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Protein

4-trimethylaminobutyraldehyde dehydrogenase

Gene

Aldh9a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine.By similarity

Catalytic activityi

4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH.
An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi: carnitine biosynthesis

This protein is involved in the pathway carnitine biosynthesis, which is part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the pathway carnitine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei254Sequence analysis1
Active sitei288Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi232 – 237NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.2.1.47. 3474.
UniPathwayiUPA00118.

Names & Taxonomyi

Protein namesi
Recommended name:
4-trimethylaminobutyraldehyde dehydrogenase (EC:1.2.1.47)
Short name:
TMABADH
Alternative name(s):
Aldehyde dehydrogenase family 9 member A1 (EC:1.2.1.3)
Gene namesi
Name:Aldh9a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1861622. Aldh9a1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • extracellular exosome Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000564862 – 4944-trimethylaminobutyraldehyde dehydrogenaseAdd BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei30N6-acetyllysine; alternateCombined sources1
Modified residuei30N6-succinyllysine; alternateCombined sources1
Modified residuei59N6-succinyllysineCombined sources1
Modified residuei298N6-acetyllysineCombined sources1
Modified residuei303N6-acetyllysine; alternateCombined sources1
Modified residuei303N6-succinyllysine; alternateCombined sources1
Modified residuei344N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9JLJ2.
MaxQBiQ9JLJ2.
PaxDbiQ9JLJ2.
PRIDEiQ9JLJ2.

2D gel databases

REPRODUCTION-2DPAGEQ9JLJ2.

PTM databases

iPTMnetiQ9JLJ2.
PhosphoSitePlusiQ9JLJ2.
SwissPalmiQ9JLJ2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026687.
CleanExiMM_ALDH9A1.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ9JLJ2. 3 interactors.
MINTiMINT-4087568.
STRINGi10090.ENSMUSP00000028004.

Structurei

3D structure databases

ProteinModelPortaliQ9JLJ2.
SMRiQ9JLJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
HOVERGENiHBG000097.
InParanoidiQ9JLJ2.
KOiK00149.
PhylomeDBiQ9JLJ2.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGTFVVSQ PLNYRGGARV EPVDASGTEK AFEPATGRVI ATFACSGEKE
60 70 80 90 100
VNLAVENAKA AFKLWSKKSG LERCQVLLEA ARIIKERKDE IATVETINNG
110 120 130 140 150
KSIFEARLDV DTCWQCLEYY AGLAASMAGE HIQLPGGSFG YTRREPLGVC
160 170 180 190 200
VGIGAWNYPF QIACWKSAPA LACGNAMIFK PSPFTPVSAL LLAEIYTKAG
210 220 230 240 250
APPGLFNVVQ GGAATGQFLC HHREVAKISF TGSVPTGVKI MEMSAKGVKP
260 270 280 290 300
ITLELGGKSP LIIFSDCNME NAVKGALMAN FLTQGQVCCN GTRVFVQKEI
310 320 330 340 350
ADKFINEVVK QTQKIKLGDP LLEDTRMGPL INAPHLERVL GFVKLAKEQG
360 370 380 390 400
ATVLCGGEVY VPEDPKLKHG YYMTPCILTN CRDDMTCVKE EIFGPVMSIL
410 420 430 440 450
TFGTEAEVLE RANDTTFGLA AGVFTRDIQR AHRVAAELQA GTCYINNYNV
460 470 480 490
SPVELPFGGY KKSGFGRENG RVTIEYYSQL KTVCVEMGDV ESAF
Length:494
Mass (Da):53,515
Last modified:October 1, 2000 - v1
Checksum:iCBB27755330E0A23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170919 mRNA. Translation: AAF43599.1.
BC003297 mRNA. Translation: AAH03297.1.
RefSeqiNP_064377.2. NM_019993.3.
UniGeneiMm.292539.
Mm.330055.

Genome annotation databases

GeneIDi56752.
KEGGimmu:56752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170919 mRNA. Translation: AAF43599.1.
BC003297 mRNA. Translation: AAH03297.1.
RefSeqiNP_064377.2. NM_019993.3.
UniGeneiMm.292539.
Mm.330055.

3D structure databases

ProteinModelPortaliQ9JLJ2.
SMRiQ9JLJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JLJ2. 3 interactors.
MINTiMINT-4087568.
STRINGi10090.ENSMUSP00000028004.

PTM databases

iPTMnetiQ9JLJ2.
PhosphoSitePlusiQ9JLJ2.
SwissPalmiQ9JLJ2.

2D gel databases

REPRODUCTION-2DPAGEQ9JLJ2.

Proteomic databases

EPDiQ9JLJ2.
MaxQBiQ9JLJ2.
PaxDbiQ9JLJ2.
PRIDEiQ9JLJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56752.
KEGGimmu:56752.

Organism-specific databases

CTDi223.
MGIiMGI:1861622. Aldh9a1.

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
HOVERGENiHBG000097.
InParanoidiQ9JLJ2.
KOiK00149.
PhylomeDBiQ9JLJ2.

Enzyme and pathway databases

UniPathwayiUPA00118.
BRENDAi1.2.1.47. 3474.

Miscellaneous databases

PROiQ9JLJ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026687.
CleanExiMM_ALDH9A1.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL9A1_MOUSE
AccessioniPrimary (citable) accession number: Q9JLJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.