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Q9JLI8

- SART3_MOUSE

UniProt

Q9JLI8 - SART3_MOUSE

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Protein

Squamous cell carcinoma antigen recognized by T-cells 3

Gene

Sart3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. poly(A) RNA binding Source: Ensembl
  3. RNA binding Source: MGI

GO - Biological processi

  1. cell morphogenesis Source: MGI
  2. hematopoietic stem cell proliferation Source: MGI
  3. homeostasis of number of cells Source: MGI
  4. regulation of gene expression Source: MGI
  5. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Squamous cell carcinoma antigen recognized by T-cells 3
Short name:
SART-3
Short name:
mSART-3
Alternative name(s):
Tumor-rejection antigen SART3
Gene namesi
Name:Sart3
Synonyms:Kiaa0156
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1858230. Sart3.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Nucleus speckle By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 962961Squamous cell carcinoma antigen recognized by T-cells 3PRO_0000223314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei10 – 101PhosphoserineBy similarity
Modified residuei852 – 8521PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9JLI8.
PaxDbiQ9JLI8.
PRIDEiQ9JLI8.

PTM databases

PhosphoSiteiQ9JLI8.

Expressioni

Tissue specificityi

Ubiquitously expressed, with low level of expression in liver, heart and skeletal.1 Publication

Developmental stagei

Expressed from early prenatal stages, as early as E7 and increased thereafter.1 Publication

Gene expression databases

BgeeiQ9JLI8.
GenevestigatoriQ9JLI8.

Interactioni

Subunit structurei

Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with AGO1 and AGO2 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9JLI8.
SMRiQ9JLI8. Positions 103-361, 700-902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili559 – 61860Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi602 – 61817Nuclear localization signalSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 9 HAT repeats.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0724.
GeneTreeiENSGT00730000111098.
HOGENOMiHOG000063708.
HOVERGENiHBG053888.
InParanoidiQ9JLI8.
OMAiYYNLESP.
OrthoDBiEOG72ZCDB.
PhylomeDBiQ9JLI8.
TreeFamiTF317554.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR003107. HAT.
IPR008669. LSM_interact.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF05391. Lsm_interact. 1 hit.
PF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00386. HAT. 7 hits.
SM00360. RRM. 2 hits.
[Graphical view]
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9JLI8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATTAASSAS EPEVEPQAGP EAEGEEDEAK PAGVQRKVLS GAVAAEAAEA
60 70 80 90 100
KGPGWDLQRE GASGSDGDEE DAMASSAESS AGEDEWEYDE EEEKNQLEIE
110 120 130 140 150
RLEEQLSING YDYNCHVELI RLLRLEGELS RVRAARQKMS ELFPLTEELW
160 170 180 190 200
LEWLHDEISM AMDGLDREHV YELFERAVKD YICPNIWLEY GQYSVGGIGQ
210 220 230 240 250
KGGLEKVRSV FERALSSVGL HMTKGLAIWE AYREFESAIV EAARLEKVHS
260 270 280 290 300
LFRRQLAIPL YEMEATFAEY EEWSEEPMPE SVLQSYQKAL GQLEKYKPYE
310 320 330 340 350
EALLQAEAPR LAEYQAYIDF EMKIGDPARI QLIFERALVE NCLVPDLWIR
360 370 380 390 400
YSQYLDRQLK VKDLVLSVHS RAVRNCPWTV ALWSRYLLAM ERHGLDHQTI
410 420 430 440 450
SATFENALSA GFIQATDYVE IWQVYLDYLR RRVDFRQDSS KELEELRSMF
460 470 480 490 500
TRALEYLQQE VEERFSESGD PSCLIMQSWA RVEARLCNNM QKARELWDSI
510 520 530 540 550
MTRGNAKYAN MWLEYYNLER AHGDTQHCRK ALHRAVQCTS DYPEHVCEVL
560 570 580 590 600
LTMERTEGTL EDWDLAIQKT ETRLARVNEQ RMKAAEKEAA LVQQEEEKAE
610 620 630 640 650
QRKKVRAEKK ALKKKKKTRG ADKRREDEDE ENEWGEEEEE QPSKRRRTEN
660 670 680 690 700
SLASGEASAM KEETELSGKC LTIDVGPPSK QKEKAASLKR DMPKVAHDSS
710 720 730 740 750
KDSVTVFVSN LPYSIEEPEV KLRPLFEVCG EVVQIRPIFS NRGDFRGYCY
760 770 780 790 800
VEFGEEKSAQ QALELDRKIV EGRPMFVSPC VDKSKNPDFK VFRYSTTLEK
810 820 830 840 850
HKLFISGLPF SCTKEELEDI CKAHGTVKDL RLVTNRAGKP KGLAYVEYEN
860 870 880 890 900
ESQASQAVMK MDGMTIRENV IKVAISNPPQ RKVPEKPEVR TAPGAPMLPR
910 920 930 940 950
QMYGARGKGR TQLSLLPRAL QRQGAAPQAE NGPAPGPAVA PSVATEAPKM
960
SNADFAKLLL RK
Length:962
Mass (Da):109,619
Last modified:October 1, 2000 - v1
Checksum:i23BC235125E7A09C
GO
Isoform 2 (identifier: Q9JLI8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-401: DRQLKVKDLV...RHGLDHQTIS → PCCAELPMDS...RSECRLHPGH
     402-962: Missing.

