Genome view]
GeneID	56752.
KEGG	mmu:56752.
NMPDR	fig|10090.3.peg.1427.
UCSC	uc007dkx.1. mouse.
Organism-specific databases
CTD	56752.
MGI	MGI:1861622. Aldh9a1.
Phylogenomic databases
HOVERGEN	Q9JLJ2.
InParanoid	Q9JLJ2.
PhylomeDB	Q9JLJ2.
Enzyme and pathway databases
BRENDA	1.2.1.3. 244. 1.2.1.47. 244.
Gene expression databases
ArrayExpress	Q9JLJ2.
Bgee	Q9JLJ2.
CleanEx	MM_ALDH9A1.
Genevestigator	Q9JLJ2.
GermOnline	ENSMUSG00000026687. Mus musculus.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

AL9A1_MOUSE

Accession

Primary (citable) accession number: Q9JLJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	October 1, 2000
Last modified:	January 19, 2010
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)