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Protein

4-trimethylaminobutyraldehyde dehydrogenase

Gene

Aldh9a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine.By similarity

Catalytic activityi

4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH.
An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi: carnitine biosynthesis

This protein is involved in the pathway carnitine biosynthesis, which is part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the pathway carnitine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei254Sequence analysis1
Active sitei288Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi232 – 237NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BRENDAi1.2.1.47 3474
UniPathwayiUPA00118

Names & Taxonomyi

Protein namesi
Recommended name:
4-trimethylaminobutyraldehyde dehydrogenase (EC:1.2.1.47)
Short name:
TMABADH
Alternative name(s):
Aldehyde dehydrogenase family 9 member A1 (EC:1.2.1.3)
Gene namesi
Name:Aldh9a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1861622 Aldh9a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000564862 – 4944-trimethylaminobutyraldehyde dehydrogenaseAdd BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei30N6-acetyllysine; alternateCombined sources1
Modified residuei30N6-succinyllysine; alternateCombined sources1
Modified residuei59N6-succinyllysineCombined sources1
Modified residuei298N6-acetyllysineCombined sources1
Modified residuei303N6-acetyllysine; alternateCombined sources1
Modified residuei303N6-succinyllysine; alternateCombined sources1
Modified residuei344N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9JLJ2
MaxQBiQ9JLJ2
PaxDbiQ9JLJ2
PRIDEiQ9JLJ2

2D gel databases

REPRODUCTION-2DPAGEiQ9JLJ2

PTM databases

iPTMnetiQ9JLJ2
PhosphoSitePlusiQ9JLJ2
SwissPalmiQ9JLJ2

Expressioni

Gene expression databases

CleanExiMM_ALDH9A1

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ9JLJ2 3 interactors.
MINTiQ9JLJ2
STRINGi10090.ENSMUSP00000028004

Structurei

3D structure databases

ProteinModelPortaliQ9JLJ2
SMRiQ9JLJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2450 Eukaryota
COG1012 LUCA
HOVERGENiHBG000097
InParanoidiQ9JLJ2
KOiK00149
PhylomeDBiQ9JLJ2

Family and domain databases

Gene3Di3.40.309.101 hit
3.40.605.101 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGTFVVSQ PLNYRGGARV EPVDASGTEK AFEPATGRVI ATFACSGEKE
60 70 80 90 100
VNLAVENAKA AFKLWSKKSG LERCQVLLEA ARIIKERKDE IATVETINNG
110 120 130 140 150
KSIFEARLDV DTCWQCLEYY AGLAASMAGE HIQLPGGSFG YTRREPLGVC
160 170 180 190 200
VGIGAWNYPF QIACWKSAPA LACGNAMIFK PSPFTPVSAL LLAEIYTKAG
210 220 230 240 250
APPGLFNVVQ GGAATGQFLC HHREVAKISF TGSVPTGVKI MEMSAKGVKP
260 270 280 290 300
ITLELGGKSP LIIFSDCNME NAVKGALMAN FLTQGQVCCN GTRVFVQKEI
310 320 330 340 350
ADKFINEVVK QTQKIKLGDP LLEDTRMGPL INAPHLERVL GFVKLAKEQG
360 370 380 390 400
ATVLCGGEVY VPEDPKLKHG YYMTPCILTN CRDDMTCVKE EIFGPVMSIL
410 420 430 440 450
TFGTEAEVLE RANDTTFGLA AGVFTRDIQR AHRVAAELQA GTCYINNYNV
460 470 480 490
SPVELPFGGY KKSGFGRENG RVTIEYYSQL KTVCVEMGDV ESAF
Length:494
Mass (Da):53,515
Last modified:October 1, 2000 - v1
Checksum:iCBB27755330E0A23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170919 mRNA Translation: AAF43599.1
BC003297 mRNA Translation: AAH03297.1
RefSeqiNP_064377.2, NM_019993.3
UniGeneiMm.292539
Mm.330055

Genome annotation databases

GeneIDi56752
KEGGimmu:56752

Similar proteinsi

Entry informationi

Entry nameiAL9A1_MOUSE
AccessioniPrimary (citable) accession number: Q9JLJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2000
Last modified: February 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome