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Q9JLI8

- SART3_MOUSE

UniProt

Q9JLI8 - SART3_MOUSE

Protein

Squamous cell carcinoma antigen recognized by T-cells 3

Gene

Sart3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. RNA binding Source: MGI

    GO - Biological processi

    1. cell morphogenesis Source: MGI
    2. hematopoietic stem cell proliferation Source: MGI
    3. homeostasis of number of cells Source: MGI
    4. regulation of gene expression Source: MGI
    5. RNA processing Source: InterPro

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Squamous cell carcinoma antigen recognized by T-cells 3
    Short name:
    SART-3
    Short name:
    mSART-3
    Alternative name(s):
    Tumor-rejection antigen SART3
    Gene namesi
    Name:Sart3
    Synonyms:Kiaa0156
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1858230. Sart3.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Nucleus speckle By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nuclear speck Source: UniProtKB-SubCell
    3. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 962961Squamous cell carcinoma antigen recognized by T-cells 3PRO_0000223314Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei10 – 101PhosphoserineBy similarity
    Modified residuei852 – 8521PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9JLI8.
    PaxDbiQ9JLI8.
    PRIDEiQ9JLI8.

    PTM databases

    PhosphoSiteiQ9JLI8.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed, with low level of expression in liver, heart and skeletal.1 Publication

    Developmental stagei

    Expressed from early prenatal stages, as early as E7 and increased thereafter.1 Publication

    Gene expression databases

    BgeeiQ9JLI8.
    GenevestigatoriQ9JLI8.

    Interactioni

    Subunit structurei

    Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with AGO1 and AGO2 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JLI8.
    SMRiQ9JLI8. Positions 103-361, 702-877.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili559 – 61860Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi602 – 61817Nuclear localization signalSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 9 HAT repeats.Curated
    Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG0724.
    GeneTreeiENSGT00730000111098.
    HOGENOMiHOG000063708.
    HOVERGENiHBG053888.
    InParanoidiQ9JLI8.
    OMAiYYNLESP.
    OrthoDBiEOG72ZCDB.
    PhylomeDBiQ9JLI8.
    TreeFamiTF317554.

    Family and domain databases

    Gene3Di3.30.70.330. 2 hits.
    InterProiIPR003107. HAT.
    IPR008669. LSM_interact.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF05391. Lsm_interact. 1 hit.
    PF00076. RRM_1. 2 hits.
    [Graphical view]
    SMARTiSM00386. HAT. 7 hits.
    SM00360. RRM. 2 hits.
    [Graphical view]
    PROSITEiPS50102. RRM. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9JLI8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATTAASSAS EPEVEPQAGP EAEGEEDEAK PAGVQRKVLS GAVAAEAAEA    50
    KGPGWDLQRE GASGSDGDEE DAMASSAESS AGEDEWEYDE EEEKNQLEIE 100
    RLEEQLSING YDYNCHVELI RLLRLEGELS RVRAARQKMS ELFPLTEELW 150
    LEWLHDEISM AMDGLDREHV YELFERAVKD YICPNIWLEY GQYSVGGIGQ 200
    KGGLEKVRSV FERALSSVGL HMTKGLAIWE AYREFESAIV EAARLEKVHS 250
    LFRRQLAIPL YEMEATFAEY EEWSEEPMPE SVLQSYQKAL GQLEKYKPYE 300
    EALLQAEAPR LAEYQAYIDF EMKIGDPARI QLIFERALVE NCLVPDLWIR 350
    YSQYLDRQLK VKDLVLSVHS RAVRNCPWTV ALWSRYLLAM ERHGLDHQTI 400
    SATFENALSA GFIQATDYVE IWQVYLDYLR RRVDFRQDSS KELEELRSMF 450
    TRALEYLQQE VEERFSESGD PSCLIMQSWA RVEARLCNNM QKARELWDSI 500
    MTRGNAKYAN MWLEYYNLER AHGDTQHCRK ALHRAVQCTS DYPEHVCEVL 550
    LTMERTEGTL EDWDLAIQKT ETRLARVNEQ RMKAAEKEAA LVQQEEEKAE 600
    QRKKVRAEKK ALKKKKKTRG ADKRREDEDE ENEWGEEEEE QPSKRRRTEN 650
    SLASGEASAM KEETELSGKC LTIDVGPPSK QKEKAASLKR DMPKVAHDSS 700
    KDSVTVFVSN LPYSIEEPEV KLRPLFEVCG EVVQIRPIFS NRGDFRGYCY 750
    VEFGEEKSAQ QALELDRKIV EGRPMFVSPC VDKSKNPDFK VFRYSTTLEK 800
    HKLFISGLPF SCTKEELEDI CKAHGTVKDL RLVTNRAGKP KGLAYVEYEN 850
    ESQASQAVMK MDGMTIRENV IKVAISNPPQ RKVPEKPEVR TAPGAPMLPR 900
    QMYGARGKGR TQLSLLPRAL QRQGAAPQAE NGPAPGPAVA PSVATEAPKM 950
    SNADFAKLLL RK 962
    Length:962
    Mass (Da):109,619
    Last modified:October 1, 2000 - v1
    Checksum:i23BC235125E7A09C
    GO
    Isoform 2 (identifier: Q9JLI8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         356-401: DRQLKVKDLV...RHGLDHQTIS → PCCAELPMDS...RSECRLHPGH
         402-962: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:401
    Mass (Da):45,291
    Checksum:iAE0B8FA9BE117FFE
    GO

    Sequence cautioni

    The sequence AAH36350.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti160 – 1601M → V in BAC39661. (PubMed:16141072)Curated
    Sequence conflicti792 – 81423FRYST…FSCTK → CFLKKGVFRVGCPIGSAQ in BAC97877. (PubMed:14621295)CuratedAdd
    BLAST

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei356 – 40146DRQLK…HQTIS → PCCAELPMDSCPVESVPSGH GATWTGPSNDFCDLRERSEC RLHPGH in isoform 2. 1 PublicationVSP_017252Add
    BLAST
    Alternative sequencei402 – 962561Missing in isoform 2. 1 PublicationVSP_017253Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF172722 mRNA. Translation: AAF65228.1.
    AK053828 mRNA. Translation: BAC35544.1.
    AK129067 Transcribed RNA. Translation: BAC97877.2.
    AK086398 mRNA. Translation: BAC39661.1.
    BC036350 mRNA. Translation: AAH36350.1. Different initiation.
    BC057156 mRNA. Translation: AAH57156.1.
    CCDSiCCDS19552.1. [Q9JLI8-1]
    RefSeqiNP_058622.1. NM_016926.1. [Q9JLI8-1]
    UniGeneiMm.29594.

    Genome annotation databases

    EnsembliENSMUST00000019118; ENSMUSP00000019118; ENSMUSG00000018974. [Q9JLI8-1]
    GeneIDi53890.
    KEGGimmu:53890.
    UCSCiuc008yym.1. mouse. [Q9JLI8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF172722 mRNA. Translation: AAF65228.1 .
    AK053828 mRNA. Translation: BAC35544.1 .
    AK129067 Transcribed RNA. Translation: BAC97877.2 .
    AK086398 mRNA. Translation: BAC39661.1 .
    BC036350 mRNA. Translation: AAH36350.1 . Different initiation.
    BC057156 mRNA. Translation: AAH57156.1 .
    CCDSi CCDS19552.1. [Q9JLI8-1 ]
    RefSeqi NP_058622.1. NM_016926.1. [Q9JLI8-1 ]
    UniGenei Mm.29594.

    3D structure databases

    ProteinModelPortali Q9JLI8.
    SMRi Q9JLI8. Positions 103-361, 702-877.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9JLI8.

    Proteomic databases

    MaxQBi Q9JLI8.
    PaxDbi Q9JLI8.
    PRIDEi Q9JLI8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019118 ; ENSMUSP00000019118 ; ENSMUSG00000018974 . [Q9JLI8-1 ]
    GeneIDi 53890.
    KEGGi mmu:53890.
    UCSCi uc008yym.1. mouse. [Q9JLI8-1 ]

    Organism-specific databases

    CTDi 9733.
    MGIi MGI:1858230. Sart3.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0724.
    GeneTreei ENSGT00730000111098.
    HOGENOMi HOG000063708.
    HOVERGENi HBG053888.
    InParanoidi Q9JLI8.
    OMAi YYNLESP.
    OrthoDBi EOG72ZCDB.
    PhylomeDBi Q9JLI8.
    TreeFami TF317554.

    Miscellaneous databases

    ChiTaRSi SART3. mouse.
    NextBioi 310779.
    PROi Q9JLI8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JLI8.
    Genevestigatori Q9JLI8.

    Family and domain databases

    Gene3Di 3.30.70.330. 2 hits.
    InterProi IPR003107. HAT.
    IPR008669. LSM_interact.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF05391. Lsm_interact. 1 hit.
    PF00076. RRM_1. 2 hits.
    [Graphical view ]
    SMARTi SM00386. HAT. 7 hits.
    SM00360. RRM. 2 hits.
    [Graphical view ]
    PROSITEi PS50102. RRM. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse homologue of the human SART3 gene encoding tumor-rejection antigen."
      Harada K., Yamada A., Mine T., Kawagoe N., Takasu H., Itoh K.
      Jpn. J. Cancer Res. 91:239-247(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: BALB/c.
      Tissue: Squamous cell carcinoma.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Embryonic tail.
    3. Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Eye and Head.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: NMRI.
      Tissue: Mammary gland and Mammary tumor.
    6. "Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients."
      Yang D., Nakao M., Shichijo S., Sasatomi T., Takasu H., Matsumoto H., Mori K., Hayashi A., Yamana H., Shirouzu K., Itoh K.
      Cancer Res. 59:4056-4063(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: REGION.

    Entry informationi

    Entry nameiSART3_MOUSE
    AccessioniPrimary (citable) accession number: Q9JLI8
    Secondary accession number(s): Q6ZQI2
    , Q8BPK9, Q8C3B7, Q8CFU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3