4-trimethylaminobutyraldehyde dehydrogenase

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Q9JLJ2 (AL9A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 96. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
4-trimethylaminobutyraldehyde dehydrogenase
Short name=TMABADH
EC=1.2.1.47

Alternative name(s):
Aldehyde dehydrogenase family 9 member A1
EC=1.2.1.3

Gene names

Name:

Aldh9a1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	494 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine By similarity.
Catalytic activity	4-trimethylammoniobutanal + NAD⁺ + H₂O = 4-trimethylammoniobutanoate + NADH. An aldehyde + NAD⁺ + H₂O = a carboxylate + NADH.
Pathway	Amine and polyamine biosynthesis; carnitine biosynthesis.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	carnitine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway carnitine metabolic process Inferred from direct assay Ref.1. Source: MGI cellular aldehyde metabolic process Inferred from electronic annotation. Source: Compara neurotransmitter biosynthetic process Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from direct assay Ref.1. Source: MGI mitochondrion Inferred from direct assay PubMed 18614015. Source: MGI plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	4-trimethylammoniobutyraldehyde dehydrogenase activity Inferred from electronic annotation. Source: EC aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 494

493

4-trimethylaminobutyraldehyde dehydrogenase

PRO_0000056486

Regions

Nucleotide binding

232 – 237

NAD By similarity

Sites

Active site

254

Potential

Active site

288

Potential

Amino acid modifications

Modified residue

N-acetylserine By similarity

Modified residue

298

N6-acetyllysine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q9JLJ2 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: CBB27755330E0A23
Show »

FASTA

494

53,515

        10         20         30         40         50         60 
MSTGTFVVSQ PLNYRGGARV EPVDASGTEK AFEPATGRVI ATFACSGEKE VNLAVENAKA 

        70         80         90        100        110        120 
AFKLWSKKSG LERCQVLLEA ARIIKERKDE IATVETINNG KSIFEARLDV DTCWQCLEYY 

       130        140        150        160        170        180 
AGLAASMAGE HIQLPGGSFG YTRREPLGVC VGIGAWNYPF QIACWKSAPA LACGNAMIFK 

       190        200        210        220        230        240 
PSPFTPVSAL LLAEIYTKAG APPGLFNVVQ GGAATGQFLC HHREVAKISF TGSVPTGVKI 

       250        260        270        280        290        300 
MEMSAKGVKP ITLELGGKSP LIIFSDCNME NAVKGALMAN FLTQGQVCCN GTRVFVQKEI 

       310        320        330        340        350        360 
ADKFINEVVK QTQKIKLGDP LLEDTRMGPL INAPHLERVL GFVKLAKEQG ATVLCGGEVY 

       370        380        390        400        410        420 
VPEDPKLKHG YYMTPCILTN CRDDMTCVKE EIFGPVMSIL TFGTEAEVLE RANDTTFGLA 

       430        440        450        460        470        480 
AGVFTRDIQR AHRVAAELQA GTCYINNYNV SPVELPFGGY KKSGFGRENG RVTIEYYSQL 

       490 
KTVCVEMGDV ESAF

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis." Vaz F.M., Fouchier S.W., Ofman R., Sommer M., Wanders R.J.A. J. Biol. Chem. 275:7390-7394(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
[3]	Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 39-59; 74-82; 88-101; 228-239; 247-274; 317-338; 348-366; 412-426 AND 472-494, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF170919 mRNA. Translation: AAF43599.1. BC003297 mRNA. Translation: AAH03297.1.
IPI	IPI00124372.
RefSeq	NP_064377.2. NM_019993.3.
UniGene	Mm.330055. Mm.474999.
3D structure databases
ProteinModelPortal	Q9JLJ2.
SMR	Q9JLJ2. Positions 2-494.
ModBase	Search...
PTM databases
PhosphoSite	Q9JLJ2.
2D gel databases
REPRODUCTION-2DPAGE	Q9JLJ2.
Proteomic databases
PaxDb	Q9JLJ2.
PRIDE	Q9JLJ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	56752.
KEGG	mmu:56752.
Organism-specific databases
CTD	223.
MGI	MGI:1861622. Aldh9a1.
Phylogenomic databases
eggNOG	COG1012.
HOVERGEN	HBG000097.
InParanoid	Q9JLJ2.
KO	K00149.
OrthoDB	EOG4THVSW.
Enzyme and pathway databases
UniPathway	UPA00118.
Gene expression databases
ArrayExpress	Q9JLJ2.
Bgee	Q9JLJ2.
CleanEx	MM_ALDH9A1.
Genevestigator	Q9JLJ2.
GermOnline	ENSMUSG00000026687. Mus musculus.
Family and domain databases
Gene3D	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	313278.
SOURCE	Search...

Entry information

Entry name

AL9A1_MOUSE

Accession

Primary (citable) accession number: Q9JLJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents