SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9JLJ0

- LITAF_MOUSE

UniProt

Q9JLJ0 - LITAF_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog

Gene
Litaf, N4wbp3, Tbx1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF-alpha) gene expression.2 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. signal transducer activity Source: UniProtKB
  3. WW domain binding Source: UniProtKB

GO - Biological processi

  1. aging Source: Ensembl
  2. apoptotic process Source: UniProtKB-KW
  3. cellular response to lipopolysaccharide Source: MGI
  4. negative regulation of NF-kappaB import into nucleus Source: MGI
  5. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  6. regulation of cytokine production Source: MGI
  7. regulation of transcription, DNA-templated Source: UniProtKB-KW
  8. response to lipopolysaccharide Source: MGI
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
Short name:
LPS-induced TNF-alpha factor homolog
Alternative name(s):
Estrogen-enhanced transcript protein
Short name:
mEET
LITAF-like protein
NEDD4 WW domain-binding protein 3
Gene namesi
Name:Litaf
Synonyms:N4wbp3, Tbx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1929512. Litaf.

Subcellular locationi

Lysosome membrane; Peripheral membrane protein; Cytoplasmic side By similarity
Note: Associated with membranes of lysosomes By similarity.1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. lysosomal membrane Source: MGI
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi23 – 231Y → A: Abolishes interaction with NEDD4. 1 Publication
Mutagenesisi61 – 611Y → A: No effect on interaction with NEDD4. 1 Publication

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Lipopolysaccharide-induced tumor necrosis factor-alpha factor homologPRO_0000084441Add
BLAST

Proteomic databases

PRIDEiQ9JLJ0.

PTM databases

PhosphoSiteiQ9JLJ0.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in liver.2 Publications

Developmental stagei

Strong expression is detected at E.7 and drops at E11.1 Publication

Inductioni

By estrogen and lipopolysaccharides (LPS).2 Publications

Gene expression databases

ArrayExpressiQ9JLJ0.
BgeeiQ9JLJ0.
CleanExiMM_LITAF.
MM_TBX1.
GenevestigatoriQ9JLJ0.

Interactioni

Subunit structurei

Interacts with WWOX By similarity. Interacts with NEDD4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Nedd4P469355EBI-643664,EBI-773516

Protein-protein interaction databases

BioGridi208144. 2 interactions.
IntActiQ9JLJ0. 2 interactions.
MINTiMINT-147796.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi20 – 234WW-binding

Domaini

The WW-binding motif mediates interaction with NEDD4, and probably WWOX By similarity.1 Publication

Sequence similaritiesi

Belongs to the CDIP1/LITAF family.

Phylogenomic databases

eggNOGiNOG41852.
GeneTreeiENSGT00540000071542.
HOGENOMiHOG000039585.
HOVERGENiHBG006272.
InParanoidiQ9JLJ0.
OMAiPFCIDAL.
OrthoDBiEOG7XH6RR.
PhylomeDBiQ9JLJ0.
TreeFamiTF313294.

Family and domain databases

InterProiIPR006629. LITAF.
[Graphical view]
PfamiPF10601. zf-LITAF-like. 1 hit.
[Graphical view]
SMARTiSM00714. LITAF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JLJ0-1 [UniParc]FASTAAdd to Basket

« Hide

MSAPGPYQAA AGPSVVPTAP PTYEETVGVN SYYPTPPAPM PGPATGLITG    50
PDGKGMNPPS YYTQPVPVPN ANAIAVQTVY VQQPVSFYDR PVQMCCPSCS 100
KMIVTQLSYN AGALTWLSCG SLCLLGCVAG CCFIPFCVDA LQDVDHYCPN 150
CKALLGTYKR L 161
Length:161
Mass (Da):16,946
Last modified:October 1, 2000 - v1
Checksum:i7397F79C5AD0CD79
GO

Sequence cautioni

The sequence AAG44246.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF171100 mRNA. Translation: AAF27312.1.
AF230522 mRNA. Translation: AAO49168.1.
AK018578 mRNA. Translation: BAB31289.1.
AK076162 mRNA. Translation: BAC36228.1.
AK151053 mRNA. Translation: BAE30070.1.
AK159533 mRNA. Translation: BAE35161.1.
BC018559 mRNA. Translation: AAH18559.1.
AF220207 mRNA. Translation: AAG44246.1. Different initiation.
CCDSiCCDS27958.1.
RefSeqiNP_064364.1. NM_019980.2.
XP_006522490.1. XM_006522427.1.
UniGeneiMm.294753.

Genome annotation databases

EnsembliENSMUST00000023143; ENSMUSP00000023143; ENSMUSG00000022500.
ENSMUST00000117360; ENSMUSP00000112667; ENSMUSG00000022500.
GeneIDi56722.
KEGGimmu:56722.
UCSCiuc007yen.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF171100 mRNA. Translation: AAF27312.1 .
AF230522 mRNA. Translation: AAO49168.1 .
AK018578 mRNA. Translation: BAB31289.1 .
AK076162 mRNA. Translation: BAC36228.1 .
AK151053 mRNA. Translation: BAE30070.1 .
AK159533 mRNA. Translation: BAE35161.1 .
BC018559 mRNA. Translation: AAH18559.1 .
AF220207 mRNA. Translation: AAG44246.1 . Different initiation.
CCDSi CCDS27958.1.
RefSeqi NP_064364.1. NM_019980.2.
XP_006522490.1. XM_006522427.1.
UniGenei Mm.294753.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 208144. 2 interactions.
IntActi Q9JLJ0. 2 interactions.
MINTi MINT-147796.

PTM databases

PhosphoSitei Q9JLJ0.

Proteomic databases

PRIDEi Q9JLJ0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023143 ; ENSMUSP00000023143 ; ENSMUSG00000022500 .
ENSMUST00000117360 ; ENSMUSP00000112667 ; ENSMUSG00000022500 .
GeneIDi 56722.
KEGGi mmu:56722.
UCSCi uc007yen.2. mouse.

Organism-specific databases

CTDi 9516.
MGIi MGI:1929512. Litaf.

Phylogenomic databases

eggNOGi NOG41852.
GeneTreei ENSGT00540000071542.
HOGENOMi HOG000039585.
HOVERGENi HBG006272.
InParanoidi Q9JLJ0.
OMAi PFCIDAL.
OrthoDBi EOG7XH6RR.
PhylomeDBi Q9JLJ0.
TreeFami TF313294.

Miscellaneous databases

NextBioi 313198.
PROi Q9JLJ0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JLJ0.
Bgeei Q9JLJ0.
CleanExi MM_LITAF.
MM_TBX1.
Genevestigatori Q9JLJ0.

Family and domain databases

InterProi IPR006629. LITAF.
[Graphical view ]
Pfami PF10601. zf-LITAF-like. 1 hit.
[Graphical view ]
SMARTi SM00714. LITAF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Negative regulation of monocyte chemoattractant protein-1 gene expression by a mouse estrogen-enhanced transcript."
    Xie L.-P., Fu W.-X., Jin C., Dong X.-Y., Chen W.-F.
    Eur. J. Immunol. 32:2837-2846(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION, SUBCELLULAR LOCATION.
    Tissue: Thymus.
  2. "Molecular cloning and characterization of mouse LITAF cDNA: role in the regulation of tumor necrosis factor-alpha (TNF-alpha) gene expression."
    Bolcato-Bellemin A.-L., Mattei M.-G., Fenton M., Amar S.
    J. Endotoxin Res. 10:15-23(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION, DEVELOPMENTAL STAGE.
    Tissue: Heart.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Colon and Head.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4."
    Jolliffe C.N., Harvey K.F., Haines B.P., Parasivam G., Kumar S.
    Biochem. J. 351:557-565(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-130, INTERACTION WITH NEDD4, MUTAGENESIS OF TYR-23 AND TYR-61, DOMAIN.
    Tissue: Embryo.

Entry informationi

Entry nameiLITAF_MOUSE
AccessioniPrimary (citable) accession number: Q9JLJ0
Secondary accession number(s): Q9EQI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi