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Q9JLJ0

- LITAF_MOUSE

UniProt

Q9JLJ0 - LITAF_MOUSE

Protein

Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog

Gene

Litaf

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF-alpha) gene expression.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. signal transducer activity Source: UniProtKB
    3. WW domain binding Source: UniProtKB

    GO - Biological processi

    1. aging Source: Ensembl
    2. apoptotic process Source: UniProtKB-KW
    3. cellular response to lipopolysaccharide Source: MGI
    4. negative regulation of NF-kappaB import into nucleus Source: MGI
    5. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    6. regulation of cytokine production Source: MGI
    7. regulation of transcription, DNA-templated Source: UniProtKB-KW
    8. response to lipopolysaccharide Source: MGI
    9. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
    Short name:
    LPS-induced TNF-alpha factor homolog
    Alternative name(s):
    Estrogen-enhanced transcript protein
    Short name:
    mEET
    LITAF-like protein
    NEDD4 WW domain-binding protein 3
    Gene namesi
    Name:Litaf
    Synonyms:N4wbp3, Tbx1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1929512. Litaf.

    Subcellular locationi

    Lysosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: Associated with membranes of lysosomes.By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB
    2. lysosomal membrane Source: MGI
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Lysosome, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi23 – 231Y → A: Abolishes interaction with NEDD4. 1 Publication
    Mutagenesisi61 – 611Y → A: No effect on interaction with NEDD4. 1 Publication

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 161161Lipopolysaccharide-induced tumor necrosis factor-alpha factor homologPRO_0000084441Add
    BLAST

    Proteomic databases

    PRIDEiQ9JLJ0.

    PTM databases

    PhosphoSiteiQ9JLJ0.

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in liver.2 Publications

    Developmental stagei

    Strong expression is detected at E.7 and drops at E11.1 Publication

    Inductioni

    By estrogen and lipopolysaccharides (LPS).2 Publications

    Gene expression databases

    ArrayExpressiQ9JLJ0.
    BgeeiQ9JLJ0.
    CleanExiMM_LITAF.
    MM_TBX1.
    GenevestigatoriQ9JLJ0.

    Interactioni

    Subunit structurei

    Interacts with WWOX By similarity. Interacts with NEDD4.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Nedd4P469355EBI-643664,EBI-773516

    Protein-protein interaction databases

    BioGridi208144. 2 interactions.
    IntActiQ9JLJ0. 2 interactions.
    MINTiMINT-147796.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi20 – 234WW-binding

    Domaini

    The WW-binding motif mediates interaction with NEDD4, and probably WWOX.By similarity

    Sequence similaritiesi

    Belongs to the CDIP1/LITAF family.Curated

    Phylogenomic databases

    eggNOGiNOG41852.
    GeneTreeiENSGT00540000071542.
    HOGENOMiHOG000039585.
    HOVERGENiHBG006272.
    InParanoidiQ9JLJ0.
    OMAiPFCIDAL.
    OrthoDBiEOG7XH6RR.
    PhylomeDBiQ9JLJ0.
    TreeFamiTF313294.

    Family and domain databases

    InterProiIPR006629. LITAF.
    [Graphical view]
    PfamiPF10601. zf-LITAF-like. 1 hit.
    [Graphical view]
    SMARTiSM00714. LITAF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JLJ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAPGPYQAA AGPSVVPTAP PTYEETVGVN SYYPTPPAPM PGPATGLITG    50
    PDGKGMNPPS YYTQPVPVPN ANAIAVQTVY VQQPVSFYDR PVQMCCPSCS 100
    KMIVTQLSYN AGALTWLSCG SLCLLGCVAG CCFIPFCVDA LQDVDHYCPN 150
    CKALLGTYKR L 161
    Length:161
    Mass (Da):16,946
    Last modified:October 1, 2000 - v1
    Checksum:i7397F79C5AD0CD79
    GO

    Sequence cautioni

    The sequence AAG44246.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF171100 mRNA. Translation: AAF27312.1.
    AF230522 mRNA. Translation: AAO49168.1.
    AK018578 mRNA. Translation: BAB31289.1.
    AK076162 mRNA. Translation: BAC36228.1.
    AK151053 mRNA. Translation: BAE30070.1.
    AK159533 mRNA. Translation: BAE35161.1.
    BC018559 mRNA. Translation: AAH18559.1.
    AF220207 mRNA. Translation: AAG44246.1. Different initiation.
    CCDSiCCDS27958.1.
    RefSeqiNP_064364.1. NM_019980.2.
    XP_006522490.1. XM_006522427.1.
    UniGeneiMm.294753.

    Genome annotation databases

    EnsembliENSMUST00000023143; ENSMUSP00000023143; ENSMUSG00000022500.
    ENSMUST00000117360; ENSMUSP00000112667; ENSMUSG00000022500.
    GeneIDi56722.
    KEGGimmu:56722.
    UCSCiuc007yen.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF171100 mRNA. Translation: AAF27312.1 .
    AF230522 mRNA. Translation: AAO49168.1 .
    AK018578 mRNA. Translation: BAB31289.1 .
    AK076162 mRNA. Translation: BAC36228.1 .
    AK151053 mRNA. Translation: BAE30070.1 .
    AK159533 mRNA. Translation: BAE35161.1 .
    BC018559 mRNA. Translation: AAH18559.1 .
    AF220207 mRNA. Translation: AAG44246.1 . Different initiation.
    CCDSi CCDS27958.1.
    RefSeqi NP_064364.1. NM_019980.2.
    XP_006522490.1. XM_006522427.1.
    UniGenei Mm.294753.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208144. 2 interactions.
    IntActi Q9JLJ0. 2 interactions.
    MINTi MINT-147796.

    PTM databases

    PhosphoSitei Q9JLJ0.

    Proteomic databases

    PRIDEi Q9JLJ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023143 ; ENSMUSP00000023143 ; ENSMUSG00000022500 .
    ENSMUST00000117360 ; ENSMUSP00000112667 ; ENSMUSG00000022500 .
    GeneIDi 56722.
    KEGGi mmu:56722.
    UCSCi uc007yen.2. mouse.

    Organism-specific databases

    CTDi 9516.
    MGIi MGI:1929512. Litaf.

    Phylogenomic databases

    eggNOGi NOG41852.
    GeneTreei ENSGT00540000071542.
    HOGENOMi HOG000039585.
    HOVERGENi HBG006272.
    InParanoidi Q9JLJ0.
    OMAi PFCIDAL.
    OrthoDBi EOG7XH6RR.
    PhylomeDBi Q9JLJ0.
    TreeFami TF313294.

    Miscellaneous databases

    NextBioi 313198.
    PROi Q9JLJ0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JLJ0.
    Bgeei Q9JLJ0.
    CleanExi MM_LITAF.
    MM_TBX1.
    Genevestigatori Q9JLJ0.

    Family and domain databases

    InterProi IPR006629. LITAF.
    [Graphical view ]
    Pfami PF10601. zf-LITAF-like. 1 hit.
    [Graphical view ]
    SMARTi SM00714. LITAF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Negative regulation of monocyte chemoattractant protein-1 gene expression by a mouse estrogen-enhanced transcript."
      Xie L.-P., Fu W.-X., Jin C., Dong X.-Y., Chen W.-F.
      Eur. J. Immunol. 32:2837-2846(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION, SUBCELLULAR LOCATION.
      Tissue: Thymus.
    2. "Molecular cloning and characterization of mouse LITAF cDNA: role in the regulation of tumor necrosis factor-alpha (TNF-alpha) gene expression."
      Bolcato-Bellemin A.-L., Mattei M.-G., Fenton M., Amar S.
      J. Endotoxin Res. 10:15-23(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION, DEVELOPMENTAL STAGE.
      Tissue: Heart.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow, Colon and Head.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    5. "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4."
      Jolliffe C.N., Harvey K.F., Haines B.P., Parasivam G., Kumar S.
      Biochem. J. 351:557-565(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-130, INTERACTION WITH NEDD4, MUTAGENESIS OF TYR-23 AND TYR-61, DOMAIN.
      Tissue: Embryo.

    Entry informationi

    Entry nameiLITAF_MOUSE
    AccessioniPrimary (citable) accession number: Q9JLJ0
    Secondary accession number(s): Q9EQI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3