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Protein

Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog

Gene

Litaf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF-alpha) gene expression.2 Publications

GO - Molecular functioni

GO - Biological processi

  • aging Source: Ensembl
  • apoptotic process Source: UniProtKB-KW
  • cellular response to lipopolysaccharide Source: MGI
  • negative regulation of NF-kappaB import into nucleus Source: MGI
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • regulation of cytokine production Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • response to lipopolysaccharide Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
Short name:
LPS-induced TNF-alpha factor homolog
Alternative name(s):
Estrogen-enhanced transcript protein
Short name:
mEET
LITAF-like protein
NEDD4 WW domain-binding protein 3
Gene namesi
Name:Litaf
Synonyms:N4wbp3, Tbx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1929512. Litaf.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi23Y → A: Abolishes interaction with NEDD4. 1 Publication1
Mutagenesisi61Y → A: No effect on interaction with NEDD4. 1 Publication1

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844411 – 161Lipopolysaccharide-induced tumor necrosis factor-alpha factor homologAdd BLAST161

Proteomic databases

PaxDbiQ9JLJ0.
PRIDEiQ9JLJ0.

PTM databases

iPTMnetiQ9JLJ0.
PhosphoSitePlusiQ9JLJ0.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in liver.2 Publications

Developmental stagei

Strong expression is detected at E.7 and drops at E11.1 Publication

Inductioni

By estrogen and lipopolysaccharides (LPS).2 Publications

Gene expression databases

BgeeiENSMUSG00000022500.
CleanExiMM_LITAF.
MM_TBX1.
ExpressionAtlasiQ9JLJ0. baseline and differential.
GenevisibleiQ9JLJ0. MM.

Interactioni

Subunit structurei

Interacts with WWOX (By similarity). Interacts with NEDD4.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Nedd4P469355EBI-643664,EBI-773516

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208144. 2 interactors.
IntActiQ9JLJ0. 2 interactors.
MINTiMINT-147796.
STRINGi10090.ENSMUSP00000023143.

Structurei

3D structure databases

ProteinModelPortaliQ9JLJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi20 – 23WW-binding4

Domaini

The WW-binding motif mediates interaction with NEDD4, and probably WWOX.By similarity

Sequence similaritiesi

Belongs to the CDIP1/LITAF family.Curated

Phylogenomic databases

eggNOGiENOG410IVVU. Eukaryota.
ENOG41122PJ. LUCA.
GeneTreeiENSGT00540000071542.
HOGENOMiHOG000039585.
HOVERGENiHBG006272.
InParanoidiQ9JLJ0.
KOiK19363.
OMAiPFCIDAL.
OrthoDBiEOG091G0XNM.
PhylomeDBiQ9JLJ0.
TreeFamiTF313294.

Family and domain databases

InterProiIPR006629. LITAF.
[Graphical view]
PfamiPF10601. zf-LITAF-like. 1 hit.
[Graphical view]
SMARTiSM00714. LITAF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JLJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPGPYQAA AGPSVVPTAP PTYEETVGVN SYYPTPPAPM PGPATGLITG
60 70 80 90 100
PDGKGMNPPS YYTQPVPVPN ANAIAVQTVY VQQPVSFYDR PVQMCCPSCS
110 120 130 140 150
KMIVTQLSYN AGALTWLSCG SLCLLGCVAG CCFIPFCVDA LQDVDHYCPN
160
CKALLGTYKR L
Length:161
Mass (Da):16,946
Last modified:October 1, 2000 - v1
Checksum:i7397F79C5AD0CD79
GO

Sequence cautioni

The sequence AAG44246 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171100 mRNA. Translation: AAF27312.1.
AF230522 mRNA. Translation: AAO49168.1.
AK018578 mRNA. Translation: BAB31289.1.
AK076162 mRNA. Translation: BAC36228.1.
AK151053 mRNA. Translation: BAE30070.1.
AK159533 mRNA. Translation: BAE35161.1.
BC018559 mRNA. Translation: AAH18559.1.
AF220207 mRNA. Translation: AAG44246.1. Different initiation.
CCDSiCCDS27958.1.
RefSeqiNP_064364.1. NM_019980.2.
XP_006522490.1. XM_006522427.1.
UniGeneiMm.294753.

Genome annotation databases

EnsembliENSMUST00000023143; ENSMUSP00000023143; ENSMUSG00000022500.
ENSMUST00000117360; ENSMUSP00000112667; ENSMUSG00000022500.
GeneIDi56722.
KEGGimmu:56722.
UCSCiuc007yen.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171100 mRNA. Translation: AAF27312.1.
AF230522 mRNA. Translation: AAO49168.1.
AK018578 mRNA. Translation: BAB31289.1.
AK076162 mRNA. Translation: BAC36228.1.
AK151053 mRNA. Translation: BAE30070.1.
AK159533 mRNA. Translation: BAE35161.1.
BC018559 mRNA. Translation: AAH18559.1.
AF220207 mRNA. Translation: AAG44246.1. Different initiation.
CCDSiCCDS27958.1.
RefSeqiNP_064364.1. NM_019980.2.
XP_006522490.1. XM_006522427.1.
UniGeneiMm.294753.

3D structure databases

ProteinModelPortaliQ9JLJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208144. 2 interactors.
IntActiQ9JLJ0. 2 interactors.
MINTiMINT-147796.
STRINGi10090.ENSMUSP00000023143.

PTM databases

iPTMnetiQ9JLJ0.
PhosphoSitePlusiQ9JLJ0.

Proteomic databases

PaxDbiQ9JLJ0.
PRIDEiQ9JLJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023143; ENSMUSP00000023143; ENSMUSG00000022500.
ENSMUST00000117360; ENSMUSP00000112667; ENSMUSG00000022500.
GeneIDi56722.
KEGGimmu:56722.
UCSCiuc007yen.2. mouse.

Organism-specific databases

CTDi9516.
MGIiMGI:1929512. Litaf.

Phylogenomic databases

eggNOGiENOG410IVVU. Eukaryota.
ENOG41122PJ. LUCA.
GeneTreeiENSGT00540000071542.
HOGENOMiHOG000039585.
HOVERGENiHBG006272.
InParanoidiQ9JLJ0.
KOiK19363.
OMAiPFCIDAL.
OrthoDBiEOG091G0XNM.
PhylomeDBiQ9JLJ0.
TreeFamiTF313294.

Miscellaneous databases

PROiQ9JLJ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022500.
CleanExiMM_LITAF.
MM_TBX1.
ExpressionAtlasiQ9JLJ0. baseline and differential.
GenevisibleiQ9JLJ0. MM.

Family and domain databases

InterProiIPR006629. LITAF.
[Graphical view]
PfamiPF10601. zf-LITAF-like. 1 hit.
[Graphical view]
SMARTiSM00714. LITAF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLITAF_MOUSE
AccessioniPrimary (citable) accession number: Q9JLJ0
Secondary accession number(s): Q9EQI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.