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Reviewed, UniProtKB/Swiss-Prot Q9JLJ2 (AL9A1_MOUSE)

Last modified January 19, 2010. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    4-trimethylaminobutyraldehyde dehydrogenase
      Short name=TMABADH
    EC=1.2.1.47
Alternative name(s):
    Aldehyde dehydrogenase family 9 member A1
    EC=1.2.1.3
Gene names
Name: Aldh9a1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine By similarity.

Catalytic activity

4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH.

An aldehyde + NAD+ + H2O = an acid + NADH.

Pathway

Amine and polyamine biosynthesis; carnitine biosynthesis.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 4944934-trimethylaminobutyraldehyde dehydrogenase
PRO_0000056486

Regions

Nucleotide binding232 – 2376NAD By similarity

Sites

Active site2541 Potential
Active site2881 Potential

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue2981N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JLJ2-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: CBB27755330E0A23

FASTA49453,515
        10         20         30         40         50         60 
MSTGTFVVSQ PLNYRGGARV EPVDASGTEK AFEPATGRVI ATFACSGEKE VNLAVENAKA 

        70         80         90        100        110        120 
AFKLWSKKSG LERCQVLLEA ARIIKERKDE IATVETINNG KSIFEARLDV DTCWQCLEYY 

       130        140        150        160        170        180 
AGLAASMAGE HIQLPGGSFG YTRREPLGVC VGIGAWNYPF QIACWKSAPA LACGNAMIFK 

       190        200        210        220        230        240 
PSPFTPVSAL LLAEIYTKAG APPGLFNVVQ GGAATGQFLC HHREVAKISF TGSVPTGVKI 

       250        260        270        280        290        300 
MEMSAKGVKP ITLELGGKSP LIIFSDCNME NAVKGALMAN FLTQGQVCCN GTRVFVQKEI 

       310        320        330        340        350        360 
ADKFINEVVK QTQKIKLGDP LLEDTRMGPL INAPHLERVL GFVKLAKEQG ATVLCGGEVY 

       370        380        390        400        410        420 
VPEDPKLKHG YYMTPCILTN CRDDMTCVKE EIFGPVMSIL TFGTEAEVLE RANDTTFGLA 

       430        440        450        460        470        480 
AGVFTRDIQR AHRVAAELQA GTCYINNYNV SPVELPFGGY KKSGFGRENG RVTIEYYSQL 

       490 
KTVCVEMGDV ESAF 

« Hide

References

« Hide 'large scale' references
[1]"Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis."
Vaz F.M., Fouchier S.W., Ofman R., Sommer M., Wanders R.J.A.
J. Biol. Chem. 275:7390-7394(2000) [PubMed: 10702312] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[3]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 39-59; 74-82; 88-101; 228-239; 247-274; 317-338; 348-366; 412-426 AND 472-494, MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF170919 mRNA. Translation: AAF43599.1.
BC003297 mRNA. Translation: AAH03297.1.
IPIIPI00124372.
RefSeqNP_064377.2.
UniGeneMm.330055
Mm.474999

3D structure databases

SMRQ9JLJ2. Positions 2-492.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9JLJ2.

PTM databases

PhosphoSiteQ9JLJ2.

2-D gel databases

REPRODUCTION-2DPAGEQ9JLJ2.

Proteomic databases

PRIDEQ9JLJ2.

Genome annotation databases

EnsemblENSMUST00000028004; ENSMUSP00000028004; ENSMUSG00000026687; Mus musculus. [Genome view]
GeneID56752.
KEGGmmu:56752.
NMPDRfig|10090.3.peg.1427.
UCSCuc007dkx.1. mouse.

Organism-specific databases

CTD56752.
MGIMGI:1861622. Aldh9a1.

Phylogenomic databases

HOVERGENQ9JLJ2.
InParanoidQ9JLJ2.
PhylomeDBQ9JLJ2.

Enzyme and pathway databases

BRENDA1.2.1.3. 244.
1.2.1.47. 244.

Gene expression databases

ArrayExpressQ9JLJ2.
BgeeQ9JLJ2.
CleanExMM_ALDH9A1.
GenevestigatorQ9JLJ2.
GermOnlineENSMUSG00000026687. Mus musculus.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

Entry information

Entry nameAL9A1_MOUSE
AccessionPrimary (citable) accession number: Q9JLJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2000
Last modified: January 19, 2010
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents