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Q9JLI8

- SART3_MOUSE

UniProt

Q9JLI8 - SART3_MOUSE

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Protein
Squamous cell carcinoma antigen recognized by T-cells 3
Gene
Sart3, Kiaa0156
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. RNA binding Source: MGI
  2. nucleotide binding Source: InterPro

GO - Biological processi

  1. RNA processing Source: InterPro
  2. cell morphogenesis Source: MGI
  3. hematopoietic stem cell proliferation Source: MGI
  4. homeostasis of number of cells Source: MGI
  5. regulation of gene expression Source: MGI
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Squamous cell carcinoma antigen recognized by T-cells 3
Short name:
SART-3
Short name:
mSART-3
Alternative name(s):
Tumor-rejection antigen SART3
Gene namesi
Name:Sart3
Synonyms:Kiaa0156
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1858230. Sart3.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Nucleus speckle By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nuclear speck Source: UniProtKB-SubCell
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 962961Squamous cell carcinoma antigen recognized by T-cells 3
PRO_0000223314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei10 – 101Phosphoserine By similarity
Modified residuei852 – 8521Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9JLI8.
PaxDbiQ9JLI8.
PRIDEiQ9JLI8.

PTM databases

PhosphoSiteiQ9JLI8.

Expressioni

Tissue specificityi

Ubiquitously expressed, with low level of expression in liver, heart and skeletal.1 Publication

Developmental stagei

Expressed from early prenatal stages, as early as E7 and increased thereafter.1 Publication

Gene expression databases

BgeeiQ9JLI8.
GenevestigatoriQ9JLI8.

Interactioni

Subunit structurei

Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with AGO1 and AGO2 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9JLI8.
SMRiQ9JLI8. Positions 103-361, 702-877.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili559 – 61860 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi602 – 61817Nuclear localization signal Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 9 HAT repeats.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0724.
GeneTreeiENSGT00730000111098.
HOGENOMiHOG000063708.
HOVERGENiHBG053888.
InParanoidiQ9JLI8.
OMAiYYNLESP.
OrthoDBiEOG72ZCDB.
PhylomeDBiQ9JLI8.
TreeFamiTF317554.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR003107. HAT.
IPR008669. LSM_interact.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF05391. Lsm_interact. 1 hit.
PF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00386. HAT. 7 hits.
SM00360. RRM. 2 hits.
[Graphical view]
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9JLI8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATTAASSAS EPEVEPQAGP EAEGEEDEAK PAGVQRKVLS GAVAAEAAEA    50
KGPGWDLQRE GASGSDGDEE DAMASSAESS AGEDEWEYDE EEEKNQLEIE 100
RLEEQLSING YDYNCHVELI RLLRLEGELS RVRAARQKMS ELFPLTEELW 150
LEWLHDEISM AMDGLDREHV YELFERAVKD YICPNIWLEY GQYSVGGIGQ 200
KGGLEKVRSV FERALSSVGL HMTKGLAIWE AYREFESAIV EAARLEKVHS 250
LFRRQLAIPL YEMEATFAEY EEWSEEPMPE SVLQSYQKAL GQLEKYKPYE 300
EALLQAEAPR LAEYQAYIDF EMKIGDPARI QLIFERALVE NCLVPDLWIR 350
YSQYLDRQLK VKDLVLSVHS RAVRNCPWTV ALWSRYLLAM ERHGLDHQTI 400
SATFENALSA GFIQATDYVE IWQVYLDYLR RRVDFRQDSS KELEELRSMF 450
TRALEYLQQE VEERFSESGD PSCLIMQSWA RVEARLCNNM QKARELWDSI 500
MTRGNAKYAN MWLEYYNLER AHGDTQHCRK ALHRAVQCTS DYPEHVCEVL 550
LTMERTEGTL EDWDLAIQKT ETRLARVNEQ RMKAAEKEAA LVQQEEEKAE 600
QRKKVRAEKK ALKKKKKTRG ADKRREDEDE ENEWGEEEEE QPSKRRRTEN 650
SLASGEASAM KEETELSGKC LTIDVGPPSK QKEKAASLKR DMPKVAHDSS 700
KDSVTVFVSN LPYSIEEPEV KLRPLFEVCG EVVQIRPIFS NRGDFRGYCY 750
VEFGEEKSAQ QALELDRKIV EGRPMFVSPC VDKSKNPDFK VFRYSTTLEK 800
HKLFISGLPF SCTKEELEDI CKAHGTVKDL RLVTNRAGKP KGLAYVEYEN 850
ESQASQAVMK MDGMTIRENV IKVAISNPPQ RKVPEKPEVR TAPGAPMLPR 900
QMYGARGKGR TQLSLLPRAL QRQGAAPQAE NGPAPGPAVA PSVATEAPKM 950
SNADFAKLLL RK 962
Length:962
Mass (Da):109,619
Last modified:October 1, 2000 - v1
Checksum:i23BC235125E7A09C
GO
Isoform 2 (identifier: Q9JLI8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-401: DRQLKVKDLV...RHGLDHQTIS → PCCAELPMDS...RSECRLHPGH
     402-962: Missing.

Note: No experimental confirmation available.

Show »
Length:401
Mass (Da):45,291
Checksum:iAE0B8FA9BE117FFE
GO

Sequence cautioni

The sequence AAH36350.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei356 – 40146DRQLK…HQTIS → PCCAELPMDSCPVESVPSGH GATWTGPSNDFCDLRERSEC RLHPGH in isoform 2.
VSP_017252Add
BLAST
Alternative sequencei402 – 962561Missing in isoform 2.
VSP_017253Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601M → V in BAC39661. 1 Publication
Sequence conflicti792 – 81423FRYST…FSCTK → CFLKKGVFRVGCPIGSAQ in BAC97877. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF172722 mRNA. Translation: AAF65228.1.
AK053828 mRNA. Translation: BAC35544.1.
AK129067 Transcribed RNA. Translation: BAC97877.2.
AK086398 mRNA. Translation: BAC39661.1.
BC036350 mRNA. Translation: AAH36350.1. Different initiation.
BC057156 mRNA. Translation: AAH57156.1.
CCDSiCCDS19552.1. [Q9JLI8-1]
RefSeqiNP_058622.1. NM_016926.1. [Q9JLI8-1]
UniGeneiMm.29594.

Genome annotation databases

EnsembliENSMUST00000019118; ENSMUSP00000019118; ENSMUSG00000018974. [Q9JLI8-1]
GeneIDi53890.
KEGGimmu:53890.
UCSCiuc008yym.1. mouse. [Q9JLI8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF172722 mRNA. Translation: AAF65228.1 .
AK053828 mRNA. Translation: BAC35544.1 .
AK129067 Transcribed RNA. Translation: BAC97877.2 .
AK086398 mRNA. Translation: BAC39661.1 .
BC036350 mRNA. Translation: AAH36350.1 . Different initiation.
BC057156 mRNA. Translation: AAH57156.1 .
CCDSi CCDS19552.1. [Q9JLI8-1 ]
RefSeqi NP_058622.1. NM_016926.1. [Q9JLI8-1 ]
UniGenei Mm.29594.

3D structure databases

ProteinModelPortali Q9JLI8.
SMRi Q9JLI8. Positions 103-361, 702-877.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9JLI8.

Proteomic databases

MaxQBi Q9JLI8.
PaxDbi Q9JLI8.
PRIDEi Q9JLI8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019118 ; ENSMUSP00000019118 ; ENSMUSG00000018974 . [Q9JLI8-1 ]
GeneIDi 53890.
KEGGi mmu:53890.
UCSCi uc008yym.1. mouse. [Q9JLI8-1 ]

Organism-specific databases

CTDi 9733.
MGIi MGI:1858230. Sart3.
Rougei Search...

Phylogenomic databases

eggNOGi COG0724.
GeneTreei ENSGT00730000111098.
HOGENOMi HOG000063708.
HOVERGENi HBG053888.
InParanoidi Q9JLI8.
OMAi YYNLESP.
OrthoDBi EOG72ZCDB.
PhylomeDBi Q9JLI8.
TreeFami TF317554.

Miscellaneous databases

ChiTaRSi SART3. mouse.
NextBioi 310779.
PROi Q9JLI8.
SOURCEi Search...

Gene expression databases

Bgeei Q9JLI8.
Genevestigatori Q9JLI8.

Family and domain databases

Gene3Di 3.30.70.330. 2 hits.
InterProi IPR003107. HAT.
IPR008669. LSM_interact.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF05391. Lsm_interact. 1 hit.
PF00076. RRM_1. 2 hits.
[Graphical view ]
SMARTi SM00386. HAT. 7 hits.
SM00360. RRM. 2 hits.
[Graphical view ]
PROSITEi PS50102. RRM. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse homologue of the human SART3 gene encoding tumor-rejection antigen."
    Harada K., Yamada A., Mine T., Kawagoe N., Takasu H., Itoh K.
    Jpn. J. Cancer Res. 91:239-247(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/c.
    Tissue: Squamous cell carcinoma.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryonic tail.
  3. Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Eye and Head.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: NMRI.
    Tissue: Mammary gland and Mammary tumor.
  6. "Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients."
    Yang D., Nakao M., Shichijo S., Sasatomi T., Takasu H., Matsumoto H., Mori K., Hayashi A., Yamana H., Shirouzu K., Itoh K.
    Cancer Res. 59:4056-4063(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGION.

Entry informationi

Entry nameiSART3_MOUSE
AccessioniPrimary (citable) accession number: Q9JLI8
Secondary accession number(s): Q6ZQI2
, Q8BPK9, Q8C3B7, Q8CFU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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