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Protein

Selenoprotein K

Gene

Selk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for Ca2+ flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes.2 Publications

GO - Molecular functioni

GO - Biological processi

  • calcium ion transport Source: MGI
  • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: MGI
  • macrophage derived foam cell differentiation Source: MGI
  • positive regulation of cell migration Source: MGI
  • positive regulation of chemokine secretion Source: UniProtKB
  • positive regulation of defense response to virus by host Source: UniProtKB
  • positive regulation of interleukin-6 secretion Source: UniProtKB
  • positive regulation of monocyte chemotactic protein-1 production Source: UniProtKB
  • positive regulation of T cell migration Source: MGI
  • positive regulation of T cell proliferation Source: MGI
  • positive regulation of tumor necrosis factor production Source: UniProtKB
  • protein palmitoylation Source: MGI
  • regulation of calcium-mediated signaling Source: UniProtKB
  • regulation of protein transport Source: MGI
  • respiratory burst after phagocytosis Source: MGI
  • response to oxidative stress Source: MGI
Complete GO annotation...

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein K
Short name:
SelK
Gene namesi
Name:Selk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1931466. Selk.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4223HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Normal growth, fertility and immune system development. Reduced receptor-mediated Ca2+ flux in T-cells, neutrophils and macrophages. Reduced T-cell proliferation and reduced T-cell and neutrophil migration. Decreased viral clearance and increased mortality following infection with West Nile virus. Bone marrow-derived macrophages from knockout mice display decreased uptake of acetylated or oxidized low-density lipoprotein, reduced foam cell formation and decreased palmitoylation and cell surface expression of CD36.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 9493Selenoprotein KPRO_0000097670Add
BLAST

Post-translational modificationi

Cleaved by CAPN2/m-calpain in resting macrophages but not in activated macrophages. Macrophage activation up-regulates expression of the calpain inhibitor CAST/calpastatin, resulting in inhibition of CAPN2 activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei81 – 822Cleavage; by CAPN2

Proteomic databases

EPDiQ9JLJ1.
MaxQBiQ9JLJ1.
PaxDbiQ9JLJ1.
PeptideAtlasiQ9JLJ1.
PRIDEiQ9JLJ1.

PTM databases

iPTMnetiQ9JLJ1.
PhosphoSiteiQ9JLJ1.

Expressioni

Tissue specificityi

High expression in spleen and intestine (at protein level). Expressed in a range of immune cells including T and B-cells and also in myeloid cells including macrophages, neutrophils and dendritic cells (at protein level).2 Publications

Inductioni

By increased dietary selenium. Expression is significantly decreased by a low selenium diet.1 Publication

Gene expression databases

BgeeiENSMUSG00000042682.
CleanExiMM_SELK.
GenevisibleiQ9JLJ1. MM.

Interactioni

Subunit structurei

Interacts with DERL1, DERL2, DERL3 and VIMP/SELS. The SELK-VIMP complex interacts with VCP. Part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, VIMP, STT3A AND VCP.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107887.

Family & Domainsi

Sequence similaritiesi

Belongs to the selenoprotein K family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0AZ. Eukaryota.
ENOG410XWKI. LUCA.
GeneTreeiENSGT00390000016119.
HOGENOMiHOG000013002.
HOVERGENiHBG108467.
InParanoidiQ9JLJ1.
OMAiMGRINHW.
OrthoDBiEOG091G1A6A.
PhylomeDBiQ9JLJ1.
TreeFamiTF328380.

Family and domain databases

InterProiIPR024491. Se_SelK/SelG.
[Graphical view]
PfamiPF10961. DUF2763. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYISNGQVL DSRNQSPWRV SFLTDFFWGI AEFVVFFFKT LLQQDVKKRR
60 70 80 90
GYGSSSDSRY DDGRGPPGNP PRRMGRISHL RGPSPPPMAG GUGR
Length:94
Mass (Da):10,642
Last modified:February 26, 2008 - v3
Checksum:i840B51DC9CF7B8F2
GO

Sequence cautioni

The sequence AAF27311 differs from that shown. Reason: Erroneous termination at position 92. Translated as Sec.Curated

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei92 – 921SelenocysteineBy similarity

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170920 mRNA. Translation: AAF27311.1. Sequence problems.
AK003206 mRNA. Translation: BAB22642.2.
AK006674 mRNA. Translation: BAB24699.2.
AK007523 mRNA. Translation: BAB25088.2.
AK008419 mRNA. Translation: BAB25657.2.
BC038049 mRNA. Translation: AAH38049.3.
BC096044 mRNA. Translation: AAH96044.1.
BC096677 mRNA. Translation: AAH96677.2.
CCDSiCCDS36844.1.
RefSeqiNP_064363.2. NM_019979.2.
UniGeneiMm.104491.

Genome annotation databases

EnsembliENSMUST00000112268; ENSMUSP00000107887; ENSMUSG00000042682.
GeneIDi80795.
KEGGimmu:80795.
UCSCiuc007sul.1. mouse.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170920 mRNA. Translation: AAF27311.1. Sequence problems.
AK003206 mRNA. Translation: BAB22642.2.
AK006674 mRNA. Translation: BAB24699.2.
AK007523 mRNA. Translation: BAB25088.2.
AK008419 mRNA. Translation: BAB25657.2.
BC038049 mRNA. Translation: AAH38049.3.
BC096044 mRNA. Translation: AAH96044.1.
BC096677 mRNA. Translation: AAH96677.2.
CCDSiCCDS36844.1.
RefSeqiNP_064363.2. NM_019979.2.
UniGeneiMm.104491.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107887.

PTM databases

iPTMnetiQ9JLJ1.
PhosphoSiteiQ9JLJ1.

Proteomic databases

EPDiQ9JLJ1.
MaxQBiQ9JLJ1.
PaxDbiQ9JLJ1.
PeptideAtlasiQ9JLJ1.
PRIDEiQ9JLJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112268; ENSMUSP00000107887; ENSMUSG00000042682.
GeneIDi80795.
KEGGimmu:80795.
UCSCiuc007sul.1. mouse.

Organism-specific databases

CTDi58515.
MGIiMGI:1931466. Selk.

Phylogenomic databases

eggNOGiENOG410J0AZ. Eukaryota.
ENOG410XWKI. LUCA.
GeneTreeiENSGT00390000016119.
HOGENOMiHOG000013002.
HOVERGENiHBG108467.
InParanoidiQ9JLJ1.
OMAiMGRINHW.
OrthoDBiEOG091G1A6A.
PhylomeDBiQ9JLJ1.
TreeFamiTF328380.

Miscellaneous databases

ChiTaRSiSelk. mouse.
PROiQ9JLJ1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042682.
CleanExiMM_SELK.
GenevisibleiQ9JLJ1. MM.

Family and domain databases

InterProiIPR024491. Se_SelK/SelG.
[Graphical view]
PfamiPF10961. DUF2763. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSELK_MOUSE
AccessioniPrimary (citable) accession number: Q9JLJ1
Secondary accession number(s): Q8CI00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: February 26, 2008
Last modified: September 7, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.