Note: No experimental confirmation available.

Show »
Length:401
Mass (Da):45,291
Checksum:iAE0B8FA9BE117FFE
GO

Sequence cautioni

The sequence AAH36350.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601M → V in BAC39661. (PubMed:16141072)Curated
Sequence conflicti792 – 81423FRYST…FSCTK → CFLKKGVFRVGCPIGSAQ in BAC97877. (PubMed:14621295)CuratedAdd
BLAST

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei356 – 40146DRQLK…HQTIS → PCCAELPMDSCPVESVPSGH GATWTGPSNDFCDLRERSEC RLHPGH in isoform 2. 1 PublicationVSP_017252Add
BLAST
Alternative sequencei402 – 962561Missing in isoform 2. 1 PublicationVSP_017253Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172722 mRNA. Translation: AAF65228.1.
AK053828 mRNA. Translation: BAC35544.1.
AK129067 Transcribed RNA. Translation: BAC97877.2.
AK086398 mRNA. Translation: BAC39661.1.
BC036350 mRNA. Translation: AAH36350.1. Different initiation.
BC057156 mRNA. Translation: AAH57156.1.
CCDSiCCDS19552.1. [Q9JLI8-1]
RefSeqiNP_058622.1. NM_016926.1. [Q9JLI8-1]
UniGeneiMm.29594.

Genome annotation databases

EnsembliENSMUST00000019118; ENSMUSP00000019118; ENSMUSG00000018974. [Q9JLI8-1]
GeneIDi53890.
KEGGimmu:53890.
UCSCiuc008yym.1. mouse. [Q9JLI8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172722 mRNA. Translation: AAF65228.1 .
AK053828 mRNA. Translation: BAC35544.1 .
AK129067 Transcribed RNA. Translation: BAC97877.2 .
AK086398 mRNA. Translation: BAC39661.1 .
BC036350 mRNA. Translation: AAH36350.1 . Different initiation.
BC057156 mRNA. Translation: AAH57156.1 .
CCDSi CCDS19552.1. [Q9JLI8-1 ]
RefSeqi NP_058622.1. NM_016926.1. [Q9JLI8-1 ]
UniGenei Mm.29594.

3D structure databases

ProteinModelPortali Q9JLI8.
SMRi Q9JLI8. Positions 103-361, 700-902.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9JLI8.

Proteomic databases

MaxQBi Q9JLI8.
PaxDbi Q9JLI8.
PRIDEi Q9JLI8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019118 ; ENSMUSP00000019118 ; ENSMUSG00000018974 . [Q9JLI8-1 ]
GeneIDi 53890.
KEGGi mmu:53890.
UCSCi uc008yym.1. mouse. [Q9JLI8-1 ]

Organism-specific databases

CTDi 9733.
MGIi MGI:1858230. Sart3.
Rougei Search...

Phylogenomic databases

eggNOGi COG0724.
GeneTreei ENSGT00730000111098.
HOGENOMi HOG000063708.
HOVERGENi HBG053888.
InParanoidi Q9JLI8.
OMAi YYNLESP.
OrthoDBi EOG72ZCDB.
PhylomeDBi Q9JLI8.
TreeFami TF317554.

Miscellaneous databases

ChiTaRSi Sart3. mouse.
NextBioi 310779.
PROi Q9JLI8.
SOURCEi Search...

Gene expression databases

Bgeei Q9JLI8.
Genevestigatori Q9JLI8.

Family and domain databases

Gene3Di 3.30.70.330. 2 hits.
InterProi IPR003107. HAT.
IPR008669. LSM_interact.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF05391. Lsm_interact. 1 hit.
PF00076. RRM_1. 2 hits.
[Graphical view ]
SMARTi SM00386. HAT. 7 hits.
SM00360. RRM. 2 hits.
[Graphical view ]
PROSITEi PS50102. RRM. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse homologue of the human SART3 gene encoding tumor-rejection antigen."
    Harada K., Yamada A., Mine T., Kawagoe N., Takasu H., Itoh K.
    Jpn. J. Cancer Res. 91:239-247(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/c.
    Tissue: Squamous cell carcinoma.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryonic tail.
  3. Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Eye and Head.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: NMRI.
    Tissue: Mammary gland and Mammary tumor.
  6. "Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients."
    Yang D., Nakao M., Shichijo S., Sasatomi T., Takasu H., Matsumoto H., Mori K., Hayashi A., Yamana H., Shirouzu K., Itoh K.
    Cancer Res. 59:4056-4063(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGION.

Entry informationi

Entry nameiSART3_MOUSE
AccessioniPrimary (citable) accession number: Q9JLI8
Secondary accession number(s): Q6ZQI2
, Q8BPK9, Q8C3B7, Q8CFU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3